Iter-4360dd15-0120-transcript
第 120 轮执行轨迹
→ call search_memory({"limit":8,"query":"4360dd15 BOLERO-2 correction erratum abstract investigator-assessed PFS"}) → call list_recent({"n":8})
→ call list_by_tag({"limit":10,"tag":"4360dd15"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→"}, {"title": "Iter-4360dd15-0094-transcript", "tags": "iteration transcript", "modified": "20260424210844000", "preview": "!! 第 94 轮执行轨迹 → call search_m"}, {"title": "Iter-4360dd15-0114-transcript", "tags": "iteration transcript", "modified": "20260424215258000", "preview": "!! 第 114 轮执行轨迹 【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0119-reflection", "modified": "20260424220217000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424220217000", "tags": "pinned focus"}, {"title": "先锁书目信息，再查更正", "modified": "20260424220217000", "tags": "lesson evidence-chain bibliography erratum"}, {"title": "Iter-4360dd15-0119-transcript", "modified": "20260424220210000", "tags": "iteration transcript"}, {"title": "BOLERO-2 PMCID and abstract PFS sentence directly verified from PMC", "modified": "20260424220204000", "tags": "fact knowledge 4360dd15 clinical-trials evidence-chain"}, {"title": "Iter-4360dd15-0118-reflection", "modified": "20260424220056000", "tags": "iteration reflection"}, {"title": "先锁主文再抽全字段", "modified": "20260424220056000", "tags": "lesson evidence-chain metadata-first"}, {"title": "Iter-4360dd15-0118-transcript", "modified": "20260424220050000", "tags": "iteration transcript"}]}
【tool:list_by_tag】
{"ok": true, "items": [{"title": "BOLERO-2 PMCID and abstract PFS sentence directly verified from PMC", "modified": "20260424220204000"}, {"title": "BOLERO-2 PMID PMCID DOI confirmed from Europe PMC and PMC", "modified": "20260424220045000"}, {"title": "BOLERO-2 主文数值与 PMID/DOI 的直接抽取（Springer OA + NCBI export）", "modified": "20260424215916000"}, {"title": "BOLERO-2 主要终点具体结果数值（Springer OA）", "modified": "20260424215736000"}, {"title": "BOLERO-2 可访问非-NEJM 设计/终点证据已补齐", "modified": "20260424215252000"}, {"title": "BOLERO-2 PMID 22149876 的可访问非-NEJM 设计/终点复核", "modified": "20260424215102000"}, {"title": "BOLERO-2 PMID 22149876 的第二独立复核来源与 primary endpoint", "modified": "20260424214827000"}, {"title": "BOLERO-2 原始主报告 PMID 22149876 与 primary endpoint PFS", "modified": "20260424214522000"}, {"title": "PMID 22149876 is the original BOLERO-2 phase 3 primary report, not 24267730", "modified": "20260424214401000"}, {"title": "PMID 24267730 is a subgroup analysis, not the first original human trial", "modified": "20260424214147000"}]}
→ call read_note({"title":"NEXT_FOCUS"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0119）\n\n只核对一个点：BOLERO-2 的 correction/erratum 是否改动了摘要里的 investigator-assessed PFS 原句或任何书目信息。"}
→ call web_search({"limit":8,"query":"BOLERO-2 correction erratum investigator-assessed PFS abstract correction"})
→ call search_memory({"limit":8,"query":"4360dd15 BOLERO-2 erratum correction correction notice"})
→ call list_tools({})
【tool:web_search】
{"ok": true, "query": "BOLERO-2 correction erratum investigator-assessed PFS abstract correction", "results": [{"title": "Everolimus plus exemestane for hormone-receptor-positive, human ...", "url": "https://www.annalsofoncology.org/article/S0923-7534(19)36905-4/fulltext", "snippet": "The BOLERO-2 study previously demonstrated that adding everolimus (EVE) to exemestane (EXE) significantly improved progression-free survival ( PFS ) by more than twofold in patients with hormone-receptor-positive (HR +), HER2-negative advanced breast cancer that recurred or progressed during/after treatment with nonsteroidal aromatase inhibitors (NSAIs). The overall survival (OS) analysis is ..."}, {"title": "Everolimus plus exemestane for hormone-receptor-positive, human ...", "url": "https://escholarship.org/uc/item/9w5782j7", "snippet": "The BOLERO-2 study previously demonstrated that adding everolimus (EVE) to exemestane (EXE) significantly improved progression-free survival ( PFS ) by more than twofold in patients with hormone-receptor-positive (HR (+)), HER2-negative advanced breast cancer that recurred or progressed during/after treatment with nonsteroidal aromatase ..."}, {"title": "PDF Erratum to: Everolimus Plus Exemestane in Postmenopausal ... - Springer", "url": "https://link.springer.com/content/pdf/10.1007/s12325-014-0150-8.pdf", "snippet": "The incorrect sentence in the abstract is: Final study results with median 18-month follow-up show that median PFS remained significantly long
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"}) → call list_recent({\"n\":10}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 38310895 NEXT_FOCUS 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":10}) → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":8,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": 【tool:list_tools】
{"ok": true, "tools": [{"name": "search_memory", "description": "在 TiddlyWiki 长期记忆中按关键字搜索（支持中文空格分隔），返回标题、标签、预览。每轮迭代开始前应先调用以回忆。", "custom": false}, {"name": "read_note", "description": "读取某一条 tiddler 的完整正文。", "custom": false}, {"name": "write_note", "description": "向 TiddlyWiki 写入（或覆盖）一条 tiddler。这是 Sisyphus 的长期记忆入口——每轮至少写一条。建议标签：knowledge, experiment, reflection, plan, idea, fact, question, lesson。TiddlyWiki 标记：!! 小标题，''粗体''，//斜体//，[[其它tiddler]]。", "custom": false}, {"name": "list_recent", "description": "列出最近修改过的 tiddler。", "custom": false}, {"name": "list_by_tag", "description": "按标签列出相关 tiddler。", "custom": false}, {"name": "run_python", "description": "在 workspace/ 下以子进程执行一段 Python 代码，返回 stdout/stderr。用于计算、模拟、验证假设、抓取公开数据（禁止任何破坏性操作）。", "custom": false}, {"name": "read_file", "description": "读取 workspace/ 下的某个文件。", "custom": false}, {"name": "write_file", "description": "向 workspace/ 下写入文件（默认覆盖，append=true 时追加）。", "custom": false}, {"name": "list_files", "description": "列出 workspace/ 下的文件。", "custom": false}, {"name": "web_fetch", "description": "抓取任意公开 URL（GET），返回剥离 HTML 后的纯文本。适合读论文摘要、文档、博客、百科。", "custom": false}, {"name": "web_search", "description": "用 DuckDuckGo 搜索互联网，返回 title/url/snippet 列表。找入口、找链接、调研时用。", "custom": false}, {"name": "wiki_search", "description": "维基百科搜索：返回若干条目的摘要和 URL。lang 默认 en，可传 zh 等。", "custom": false}, {"name": "arxiv_search", "description": "arXiv 论文检索：标题/作者/摘要/链接。理论、数学、物理、CS、bio 类前沿论文的主入口。", "custom": false}, {"name": "pubmed_search", "descriptio
→ call web_fetch({"max_chars":8000,"url":"https://link.springer.com/content/pdf/10.1007/s12325-014-0150-8.pdf"})
→ call pubmed_search({"limit":10,"query":"Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer BOLERO-2 Final Progression-Free Survival Analysis erratum"})
【tool:web_fetch】
{"ok": false, "error": "[SSL: UNEXPECTED_EOF_WHILE_READING] EOF occurred in violation of protocol (_ssl.c:1028)"}
【tool:pubmed_search】
{"ok": true, "query": "Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer BOLERO-2 Final Progression-Free Survival Analysis erratum", "results": []}
→ call web_search({"limit":10,"query":"\"Erratum to\" \"Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer\""})
→ call web_search({"limit":10,"query":"site:pubmed.ncbi.nlm.nih.gov BOLERO-2 erratum everolimus exemestane"})
→ call search_memory({"limit":8,"query":"4360dd15 erratum BOLERO-2 title abstract corrected sentence"})
【tool:web_search】
{"ok": true, "query": "\"Erratum to\" \"Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer\"", "results": [{"title": "Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with ...", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4713958/", "snippet": "Erratum to : Everolimus Plus Exemestane in Postmenopausal Patients with HR + Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis Denise A Yardley 1, , Shinzaburo Noguchi"}, {"title": "Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with ...", "url": "https://link.springer.com/article/10.1007/s12325-014-0150-8", "snippet": "Erratum to : Everolimus Plus Exemestane in Postmenopausal Patients with HR + Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis Erratum Published: 11 September 2014 Volume 31, pages 1008-1009, (2014) Cite this article Download PDF Save article Denise A. Yardley, Shinzaburo Noguchi, Kathleen I. Pritchard, Howard A. Burris III ..."}, {"title": "Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with ...", "url": "https://www.researchgate.net/publication/258044358_Erratum_to_Everolimus_Plus_Exemestane_in_Postmenopausal_Patients_with_HR_Breast_Cancer_BOLERO-2_Final_Progression-Free_Survival_Analysis", "snippet": "Erratum to : Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer : BOLERO-2 Final Progression-Free Survival Analysis"}, {"title": "Erratum to: Everolimus Plus Exemestane in ... - S
【tool:web_search】
{"ok": true, "query": "site:pubmed.ncbi.nlm.nih.gov BOLERO-2 erratum everolimus exemestane", "results": [{"title": "The BOLERO-2 trial: the addition of everolimus to exemestane in the ...", "url": "https://pubmed.ncbi.nlm.nih.gov/22764762/", "snippet": "The BOLERO-2 trial examined the effects on progression-free survival of the addition of everolimus to exemestane in a patient population of postmenopausal, hormone receptor-positive, advanced breast cancer."}, {"title": "Efficacy and safety of everolimus plus exemestane in ... - PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/29992557/", "snippet": "The ORR in 4EVER was lower than in BOLERO-2 , likely due to inclusion of patients with more advanced disease and extensive pretreatment. These data confirm the clinical benefits and known safety profile of everolimus plus exemestane in postmenopausal women with HR+, HER2- aBC."}, {"title": "Everolimus plus exemestane for the treatment of advanced ... - PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/25810012/", "snippet": "This review will summarize the overall findings from BOLERO-2 and will consider available subanalyses by age, Asian origin, visceral or bone metastases, and prior therapy, with the aim of identifying populations most likely to benefit from everolimus therapy."}, {"title": "Incidence and time course of everolimus-related adverse events in ...", "url": "https://pubmed.ncbi.nlm.nih.gov/24615500/", "snippet": "NCT00863655. Abstract Background: In the BOLERO-2 trial
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→"}, {"title": "Iter-4360dd15-0094-transcript", "tags": "iteration transcript", "modified": "20260424210844000", "preview": "!! 第 94 轮执行轨迹 → call search_m"}, {"title": "Iter-4360dd15-0090-transcript", "tags": "iteration transcript", "modified": "20260424210019000", "preview": "!! 第 90 轮执行轨迹 → call web_fetch({"max_chars":12000,"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4713958/"})
→ call web_fetch({"max_chars":12000,"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3817318/"})
→ call web_search({"limit":10,"query":"PMC BOLERO-2 final progression-free survival analysis erratum PMC original"})
【tool:web_fetch】
{"ok": true, "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4713958/", "status": 200, "content_type": "text/html; charset=utf-8", "text": "Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis - PMC Skip to main content An official website of the United States government Here's how you know Here's how you know Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( Lock Locked padlock icon ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites. Search Log in Dashboard Publications Account settings Log out Search… Search NCBI Primary site navigation Search Logged in as: Dashboard Publications Account settings Log in Search PMC Full-Text Archive Search in PMC Journal List User Guide PERMALINK Copy As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Adv Ther . 2014 Sep 11;31:1008–1009. doi: 10.1007/s12325-014-0150-8 Search in PMC Search in PubMed View in NLM Catalog Add to search Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with HR + Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis Denise A Yardley De
【tool:web_fetch】
{"ok": true, "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3817318/", "status": 200, "content_type": "text/html; charset=utf-8", "text": "'Socioeconomic position and survival after cervical cancer: influence of cancer stage, comorbidity and smoking among Danish women diagnosed between 2005 and 2010 - PMC Skip to main content An official website of the United States government Here's how you know Here's how you know Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( Lock Locked padlock icon ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites. Search Log in Dashboard Publications Account settings Log out Search… Search NCBI Primary site navigation Search Logged in as: Dashboard Publications Account settings Log in Search PMC Full-Text Archive Search in PMC Journal List User Guide PERMALINK Copy As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Br J Cancer . 2013 Sep 12;109(9):2489–2495. doi: 10.1038/bjc.2013.558 Search in PMC Search in PubMed View in NLM Catalog Add to search 'Socioeconomic position and survival after cervical cancer: influence of cancer stage, comorbidity and smoking among Danish women d
【tool:web_search】
{"ok": true, "query": "PMC BOLERO-2 final progression-free survival analysis erratum PMC original", "results": [{"title": "Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with ...", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4713958/", "snippet": "This corrects the article \" Everolimus Plus Exemestane in Postmenopausal Patients with HR + Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis \" in volume 30 on page 870."}, {"title": "Erratum to: Everolimus Plus Exemestane in Postmenopausal ... - Europe PMC", "url": "https://europepmc.org/article/PMC/PMC4713958", "snippet": "Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis"}, {"title": "Everolimus in Postmenopausal Hormone-Receptor-Positive Advanced Breast ...", "url": "https://www.nejm.org/doi/full/10.1056/NEJMoa1109653", "snippet": "Everolimus combined with an aromatase inhibitor improved progression-free survival in patients with hormone-receptor-positive advanced breast cancer previously treated with nonsteroidal ..."}, {"title": "Erratum to: Everolimus Plus Exemestane in Postmenopausal ... - Springer", "url": "https://link.springer.com/article/10.1007/s12325-014-0150-8", "snippet": "Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with HR + Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis Erratum Published: 11 September 2014 Volume 31, pages 1008-1009, (2014) Cite t
→ call write_note({"tags":["fact","knowledge","4360dd15","clinical-trials","evidence-chain","erratum"],"text":"!! BOLERO-2 的 erratum 只改了摘要里的亚组表述，没有改 investigator-assessed PFS 数值或书目信息\n\n''核对对象''\n- 原文：''Everolimus Plus Exemestane in Postmenopausal Patients with HR+ Breast Cancer: BOLERO-2 Final Progression-Free Survival Analysis''\n- Erratum：''Erratum to: Everolimus Plus Exemestane in Postmenopausal Patients with H)
【tool:write_note】
{"ok": true, "path": "C:\\Users\\yh599\\Documents\\GitHub\\LLM-yh\\Sisyphus\\wiki\\tiddlers\\BOLERO-2_erratum_does_not_change_abstract_investigator-assessed_PFS_sentence_or_bibliographic_metadata.tid", "title": "BOLERO-2 erratum does not change abstract investigator-assessed PFS sentence or bibliographic metadata"}
【assistant】
已核对：BOLERO-2 的 correction/erratum **没有改动摘要里的 investigator-assessed PFS 数值句**，也**没有改动书目信息**；它只更正了一个亚组归类表述（把“disease recurrence during or within 12 months of completion of adjuvant therapy”不再误写成 prospectively defined）。
我已把结论写入长期记忆：
- BOLERO-2 erratum does not change abstract investigator-assessed PFS sentence or bibliographic metadata
证据要点：
- erratum 明确给出错误句与正确句；
- 两句中的 PFS 数值块完全一致：7.8 vs 3.2 months，HR 0.45 (95% CI 0.38–0.54)，P < 0.0001；
- 更正仅作用于摘要里的一句亚组措辞。
<NEXT_FOCUS>下一轮只核对一个更窄的问题：BOLERO-2 原文摘要中的 investigator-assessed PFS 句子是否与 PMC/Europe PMC/出版社页面三方完全逐字一致。</NEXT_FOCUS>
```