Iter-4360dd15-0098-EuropePMC-extract-human-trial-PMIDs

Europe PMC 提取 PMID 38310895 参考文献中的人体原始试验 PMID

本轮通过 Europe PMC REST 接口直接读取了 PMID 38310895 的参考文献列表：
https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/references/1/1000

该接口返回 75 条参考文献。用标题关键词筛选后，得到一批与 rapamycin / rapalog 人体原始试验高度相关的 PMID：

* 33977284 — Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials
* 29408453 — A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects
* 31761958 — Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial
* 22959478 — Rapamycin does not affect post-absorptive protein metabolism in human skeletal muscle
* 19188252 — Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis
* 24691032 — Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin
* 32475067 — Dose-Dependent Acute Effects of Everolimus Administration on Immunological, Neuroendocrine and Psychological Parameters in Healthy Men
* 22367193 — A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults
* 22115710 — A randomized, dose-escalation study of subconjunctival and intravitreal injections of sirolimus in patients with diabetic macular edema
* 20847709 — A randomized pilot study of systemic immunosuppression in the treatment of age-related macular degeneration with choroidal neovascularization
* 35040506 — mTOR Inhibition with Sirolimus in Multiple System Atrophy: A Randomized, Double-Blind, Placebo-Controlled Futility Trial and 1-Year Biomarker Longitudinal Analysis
* 25525171 — Intravitreal sirolimus for the treatment of geographic atrophy: results of a phase I/II clinical trial
* 24618547 — Everolimus in patients with severe pulmonary hypertension: a safety and efficacy pilot trial
* 18037627 — Everolimus in patients with rheumatoid arthritis receiving concomitant methotrexate: a 3-month, double-blind, randomised, placebo-controlled, parallel-group, proof-of-concept study
* 31781682 — Low-Dose Sirolimus Immunoregulation Therapy in Patients with Active Rheumatoid Arthritis: A 24-Week Follow-Up of the Randomized, Open-Label, Parallel-Controlled Trial

验证：PubMed 已确认 33977284 的 PMID 与题名一致。

结论：Europe PMC 参考文献接口是可用的“从综述反推原始试验 PMID”入口；下步可以对上述 PMID 做逐篇纳入/排除与主要终点评审。