BOLERO-2 PMID 22149876 vs PMC4713958: verbatim abstract diff

BOLERO-2 PMID 22149876 vs PMC4713958: verbatim abstract sentence diff

Metadata

- PMID: 22149876
- Article title: ''Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer.''
- Erratum PMC: 4713958
- Erratum DOI: 10.1007/s12325-014-0150-8

Original abstract sentence (PMID 22149876)

''Final study results with median 18-month follow-up show that median PFS remained significantly longer with everolimus plus exemestane versus placebo plus exemestane [investigator review: 7.8 versus 3.2 months, respectively; hazard ratio = 0.45 (95% confidence interval 0.38–0.54); log-rank P < 0.0001; central review: 11.0 versus 4.1 months, respectively; hazard ratio = 0.38 (95% confidence interval 0.31–0.48); log-rank P < 0.0001] in the overall population and in all prospectively defined subgroups, including patients with visceral metastases, patients with recurrence during or within 12 months of completion of adjuvant therapy, and irrespective of age.''

Erratum-corrected sentence (PMC4713958)

''Final study results with median 18-month follow-up show that median PFS remained significantly longer with everolimus plus exemestane versus placebo plus exemestane [investigator review: 7.8 versus 3.2 months, respectively; hazard ratio = 0.45 (95% confidence interval 0.38–0.54); log-rank P < 0.0001; central review: 11.0 versus 4.1 months, respectively; hazard ratio = 0.38 (95% confidence interval 0.31–0.48); log-rank P < 0.0001] in the overall population and in all prospectively defined subgroups, including patients with visceral metastases, and irrespective of age.''

Unique change

- Deleted exactly one subgroup phrase:
- original: ''patients with recurrence during or within 12 months of completion of adjuvant therapy,''
- No change to PFS values, hazard ratios, confidence intervals, P values, or the overall conclusion.

Minimal machine-checkable diff

orig = '...including patients with visceral metastases, patients with recurrence during or within 12 months of completion of adjuvant therapy, and irrespective of age.'
cor  = '...including patients with visceral metastases, and irrespective of age.'

Verification note

- Python diff confirmed the corrected sentence is exactly the original sentence with that one subgroup phrase removed.
- PubMed search confirmed PMID 22149876 points to the NEJM BOLERO-2 primary report.