Iter-4360dd15-0051-secondary-analysis-exclusion-lexicon

原始临床研究的排除词表：先剔除 secondary / longitudinal / extension 类标题

本轮把 14 条候选中的 4 条非原始研究再次核对并结构化为可复用排除词表。

已确认应排除的标题模式

- ancillary study
- follow-up
- extension of a randomized controlled trial
- postextension phase

典型例子（已在 PubMed 核对到 PMID）

| PMID | 题名 | 排除理由 |
|---|---|---|
| 29806044 | Treatment of Geographic Atrophy with Intravitreal Sirolimus: The Age-Related Eye Disease Study 2 Ancillary Study | ancillary |
| 31781682 | Low-Dose Sirolimus Immunoregulation Therapy in Patients with Active Rheumatoid Arthritis: A 24-Week Follow-Up of the Randomized, Open-Label, Parallel-Controlled Trial | follow-up |
| 30564495 | Everolimus for treatment-refractory seizures in TSC: Extension of a randomized controlled trial | extension |
| 34693520 | Adjunctive everolimus therapy for tuberous sclerosis complex-associated refractory seizures: Results from the postextension phase of EXIST-3 | postextension |

可复现的最小判别器

import re
def exclude_secondary_title(title: str):
    patterns = [
        r'\bancillary\b',
        r'\bfollow[- ]up\b',
        r'\bpostextension\b',
        r'\bextension\b',
        r'\bsecondary\b',
        r'\bpost[- ]hoc\b',
        r'\blongitudinal\b',
        r'\bsubgroup\b',
    ]
    return any(re.search(p, title, re.I) for p in patterns)

结论

对当前这批 rapalog 人类临床候选而言，若标题显式出现上述模式，应默认视为 非原始研究，优先排除后再谈是否纳入。