Iter-4360dd15-0056-pubmed-boundary-confirmation

第 56 轮：PubMed 边界条目复核

本轮只做一件事：对上一轮审计表里最容易混淆的边界条目做 PubMed 映射复核，确认题名、PMID 与研究阶段标记一致。

复核结果

| PMID | PubMed 题名 | 结论 |
|---|---|---|
| 35040506 | mTOR Inhibition with Sirolimus in Multiple System Atrophy: A Randomized, Double-Blind, Placebo-Controlled Futility Trial and 1-Year Biomarker Longitudinal Analysis. | 原始临床试验；"longitudinal analysis" 只是随访/生物标志物分析，不构成自动排除 |
| 29992557 | Efficacy and safety of everolimus plus exemestane... Results of the single-arm, phase IIIB 4EVER trial. | 原始单臂 phase IIIB 试验 |
| 30564495 | Everolimus for treatment-refractory seizures in TSC: Extension of a randomized controlled trial. | extension，排除 |
| 31781682 | Low-Dose Sirolimus Immunoregulation Therapy... A 24-Week Follow-Up... | follow-up，排除 |
| 34693520 | Adjunctive everolimus therapy... Results from the postextension phase of EXIST-3. | postextension，排除 |
| 29806044 | Treatment of Geographic Atrophy with Intravitreal Sirolimus: The Age-Related Eye Disease Study 2 Ancillary Study. | ancillary study，排除 |

可复现查询

- PubMed query: 35040506 sirolimus multiple system atrophy futility trial longitudinal analysis
- PubMed query: 29992557 4EVER trial everolimus exemestane phase IIIB
- PubMed query: 30564495 everolimus extension randomized controlled trial TSC seizures
- PubMed query: 31781682 low-dose sirolimus immunoregulation therapy follow-up randomized open-label parallel-controlled trial
- PubMed query: 34693520 everolimus postextension phase EXIST-3 refractory seizures
- PubMed query: 29806044 treatment of geographic atrophy with intravitreal sirolimus ancillary study

规则更新

- 题名中出现 longitudinal analysis 不应自动判为排除；需看是否与原始试验并列出现。
- 对 extension / follow-up / ancillary / postextension 这类字样，标题本身已足够支持排除。