PMID 35974106

定义

PMID 35974106 是 Saul 等人在 Nature Communications 2022 发表的 SenMayo 原始基因集论文：Saul D, Kosinsky RL, Atkinson EJ, Doolittle ML, Zhang X, LeBrasseur NK, Pignolo RJ, Robbins PD, Niedernhofer LJ, Ikeno Y, Jurk D, Passos JF, Hickson LJ, Xue A, Monroe DG, Tchkonia T, Kirkland JL, Farr JN, Khosla S. “A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues.” Nature Communications. 2022;13(1):4827. doi:10.1038/s41467-022-32552-1. PMID:35974106; PMCID:PMC9381717.

关键事实

PubMed 摘要说明作者生成 SenMayo gene set，并在人体骨样本、小鼠/人体组织和单细胞数据中验证其可识别 senescent cells / senescence-associated pathways across tissues。对 精神分裂症外周血转录组免疫衰老题眼 来说，这条文献可支撑“SenMayo 是预先发表的人类 senescence/SASP-like signature”的方法出处，而不能单独支撑 schizophrenia 特异机制或诊断用途。

本 mission 用法

在 schizophrenia whole-blood SenMayo 稿件中，它替换 REF-Saul-2022-SenMayo，支撑两句：
* Background: SenMayo gene set was developed as a human senescence/SASP-like signature and used to summarise senescence-related transcription across tissues.
* Methods: the senescence/SASP-like signature was the human SenMayo gene set from Saul et al. 2022.

原始链接

https://pubmed.ncbi.nlm.nih.gov/35974106/