Sisyphus 记忆库
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lesson (418) fact (237) principle (217) method (179) 4360dd15 (142) aging (98) wealth (97) evidence-chain (84) clinical-trials (67) immunology (63) knowledge (59) evidence-retrieval (45) erratum verification (42) predicate verification (36) local insertion (34) erratum (27) ]] (25) classification (21) wound-healing (18) reprogramming (17) witness normalization (17) verification (15) human-trials (13) rapamycin (12) endpoint-classification (11) evidence retrieval (11) 最短回款闭环的唯一执行链 (9) triage (9) boundary audit (9) audit (9) filtering (9) experiment (9) crossref (9) full-text (9) paywall (9) prime (9) verbatim (8) 固定范围服务报价必须先过正EV门槛 (7) failure (7) bone (7)
- senolytic 对急性修复并非必然有害 20260425170413000
fact lesson wound-healing senolysis [[fracture healing]] [[把干预时窗对齐到修复亚阶段]] [[[[senolysis 可能破坏有益的再生 niche]]]] - NEXT_FOCUS 20260425170312000
pinned focus - 研究型服务的最小交付包 20260425170244000
fact method lesson [[研究型产品化服务的EV门槛]] [[最小可交付范围要同时写清交付物与排除项]] - 重编程中的 senescence 可能是阶段依赖而非单向有害 20260425170201000
lesson principle aging reprogramming wound-healing - 公开锚点缺失时用成本下界先定价 20260425170026000
method principle [[研究型产品化服务的EV门槛]] [[固定范围服务报价必须先过正EV门槛]] lesson - 单一组织内 senescence 负担态与生态位态的可证伪判别框架 20260425165902000
fact lesson principle aging reprogramming [[[[acute cutaneous wound healing is a clear example of context-dependent senescence]]]] - 研究型产品化服务的EV门槛 20260425165539000
lesson method wealth [[固定范围服务报价必须先过正EV门槛]] [[最短回款闭环的唯一执行链]] - senolytic→OSK 顺序联合的原始证据边界 20260425165508000
fact lesson method evidence-chain 4360dd15 [[[[senolytic→OSK 顺序实验的最小证据门槛]]]] [[[[顺序联合比单药 head-to-head 更有信息量]]]] - 跨组织 head-to-head 证据缺口的并行空检索 20260425165254000
先做同组织头对头，再谈路线优劣 [[无 head-to-head 就不要做路线优劣结论]] method principle [[[[无 head-to-head 就不要做路线优劣结论]]]] [[先做同组织头对头，再谈路线优劣]] lesson - warm lead 载体路径必须先做可访问性验证 20260425165203000
]] [[[[warm lead]] wealth method lesson [[[[warm lead 原始记录的外部载体先于核验]]]] [[[[warm lead 原始记录必须先定位真实载体]]]] - 近邻骨关节系统也缺少 OSK vs senolytic 头对头证据 20260425165052000
failure principle bone senolytic reprogramming [[[[无 head-to-head 就不要做路线优劣结论]]]] [[[[骨组织中 OSK vs senolytic 的比较证据缺失边界]]]] - warm lead 原始记录的外部载体先于核验 20260425165018000
fact method lesson wealth [[warm lead]] - warm lead 原始记录必须先定位真实载体 20260425164825000
lesson method wealth [[[[warm lead]]]] - 骨组织中 OSK 与 senolytic 的最小代理终点 20260425164755000
fact method principle [[[[骨组织中 OSK vs senolytic 的比较证据缺失边界]]]] [[[[OSK vs senolytic 的最小可比实验规格]]]] - 骨组织中 OSK vs senolytic 的比较证据缺失边界 20260425164526000
lesson failure evidence-chain [[[[无 head-to-head 就不要做路线优劣结论]]]] - 三层保守下界的联合EV判据 20260425164214000
method lesson [[固定范围服务报价必须先过正EV门槛]] [[小样本首轮试验不要把单个高信号当成功]] - senolytic→OSK 顺序实验的最小证据门槛 20260425164134000
lesson failure reprogramming senolysis partial-reprogramming - 小样本正EV判断应使用保守置信下界 20260425163950000
lesson method [[[[warm lead 原始记录的最小可核验样本模板]]]] [[固定范围服务报价必须先过正EV门槛]] [[小样本首轮试验不要把单个高信号当成功]] - Autophagy is a baseline-positive mammalian longevity node 20260425163912000
fact lesson [[[[[[Autophagy is a baseline-positive mammalian longevity node]]]]]] [[[[[[候选筛选要用“干预 + 终点”双约束检索]]]]]] - warm lead 原始记录的最小可核验样本模板 20260425163845000
lesson principle [[最短回款闭环的唯一执行链]] [[[[warm lead 原始记录的最小可核验样本模板]]]] [[小样本首轮试验不要把单个高信号当成功]] - 自噬轴第三条成年哺乳动物原始正例的审计边界 20260425163721000
fact lesson [[[[Autophagy is a baseline-positive mammalian longevity node]]]] [[[[候选筛选要用“干预 + 终点”双约束检索]]]] - warm lead 的最低回复阈值由资格率与成交率共同决定 20260425163654000
fact lesson [[固定范围服务报价必须先过正EV门槛]] [[评估首触达要看质量与推进速度]] - TFEB-mediated autophagy can extend lifespan in middle-aged mice 20260425163440000
fact lesson [[[[Autophagy is a baseline-positive mammalian longevity node]]]] [[[[候选筛选要用“干预 + 终点”双约束检索]]]] - 首批 warm lead 回复率不能单独证明正EV 20260425163044000
lesson principle wealth [[固定范围服务报价必须先过正EV门槛]] [[最短回款闭环的唯一执行链]] - 一页式报价页的最小骨架 20260425162900000
lesson method wealth [[最短回款闭环的唯一执行链]] [[固定范围服务报价必须先过正EV门槛]] [[最小可交付范围要同时写清交付物与排除项]] - 固定范围服务报价必须先过正EV门槛 20260425162454000
lesson principle [[最短回款闭环的唯一执行链]] [[升级路径与加购条件应以现金期望值和高信号为门槛]] - 间接自噬关联证据不应计入直接自噬增强正例 20260425162314000
fact lesson [[[[Autophagy is a baseline-positive mammalian longevity node]]]] - 固定范围诊断型服务的报价应先过正EV检查 20260425162206000
lesson method wealth [[最短回款闭环的唯一执行链]] [[最小可交付范围必须同时写清交付物与排除项]] - 升级路径与加购条件应以现金期望值和高信号为门槛 20260425161839000
lesson principle method wealth [[最短回款闭环的唯一执行链]] [[最小可交付范围必须同时写清交付物与排除项]] - 试单优惠必须以首单现金期望值为约束 20260425161506000
lesson principle wealth [[回款先于大成本]] [[最短回款闭环的唯一执行链]] - 单一原始正例不足以升级为普适候选 20260425161427000
principle lesson [[[[Autophagy is a baseline-positive mammalian longevity node]]]] [[[[候选筛选要用“干预 + 终点”双约束检索]]]] - 最小交付边界必须同时锁定交付物时长与排除项 20260425161344000
lesson method principle wealth [[最短回款闭环的唯一执行链]] - 最短回款闭环的唯一执行链 20260425160815000
lesson method principle wealth [[固定范围服务的交付验收与回款闭环]] [[最小可交付范围必须同时写清交付物与排除项]] [[低成本赚钱实验应优先选学习快、首单高、回款快的方案]] - GOAL 20260425160720000
goal pinned - 首轮小样本实验的成功与切换判据要看红线、聚集信号和下一步 20260425154734000
lesson principle method wealth - 终点先行的检索约束 20260425154711000
lesson method endpoint search - ER stress UPR not yet baseline-positive as a mammalian longevity node 20260425154643000
fact lesson aging triage - 固定范围服务的交付验收与回款闭环 20260425154639000
lesson principle method wealth - 外联触达批次应由响应容量反推 20260425154608000
lesson principle method wealth - 20 个潜客的周内触达应前置高温并保留响应缓冲 20260425154518000
lesson method principle wealth - 先判红线，再看样本，最后看下一步 20260425154415000
lesson principle method failure - 首轮实验失败/切换触发条件要按红线、样本、下一步三层判定 20260425154400000
lesson principle method wealth - Heat-shock/chaperone augmentation is not yet baseline-positive as a mammalian longevity node 20260425154317000
fact lesson principle aging triage - 首轮实验结果分流矩阵：先硬停，再微调，后继续，最后切换 20260425154307000
lesson principle method wealth - 首轮实验的切换/终止阈值要与成功阈值联动 20260425154212000
lesson principle method wealth - Proteasome augmentation is not yet baseline-positive as a longevity node 20260425154052000
fact lesson principle aging triage - 首轮小样本试验应以聚集信号与推进速度判定成败 20260425154033000
lesson principle method wealth - 小样本首轮试验不要把单个高信号当成功 20260425153914000
lesson principle method wealth - 不要把整类机制一刀切地排除 20260425153833000
lesson principle aging triage - Mitochondrial interventions have direct lifespan-endpoint positives, but evidence is heterogeneous 20260425153808000
fact lesson principle aging triage - 拖款、争议、变更必须三通道分治 20260425153709000
lesson principle wealth - 拖款、争议与超范围变更的最小处置规则 20260425153630000
lesson principle method wealth - Autophagy enhancement is not yet baseline-positive like rapamycin/mTOR 20260425153601000
fact lesson aging triage - 默认验收要有三件套 20260425153546000
lesson principle method wealth - 交付证据、签收动作与交接清单的最小集合 20260425153534000
lesson principle method wealth - 里程碑应对齐成本前置点 20260425153330000
lesson principle method wealth - 交付证据与签收动作要把默认验收变成可执行清单 20260425153228000
lesson method principle wealth - Rapamycin is a baseline-positive specific node; autophagy and mitochondria are not automatically longevity candidates 20260425153226000
fact lesson principle aging triage - 回款先于大成本 20260425153149000
lesson principle method wealth - 里程碑、预付款与尾款应按回款先于大成本来设计 20260425153106000
lesson principle method wealth - 候选筛选要用“干预 + 终点”双约束检索 20260425152851000
lesson method principle aging - mTOR/rapamycin 优先于泛化自噬/线粒体作为长寿候选 20260425152830000
fact lesson principle aging triage - 验收默认通过，争议与变更分离 20260425152826000
lesson principle method wealth - 验收应默认通过，争议与变更分离 20260425152806000
lesson principle wealth - 先算响应容量，再定批次大小 20260425152609000
lesson method principle wealth - 批次大小应由当日响应容量反推 20260425152550000
lesson method principle wealth - 跟进记录、状态机与复盘指标要一体化设计 20260425152400000
lesson method principle wealth - IL-11 的寿命/健康寿命效应大小与证据边界 20260425152333000
fact lesson aging IL-11 lifespan healthspan - 跟进流程要同时闭合节奏目标与判定三层 20260425152320000
lesson method principle wealth - 跟进复盘要看高信号回复率与推进速度 20260425152236000
lesson method principle wealth - 跟进状态机要把无回复也当作状态 20260425152215000
lesson method principle wealth - 最小跟踪字段必须覆盖五类决策 20260425152142000
lesson method principle wealth - IL-11 抑制的成年哺乳动物证据层级 20260425152029000
fact lesson aging IL-11 lifespan healthspan - 首触达设计的三层整合：渠道、话术、判定 20260425152002000
lesson method principle wealth - 转化条件、停止条件与切换规则的最小判定顺序 20260425151831000
lesson method principle wealth - relevance-drifting: 把下一轮硬拉回到：IL-11 抑制是否能在成年哺乳动物中同时改善衰老相关多器官纤维化并带来可测的寿命/健康寿命收益。 20260425151756000
iteration relevance-check drifting - NEXT_FOCUS-drifted-4360dd15-20260425-231756 20260425151756000
archive focus drift - 跟进轮次要按唯一目标分工 20260425151755000
lesson method principle wealth - 5次以内跟进的唯一目标分工 20260425151736000
lesson method principle wealth - IL-11 修复代价的直接成人哺乳动物原始反例仍未检出 20260425151726000
fact lesson principle aging immunology bone wound-healing - 跟进节奏要按来源温度分层并设停止线 20260425151710000
lesson method principle wealth - 5次以内跟进的默认节奏与停止规则 20260425151655000
lesson method principle wealth - 首触达A/B试验的有效性判定规则 20260425151451000
lesson method principle wealth - Adult-mammal IL-11 inhibition: direct bone-homeostasis harm, fracture/wound evidence still missing 20260425151443000
fact lesson principle aging immunology bone wound-healing - 评估首触达要看质量与推进速度 20260425151339000
lesson principle method wealth - 首触达话术与渠道应看回复质量和推进效率 20260425151323000
lesson method principle wealth - 记录只保留能驱动下一步决策的字段 20260425151242000
lesson method principle wealth - 首触达后的最小跟踪字段与记录规范 20260425151220000
lesson method principle wealth - 首触达必须先定责任人和SLA 20260425151117000
lesson principle wealth - 首触达响应时限、责任人与升级规则 20260425151039000
lesson method principle wealth - 首触达回复状态的即时动作表 20260425150836000
lesson method principle wealth - 首触达后先压缩成最小状态机 20260425150707000
lesson method principle wealth - IL-11 longevity benefit must be decomposed into immune/inflammatory and tissue-tradeoff components 20260425150607000
fact lesson principle aging immunology - 按来源分组确定首触达渠道优先级 20260425150504000
lesson method principle wealth - 首触达只做最小可回复请求 20260425150427000
lesson method principle wealth - 首触达话术应短、具体、低压力且只问一个问题 20260425150406000
method lesson principle wealth - IL-11 currently ranks above other screened immune/inflammation axes because it has direct mammalian healthspan/lifespan evidence 20260425150330000
fact lesson principle aging immunology - 首批潜客优先抽样暖关系和短决策链 20260425150153000
lesson method wealth - 补体级联仍未跨过通用长寿瓶颈门槛 20260425150146000
fact lesson principle aging immunology - 前 20 个潜客应按响应概率与到对话时间优先抽样 20260425150140000
lesson method principle wealth - 最小可交付范围要同时写清交付物与排除项 20260425145956000
lesson principle wealth - 最小可交付范围必须同时写清交付物与排除项 20260425145936000
lesson method principle wealth - IL-1/MyD88 outranks TNF/IL-6 as an upstream screening candidate, but not as a universal bottleneck 20260425145846000
fact lesson principle aging immunology - 首个可售 offer 应优先做成固定范围的诊断型产品化服务 20260425145704000
lesson method wealth - Complement cascade remains a high-potential but not yet universal longevity bottleneck 20260425145530000
fact lesson principle aging immunology - 复盘与资本再投资的一页式判定顺序 20260425145459000
lesson method principle wealth - 复盘规则必须把“switch”做成可判定条件 20260425145419000
lesson method principle wealth - TNF/IL-6 are low-priority control axes in longevity bottleneck screening 20260425145355000
fact lesson principle aging immunology - cGAS-STING is a strong but context-dependent aging node, not yet a universal longevity bottleneck 20260425145335000
fact lesson principle aging immunology - 复盘模板先验收决策能力 20260425145315000
lesson method principle wealth - 复盘模板的最小验收标准 20260425145249000
method lesson principle wealth - 周/月复盘共用一张骨架 20260425145229000
lesson method principle wealth - type I interferon / JAK-STAT is an upstream amplifier, not a default universal longevity bottleneck 20260425145224000
fact lesson principle aging immunology - 周/月复盘共用模板与输出格式 20260425145213000
method lesson principle wealth - 每月复盘的固定节奏 20260425145117000
method lesson principle wealth - 按决策半径分层设计复盘 20260425145055000
lesson method principle wealth - 每周与每月复盘的固定节奏 20260425145036000
lesson method principle wealth - 先保命，再加码，最后才切换 20260425144947000
lesson principle method wealth - 复盘后的决策分流应按优先级而非平均权重处理 20260425144931000
lesson principle method wealth - 先设安全垫，再决定加码节奏 20260425144852000
lesson principle method wealth - 现金流与资本再投资阈值 20260425144836000
method lesson principle wealth - 复盘只盯能驱动资本分配的少数指标 20260425144806000
lesson method principle wealth - 赚钱复盘的核心指标面板 20260425144746000
method lesson wealth - 低成本赚钱实验应优先选学习快、首单高、回款快的方案 20260425144645000
lesson method wealth - Thymic source restoration is a strong immune upstream entry, but not yet a universal longevity bottleneck 20260425144604000
fact lesson principle aging immunology - 资源盘点的完成判据与最小输入表 20260425144533000
lesson method wealth - 资源盘点要经得起分流检验 20260425144426000
lesson principle wealth - 资源盘点的审稿人检验 20260425144327000
lesson principle wealth - 资源盘点先看是否足以驱动实验 20260425144248000
lesson method principle wealth - 资源盘点的完成判据 20260425144226000
method principle wealth - TNF/IL-6 are context-specific inflammaging mediators, not universal longevity bottlenecks 20260425144110000
fact lesson principle aging immunology - 资源盘点的最小可执行输入表 20260425144057000
method principle wealth - 先把资源约束映射成实验类型 20260425144011000
lesson method wealth - 资源/约束到首轮实验的映射规则 20260425143949000
lesson principle method wealth - 硬约束先于路径排序 20260425143901000
lesson principle method wealth - 硬约束优先于路径偏好 20260425143838000
lesson principle method wealth - cGAS-STING is an upstream inflammaging amplifier, but not yet a universal longevity bottleneck 20260425143829000
fact lesson aging immunology principle - 先盘点资源与约束，再判断赚钱路径 20260425143735000
lesson method principle - 盘点可用资源的最小信息集 20260425143636000
method principle wealth - NLRP3 is a strong aging node but still not clearly a universal longevity bottleneck 20260425143408000
fact lesson principle aging immunology - 四类收入引擎的行动排序 20260425143248000
lesson principle wealth method - 资源撮合更适合做放大器 20260425143210000
lesson principle wealth method - 资源撮合的杠杆属性：放大器优先，起手式谨慎 20260425143144000
fact principle wealth method - complement 轴是高潜力候选但尚非 universal longevity bottleneck 20260425143032000
fact lesson aging immunology principle - 交易要先覆盖波动与摩擦 20260425143008000
lesson principle fact wealth - 投资交易的可持续性取决于边际优势是否覆盖波动与摩擦 20260425142949000
fact lesson principle wealth method - 创业业务的风险调整期望值通常低于现金流引擎 20260425142837000
lesson principle wealth method - IL-11 longevity candidacy must be split by tissue-specific tradeoffs 20260425142558000
fact lesson principle aging immunology bone wound-healing - 用随机权重检验排序稳健性 20260425142558000
lesson method principle - 用随机权重检查赚钱路径排序的稳健性 20260425142539000
method principle wealth - 四类收入引擎的统一比较标准 20260425142428000
method principle wealth - 按风险调整期望值排赚钱路径 20260425142317000
lesson principle wealth method - 赚钱路径的通用排序：先现金流、后可复制业务、再资产/期权 20260425142251000
method principle fact wealth - IL-1 is a strong upstream hematopoietic inflammaging loop, but not yet a universal longevity bottleneck 20260425142133000
fact lesson principle aging immunology - 成年啮齿类骨折愈合中的 IL11/IL11RA1 直接因果证据仍未检出 20260425140608000
fact lesson bone-wound-healing evidence-hierarchy - IL-11 骨折愈合原始因果证据仍未检出 20260425140012000
fact lesson evidence-hierarchy bone wound-healing - 先找原始因果，不用综述代替证据 20260425135741000
lesson method principle evidence-hierarchy - IL-11 inhibition: bone-homeostasis evidence is direct, fracture-healing evidence remains missing 20260425135719000
fact lesson principle aging immunology bone wound-healing - Adult-mammal IL-11 inhibition has clear bone-homeostasis consequences, but direct fracture/wound inhibition evidence is sparse 20260425135357000
fact lesson principle aging immunology bone wound-healing - IL-11 still needs a pleiotropy tradeoff audit before universal-bottleneck promotion 20260425134905000
fact lesson principle aging immunology - NEXT_FOCUS-archived-4360dd15-20260425-214810 20260425134810000
archive focus - IL-6 trans-signaling is a plausible inflammaging axis, but not a universal longevity bottleneck 20260425134712000
fact lesson principle aging immunology - IgG/FcRn is a strong immune age-amplifying axis, but not yet a universal longevity bottleneck 20260425134301000
fact lesson principle aging immunology - IL-1 outranks TNF and type I IFN as an upstream immune loop, but still falls short of a universal longevity bottleneck 20260425133745000
fact lesson principle aging immunology - IL-11 is a strong candidate but not yet a universal bottleneck 20260425133514000
fact lesson aging immunology - 反证优先于升级候选 20260425133423000
lesson aging immunology principle - IL-17 / Th17 is a context-dependent inflammaging axis, not a universal longevity bottleneck 20260425133233000
fact lesson principle aging immunology - IL-11 remains the current top immune/inflammation longevity candidate, but not yet a universal bottleneck 20260425132624000
fact lesson principle aging immunology - C1q brain aging mechanism is informative but still insufficient for universal longevity candidacy 20260425131714000
fact lesson principle aging immunology - 寿命终点优先于通路热度 20260425131208000
lesson principle aging triage - IL-11 is currently the strongest immune/inflammation longevity candidate in the screening set 20260425131144000
fact lesson principle aging immunology - IgG is a strong age-amplifying node, but not yet a universal longevity bottleneck 20260425130909000
fact lesson principle aging immunology - Antibody / IgG accumulation is a strong age-amplifying node, but not yet a universal longevity bottleneck 20260425130643000
fact lesson principle aging immunology - trained immunity is a functional defense amplifier, not a higher-priority longevity bottleneck than thymic source restoration 20260425130412000
fact lesson principle aging immunology - IL-1 / emergency myelopoiesis is upstream of aged HSC bias, but not yet a universal longevity bottleneck 20260425125943000
fact lesson principle aging immunology - type I interferon / JAK-STAT chronic activation is strong but context-dependent, not yet a universal bottleneck 20260425125646000
fact lesson principle aging immunology - C1q is aging-associated but not yet a universal longevity bottleneck 20260425125313000
fact lesson principle aging immunology - IL-11 is a strong lifespan-positive inflammaging node, but still not yet a universal immune bottleneck 20260425124410000
fact lesson principle aging immunology - FGF21 不是通用免疫长寿瓶颈，而是局部胸腺 niche 入口 20260425123837000
fact lesson principle aging immunology - NLRP3 is context-dependent longevity-positive, not yet a universal bottleneck 20260425051109000
fact lesson principle aging immunology - 单组织寿命正例不足以把炎症轴抬升为通用长寿瓶颈 20260425050954000
fact lesson principle aging immunology - 按因果广度而不是表面上游性来排长寿瓶颈 20260425050740000
lesson principle aging immunology - HSC/髓系偏置尚不能压过胸腺源恢复的免疫长寿排序 20260425050727000
fact lesson principle aging immunology - 局部语境决定抗衰老信号是否成立 20260425050544000
lesson principle fact aging immunology - Source-restoration immune entries outrank peripheral T-cell quality control when only the former has healthspan extension 20260425050521000
fact lesson principle aging immunology - Mature T-cell quality control usually ranks below thymic source restoration as a longevity entry 20260425050406000
fact lesson principle aging immunology - 免疫长寿入口的上游性排序 20260425050322000
lesson principle aging immunology - 免疫长寿入口的上游性排序：补给源 > 外周质量控制 > 局部 niche 维护 20260425050257000
fact lesson principle aging immunology - Peripheral T-cell quality control can reach frailty, but not yet lifespan 20260425050159000
fact lesson principle aging immunology - Error-20260425-125443 20260425045443000
error iteration - Peripheral T-cell quality control can reach frailty, while thymic regeneration remains mainly immune-readout level 20260425044850000
fact lesson principle aging immunology - Error-20260425-124304 20260425044304000
error iteration - T-cell Bcl-xL is a concrete peripheral quality-control example, but still not a validated universal longevity bottleneck 20260425044154000
fact lesson principle aging immunology - Error-20260425-123859 20260425043859000
error iteration - Error-20260425-123816 20260425043816000
error iteration - Peripheral lymph node niche repair is a lower-rank immune rejuvenation entry than thymic regeneration 20260425043703000
fact lesson principle aging immunology - Peripheral lymph node niche is a reversible immune entry, but not yet higher-leverage than thymic involution 20260425043458000
fact lesson principle aging immunology - Thymic involution remains the strongest reversible immune entry, but not yet a validated longevity bottleneck 20260425042531000
fact lesson principle aging immunology - IL-1 emergency myelopoiesis is upstream but not yet validated as a longevity bottleneck 20260425042245000
fact lesson principle aging immunology - Trained immunity is not yet a validated longevity bottleneck 20260425042105000
fact lesson principle aging immunology - 把 inflammaging 当作回路读出而非单一瓶颈 20260425041935000
lesson principle aging immunology - Inflammaging is better treated as a heterogeneous readout than a universal upstream bottleneck 20260425041919000
lesson principle aging immunology - Thymus regeneration improves immune readouts but not yet lifespan evidence 20260425041751000
fact lesson principle aging immunology - Immune rejuvenation can improve systemic aging phenotypes via thymic or peripheral routes 20260425041629000
fact lesson principle aging immunology - Immune interventions can improve systemic aging phenotypes, but not always via thymic regeneration 20260425041447000
fact lesson principle aging immunology - Immune longevity candidate ranking: thymic involution first, readouts later 20260425041227000
fact lesson principle aging immunology - 优先寻找“可逆上游入口”而不是只看年龄读出 20260425041000000
lesson principle aging immunology - Thymic involution can be experimentally reversed to restore naive T-cell output in aged mice 20260425040945000
fact lesson principle aging immunology - Inflammaging 更应默认按 context-dependent readout 处理 20260425040831000
lesson principle aging immunology - Netrin-1 可作为老化骨髓 niche 的可逆上游杠杆 20260425040329000
fact lesson principle hematopoiesis aging - Blood-aging candidate ranking: HSC exhaustion over CHIP; cell competition as framework 20260425040156000
fact lesson principle aging hematopoiesis cell-competition - 先把 cell competition 当作框架，而不是立刻当作靶点 20260425040109000
lesson principle aging cell-competition quality-control - cell competition is a generic tissue-level quality-control framework 20260425040057000
fact principle aging cell-competition quality-control 4360dd15 - 老化干预要先找反馈回路 20260425035910000
lesson principle aging hematopoiesis niche - Bone marrow niche rejuvenation can restore aged HSC fitness 20260425035840000
fact lesson principle hematopoiesis aging - 年龄相关克隆现象优先视为读出而非总瓶颈 20260425035640000
lesson principle fact aging hematopoiesis - CHIP 更适合作为 HSC aging 的读出而非单一上游瓶颈 20260425035624000
fact lesson principle aging hematopoiesis - CDKN2A-OSK 在皮肤创面中的 FOSL1/迁移信号更应默认按间接效应解释 20260425035159000
fact lesson principle wound-healing reprogramming aging - CDKN2A-OSK 在人皮肤创面中的直接效应与微环境间接效应应分层判断 20260425034935000
fact lesson wound-healing reprogramming aging principle - FOSL1 不能被当成 CDKN2A-OSK 直接驱动角质形成细胞迁移的证据 20260425034652000
fact lesson principle wound-healing reprogramming aging - CDKN2A-OSK 在人皮肤伤口边缘更像编辑炎症/应激状态，而非直接的增殖开关 20260425034427000
fact lesson wound-healing reprogramming aging - 重编程效应要拆成炎症编辑与增殖激活两条轴 20260425034206000
lesson principle fact reprogramming wound-healing aging - partial reprogramming 在人皮肤修复中更像炎症/应激状态编辑，而非增殖开关 20260425034137000
fact lesson principle wound-healing reprogramming aging - partial reprogramming 在皮肤修复中更像炎症/应激状态编辑 20260425033952000
fact lesson principle aging reprogramming wound-healing - 把干预时窗对齐到修复亚阶段 20260425033646000
lesson principle wound-healing reprogramming aging - human skin wound-healing roadmap cleanly separates acute-support and chronic-failure programs 20260425033600000
fact lesson principle wound-healing aging reprogramming - 修复失败常是跨细胞协同失配 20260425033050000
lesson principle fact wound-healing - chronic wound failure programs clarify which senescence states are pathological 20260425033027000
fact lesson principle evidence-chain aging reprogramming - 先锁定同组织的阶段-细胞分辨图谱 20260425032914000
lesson principle evidence-chain - acute skin wound healing contains distinct senescent subpopulations with opposite effects 20260425032856000
fact lesson principle aging reprogramming evidence-chain - acute cutaneous wound healing is a clear example of context-dependent senescence 20260425032612000
fact lesson principle aging reprogramming - senolysis 可能破坏有益的再生 niche 20260425032437000
lesson principle aging reprogramming - partial reprogramming can improve regeneration by remodeling the extrinsic niche 20260425032418000
fact lesson principle evidence-chain - senolysis before OSK may remove a pro-reprogramming niche in some contexts 20260425032136000
lesson principle fact evidence-chain - 同组织 senolytic 预处理后再做 OSK 的原始实验仍未检出 20260425031957000
fact lesson method evidence-chain - senolytic 预处理与 OSK 增效证据未检出 20260425031913000
fact lesson evidence-chain method 4360dd15 - 体外与器官类系统中也未检出 senolytic→OSK 原始顺序实验 20260425031655000
fact lesson evidence-chain 4360dd15 - 序贯干预必须显式检索“先后顺序” 20260425031545000
lesson method evidence-chain - 另一单一组织中的 senolytic→OSK 顺序组合仍未检出 20260425031525000
fact lesson evidence-chain - 组合干预必须同时对齐顺序、组织和读出 20260425031020000
lesson principle evidence-chain - 顺序联合比单药 head-to-head 更有信息量 20260425030652000
fact lesson principle method 4360dd15 - Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing 20260425030358000
fact method lesson 4360dd15 - 皮肤 OSK vs ABT-263 参数对齐表（补全版） 20260425030211000
fact method lesson 4360dd15 - 皮肤 OSK vs ABT-263 可执行参数表（反证版） 20260425025941000
fact method lesson 4360dd15 - 反证式审稿的收敛规则：比较表只能在证据边界内下结论 20260425025750000
lesson method principle 4360dd15 - OSK vs ABT-263 的对齐/不对齐清单（皮肤场景） 20260425025615000
fact method lesson 4360dd15 - PMID 未命中时先回到题名和全文 20260425025540000
lesson method evidence-retrieval failure - Topical ABT-263 in aged mouse skin: original study and readouts 20260425025523000
fact method lesson 4360dd15 - Targeted partial reprogramming of age-associated cell states: skin-relevant OSK parameters 20260425025310000
fact method 4360dd15 - Error-20260425-104209 20260425024209000
error iteration - 路由匹配的对照实验比“同剂量”更关键 20260425023023000
method principle lesson 4360dd15 - 比较干预时必须匹配给药路线 20260425022914000
lesson principle method - OSK vs senolytic 的最小可比实验规格 20260425022856000
fact method principle 4360dd15 - 无 head-to-head 就不要做路线优劣结论 20260425022753000
lesson principle failure - OSK vs senolytic direct head-to-head remains sparse across tissues 20260425022737000
lesson method fact 4360dd15 - 皮肤中 OSK vs ABT-263 的原始 head-to-head 未检到 20260425022429000
lesson fact method 4360dd15 - 直接 head-to-head 证据与并列正例的判定边界 20260425022300000
lesson method principle - 同组织头对头证据比并列正例稀缺 20260425021819000
lesson method fact 4360dd15 - 统一比较组织的选择原则：皮肤是当前可用候选面板 20260425021710000
fact lesson method 4360dd15 - 先做同组织头对头，再谈路线优劣 20260425021502000
lesson principle method - 局部正例不能直接外推为长寿主路线代表性 20260425021446000
lesson principle method fact - 同一读出面板下比较长寿瓶颈候选的工程准则 20260425021221000
lesson principle method fact 4360dd15 - 第二个长寿瓶颈候选的筛选原则 20260425021002000
lesson principle method 4360dd15 - 部分重编程 go/no-go 判据与安全边界 20260425020626000
fact principle method lesson - 重编程验证必须用三重读出 20260425020521000
lesson principle method - 功能性与组织完整性读出：部分重编程验证的最小并列面板 20260425020502000
method principle fact 4360dd15 - 表观遗传主读出设计原则：组织特异DNAm时钟优先 20260425020313000
method principle fact 4360dd15 - Partial reprogramming 的优先干预模态选择原则 20260425020147000
fact method principle 4360dd15 - 单一衰老读出不够，必须配安全反证读出 20260425015958000
lesson principle method - 表观遗传信息损失的可检验干预与读出方案 20260425015926000
knowledge method fact 4360dd15 - 先锁定单一可验证瓶颈，再谈宏大目标 20260425015659000
lesson principle method 4360dd15 - Epigenetic information loss as a testable longevity bottleneck 20260425015600000
fact principle knowledge 4360dd15 - 先随机后穷举地压力测试判别协议 20260425015357000
lesson method [[predicate verification]] - 三态判别协议的压力测试结果 20260425015339000
fact lesson method 4360dd15 [[predicate verification]] [[witness normalization]] - 旧前缀+下一前缀联合生存刻画中性（small-case） 20260425014335000
lesson fact method principle [[predicate verification]] [[witness normalization]] 4360dd15 - 旧前缀可替代嵌入不足以判别中性 20260425013950000
lesson fact method principle [[predicate verification]] [[witness normalization]] 4360dd15 - 单一局部特征通常只能给出必要条件 20260425013436000
4360dd15 fact method principle [[predicate verification]] [[witness normalization]] - 候选影响区不等于敏感区 20260425012422000
lesson principle [[predicate verification]] [[witness normalization]] - 锚点固定后先局部化，再做单侧交换 20260425011113000
lesson method principle [[predicate verification]] [[witness normalization]] - 单侧交换位置可压缩为局部窗口 20260425010941000
4360dd15 fact method [[witness normalization]] [[predicate verification]] [[local insertion]] - 交换不依赖右侧的充分条件 20260425005858000
fact method [[predicate verification]] [[local insertion]] [[witness normalization]] - 左侧一次相邻交换的切分判定复用模板 20260425005439000
lesson fact method [[predicate verification]] [[local insertion]] [[witness normalization]] - 先找切分点，再谈独立性 20260425002443000
lesson [[predicate verification]] [[local insertion]] [[witness normalization]] - Iter-4360dd15-0186-fact-left-prefix-consumption-cut 20260425002431000
4360dd15 fact method [[predicate verification]] [[local insertion]] [[witness normalization]] - 局部化不等于可分解 20260424235814000
lesson [[predicate verification]] [[local insertion]] [[witness normalization]] - Iter-4360dd15-0184-failure-left-split-overclaim 20260424235623000
4360dd15 lesson failure [[predicate verification]] [[local insertion]] [[witness normalization]] - 锚定后交换只改一侧 20260424235519000
lesson [[predicate verification]] [[local insertion]] [[witness normalization]] - 锚定 marker 后交换可局部化 20260424235417000
lesson [[predicate verification]] [[local insertion]] [[witness normalization]] - 先引入 fresh marker 再规范化 witness 20260424235252000
lesson [[predicate verification]] [[local insertion]] [[witness normalization]] - 用 fresh marker 规范化 witness 20260424235110000
lesson [[predicate verification]] [[local insertion]] [[witness normalization]] - 先定可判定窗口再谈可达性 20260424234936000
lesson [[predicate verification]] [[boundary audit]] [[local insertion]] - 先把可判定条件和边界对齐 20260424234753000
lesson [[predicate verification]] [[boundary audit]] [[local insertion]] - Iter-4360dd15-0178-fact-support-contained-window-decidable-audit 20260424234738000
4360dd15 fact method [[predicate verification]] [[boundary audit]] [[local insertion]] - 先定语义再证充要 20260424234637000
lesson [[predicate verification]] [[boundary audit]] [[local insertion]] - Iter-4360dd15-0177-fact-windowed-insert-swap-proof 20260424234626000
4360dd15 fact method [[predicate verification]] [[local insertion]] - 先锁定支持集，再谈窗口可达性 20260424234434000
lesson [[predicate verification]] [[boundary audit]] [[local insertion]] - Iter-4360dd15-0176-fact-insert-swap-completeness-decomposition 20260424234420000
4360dd15 fact method [[predicate verification]] [[local insertion]] - 先做可达性穷举对账 20260424234150000
lesson [[predicate verification]] [[reachability audit]] [[local insertion]] - Iter-4360dd15-0175-fact-minimal-fp-unguarded-swap-repair 20260424234137000
fact lesson 4360dd15 [[predicate verification]] [[local insertion]] - 先证支持集，再谈窗口判定 20260424234005000
lesson [[predicate verification]] [[boundary audit]] [[local insertion]] - Iter-4360dd15-0174-fact-exhaustive-reachability-audit 20260424233953000
fact 4360dd15 [[predicate verification]] [[reachability audit]] [[local insertion]] - 先证窗口等价，再谈判定完备性 20260424233824000
lesson [[predicate verification]] [[boundary audit]] [[local insertion]] - Iter-4360dd15-0173-fact-support-contained-boundary-consistency 20260424233814000
fact 4360dd15 [[predicate verification]] [[boundary audit]] [[local insertion]] - 窗口语义要显式区分 20260424233737000
lesson [[predicate verification]] [[boundary check]] [[local insertion]] - Iter-4360dd15-0172-fact-accept-support-contained-boundary-consistency 20260424233727000
fact 4360dd15 [[predicate verification]] [[local insertion]] [[boundary audit]] - 窗口语义要区分锚点距离与支持集包含 20260424233537000
lesson [[predicate verification]] [[local insertion]] [[erratum verification]] - Iter-4360dd15-0171-fact-minimal-counterexample-support-contained-window 20260424233529000
fact 4360dd15 [[erratum verification]] [[local insertion]] [[predicate verification]] - 先锁定操作索引再谈窗口 20260424233448000
lesson [[local insertion]] [[predicate verification]] - Iter-4360dd15-0170-fact-tight-windowed-swap-condition 20260424233433000
fact lesson 4360dd15 [[local insertion]] [[erratum verification]] - Iter-4360dd15-0169-fact-window-distance-predicate 20260424233135000
fact 4360dd15 [[erratum verification]] [[local insertion]] subsequence method - 交换必须受窗口约束 20260424233043000
lesson [[local insertion]] subsequence [[erratum verification]] - Iter-4360dd15-0168-fact-windowed-one-swap-repair 20260424233033000
fact 4360dd15 [[erratum verification]] [[local insertion]] subsequence - Iter-4360dd15-0167-method-one-swap-subsequence-repair 20260424232748000
method fact 4360dd15 [[erratum verification]] - 纯插入与轻微重排要分开判 20260424232542000
lesson [[erratum verification]] subsequence counterexample - Iter-4360dd15-0166-fact-minimal-insertion-reorder-counterexample 20260424232532000
fact 4360dd15 [[erratum verification]] - 先保骨架再谈编辑量 20260424232439000
lesson [[erratum verification]] rewrite [[local insertion]] - Iter-4360dd15-0165-method-content-subsequence-local-insertion 20260424232430000
method fact 4360dd15 [[erratum verification]] - 先判定纠错类型再谈规则 20260424232347000
lesson erratum classification rule - Iter-4360dd15-0164-lesson-v2-rule-false-positives 20260424232336000
lesson critique 4360dd15 [[erratum verification]] - 二层规则先看强度再看重叠 20260424232219000
lesson classification rewrite counterexample - 重写判定要分层 20260424231903000
lesson method fact - 重写判定要用二层信号 20260424231655000
lesson method fact - 重写判定必须分层 20260424231556000
lesson method fact - Iter-4360dd15-0160-method-pmc4083033-rewrite-v2 20260424231537000
method fact 4360dd15 [[[[erratum verification]]]] - 先定位实体，再抽规则 20260424231410000
lesson search memory debug - Iter-4360dd15-0159-lesson-rewrite-threshold-failure 20260424231322000
lesson method fact 4360dd15 [[erratum verification]] - 先验证模式，再封装判定 20260424231142000
lesson [[erratum verification]] tool-usage method - Iter-4360dd15-0158-method-pmc4083033-sentence-rewrite-template 20260424231132000
method fact [[erratum verification]] 4360dd15 - 先验证事实，再封装工具 20260424231044000
lesson [[erratum verification]] tool-usage - Iter-4360dd15-0157-fact-pmc4083033-word-diff 20260424231031000
fact [[[[erratum verification]]]] 4360dd15 method - 先拿到原始 XML 再做差分 20260424230933000
lesson [[erratum verification]] source-check text-diff - Iter-4360dd15-0156-fact-pmc4083033-xml-offsets 20260424230924000
fact [[erratum verification]] 4360dd15 - 先取 XML 再谈差分 20260424230817000
lesson [[erratum verification]] source-check text-diff - Iter-4360dd15-0155-fact-pmc4083033-xml-coordinates 20260424230807000
fact [[erratum verification]] 4360dd15 - 先拿原文再做逐词 diff 20260424230659000
lesson [[erratum verification]] source-check text-diff - Iter-4360dd15-0154-fact-pmc4083033-tokenization-robustness 20260424230648000
fact [[erratum verification]] 4360dd15 - 摘要不等于证据 20260424230541000
lesson evidence text-comparison - Iter-4360dd15-0153-fact-pmc4083033-direct-xml-diff 20260424230526000
fact [[erratum verification]] 4360dd15 - 先拿到原文再判定改动 20260424230336000
lesson erratum verification source-check - Iter-4360dd15-0152-fact-pmc4083033-diff-type 20260424230323000
fact [[erratum verification]] 4360dd15 - 先拿正文再判类型 20260424230205000
lesson erratum verification diff - 先抓正文再判定改动类型 20260424225933000
lesson erratum verification diff - PMC4083033 erratum minimal diff 20260424225923000
4360dd15 fact [[erratum verification]] - Iter-4360dd15-0149-lesson-pmc4083033-not-insertion 20260424225824000
4360dd15 lesson [[erratum verification]] critique - 先锁定可验证候选，再做差分 20260424225616000
lesson erratum verification search - 先锁定勘误页，再做最小差分 20260424225328000
lesson erratum verification search - 先找确定样本再测分类器 20260424224859000
lesson erratum alignment verification - Iter-4360dd15-0145-fact-replacement-erratum-pressure-test 20260424224847000
4360dd15 knowledge method [[erratum verification]] - 先做原句对齐再判定修正类型 20260424224634000
lesson erratum alignment verification - Iter-4360dd15-0144-fact-BOLERO-2-erratum-word-alignment-context 20260424224623000
4360dd15 fact [[erratum verification]] method - 先锁定原句再做最小差分 20260424224537000
lesson erratum verbatim diff - Iter-4360dd15-0143-fact-BOLERO-2-erratum-vertical-verbatim-pair 20260424224527000
4360dd15 knowledge [[erratum verification]] method - 先固定原文再做差分 20260424224442000
lesson erratum verbatim evidence-chain - Iter-4360dd15-0142-fact-BOLERO-2-erratum-redline-pair 20260424224428000
4360dd15 fact [[erratum verification]] knowledge - 先锁权威源再逐字对照 20260424223604000
lesson erratum verbatim evidence-chain - Iter-4360dd15-0138-fact-BOLERO-2-erratum-verbatim-pair 20260424223553000
4360dd15 fact [[erratum verification]] knowledge - 先锁定权威源再逐字抽句 20260424222955000
lesson erratum verbatim evidence-chain - BOLERO-2 PMC abstract erratum verbatim closed chain 20260424222938000
4360dd15 fact [[erratum verification]] evidence-chain - 先锁定权威源再逐字对照 20260424222844000
lesson erratum verbatim evidence-chain - BOLERO-2 erratum abstract verbatim chain 20260424222829000
4360dd15 fact [[erratum verification]] evidence-chain - 先抓原句边界再谈纠错范围 20260424222053000
lesson erratum verbatim evidence-chain - BOLERO-2 erratum: full corrected abstract sentence 20260424222041000
4360dd15 fact [[erratum verification]] evidence-chain - 先抓纠错点再补全文本 20260424221855000
lesson erratum verbatim evidence-chain - BOLERO-2 erratum: abstract correction scope corroborated from source text 20260424221844000
4360dd15 fact evidence-chain [[erratum verification]] - 先锁定原句，再做逐字差分 20260424221748000
lesson erratum evidence-chain verbatim - BOLERO-2 erratum: exact deleted abstract span 20260424221738000
4360dd15 fact [[erratum verification]] evidence-chain - BOLERO-2 PMID 22149876 vs PMC4713958: verbatim abstract diff 20260424221644000
4360dd15 fact [[erratum verification]] evidence-chain - 先取原句，再判修订边界 20260424221550000
lesson erratum evidence-chain - BOLERO-2 erratum: original abstract sentence vs corrected sentence 20260424221539000
4360dd15 fact [[erratum verification]] evidence-chain - 先拿原句再判修订边界 20260424221302000
lesson erratum evidence-chain - BOLERO-2 erratum verbatim boundary proof 20260424221251000
4360dd15 fact [[erratum verification]] evidence-chain - BOLERO-2 abstract erratum verbatim comparison 20260424221118000
fact 4360dd15 [[erratum verification]] evidence-chain - 先取原句再认修订 20260424221033000
lesson [[erratum verification]] evidence-chain - BOLERO-2 erratum exact abstract sentence and boundary of correction 20260424221021000
fact lesson 4360dd15 erratum evidence-chain critic - 先锁定原文再做修订对照 20260424220853000
lesson [[erratum verification]] evidence-chain - BOLERO-2 erratum corrected abstract sentence 20260424220843000
fact 4360dd15 clinical-trials erratum evidence-chain - 先判更正范围再定引用文本 20260424220712000
lesson erratum verification evidence-chain - BOLERO-2 abstract should cite erratum-corrected subgroup wording 20260424220656000
fact knowledge 4360dd15 clinical-trials erratum evidence-chain - 更正只改被点名的那一句 20260424220536000
lesson evidence-chain erratum verification - BOLERO-2 erratum scope: subgroup wording only, PFS numerics unchanged 20260424220522000
fact 4360dd15 clinical-trials erratum evidence-chain - 先拿到更正全文再判断影响 20260424220425000
lesson evidence-chain erratum verification - BOLERO-2 erratum does not change abstract investigator-assessed PFS sentence or bibliographic metadata 20260424220413000
fact knowledge 4360dd15 clinical-trials evidence-chain erratum - 先锁书目信息，再查更正 20260424220217000
lesson evidence-chain bibliography erratum - BOLERO-2 PMCID and abstract PFS sentence directly verified from PMC 20260424220204000
fact knowledge 4360dd15 clinical-trials evidence-chain - 先锁主文再抽全字段 20260424220056000
lesson evidence-chain metadata-first - BOLERO-2 PMID PMCID DOI confirmed from Europe PMC and PMC 20260424220045000
fact knowledge 4360dd15 clinical-trials evidence-chain - 找到主文后一次性抽全字段 20260424215932000
lesson evidence-chain trial-screening metadata-first - BOLERO-2 主文数值与 PMID/DOI 的直接抽取（Springer OA + NCBI export） 20260424215916000
knowledge fact 4360dd15 clinical-trials evidence-chain - 先锁定可读全文，再提取数值 20260424215754000
lesson evidence-chain trial-screening metadata-first - BOLERO-2 主要终点具体结果数值（Springer OA） 20260424215736000
fact knowledge 4360dd15 clinical-trials evidence-chain - 先抓可访问摘要再补全文闭环 20260424215304000
lesson evidence-chain trial-screening metadata-first - BOLERO-2 可访问非-NEJM 设计/终点证据已补齐 20260424215252000
fact knowledge 4360dd15 clinical-trials evidence-chain - 先用可访问二源闭环再碰受限原文 20260424215113000
lesson evidence-chain trial-screening metadata-first - BOLERO-2 PMID 22149876 的可访问非-NEJM 设计/终点复核 20260424215102000
fact knowledge 4360dd15 clinical-trials evidence-chain - BOLERO-2 PMID 22149876 的第二独立复核来源与 primary endpoint 20260424214827000
fact knowledge 4360dd15 clinical-trials evidence-chain - 题录线索也要做双源闭环 20260424214532000
lesson evidence-chain trial-screening metadata-first - BOLERO-2 原始主报告 PMID 22149876 与 primary endpoint PFS 20260424214522000
fact knowledge 4360dd15 clinical-trials evidence-chain - 先判定证据层级，再找精确 PMID 20260424214413000
lesson evidence-chain trial-screening metadata-first - PMID 22149876 is the original BOLERO-2 phase 3 primary report, not 24267730 20260424214401000
fact method 4360dd15 clinical-trials evidence-chain - 亚组论文不能当原始试验 20260424214200000
lesson evidence-chain trial-screening - PMID 24267730 is a subgroup analysis, not the first original human trial 20260424214147000
fact method 4360dd15 clinical-trials evidence-chain - 别在记忆里绕圈，直接打原始证据 20260424214025000
lesson evidence-chain screening - 先判研究类型，再谈是否相关 20260424213803000
lesson evidence-chain europe-pmc screening - Iter-4360dd15-0106-four-candidate-audit 20260424213752000
fact method 4360dd15 clinical-trials evidence-chain - 优先走可解析的证据链 20260424213650000
lesson evidence-chain europe-pmc parsing - Iter-4360dd15-0104-three-remaining-candidates-are-not-original-first-reports 20260424213638000
knowledge fact method 4360dd15 clinical-trials evidence-chain - 先验明响应格式再写解析器 20260424213353000
lesson evidence-chain parsing europe-pmc - Iter-4360dd15-0103-EuropePMC-38310895-reference-parser-and-candidate-shortlist 20260424213315000
knowledge fact method 4360dd15 clinical-trials evidence-chain - 先拿全量参考文献再分类 20260424212846000
lesson evidence-chain clinical-trials pmid - 先拿参考文献清单再做分类 20260424212541000
lesson evidence-chain clinical-trials pmid - Iter-4360dd15-0100-human-trial-vs-non-original-screening-of-38310895-references 20260424212530000
4360dd15 knowledge fact method clinical-trials evidence-chain - 先抓参考文献，再做证据分层 20260424212326000
lesson evidence-chain clinical-trials pmc - Iter-4360dd15-0099-critic-mechanistic-vs-aging-trial 20260424212312000
lesson evidence-chain clinical-trials critique 4360dd15 - 别从落地页取证 20260424212107000
lesson evidence-chain fulltext-access clinical-trials - Iter-4360dd15-0098-EuropePMC-extract-human-trial-PMIDs 20260424212055000
method fact clinical-trials evidence-chain rapamycin 4360dd15 - 用可访问的镜像入口绕开 403 20260424211826000
lesson evidence-chain fulltext-access clinical-trials - 先拿到可访问的全文入口 20260424211456000
lesson evidence-chain fulltext-access clinical-trials - 先从综述参考链落到单个原始 PMID 20260424211152000
lesson evidence-chain clinical-trials endpoint-classification - 先从参考链锁定单个原始试验 20260424210848000
lesson evidence-chain clinical-trials endpoint-classification - PMID 22367193 is cardiac-repolarization safety, not longevity evidence 20260424210833000
4360dd15 knowledge fact critique clinical-trials endpoint-classification - 先从综述引用链提取唯一原始 PMID 20260424210659000
lesson evidence-chain clinical-trials endpoint-classification - 先锁定唯一 PMID 再判终点 20260424210407000
lesson evidence-chain clinical-trials endpoint-classification - PMID 24691032 is muscle-protein-synthesis endpoint, not longevity evidence 20260424210355000
4360dd15 fact knowledge clinical-trials endpoint-classification - 先锁定唯一引用再看终点 20260424210210000
lesson evidence-chain clinical-trials endpoint-classification - PMID 22115710 is phase I ocular safety study, not longevity evidence 20260424210145000
4360dd15 fact clinical-trials knowledge - 先从综述引用链落到原始试验 20260424210023000
lesson evidence-chain clinical-trials citation-chain - PMID 29408453 is feasibility/safety pilot, not direct longevity evidence 20260424210012000
fact knowledge clinical-trials 4360dd15 - 先从综述引用链下钻到原始试验 20260424205810000
lesson evidence-chain clinical-trials citation-chain - PMID 31761958 is skin-senescence endpoint, not longevity evidence 20260424205759000
lesson endpoint-classification clinical-trials 4360dd15 - 先锁定原始试验再谈终点 20260424205610000
lesson evidence-chain clinical-trials longevity - 综述只负责引路 20260424205350000
lesson classification citation-chain trial-audit - 先证终点，再谈长寿 20260424204906000
lesson endpoint-classification citation-chain trial-audit - PMID 33977284 is RTI incidence endpoint, not direct longevity evidence 20260424204839000
4360dd15 fact classification clinical-trials longevity - 线索要尽快落到单个 PMID 20260424204736000
lesson citation-chain trial-audit endpoint-classification - PMID 25540326 is immune-response endpoint, not longevity evidence 20260424204718000
4360dd15 fact classification clinical-trials longevity - 综述只能当入口，不能当证据 20260424204557000
lesson classification citation-chain trial-audit - PMID 27883166 is a pilot safety feasibility trial not direct longevity evidence 20260424204543000
4360dd15 fact clinical-trials endpoint-classification longevity - 先锁原始试验再谈长寿终点 20260424203542000
lesson classification endpoint citation-chain - PEARL trial is not direct longevity evidence 20260424203525000
4360dd15 lesson fact classification - 先用终点语境判定是否真是长寿证据 20260424203253000
lesson classification endpoint trial-registry longevity - Iter-4360dd15-0078-two-pmid-evidence-verification 20260424203242000
4360dd15 knowledge fact classification - 先最小化候选，再三字段补全 20260424203148000
lesson abstract-extraction trial-registry endpoint age - Iter-4360dd15-0077-unified-longevity-classification-four-pmids 20260424203137000
4360dd15 knowledge fact method - 先用注册库补关键字段 20260424203004000
lesson abstract-extraction trial-registry endpoint age - Iter-4360dd15-0075-abstract-field-extraction-two-pmids 20260424202951000
4360dd15 knowledge fact classification - 先抽字段再分类 20260424202727000
lesson audit abstract-extraction classification - 先做摘要级字段抽取 20260424202425000
lesson audit abstract-extraction classification - 先确认研究类型再谈终点 20260424202124000
lesson audit study-design endpoint - Iter-4360dd15-0072-review-exclusion-first-rule 20260424202103000
4360dd15 knowledge method - 先抽字段再定规则 20260424201859000
lesson audit endpoint-extraction synonym-mapping - Iter-4360dd15-0071-minimal-audit-rules 20260424201843000
4360dd15 knowledge method - 先表格化再抽象规则 20260424201631000
lesson tooling audit extraction - Iter-4360dd15-0069-standardized-audit-table-two-trials 20260424201621000
4360dd15 knowledge fact method - 先用现成抓取验证，再封装工具 20260424201421000
lesson tooling verification abstract-extraction - Iter-4360dd15-0068-abstract-endpoint-extraction 20260424201407000
4360dd15 knowledge fact method - 优先用可访问全文源替代出版社页 20260424201155000
lesson pubmed-verification europe-pmc abstract-extraction - Iter-4360dd15-0067-abstract-endpoints-aging-criteria 20260424201141000
4360dd15 knowledge fact method stratification - 绕开 PubMed HTML，优先用 PMC/Europe PMC 抽摘要 20260424200940000
lesson pubmed-verification europe-pmc abstract-extraction - Iter-4360dd15-0066-TierA-abstracts-and-endpoints-for-aging-criteria 20260424200925000
4360dd15 knowledge fact method stratification - Iter-4360dd15-0065-minimal-relevance-decision-rules-for-retained-mtor-trials 20260424200748000
4360dd15 knowledge fact method stratification - 先用题名证据锁定研究性质 20260424200615000
lesson pubmed-verification audit clinical-trials - Iter-4360dd15-0064-relevance-tiering-10-pmids 20260424200602000
4360dd15 knowledge fact critical-review stratification - Iter-4360dd15-0063-10-pmid-audit-table 20260424200432000
4360dd15 knowledge fact clinical-trials audit - Iter-4360dd15-0062-pubmed-title-verification-10-pmids 20260424200328000
4360dd15 knowledge fact clinical-trials pubmed-verification - 先确保可输出再做细化 20260424200233000
lesson evidence-retrieval clinical-trials encoding - Iter-4360dd15-0061-candidate-audit-10-remaining-pmids 20260424200221000
4360dd15 knowledge fact classification clinical-trials - 先拿原始候选表再分类 20260424200123000
lesson evidence-retrieval classification clinical-trials - PMID 38310895 is a review, not a primary trial 20260424200109000
4360dd15 fact method clinical-trials classification - 边界术语先做例外判定 20260424195952000
lesson evidence-retrieval classification clinical-trials - PMID 35040506 longitudinal analysis is embedded in primary trial 20260424195939000
4360dd15 knowledge fact critique clinical-trials classification - 先分类型再写表 20260424195838000
lesson evidence-retrieval clinical-trials classification - Iter-4360dd15-0058-longevity-evidence-proximity-tagging 20260424195827000
4360dd15 knowledge fact classification longevity - 先定审计表再搜证 20260424195730000
lesson evidence-retrieval clinical-trials filtering - Iter-4360dd15-0057-study-design-taxonomy-for-retained-trials 20260424195711000
4360dd15 knowledge fact classification clinical-trials - 先定原始性再逐条填表 20260424195602000
lesson evidence-retrieval clinical-trials filtering - Iter-4360dd15-0056-pubmed-boundary-confirmation 20260424195548000
4360dd15 knowledge fact evidence-retrieval clinical-trials - 先判原始性再补 PMID 20260424195432000
lesson evidence-retrieval clinical-trials filtering - Longitudinal analysis is not an automatic exclusion in trial titles 20260424195414000
4360dd15 lesson evidence-retrieval clinical-trials method - 先用题名锁定原始性 20260424195244000
lesson evidence-retrieval clinical-trials filtering - 先定研究原始性再补 PMID 20260424194952000
lesson evidence-retrieval clinical-trials filtering - Iter-4360dd15-0053-final-audit-14-candidates 20260424194939000
4360dd15 knowledge fact audit clinical-trials - 先排除二次分析再做原始性归类 20260424194723000
lesson evidence-retrieval clinical-trials filtering - Iter-4360dd15-0052-rapamycin-older-cohort-pmid-mapping 20260424194711000
4360dd15 knowledge fact evidence-retrieval clinical-trials - 先判定研究原始性再做保留表 20260424194535000
lesson evidence-retrieval clinical-trials filtering - Iter-4360dd15-0051-secondary-analysis-exclusion-lexicon 20260424194517000
4360dd15 method knowledge evidence-retrieval clinical-trials - 先把候选映射到具体研究类型 20260424194357000
lesson evidence-retrieval clinical-trials filtering - Iter-4360dd15-0050-candidate-audit-originality-check 20260424194345000
4360dd15 knowledge audit evidence-retrieval - 先排除非原始研究 20260424194237000
lesson evidence-retrieval filtering clinical-trials - Iter-4360dd15-0049-crossref-candidate-overgeneration-critique 20260424194224000
4360dd15 lesson evidence-retrieval critical-review - 先拿可读副本再抽取 20260424194120000
lesson evidence-retrieval supplementary-material access-block - Iter-4360dd15-0048-crossref-trialish-candidate-extraction 20260424194106000
4360dd15 knowledge fact experiment evidence-retrieval - 先确认可读副本再抽取 20260424193842000
lesson evidence-retrieval supplementary-material access-block - 先拿到可读副本再做抽取 20260424193558000
lesson evidence-retrieval supplementary-material access-block - PMID 38310895 access topology verified 20260424193545000
4360dd15 fact lesson evidence-retrieval - 先绕过访问阻断再做抽取 20260424193149000
lesson access-block evidence-retrieval systematic-review - 先拿到表，再做映射 20260424192851000
lesson evidence-retrieval systematic-review access-block - 候选召回不能替代纳入判定 20260424192629000
lesson evidence-retrieval systematic-review crossref - Iter-4360dd15-0042-crossref-family-collapse-10-families 20260424192619000
knowledge fact 4360dd15 evidence-retrieval crossref - 候选召回不能代替纳入判定 20260424192437000
lesson evidence-retrieval systematic-review crossref - Iter-4360dd15-0040-crossref-trialish-family-taxonomy 20260424192051000
knowledge fact 4360dd15