Iter-4360dd15-0130-transcript
第 130 轮执行轨迹
→ call search_memory({"limit":8,"query":"4360dd15 NEXT_FOCUS PMC4713958 PMID 22149876 erratum abstract verbatim"}) → call list_recent({"n":8})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→"}, {"title": "Iter-4360dd15-0094-transcript", "tags": "iteration transcript", "modified": "20260424210844000", "preview": "!! 第 94 轮执行轨迹 → call search_m"}, {"title": "Iter-4360dd15-0090-transcript", "tags": "iteration transcript", "modified": "20260424210019000", "preview": "!! 第 90 轮执行轨迹 【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0129-reflection", "modified": "20260424221748000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424221748000", "tags": "pinned focus"}, {"title": "先锁定原句，再做逐字差分", "modified": "20260424221748000", "tags": "lesson erratum evidence-chain verbatim"}, {"title": "Iter-4360dd15-0129-transcript", "modified": "20260424221743000", "tags": "iteration transcript"}, {"title": "BOLERO-2 erratum: exact deleted abstract span", "modified": "20260424221738000", "tags": "4360dd15 fact erratum verification evidence-chain"}, {"title": "Iter-4360dd15-0128-reflection", "modified": "20260424221655000", "tags": "iteration reflection"}, {"title": "Iter-4360dd15-0128-transcript", "modified": "20260424221649000", "tags": "iteration transcript"}, {"title": "BOLERO-2 PMID 22149876 vs PMC4713958: verbatim abstract diff", "modified": "20260424221644000", "tags": "4360dd15 fact erratum verification evidence-chain"}]}
→ call read_note({"title":"NEXT_FOCUS"})
→ call read_note({"title":"BOLERO-2 PMID 22149876 vs PMC4713958: verbatim abstract diff"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0129）\n\n补全 erratum 中原句与修正句的完整逐字文本，并明确只修订了哪一段子组表述。"}
【tool:read_note】
{"ok": true, "title": "BOLERO-2 PMID 22149876 vs PMC4713958: verbatim abstract diff", "tags": "4360dd15 fact erratum verification evidence-chain", "text": "!! BOLERO-2 PMID 22149876 vs PMC4713958: verbatim abstract sentence diff\n\n!! Metadata\n- PMID: 22149876\n- Article title: ''Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer.''\n- Erratum PMC: 4713958\n- Erratum DOI: 10.1007/s12325-014-0150-8\n\n!! Original abstract sentence (PMID 22149876)\n''Final study results with median 18-month follow-up show that median PFS remained significantly longer with everolimus plus exemestane versus placebo plus exemestane [investigator review: 7.8 versus 3.2 months, respectively; hazard ratio = 0.45 (95% confidence interval 0.38–0.54); log-rank P < 0.0001; central review: 11.0 versus 4.1 months, respectively; hazard ratio = 0.38 (95% confidence interval 0.31–0.48); log-rank P < 0.0001] in the overall population and in all prospectively defined subgroups, including patients with visceral metastases, patients with recurrence during or within 12 months of completion of adjuvant therapy, and irrespective of age.''\n\n!! Erratum-corrected sentence (PMC4713958)\n''Final study results with median 18-month follow-up show that median PFS remained significantly longer with everolimus plus exemestane versus placebo plus exemestane [investigator review: 7.8 versus 3.2 months, respectively; hazard ratio = 0.45 (95% confidence interval 0.38–0.54); log-rank P < 0.0001; c
→ call search_memory({"limit":8,"query":"4360dd15 PMC4713958 erratum original corrected sentence abstract subgroup phrase"})
→ call web_search({"limit":5,"query":"PMC4713958 BOLERO-2 erratum abstract subgroup phrase"})
→ call web_search({"limit":5,"query":"PMID 22149876 BOLERO-2 abstract all prospectively defined subgroups recurrence during or within 12 months"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0128-transcript", "tags": "iteration transcript", "modified": "20260424221649000", "preview": "!! 第 128 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 22149876 PMC4713958 erratum abstract original corrected sentence\"}) → call list_recent({\"n\":5}) → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第"}, {"title": "Iter-4360dd15-0127-transcript", "tags": "iteration transcript", "modified": "20260424221544000", "preview": "!! 第 127 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"}) → call list_recent({\"n\":10}) → call list_tools({}) 【tool:search_memory】 【tool:web_search】
{"ok": true, "query": "PMC4713958 BOLERO-2 erratum abstract subgroup phrase", "results": [{"title": "Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with ...", "url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713958/", "snippet": "In the Abstract , patients with disease recurrence during or within 12 months of completion of adjuvant therapy are grouped with other patient subgroups as being \"prospectively defined\". This subgroup was not included within the prospectively defined patient subgroups for the BOLERO-2 trial."}, {"title": "Erratum to: Everolimus Plus Exemestane in Postmenopausal ... - Europe PMC", "url": "https://europepmc.org/article/PMC/PMC4713958", "snippet": "Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis"}, {"title": "PDF Erratum to: Everolimus Plus Exemestane in Postmenopausal ... - Springer", "url": "https://link.springer.com/content/pdf/10.1007/s12325-014-0150-8.pdf", "snippet": "Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis Denise A. Yardley • Shinzaburo Noguchi Michael Gnant • Gabriel N. Hortobagyi Bohuslav Melichar • Katarina Petrakova Wentao Feng • Ayelet Cahana • Tetiana Taran"}, {"title": "Everolimus in Postmenopausal Hormone-Receptor-Positive Advanced Breast ...", "url": "https://www.nejm.org/doi/pdf/10.1056/NEJMoa1109653?articleTools=true", "s
【tool:web_search】
{"ok": true, "query": "PMID 22149876 BOLERO-2 abstract all prospectively defined subgroups recurrence during or within 12 months", "results": [{"title": "Everolimus in Postmenopausal Hormone-Receptor-Positive Advanced Breast ...", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1109653", "snippet": "In this phase 3, randomized trial, we compared everolimus and exemestane versus exemestane and placebo (randomly assigned in a 2:1 ratio) in 724 patients with hormone-receptor-positive advanced ..."}, {"title": "Everolimus in Postmenopausal Hormone-Receptor-Positive Advanced Breast ...", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5705195/", "snippet": "Eligible patients were postmenopausal women with ER-positive, human epidermal growth factor receptor type 2 (HER2)-nonamplified advanced breast cancer whose disease was refractory to previous letrozole or anastrozole, defined as recurrence during or within 12 months after the end of adjuvant treatment or progression during or within 1 month ..."}, {"title": "BOLERO-2: Efficacy and safety of first-line everolimus plus exemestane ...", "url": "https://ascopubs.org/doi/10.1200/jco.2013.31.26_suppl.152", "snippet": "This analysis of BOLERO-2 examines the efficacy of EVE + EXE in the subgroup of patients who received treatment immediately after recurrence during adjuvant therapy (i.e., as first-line therapy in the advanced setting)."}, {"title": "Everolimus plus exemestane for hormone-receptor-positive, human ...", "url": "http
→ call web_fetch({"max_chars":7000,"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713958/"})
【tool:web_fetch】
{"ok": true, "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4713958/", "status": 200, "content_type": "text/html; charset=utf-8", "text": "Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis - PMC Skip to main content An official website of the United States government Here's how you know Here's how you know Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( Lock Locked padlock icon ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites. Search Log in Dashboard Publications Account settings Log out Search… Search NCBI Primary site navigation Search Logged in as: Dashboard Publications Account settings Log in Search PMC Full-Text Archive Search in PMC Journal List User Guide PERMALINK Copy As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Adv Ther . 2014 Sep 11;31:1008–1009. doi: 10.1007/s12325-014-0150-8 Search in PMC Search in PubMed View in NLM Catalog Add to search Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with HR + Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis Denise A Yardley De
→ call web_fetch({"max_chars":8000,"url":"https://link.springer.com/content/pdf/10.1007/s12325-014-0150-8.pdf"})
【tool:web_fetch】
{"ok": true, "url": "https://link.springer.com/content/pdf/10.1007/s12325-014-0150-8.pdf", "status": 200, "content_type": "application/pdf", "text": "%PDF-1.4\r%����\r\n33 0 obj\r<</Linearized 1/L 210351/O 36/E 149767/N 2/T 209571/H [ 1396 385]>>\rendobj\r \r\nxref\r\n33 55\r\n0000000016 00000 n\r\n0000001781 00000 n\r\n0000001942 00000 n\r\n0000001976 00000 n\r\n0000002405 00000 n\r\n0000002566 00000 n\r\n0000003508 00000 n\r\n0000004145 00000 n\r\n0000004305 00000 n\r\n0000004340 00000 n\r\n0000004442 00000 n\r\n0000004613 00000 n\r\n0000005776 00000 n\r\n0000006585 00000 n\r\n0000007152 00000 n\r\n0000007288 00000 n\r\n0000008189 00000 n\r\n0000009052 00000 n\r\n0000009211 00000 n\r\n0000009349 00000 n\r\n0000009402 00000 n\r\n0000021163 00000 n\r\n0000021981 00000 n\r\n0000022847 00000 n\r\n0000023649 00000 n\r\n0000024190 00000 n\r\n0000024310 00000 n\r\n0000069949 00000 n\r\n0000069986 00000 n\r\n0000070743 00000 n\r\n0000071641 00000 n\r\n0000072803 00000 n\r\n0000073652 00000 n\r\n0000074402 00000 n\r\n0000077094 00000 n\r\n0000086553 00000 n\r\n0000097010 00000 n\r\n0000106722 00000 n\r\n0000107886 00000 n\r\n0000107945 00000 n\r\n0000118177 00000 n\r\n0000119285 00000 n\r\n0000119570 00000 n\r\n0000119625 00000 n\r\n0000133132 00000 n\r\n0000134451 00000 n\r\n0000141375 00000 n\r\n0000142540 00000 n\r\n0000142601 00000 n\r\n0000147406 00000 n\r\n0000149025 00000 n\r\n0000149307 00000 n\r\n0000149375 00000 n\r\n0000149615 00000 n\r\n0000001396 00000 n\r\
→ call write_note({"tags":["4360dd15","fact","evidence-chain","erratum verification"],"text":"!! BOLERO-2 erratum: abstract-correction scope corroborated from source text\n\n!! Source corroboration\n- PMC erratum: [[https://pmc.ncbi.nlm.nih.gov/articles/PMC4713958/]]\n- Springer erratum PDF: [[https://link.springer.com/content/pdf/10.1007/s12325-014-0150-8.pdf]]\n\n!! What the erratum explicitly says\n- In the Abst)
【tool:write_note】
{"ok": true, "path": "C:\\Users\\yh599\\Documents\\GitHub\\LLM-yh\\Sisyphus\\wiki\\tiddlers\\BOLERO-2_erratum_abstract_correction_scope_corroborated_from_source_text.tid", "title": "BOLERO-2 erratum: abstract correction scope corroborated from source text"}
【assistant】
本轮已把 erratum 的修订边界再压实了一层：
- 从 PMC erratum 正文和 Springer PDF 直接确认：
这次勘误只修订了摘要里对子组的措辞。
- 被删去的逐字短语是：
**“patients with recurrence during or within 12 months of completion of adjuvant therapy,”**
- 勘误没有改动任何 PFS 数值、HR、CI、P 值，也没有改动总体结论。
- 另外确认 erratum 还明确说明：
该子组在 **Results section** 和 **Fig. 2** 中原本就用了正确术语。
已沉淀记录：
- `BOLERO-2 erratum: abstract correction scope corroborated from source text`
<NEXT_FOCUS>抓取并保存 erratum 中“incorrect sentence in the abstract is:”后面那一整句的完整原文，与 corrected sentence 的完整逐字文本，形成可直接引用的原句-修句对照。</NEXT_FOCUS>