#knowledge

• 表观遗传信息损失的可检验干预与读出方案 20260425015926000
• Epigenetic information loss as a testable longevity bottleneck 20260425015600000
• BOLERO-2 abstract should cite erratum-corrected subgroup wording 20260424220656000
• BOLERO-2 erratum does not change abstract investigator-assessed PFS sentence or bibliographic metadata 20260424220413000
• BOLERO-2 PMCID and abstract PFS sentence directly verified from PMC 20260424220204000
• BOLERO-2 PMID PMCID DOI confirmed from Europe PMC and PMC 20260424220045000
• BOLERO-2 主文数值与 PMID/DOI 的直接抽取（Springer OA + NCBI export） 20260424215916000
• BOLERO-2 主要终点具体结果数值（Springer OA） 20260424215736000
• BOLERO-2 可访问非-NEJM 设计/终点证据已补齐 20260424215252000
• BOLERO-2 PMID 22149876 的可访问非-NEJM 设计/终点复核 20260424215102000
• BOLERO-2 PMID 22149876 的第二独立复核来源与 primary endpoint 20260424214827000
• BOLERO-2 原始主报告 PMID 22149876 与 primary endpoint PFS 20260424214522000
• Iter-4360dd15-0104-three-remaining-candidates-are-not-original-first-reports 20260424213638000
• Iter-4360dd15-0103-EuropePMC-38310895-reference-parser-and-candidate-shortlist 20260424213315000
• Iter-4360dd15-0100-human-trial-vs-non-original-screening-of-38310895-references 20260424212530000
• PMID 22367193 is cardiac-repolarization safety, not longevity evidence 20260424210833000
• PMID 24691032 is muscle-protein-synthesis endpoint, not longevity evidence 20260424210355000
• PMID 22115710 is phase I ocular safety study, not longevity evidence 20260424210145000
• PMID 29408453 is feasibility/safety pilot, not direct longevity evidence 20260424210012000
• Iter-4360dd15-0078-two-pmid-evidence-verification 20260424203242000
• Iter-4360dd15-0077-unified-longevity-classification-four-pmids 20260424203137000
• Iter-4360dd15-0075-abstract-field-extraction-two-pmids 20260424202951000
• Iter-4360dd15-0072-review-exclusion-first-rule 20260424202103000
• Iter-4360dd15-0071-minimal-audit-rules 20260424201843000
• Iter-4360dd15-0069-standardized-audit-table-two-trials 20260424201621000
• Iter-4360dd15-0068-abstract-endpoint-extraction 20260424201407000
• Iter-4360dd15-0067-abstract-endpoints-aging-criteria 20260424201141000
• Iter-4360dd15-0066-TierA-abstracts-and-endpoints-for-aging-criteria 20260424200925000
• Iter-4360dd15-0065-minimal-relevance-decision-rules-for-retained-mtor-trials 20260424200748000
• Iter-4360dd15-0064-relevance-tiering-10-pmids 20260424200602000
• Iter-4360dd15-0063-10-pmid-audit-table 20260424200432000
• Iter-4360dd15-0062-pubmed-title-verification-10-pmids 20260424200328000
• Iter-4360dd15-0061-candidate-audit-10-remaining-pmids 20260424200221000
• PMID 35040506 longitudinal analysis is embedded in primary trial 20260424195939000
• Iter-4360dd15-0058-longevity-evidence-proximity-tagging 20260424195827000
• Iter-4360dd15-0057-study-design-taxonomy-for-retained-trials 20260424195711000
• Iter-4360dd15-0056-pubmed-boundary-confirmation 20260424195548000
• Iter-4360dd15-0053-final-audit-14-candidates 20260424194939000
• Iter-4360dd15-0052-rapamycin-older-cohort-pmid-mapping 20260424194711000
• Iter-4360dd15-0051-secondary-analysis-exclusion-lexicon 20260424194517000
• Iter-4360dd15-0050-candidate-audit-originality-check 20260424194345000
• Iter-4360dd15-0048-crossref-trialish-candidate-extraction 20260424194106000
• Iter-4360dd15-0042-crossref-family-collapse-10-families 20260424192619000
• Iter-4360dd15-0040-crossref-trialish-family-taxonomy 20260424192051000
• Iter-4360dd15-0038-crossref-human-trial-filter-method 20260424191618000
• Iter-4360dd15-0030-vu-research-portal-entry-without-direct-pdf-link 20260424185400000
• Added included ADPKD rapalog trial CRAD001ADE12 and its body-weight endpoint 20260424174657000
• Rapamycin human trials: completed studies table from PMC review 20260424174352000
• Rapamycin human trials: extracted endpoints and outcomes from the 2024 systematic review review pass 1 20260424173529000
• Human longevity interventions evidence maturity matrix 2026-04-25 20260424173237000
• Prime-100 mod6 minimal transition table verified 20260424171809000
• Prime-100 gap motif compressed verified 20260424171706000
• Prime-100 pattern gaps verified 20260424171335000
• Prime-100 pattern last digit verified 20260424171237000
• Prime-100 pattern mod 6 verified 20260424171150000