Iter-4360dd15-0107-transcript

修改：20260424214019000

第 107 轮执行轨迹

  → call search_memory({"limit":10,"query":"4360dd15 24267730 original human trial review follow-up safety"})
  → call list_recent({"n":8})
  → call list_tools({})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹

   → cal"}, {"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹

→ call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型保留排除理由 extension follow-up secondary analysis\"}) → call list_recent({\"n\":10}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹

   →"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1 included trials endpoint\"}) → call list_recent({\"n\":6}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"tit

【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0106-reflection", "modified": "20260424213803000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424213803000", "tags": "pinned focus"}, {"title": "先判研究类型，再谈是否相关", "modified": "20260424213803000", "tags": "lesson evidence-chain europe-pmc screening"}, {"title": "Iter-4360dd15-0106-transcript", "modified": "20260424213759000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0106-four-candidate-audit", "modified": "20260424213752000", "tags": "fact method 4360dd15 clinical-trials evidence-chain"}, {"title": "Iter-4360dd15-0105-reflection", "modified": "20260424213650000", "tags": "iteration reflection"}, {"title": "优先走可解析的证据链", "modified": "20260424213650000", "tags": "lesson evidence-chain europe-pmc parsing"}, {"title": "Iter-4360dd15-0105-transcript", "modified": "20260424213644000", "tags": "iteration transcript"}]}

【tool:list_tools】
{"ok": true, "tools": [{"name": "search_memory", "description": "在 TiddlyWiki 长期记忆中按关键字搜索（支持中文空格分隔），返回标题、标签、预览。每轮迭代开始前应先调用以回忆。", "custom": false}, {"name": "read_note", "description": "读取某一条 tiddler 的完整正文。", "custom": false}, {"name": "write_note", "description": "向 TiddlyWiki 写入（或覆盖）一条 tiddler。这是 Sisyphus 的长期记忆入口——每轮至少写一条。建议标签：knowledge, experiment, reflection, plan, idea, fact, question, lesson。TiddlyWiki 标记：!! 小标题，''粗体''，斜体，其它tiddler。", "custom": false}, {"name": "list_recent", "description": "列出最近修改过的 tiddler。", "custom": false}, {"name": "list_by_tag", "description": "按标签列出相关 tiddler。", "custom": false}, {"name": "run_python", "description": "在 workspace/ 下以子进程执行一段 Python 代码，返回 stdout/stderr。用于计算、模拟、验证假设、抓取公开数据（禁止任何破坏性操作）。", "custom": false}, {"name": "read_file", "description": "读取 workspace/ 下的某个文件。", "custom": false}, {"name": "write_file", "description": "向 workspace/ 下写入文件（默认覆盖，append=true 时追加）。", "custom": false}, {"name": "list_files", "description": "列出 workspace/ 下的文件。", "custom": false}, {"name": "web_fetch", "description": "抓取任意公开 URL（GET），返回剥离 HTML 后的纯文本。适合读论文摘要、文档、博客、百科。", "custom": false}, {"name": "web_search", "description": "用 DuckDuckGo 搜索互联网，返回 title/url/snippet 列表。找入口、找链接、调研时用。", "custom": false}, {"name": "wiki_search", "description": "维基百科搜索：返回若干条目的摘要和 URL。lang 默认 en，可传 zh 等。", "custom": false}, {"name": "arxiv_search", "description": "arXiv 论文检索：标题/作者/摘要/链接。理论、数学、物理、CS、bio 类前沿论文的主入口。", "custom": false}, {"name": "pubmed_search", "descriptio

→ call read_note({"title":"NEXT_FOCUS"})

→ call read_note({"title":"Iter-4360dd15-0106-four-candidate-audit"})

【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0106）\n\n只盯 24267730 和剩余未判定 PMID，用 Europe PMC/PubMed 直接确认其是否为首次原始人体试验，而不是综述、延伸随访或安全性汇总。"}

【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0106-four-candidate-audit", "tags": "fact method 4360dd15 clinical-trials evidence-chain", "text": "!! 4 个候选 PMID 的逐条排除结果（Europe PMC / web snippet 证据）\n\n本轮只做一件事：把 19963096、24151517、30564495、24267730 逐条判定是否属于“原始人体首次报告”。结论是：**4 条都应排除出原始首次报告池**。\n\n|| PMID || 题名 || 证据类型 || 判定 || 关键证据 ||\n| 19963096 | *Intravenous temsirolimus in cancer patients: clinical pharmacology and dosing considerations.* | Review / 药理综述 | **排除** | DuckDuckGo 结果直接给出 Europe PMC 条目标注 Review；snippet 指向临床药理与剂量考量，而非首次人体试验。 | https://europepmc.org/article/MED/19963096 |\n| 24151517 | *Systemic and nonrenal adverse effects occurring in renal transplant patients treated with mTOR inhibitors.* | adverse effects 汇总 / 综述性总结 | **排除** | Europe PMC / PMC snippet 明确聚焦 adverse effects、recognized and treated，内容是移植患者不良反应总结，不是新试验首次报告。 | https://europepmc.org/article/MED/24151517 |\n| 30564495 | *Everolimus for treatment-refractory seizures in TSC: Extension of a randomized controlled trial.* | extension / 随访分析 | **排除** | 题名已明确写出 Extension of a randomized controlled trial；这类文献是延伸阶段，不是原始首次报告。 | https://europepmc.org/article/MED/30564495 |\n| 24267730 | *Safety and efficacy of everolimus with exemestane vs. exemestane alone in elderly patients with HER2-negative, hormone receptor-positive breast cancer in BOLERO-2.* | 亚组分析 / 二次分析 | **排除** | Europe PMC / PubMed snippet 指向 BOLERO-2；同主题的原始 III 期试验已存在（例如 NEJM 2012 的 BOLERO-2 主试验），该条是 elderly subgroup 的安全/疗效分析，不是首次试

→ call search_memory({"limit":12,"query":"4360dd15 38310895 remaining candidate PMID original first report human trial"})

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹

→ cal"}, {"title": "Iter-4360dd15-0090-transcript", "tags": "iteration transcript", "modified": "20260424210019000", "preview": "!! 第 90 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 原始人类试验 PMID 主要终点\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":8,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹

→ call search_memory({\\\"limit"}, {"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹

   → call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"})    → call list_recent({\"n\":10})    → call list_tools({})  【tool:search_memory
  → call search_memory({"limit":20,"query":"4360dd15 未判定 PMID 38310895 候选 original first report"})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹

   →"}, {"title": "Iter-4360dd15-0094-transcript", "tags": "iteration transcript", "modified": "20260424210844000", "preview": "!! 第 94 轮执行轨迹

→ call search_memory({\"limit\":10,\"query\":\"4360dd15 38310895 NEXT_FOCUS 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":10}) → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹

   → call search_m"}, {"title": "Iter-4360dd15-0090-transcript", "tags": "iteration transcript", "modified": "20260424210019000", "preview": "!! 第 90 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":8,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\":

→ call search_memory({"limit":20,"query":"38310895 candidate PMID remaining unjudged original human trial Europe PMC"})

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0097-transcript", "tags": "iteration transcript", "modified": "20260424211821000", "preview": "!! 第 97 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 rapamycin review original human trial PMID table references\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 1"}, {"title": "Iter-4360dd15-0106-transcript", "tags": "iteration transcript", "modified": "20260424213759000", "preview": "!! 第 106 轮执行轨迹

→ call search_memory({\"limit\":10,\"query\":\"4360dd15 19963096 24151517 30564495 24267730 Europe PMC 原始人体试验\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0105-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424213644000\", \"preview\": \"!! 第 105 轮执行轨迹

"}, {"title": "Iter-4360dd15-0088-transcript", "tags": "iteration transcript", "modified": "20260424205606000", "preview": "!! 第 88 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 参考文献原始人类试验 PMID mTOR rapalog 主要终点\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iterati

→ call search_memory({"limit":20,"query":"4360dd15 unjudged PMID remaining candidate 38310895"})

→ call search_memory({"limit":20,"query":"4360dd15 38310895 remaining candidate original first report trial"})

→ call search_memory({"limit":20,"query":"4360dd15 24267730 remaining PMID"})

→ call search_memory({"limit":20,"query":"4360dd15 38310895 Europe PMC references 75 PMID list"})

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹

   → call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"})    → call list_recent({\"n\":10})    → call list_tools({})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹

→"}, {"title": "Iter-4360dd15-0094-transcript", "tags": "iteration transcript", "modified": "20260424210844000", "preview": "!! 第 94 轮执行轨迹

   → call search_memory({\"limit\":10,\"query\":\"4360dd15 38310895 NEXT_FOCUS 原始人类试验 PMID 主要终点\"})    → call list_recent({\"n\":10})    → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹

→ call search_m"}, {"title": "Iter-4360dd15-0090-transcript", "tags": "iteration transcript", "modified": "20260424210019000", "preview": "!! 第 90 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 原始人类试验 PMID 主要终点\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":8,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": 【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹

   → cal"}, {"title": "Iter-4360dd15-0094-transcript", "tags": "iteration transcript", "modified": "20260424210844000", "preview": "!! 第 94 轮执行轨迹

   → call search_m"}, {"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹

   → call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"})    → call list_recent({\"n\":10})    → call list_tools({})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹

→"}, {"title": "Iter-4360dd15-0094-transcript", "tags": "iteration transcript", "modified": "20260424210844000", "preview": "!! 第 94 轮执行轨迹

   → call search_memory({\"limit\":10,\"query\":\"4360dd15 38310895 NEXT_FOCUS 原始人类试验 PMID 主要终点\"})    → call list_recent({\"n\":10})    → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹

→ call search_m"}, {"title": "Iter-4360dd15-0090-transcript", "tags": "iteration transcript", "modified": "20260424210019000", "preview": "!! 第 90 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 原始人类试验 PMID 主要终点\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":8,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": 【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0097-transcript", "tags": "iteration transcript", "modified": "20260424211821000", "preview": "!! 第 97 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 rapamycin review original human trial PMID table references\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 1"}, {"title": "Iter-4360dd15-0094-transcript", "tags": "iteration transcript", "modified": "20260424210844000", "preview": "!! 第 94 轮执行轨迹

   → call search_memory({\"limit\":10,\"query\":\"4360dd15 38310895 NEXT_FOCUS 原始人类试验 PMID 主要终点\"})    → call list_recent({\"n\":10})    → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹

→ call search_m"}, {"title": "Iter-4360dd15-0088-transcript", "tags": "iteration transcript", "modified": "20260424205606000", "preview": "!! 第 88 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 参考文献 原始人类试验 PMID mTOR rapalog 主要终点\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iterati