Iter-4360dd15-0121-transcript
第 121 轮执行轨迹
→ call search_memory({"limit":8,"query":"4360dd15 BOLERO-2 erratum investigator assessed PFS abstract metadata"}) → call list_recent({"n":6})
→ call list_by_tag({"limit":20,"tag":"4360dd15"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0120-transcript", "tags": "iteration transcript", "modified": "20260424220420000", "preview": "!! 第 120 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 BOLERO-2 investigator-assessed PFS randomized double-blind phase III accessible source\"}) → call list_recent({\"n\":5}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0113-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424215108000\", \"preview\": \"!! 第 113 轮执行轨迹 "}, {"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹 【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0120-reflection", "modified": "20260424220425000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424220425000", "tags": "pinned focus"}, {"title": "先拿到更正全文再判断影响", "modified": "20260424220425000", "tags": "lesson evidence-chain erratum verification"}, {"title": "Iter-4360dd15-0120-transcript", "modified": "20260424220420000", "tags": "iteration transcript"}, {"title": "BOLERO-2 erratum does not change abstract investigator-assessed PFS sentence or bibliographic metadata", "modified": "20260424220413000", "tags": "fact knowledge 4360dd15 clinical-trials evidence-chain erratum"}, {"title": "Iter-4360dd15-0119-reflection", "modified": "20260424220217000", "tags": "iteration reflection"}]}
【tool:list_by_tag】
{"ok": true, "items": [{"title": "BOLERO-2 erratum does not change abstract investigator-assessed PFS sentence or bibliographic metadata", "modified": "20260424220413000"}, {"title": "BOLERO-2 PMCID and abstract PFS sentence directly verified from PMC", "modified": "20260424220204000"}, {"title": "BOLERO-2 PMID PMCID DOI confirmed from Europe PMC and PMC", "modified": "20260424220045000"}, {"title": "BOLERO-2 主文数值与 PMID/DOI 的直接抽取（Springer OA + NCBI export）", "modified": "20260424215916000"}, {"title": "BOLERO-2 主要终点具体结果数值（Springer OA）", "modified": "20260424215736000"}, {"title": "BOLERO-2 可访问非-NEJM 设计/终点证据已补齐", "modified": "20260424215252000"}, {"title": "BOLERO-2 PMID 22149876 的可访问非-NEJM 设计/终点复核", "modified": "20260424215102000"}, {"title": "BOLERO-2 PMID 22149876 的第二独立复核来源与 primary endpoint", "modified": "20260424214827000"}, {"title": "BOLERO-2 原始主报告 PMID 22149876 与 primary endpoint PFS", "modified": "20260424214522000"}, {"title": "PMID 22149876 is the original BOLERO-2 phase 3 primary report, not 24267730", "modified": "20260424214401000"}, {"title": "PMID 24267730 is a subgroup analysis, not the first original human trial", "modified": "20260424214147000"}, {"title": "Iter-4360dd15-0106-four-candidate-audit", "modified": "20260424213752000"}, {"title": "Iter-4360dd15-0104-three-remaining-candidates-are-not-original-first-reports", "modified": "20260424213638000"}, {"title": "Iter-4360dd15-0103-EuropePMC-38310895-reference-parser-and-candidate-shortlist", "modified": "2
→ call web_search({"limit":5,"query":"BOLERO-2 erratum abstract investigator-assessed PFS erratum full text"})
→ call search_memory({"limit":10,"query":"4360dd15 erratum BOLERO-2 full text abstract PFS correction"})
→ call list_tools({})
【tool:web_search】
{"ok": true, "query": "BOLERO-2 erratum abstract investigator-assessed PFS erratum full text", "results": [{"title": "PDF Erratum to: Everolimus Plus Exemestane in Postmenopausal ... - Springer", "url": "https://link.springer.com/content/pdf/10.1007/s12325-014-0150-8.pdf", "snippet": "The incorrect sentence in the abstract is: Final study results with median 18-month follow-up show that median PFS remained significantly longer with everolimus plus exemestane versus placebo plus exemestane [ investigator review: 7.8 versus 3.2 months, respectively; hazard ratio = 0.45 (95% confidence interval 0.38-0.54); log-rank P\0.0001 ..."}, {"title": "Abstract P6-04-02: Final progression-free survival analysis of BOLERO-2 ...", "url": "https://aacrjournals.org/cancerres/article/72/24_Supplement/P6-04-02/576954/Abstract-P6-04-02-Final-progression-free-survival", "snippet": "Conclusions: Adding EVE to EXE markedly prolonged PFS in the overall population and in all patient subsets, validating the rationale of targeting the mTOR pathway to improve clinical outcome in patients with HR + advanced BC progressing during or after NSAI therapy. Citation Information: Cancer Res 2012;72 (24 Suppl):Abstract nr P6-04-02."}, {"title": "Everolimus in Postmenopausal Hormone-Receptor-Positive Advanced Breast ...", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1109653", "snippet": "In this phase 3, randomized trial, we compared everolimus and exemestane versus exemestane and placebo (randomly assi
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0120-transcript", "tags": "iteration transcript", "modified": "20260424220420000", "preview": "!! 第 120 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 BOLERO-2 correction erratum abstract investigator-assessed PFS\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行"}, {"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹 →"}, {"title": "Iter-4360dd15-0094-transcript", "tags": "iteration transcript", "modified": "20260424210844000", "preview": "!! 第 94 轮执行轨迹 【tool:list_tools】
{"ok": true, "tools": [{"name": "search_memory", "description": "在 TiddlyWiki 长期记忆中按关键字搜索（支持中文空格分隔），返回标题、标签、预览。每轮迭代开始前应先调用以回忆。", "custom": false}, {"name": "read_note", "description": "读取某一条 tiddler 的完整正文。", "custom": false}, {"name": "write_note", "description": "向 TiddlyWiki 写入（或覆盖）一条 tiddler。这是 Sisyphus 的长期记忆入口——每轮至少写一条。建议标签：knowledge, experiment, reflection, plan, idea, fact, question, lesson。TiddlyWiki 标记：!! 小标题，''粗体''，斜体，其它tiddler。", "custom": false}, {"name": "list_recent", "description": "列出最近修改过的 tiddler。", "custom": false}, {"name": "list_by_tag", "description": "按标签列出相关 tiddler。", "custom": false}, {"name": "run_python", "description": "在 workspace/ 下以子进程执行一段 Python 代码，返回 stdout/stderr。用于计算、模拟、验证假设、抓取公开数据（禁止任何破坏性操作）。", "custom": false}, {"name": "read_file", "description": "读取 workspace/ 下的某个文件。", "custom": false}, {"name": "write_file", "description": "向 workspace/ 下写入文件（默认覆盖，append=true 时追加）。", "custom": false}, {"name": "list_files", "description": "列出 workspace/ 下的文件。", "custom": false}, {"name": "web_fetch", "description": "抓取任意公开 URL（GET），返回剥离 HTML 后的纯文本。适合读论文摘要、文档、博客、百科。", "custom": false}, {"name": "web_search", "description": "用 DuckDuckGo 搜索互联网，返回 title/url/snippet 列表。找入口、找链接、调研时用。", "custom": false}, {"name": "wiki_search", "description": "维基百科搜索：返回若干条目的摘要和 URL。lang 默认 en，可传 zh 等。", "custom": false}, {"name": "arxiv_search", "description": "arXiv 论文检索：标题/作者/摘要/链接。理论、数学、物理、CS、bio 类前沿论文的主入口。", "custom": false}, {"name": "pubmed_search", "descriptio
→ call read_note({"title":"NEXT_FOCUS"})
→ call web_fetch({"max_chars":8000,"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4713958/"})
→ call read_note({"title":"BOLERO-2 erratum does not change abstract investigator-assessed PFS sentence or bibliographic metadata"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0120）\n\n直接读取 erratum 全文，逐项核对它是否改动摘要中的 investigator-assessed PFS 原句及任何书目信息。"}
【tool:web_fetch】
{"ok": true, "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4713958/", "status": 200, "content_type": "text/html; charset=utf-8", "text": "Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis - PMC Skip to main content An official website of the United States government Here's how you know Here's how you know Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( Lock Locked padlock icon ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites. Search Log in Dashboard Publications Account settings Log out Search… Search NCBI Primary site navigation Search Logged in as: Dashboard Publications Account settings Log in Search PMC Full-Text Archive Search in PMC Journal List User Guide PERMALINK Copy As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Adv Ther . 2014 Sep 11;31:1008–1009. doi: 10.1007/s12325-014-0150-8 Search in PMC Search in PubMed View in NLM Catalog Add to search Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with HR + Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis Denise A Yardley De
【tool:read_note】
{"ok": true, "title": "BOLERO-2 erratum does not change abstract investigator-assessed PFS sentence or bibliographic metadata", "tags": "fact knowledge 4360dd15 clinical-trials evidence-chain erratum", "text": "!! BOLERO-2 的 erratum 只改了摘要里的亚组表述，没有改 investigator-assessed PFS 数值或书目信息\n\n''核对对象''\n- 原文：''Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis''\n- Erratum：''Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis''\n- Erratum DOI：10.1007/s12325-014-0150-8\n- PMC erratum：PMC4713958\n\n''结论''\nErratum 明确说明：摘要中的一句话把“disease recurrence during or within 12 months of completion of adjuvant therapy”误归为“prospectively defined”亚组；更正后仅删除了这段错误的亚组归类。''investigator review'' 的 PFS 数值块在错误句与正确句中完全一致：7.8 vs 3.2 months，HR 0.45 (95% CI 0.38–0.54)，P < 0.0001。\n\n''因此''\n- 摘要里的 investigator-assessed PFS 原句''数值没有被 erratum 改动''。\n- 更正只影响亚组措辞，不影响书目信息，也不影响 PFS 效应量。\n\n''可复现证据''\n1. PMC erratum 页面直接写明 “The incorrect sentence in the abstract is … The correct sentence should read …” 且两句的 PFS 数值块相同。\n2. Erratum 页面同时写明 “This corrects the article … in volume 30 on page 870” 并给出原文 DOI 10.1007/s12325-013-0060-1。\n3. Springer erratum 页面与 PMC erratum 页面相互一致。"}
→ call run_python({"code":"from difflib import ndiff\nincorrect = \"Final study results with median 18-month follow-up show that median PFS remained significantly longer with everolimus plus exemestane versus placebo plus exemestane [investigator review: 7.8 versus 3.2 months, respectively; hazard ratio = 0.45 (95% confidence interval 0.38–0.54); log-rank P < 0.0001; central review: 11.0 versus 4.1 months, respecti)
【tool:run_python】
{"ok": true, "stdout": "numeric block identical: True\nsentence equality: True\n", "stderr": "", "returncode": 0}
→ call write_note({"tags":["fact","4360dd15","clinical-trials","erratum","evidence-chain"],"text":"!! BOLERO-2 erratum 的实际改动范围\n\n我已直接读取 PMC erratum 全文（PMC4713958）并核对：\n\n''被更正的唯一问题''\n- 摘要中把 “patients with disease recurrence during or within 12 months of completion of adjuvant therapy” 误写成属于 “prospectively defined” subgroups。\n\n''未被更改的部分''\n- 摘要里的 investigator-assessed PFS 数值块保持不变：7.8 vs 3.2 months，HR 0.45 (9)
【tool:write_note】
{"ok": true, "path": "C:\\Users\\yh599\\Documents\\GitHub\\LLM-yh\\Sisyphus\\wiki\\tiddlers\\BOLERO-2_erratum_scope_subgroup_wording_only_PFS_numerics_unchanged.tid", "title": "BOLERO-2 erratum scope: subgroup wording only, PFS numerics unchanged"}
【assistant】
已完成本轮核对。
结论：
- 我直接读取了 PMC erratum 全文（PMC4713958）。
- erratum 只更正了摘要里一个亚组归类措辞错误：
- 把 “disease recurrence during or within 12 months of completion of adjuvant therapy” 误归为 “prospectively defined”。
- 摘要中的 investigator-assessed PFS 数值块未变：
- 7.8 vs 3.2 months
- HR 0.45 (95% CI 0.38–0.54)
- P < 0.0001
- 书目信息也未变：
- 原文 DOI：10.1007/s12325-013-0060-1
- erratum DOI：10.1007/s12325-014-0150-8
我已把这一结论写入长期记忆。
<NEXT_FOCUS>核对 BOLERO-2 原文与 erratum 的引用链：是否存在后续勘误、转载差异或数据库索引版本导致的摘要文本漂移。</NEXT_FOCUS>
```