#immunology
- IL-11 修复代价的直接成人哺乳动物原始反例仍未检出 20260425151726000
- Adult-mammal IL-11 inhibition: direct bone-homeostasis harm, fracture/wound evidence still missing 20260425151443000
- IL-11 longevity benefit must be decomposed into immune/inflammatory and tissue-tradeoff components 20260425150607000
- IL-11 currently ranks above other screened immune/inflammation axes because it has direct mammalian healthspan/lifespan evidence 20260425150330000
- 补体级联仍未跨过通用长寿瓶颈门槛 20260425150146000
- IL-1/MyD88 outranks TNF/IL-6 as an upstream screening candidate, but not as a universal bottleneck 20260425145846000
- Complement cascade remains a high-potential but not yet universal longevity bottleneck 20260425145530000
- TNF/IL-6 are low-priority control axes in longevity bottleneck screening 20260425145355000
- cGAS-STING is a strong but context-dependent aging node, not yet a universal longevity bottleneck 20260425145335000
- type I interferon / JAK-STAT is an upstream amplifier, not a default universal longevity bottleneck 20260425145224000
- Thymic source restoration is a strong immune upstream entry, but not yet a universal longevity bottleneck 20260425144604000
- TNF/IL-6 are context-specific inflammaging mediators, not universal longevity bottlenecks 20260425144110000
- cGAS-STING is an upstream inflammaging amplifier, but not yet a universal longevity bottleneck 20260425143829000
- NLRP3 is a strong aging node but still not clearly a universal longevity bottleneck 20260425143408000
- complement 轴是高潜力候选但尚非 universal longevity bottleneck 20260425143032000
- IL-11 longevity candidacy must be split by tissue-specific tradeoffs 20260425142558000
- IL-1 is a strong upstream hematopoietic inflammaging loop, but not yet a universal longevity bottleneck 20260425142133000
- IL-11 inhibition: bone-homeostasis evidence is direct, fracture-healing evidence remains missing 20260425135719000
- Adult-mammal IL-11 inhibition has clear bone-homeostasis consequences, but direct fracture/wound inhibition evidence is sparse 20260425135357000
- IL-11 still needs a pleiotropy tradeoff audit before universal-bottleneck promotion 20260425134905000
- IL-6 trans-signaling is a plausible inflammaging axis, but not a universal longevity bottleneck 20260425134712000
- IgG/FcRn is a strong immune age-amplifying axis, but not yet a universal longevity bottleneck 20260425134301000
- IL-1 outranks TNF and type I IFN as an upstream immune loop, but still falls short of a universal longevity bottleneck 20260425133745000
- IL-11 is a strong candidate but not yet a universal bottleneck 20260425133514000
- 反证优先于升级候选 20260425133423000
- IL-17 / Th17 is a context-dependent inflammaging axis, not a universal longevity bottleneck 20260425133233000
- IL-11 remains the current top immune/inflammation longevity candidate, but not yet a universal bottleneck 20260425132624000
- C1q brain aging mechanism is informative but still insufficient for universal longevity candidacy 20260425131714000
- IL-11 is currently the strongest immune/inflammation longevity candidate in the screening set 20260425131144000
- IgG is a strong age-amplifying node, but not yet a universal longevity bottleneck 20260425130909000
- Antibody / IgG accumulation is a strong age-amplifying node, but not yet a universal longevity bottleneck 20260425130643000
- trained immunity is a functional defense amplifier, not a higher-priority longevity bottleneck than thymic source restoration 20260425130412000
- IL-1 / emergency myelopoiesis is upstream of aged HSC bias, but not yet a universal longevity bottleneck 20260425125943000
- type I interferon / JAK-STAT chronic activation is strong but context-dependent, not yet a universal bottleneck 20260425125646000
- C1q is aging-associated but not yet a universal longevity bottleneck 20260425125313000
- IL-11 is a strong lifespan-positive inflammaging node, but still not yet a universal immune bottleneck 20260425124410000
- FGF21 不是通用免疫长寿瓶颈，而是局部胸腺 niche 入口 20260425123837000
- NLRP3 is context-dependent longevity-positive, not yet a universal bottleneck 20260425051109000
- 单组织寿命正例不足以把炎症轴抬升为通用长寿瓶颈 20260425050954000
- 按因果广度而不是表面上游性来排长寿瓶颈 20260425050740000
- HSC/髓系偏置尚不能压过胸腺源恢复的免疫长寿排序 20260425050727000
- 局部语境决定抗衰老信号是否成立 20260425050544000
- Source-restoration immune entries outrank peripheral T-cell quality control when only the former has healthspan extension 20260425050521000
- Mature T-cell quality control usually ranks below thymic source restoration as a longevity entry 20260425050406000
- 免疫长寿入口的上游性排序 20260425050322000
- 免疫长寿入口的上游性排序：补给源 > 外周质量控制 > 局部 niche 维护 20260425050257000
- Peripheral T-cell quality control can reach frailty, but not yet lifespan 20260425050159000
- Peripheral T-cell quality control can reach frailty, while thymic regeneration remains mainly immune-readout level 20260425044850000
- T-cell Bcl-xL is a concrete peripheral quality-control example, but still not a validated universal longevity bottleneck 20260425044154000
- Peripheral lymph node niche repair is a lower-rank immune rejuvenation entry than thymic regeneration 20260425043703000
- Peripheral lymph node niche is a reversible immune entry, but not yet higher-leverage than thymic involution 20260425043458000
- Thymic involution remains the strongest reversible immune entry, but not yet a validated longevity bottleneck 20260425042531000
- IL-1 emergency myelopoiesis is upstream but not yet validated as a longevity bottleneck 20260425042245000
- Trained immunity is not yet a validated longevity bottleneck 20260425042105000
- 把 inflammaging 当作回路读出而非单一瓶颈 20260425041935000
- Inflammaging is better treated as a heterogeneous readout than a universal upstream bottleneck 20260425041919000
- Thymus regeneration improves immune readouts but not yet lifespan evidence 20260425041751000
- Immune rejuvenation can improve systemic aging phenotypes via thymic or peripheral routes 20260425041629000
- Immune interventions can improve systemic aging phenotypes, but not always via thymic regeneration 20260425041447000
- Immune longevity candidate ranking: thymic involution first, readouts later 20260425041227000
- 优先寻找“可逆上游入口”而不是只看年龄读出 20260425041000000
- Thymic involution can be experimentally reversed to restore naive T-cell output in aged mice 20260425040945000
- Inflammaging 更应默认按 context-dependent readout 处理 20260425040831000