Iter-4360dd15-0101-transcript
第 101 轮执行轨迹
→ call search_memory({"limit":10,"query":"4360dd15 38310895 references PMID 原始试验 参考文献"})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→"}, {"title": "Iter-4360dd15-0094-transcript", "tags": "iteration transcript", "modified": "20260424210844000", "preview": "!! 第 94 轮执行轨迹 → call search_m"}, {"title": "Iter-4360dd15-0090-transcript", "tags": "iteration transcript", "modified": "20260424210019000", "preview": "!! 第 90 轮执行轨迹 → call list_recent({"n":8})
【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0100-reflection", "modified": "20260424212541000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424212541000", "tags": "pinned focus"}, {"title": "先拿参考文献清单再做分类", "modified": "20260424212541000", "tags": "lesson evidence-chain clinical-trials pmid"}, {"title": "Iter-4360dd15-0100-transcript", "modified": "20260424212536000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0100-human-trial-vs-non-original-screening-of-38310895-references", "modified": "20260424212530000", "tags": "4360dd15 knowledge fact method clinical-trials evidence-chain"}, {"title": "Iter-4360dd15-0099-reflection", "modified": "20260424212326000", "tags": "iteration reflection"}, {"title": "先抓参考文献，再做证据分层", "modified": "20260424212326000", "tags": "lesson evidence-chain clinical-trials pmc"}, {"title": "Iter-4360dd15-0099-transcript", "modified": "20260424212320000", "tags": "iteration transcript"}]}
→ call read_note({"title":"NEXT_FOCUS"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0100）\n\n逐条筛完 PMID 38310895 剩余参考文献，输出每条的原始试验/非原始试验判定和对应 PMID。"}
→ call search_memory({"limit":10,"query":"4360dd15 38310895 候选 PMID 原始试验 非原始试验"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"}) → call list_recent({\"n\":10}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 38310895 NEXT_FOCUS 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":10}) → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":8,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": → call read_note({"title":"Iter-4360dd15-0100-human-trial-vs-non-original-screening-of-38310895-references"})
【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0100-human-trial-vs-non-original-screening-of-38310895-references", "tags": "4360dd15 knowledge fact method clinical-trials evidence-chain", "text": "!! PMID 38310895 参考文献的“原始人体试验 / 非原始试验”复核（第 100 轮）\n\n本轮只做一件事：把上一轮从 PMID 38310895 的 Europe PMC 参考文献里抽出来的一批候选 PMID，用 PubMed 逐条复核为“原始人体试验 / 非原始试验”。\n\n!! 复核方法\n# 先以前轮抽取的候选 PMID 为种子。\n# 再用 PubMed 逐条确认题名、期刊与研究设计词。\n# 判据：题名明确出现 //follow-up//、//longitudinal analysis//、//extension//、//ancillary//、//postextension// 时，优先判为 //非原始试验//；其余 interventional / randomized / pilot / phase I/II/III 研究且为首次报告者，判为 //原始人体试验//。\n\n!! 本轮已复核的 PMID\n!! 原始人体试验（但不一定是长寿相关）\n* 33977284 — [[Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials]]\n* 29408453 — [[A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects]]\n* 32475067 — [[Dose-Dependent Acute Effects of Everolimus Administration on Immunological, Neuroendocrine and Psychological Parameters in Healthy Men]]\n* 35040506 — [[mTOR Inhibition with Sirolimus in Multiple System Atrophy: A Randomized, Double-Blind, Placebo-Controlled Futility Trial and 1-Year Biomarker Longitudinal Analysis]]\n* 25525171 — [[Intravitreal sirolimus for the treatment of geographic atrophy: results of a phase I/II clinical trial]]\n* 24618547 — [[Everolimus in patients with severe pulmonary hyp
→ call search_memory({"limit":10,"query":"4360dd15 38310895 剩余 参考文献 PMID 列表"})
→ call search_memory({"limit":10,"query":"4360dd15 38310895 Europe PMC references PMID 75 条"})
→ call search_memory({"limit":10,"query":"4360dd15 PMID 38310895 reference chain candidate PMID"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→"}, {"title": "Iter-4360dd15-0094-transcript", "tags": "iteration transcript", "modified": "20260424210844000", "preview": "!! 第 94 轮执行轨迹 → call search_m"}, {"title": "Iter-4360dd15-0090-transcript", "tags": "iteration transcript", "modified": "20260424210019000", "preview": "!! 第 90 轮执行轨迹 【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0097-transcript", "tags": "iteration transcript", "modified": "20260424211821000", "preview": "!! 第 97 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 rapamycin review original human trial PMID table references\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 1"}, {"title": "Iter-4360dd15-0088-transcript", "tags": "iteration transcript", "modified": "20260424205606000", "preview": "!! 第 88 轮执行轨迹 → call search_memory({\\\"limit\\\":10,\\\"query\\\":\\\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理"}, {"title": "Iter-4360dd15-0099-transcript", "tags": "iteration transcript", "modified": "20260424212320000", "preview": "!! 第 99 轮执行轨迹 【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"}) → call list_recent({\"n\":10}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 38310895 NEXT_FOCUS 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":10}) → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":8,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": → call web_fetch({"max_chars":12000,"url":"https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/references/1/1000?format=json"})
【tool:web_fetch】
{"ok": true, "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/references/1/1000?format=json", "status": 200, "content_type": "application/xml", "text": "6.9 75 38310895 MED 1 1000 33069325 MED JOURNAL ARTICLE Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019. r Lancet 10258 2020 396 0140-6736 1474-547X 1160-1203 1 Y 28919117 MED JOURNAL ARTICLE Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. , Lancet 10100 2017 390 0140-6736 1474-547X 1211-1259 2 Y 37117804 MED JOURNAL ARTICLE The economic value of targeting aging. Scott AJ, Ellison M, Sinclair DA. Nat Aging 7 2021 1 2662-8465 2662-8465 616-623 3 Y 31316753 MED JOURNAL ARTICLE mTOR as a central regulator of lifespan and aging. Papadopoli D, Boulay K, Kazak L, Pollak M, Mallette FA, Topisirovic I, Hulea L. F1000Res 2019 8 2046-1402 2046-1402 F1000 Faculty Rev-998 4 Y 29190625 MED JOURNAL ARTICLE mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review. Weichhart T. Gerontology 2 2017 64 0304-324X 1423-0003 127-134 5 Y 36599349 MED JOURNAL ARTICLE Hallmarks of aging: An expanding universe. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. C
→ call run_python({"code":"import requests, xml.etree.ElementTree as ET, re, json\nurl='https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/references/1/1000?format=json'\ntext=requests.get(url, timeout=30).text\nprint(text[:500])\nprint('len', len(text))\n# try to parse as xml-ish plain text? maybe endpoint returns XML despite format=json.\n# Let's use regex to extract PMIDs and titles from the flat text)
【tool:run_python】
{"ok": true, "stdout": "<?xml version=\"1.0\" encoding=\"UTF-8\" standalone=\"yes\"?><responseWrapper xmlns:slx=\"http://www.scholix.org\" xmlns:epmc=\"https://www.europepmc.org/data\"><version>6.9</version><hitCount>75</hitCount><request><id>38310895</id><source>MED</source><offSet>1</offSet><pageSize>1000</pageSize></request><referenceList><reference><id>33069325</id><source>MED</source><citationType>JOURNAL ARTICLE</citationType><title>Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and populatio\nlen 42376\nparts 1\nno\n", "stderr": "", "returncode": 0}
→ call run_python({"code":"import requests, xml.etree.ElementTree as ET, re, json, textwrap\nurl='https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/references/1/1000'\nxml_text=requests.get(url, timeout=30).text\nroot=ET.fromstring(xml_text)\nrefs=[]\nfor ref in root.findall('.//reference'):\n pmid=ref.findtext('id')\n title=ref.findtext('title') or ''\n citationType=ref.findtext('citationType')
【tool:run_python】
{"ok": true, "stdout": "nrefs 75\n[\n {\n \"pmid\": \"33069325\",\n \"title\": \"Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019.\",\n \"type\": \"JOURNAL ARTICLE\"\n },\n {\n \"pmid\": \"28919117\",\n \"title\": \"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.\",\n \"type\": \"JOURNAL ARTICLE\"\n },\n {\n \"pmid\": \"37117804\",\n \"title\": \"The economic value of targeting aging.\",\n \"type\": \"JOURNAL ARTICLE\"\n },\n {\n \"pmid\": \"31316753\",\n \"title\": \"mTOR as a central regulator of lifespan and aging.\",\n \"type\": \"JOURNAL ARTICLE\"\n },\n {\n \"pmid\": \"29190625\",\n \"title\": \"mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review.\",\n \"type\": \"JOURNAL ARTICLE\"\n }\n]\n", "stderr": "", "returncode": 0}
→ call run_python({"code":"import requests, xml.etree.ElementTree as ET, json, re\nurl='https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/references/1/1000'\nroot=ET.fromstring(requests.get(url, timeout=30).text)\nrefs=[]\nfor i, ref in enumerate(root.findall('.//reference'), start=1):\n refs.append({'idx': i, 'pmid': ref.findtext('id'), 'title': ref.findtext('title') or ''})\n# print all titles with)
【tool:run_python】
{"ok": true, "stdout": "01 | 33069325 | Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019.\n02 | 28919117 | Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.\n03 | 37117804 | The economic value of targeting aging.\n04 | 31316753 | mTOR as a central regulator of lifespan and aging.\n05 | 29190625 | mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review.\n06 | 36599349 | Hallmarks of aging: An expanding universe.\n07 | 26403194 | Regulation of innate immune cell function by mTOR.\n08 | 30860857 | Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases.\n", "stderr": "Traceback (most recent call last):\n File \"C:\\Users\\yh599\\Documents\\GitHub\\LLM-yh\\Sisyphus\\workspace\\_run_1777066040211.py\", line 9, in <module>\n print(f\"{r['idx']:02d} | {r['pmid']} | {r['title']}\")\n ~~~~~^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^\n File \"C:\\Python313\\Lib\\encodings\\cp1252.py\", line 19, in encode\n return codecs.charmap_encode(input,self.errors,encoding_table)[0]\n ~~~~~~~~~~~~~~~~~~~~~^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^\nUnicodeEncodeError: 'charmap' codec can't encode character '
→ call run_python({"code":"import requests, xml.etree.ElementTree as ET, json\nurl='https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/references/1/1000'\nroot=ET.fromstring(requests.get(url, timeout=30).text)\nrefs=[]\nfor i, ref in enumerate(root.findall('.//reference'), start=1):\n refs.append({'idx': i, 'pmid': ref.findtext('id'), 'title': ref.findtext('title') or ''})\nprint(json.dumps(refs, ensu)
【tool:run_python】
{"ok": true, "stdout": "", "stderr": "Traceback (most recent call last):\n File \"C:\\Users\\yh599\\Documents\\GitHub\\LLM-yh\\Sisyphus\\workspace\\_run_1777066053693.py\", line 7, in <module>\n print(json.dumps(refs, ensure_ascii=False, indent=2))\n ~~~~~^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^\n File \"C:\\Python313\\Lib\\encodings\\cp1252.py\", line 19, in encode\n return codecs.charmap_encode(input,self.errors,encoding_table)[0]\n ~~~~~~~~~~~~~~~~~~~~~^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^\nUnicodeEncodeError: 'charmap' codec can't encode character '\\u03b2' in position 1387: character maps to <undefined>\n", "returncode": 1}
→ call run_python({"code":"import requests, xml.etree.ElementTree as ET, json, sys\nurl='https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/references/1/1000'\nroot=ET.fromstring(requests.get(url, timeout=30).text)\nrefs=[]\nfor i, ref in enumerate(root.findall('.//reference'), start=1):\n refs.append({'idx': i, 'pmid': ref.findtext('id'), 'title': ref.findtext('title') or ''})\ntext=json.dumps(refs, )
【tool:run_python】
{"ok": true, "stdout": " rapamycin treatment reverses age-related heart dysfunction.\"\n },\n {\n \"idx\": 49,\n \"pmid\": \"7049632\",\n \"title\": \"Glucose intolerance and aging.\"\n },\n {\n \"idx\": 50,\n \"pmid\": \"16123357\",\n \"title\": \"Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability.\"\n },\n {\n \"idx\": 51,\n \"pmid\": \"29089899\",\n \"title\": \"mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass.\"\n },\n {\n \"idx\": 52,\n \"pmid\": \"31697050\",\n \"title\": \"mTORC1 signalling is not essential for the maintenance of muscle mass and function in adult sedentary mice.\"\n },\n {\n \"idx\": 53,\n \"pmid\": \"17068216\",\n \"title\": \"Rapamycin inhibits the growth and muscle-sparing effects of clenbuterol.\"\n },\n {\n \"idx\": 54,\n \"pmid\": \"12409046\",\n \"title\": \"Ageing and infection.\"\n },\n {\n \"idx\": 55,\n \"pmid\": \"22136167\",\n \"title\": \"Regulation of immune responses by mTOR.\"\n },\n {\n \"idx\": 56,\n \"pmid\": \"19934433\",\n \"title\": \"mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells.\"\n },\n {\n \"idx\": 57,\n \"pmid\": \"19543266\",\n \"title\": \"mTOR regulates memory CD8 T-cell differentiation.\"\n },\n {\n \"idx\": 58,\n \"pmid\": \"17511761\",\n \"title\": \"Contrasting effects of cyclosporine and rapamycin in de novo
→ call run_python({"code":"import requests, xml.etree.ElementTree as ET, json, re, math, textwrap\n# Load EuropePMC refs\nroot=ET.fromstring(requests.get('https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/references/1/1000', timeout=30).text)\nrefs=[{'pmid':ref.findtext('id'),'title':ref.findtext('title') or ''} for ref in root.findall('.//reference')]\n# Reviewed PMIDs from note\nreviewed={'33977284',')
【tool:run_python】
{"ok": true, "stdout": "remaining 59\npmids ['33069325', '28919117', '37117804', '31316753', '29190625', '36599349', '26403194', '30860857', '35071488', '16915295', '19166931', '29420210', '30305865', '31746373', '34215308', '11292860', '22560223', '15253933', '14668850', '20074526', '19587680', '27549339', '24341993', '25540326', '31761958', '17329620', '29806044', '33593448', '19963096', '29997249', '24719098', '30243986', None, '23734717', '7049632', '16123357', '29089899', '31697050', '17068216', '12409046', '22136167', '19934433', '19543266', '17511761', '20653631', '23610399', '24403259', '24151517', '22863900', '24685370', '21430254', '37191826', '30564495', '34693520', '24267730', '10899009', '9914383', '37647291', '28579171']\n", "stderr": "", "returncode": 0}
→ call pubmed_search({"limit":1,"query":"37191826"})
→ call pubmed_search({"limit":1,"query":"24719098"})
→ call pubmed_search({"limit":1,"query":"30243986"})
→ call pubmed_search({"limit":1,"query":"23734717"})
→ call pubmed_search({"limit":1,"query":"17329620"})
→ call pubmed_search({"limit":1,"query":"29806044"})
→ call pubmed_search({"limit":1,"query":"33593448"})
→ call pubmed_search({"limit":1,"query":"29997249"})
→ call pubmed_search({"limit":1,"query":"24267730"})
→ call pubmed_search({"limit":1,"query":"30564495"})
【tool:pubmed_search】
{"ok": true, "query": "37191826", "results": [{"pmid": "37191826", "title": "Evaluation of off-label rapamycin use to promote healthspan in 333 adults.", "source": "Geroscience", "pubdate": "2023 Oct", "authors": ["Kaeberlein TL", "Green AS", "Haddad G", "Hudson J", "Isman A", "Nyquist A", "Rosen BS", "Suh Y"], "url": "https://pubmed.ncbi.nlm.nih.gov/37191826/"}]}
【tool:pubmed_search】
{"ok": true, "query": "24719098", "results": [{"pmid": "24719098", "title": "Ezh2 regulates adult hippocampal neurogenesis and memory.", "source": "J Neurosci", "pubdate": "2014 Apr 9", "authors": ["Zhang J", "Ji F", "Liu Y", "Lei X", "Li H", "Ji G", "Yuan Z", "Jiao J"], "url": "https://pubmed.ncbi.nlm.nih.gov/24719098/"}]}
【tool:pubmed_search】
{"ok": true, "query": "30243986", "results": [{"pmid": "30243986", "title": "Early intrathecal infusion of everolimus restores cognitive function and mood in a murine model of Alzheimer's disease.", "source": "Exp Neurol", "pubdate": "2019 Jan", "authors": ["Cassano T", "Magini A", "Giovagnoli S", "Polchi A", "Calcagnini S", "Pace L", "Lavecchia MA", "Scuderi C"], "url": "https://pubmed.ncbi.nlm.nih.gov/30243986/"}]}
【tool:pubmed_search】
{"ok": true, "query": "23734717", "results": [{"pmid": "23734717", "title": "Late-life rapamycin treatment reverses age-related heart dysfunction.", "source": "Aging Cell", "pubdate": "2013 Oct", "authors": ["Flynn JM", "O'Leary MN", "Zambataro CA", "Academia EC", "Presley MP", "Garrett BJ", "Zykovich A", "Mooney SD"], "url": "https://pubmed.ncbi.nlm.nih.gov/23734717/"}]}
【tool:pubmed_search】
{"ok": true, "query": "17329620", "results": [{"pmid": "17329620", "title": "The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man.", "source": "Diabetes", "pubdate": "2007 Jun", "authors": ["Krebs M", "Brunmair B", "Brehm A", "A