Iter-4360dd15-0099-transcript
第 99 轮执行轨迹
→ call search_memory({"limit":8,"query":"4360dd15 38310895 Europe PMC references human trial PMID"})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0097-transcript", "tags": "iteration transcript", "modified": "20260424211821000", "preview": "!! 第 97 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 参考文献 原始人类试验 PMID mTOR rapalog 主要终点\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 Europe PMC references human trial PMID rapamycin\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":10,\"tag\":\"lesson evidence-chain → call read_note({"title":"NEXT_FOCUS"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission `4360dd15` · Iter-0098）\n\n下一轮只攻克一个点：用 Europe PMC REST 或可访问的 PMC XML 直接取回 PMID 38310895 的参考文献并筛出人体原始试验 PMID。"}
→ call search_memory({"limit":8,"query":"4360dd15 38310895 reference extraction Europe PMC REST PMIDs"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0097-transcript", "tags": "iteration transcript", "modified": "20260424211821000", "preview": "!! 第 97 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 参考文献 原始人类试验 PMID mTOR rapalog 主要终点\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 Europe PMC references human trial PMID rapamycin\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":10,\"tag\":\"lesson evidence-chain → call search_memory({"limit":10,"query":"4360dd15 Europe PMC REST PMID 38310895 references"})
→ call search_memory({"limit":10,"query":"4360dd15 PMC XML 38310895 references"})
→ call list_recent({"n":6})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0097-transcript", "tags": "iteration transcript", "modified": "20260424211821000", "preview": "!! 第 97 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 参考文献 原始人类试验 PMID mTOR rapalog 主要终点\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 Europe PMC references human trial PMID rapamycin\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":10,\"tag\":\"lesson evidence-chain 【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0097-transcript", "tags": "iteration transcript", "modified": "20260424211821000", "preview": "!! 第 97 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 参考文献 原始人类试验 PMID mTOR rapalog 主要终点\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 38310895 NEXT_FOCUS 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":10}) → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0098-reflection", "modified": "20260424212107000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424212107000", "tags": "pinned focus"}, {"title": "别从落地页取证", "modified": "20260424212107000", "tags": "lesson evidence-chain fulltext-access clinical-trials"}, {"title": "Iter-4360dd15-0098-transcript", "modified": "20260424212101000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0098-EuropePMC-extract-human-trial-PMIDs", "modified": "20260424212055000", "tags": "method fact clinical-trials evidence-chain rapamycin 4360dd15"}, {"title": "Iter-4360dd15-0097-reflection", "modified": "20260424211826000", "tags": "iteration reflection"}]}
→ call read_note({"title":"Iter-4360dd15-0098-EuropePMC-extract-human-trial-PMIDs"})
【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0098-EuropePMC-extract-human-trial-PMIDs", "tags": "method fact clinical-trials evidence-chain rapamycin 4360dd15", "text": "!! Europe PMC 提取 PMID 38310895 参考文献中的人体原始试验 PMID\n\n本轮通过 Europe PMC REST 接口直接读取了 PMID 38310895 的参考文献列表：\n`https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/references/1/1000`\n\n该接口返回 75 条参考文献。用标题关键词筛选后，得到一批与 rapamycin / rapalog 人体原始试验高度相关的 PMID：\n\n* 33977284 — [[Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials]]\n* 29408453 — [[A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects]]\n* 31761958 — [[Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial]]\n* 22959478 — [[Rapamycin does not affect post-absorptive protein metabolism in human skeletal muscle]]\n* 19188252 — [[Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis]]\n* 24691032 — [[Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin]]\n* 32475067 — [[Dose-Dependent Acute Effects of Everolimus Administration on Immunological, Neuroendocrine and Psychological Parameters in Healthy Men]]\n* 22367193 — [[A single-dose placebo- and moxiflox
→ call search_memory({"limit":12,"query":"4360dd15 29408453 31761958 22959478 19188252 human trial"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0041-transcript", "tags": "iteration transcript", "modified": "20260424192431000", "preview": "!! 第 41 轮执行轨迹 → call search_memory({\\\""}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call pubmed_search({"limit":5,"query":"33977284"})
→ call pubmed_search({"limit":5,"query":"29408453"})
→ call pubmed_search({"limit":5,"query":"31761958"})
→ call pubmed_search({"limit":5,"query":"22959478"})
→ call pubmed_search({"limit":5,"query":"19188252"})
【tool:pubmed_search】
{"ok": true, "query": "33977284", "results": [{"pmid": "33977284", "title": "Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials.", "source": "Lancet Healthy Longev", "pubdate": "2021 May", "authors": ["Mannick JB", "Teo G", "Bernardo P", "Quinn D", "Russell K", "Klickstein L", "Marshall W", "Shergill S"], "url": "https://pubmed.ncbi.nlm.nih.gov/33977284/"}]}
【tool:pubmed_search】
{"ok": true, "query": "29408453", "results": [{"pmid": "29408453", "title": "A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects.", "source": "Exp Gerontol", "pubdate": "2018 May", "authors": ["Kraig E", "Linehan LA", "Liang H", "Romo TQ", "Liu Q", "Wu Y", "Benavides AD", "Curiel TJ"], "url": "https://pubmed.ncbi.nlm.nih.gov/29408453/"}]}
【tool:pubmed_search】
{"ok": true, "query": "31761958", "results": [{"pmid": "31761958", "title": "Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial.", "source": "Geroscience", "pubdate": "2019 Dec", "authors": ["Chung CL", "Lawrence I", "Hoffman M", "Elgindi D", "Nadhan K", "Potnis M", "Jin A", "Sershon C"], "url": "https://pubmed.ncbi.nlm.nih.gov/31761958/"}]}
【tool:pubmed_search】
{"ok": true, "query": "22959478", "results": [{"pmid": "22959478", "title": "Rapamycin does not affect post-absorptive protein metabolism in human skeletal muscle.", "source": "Metabolism", "pubdate": "2013 Jan", "authors": ["Dickinson JM", "Drummond MJ", "Fry CS", "Gundermann DM", "Walker DK", "Timmerman KL", "Volpi E", "Rasmussen BB"], "url": "https://pubmed.ncbi.nlm.nih.gov/22959478/"}]}
【tool:pubmed_search】
{"ok": true, "query": "19188252", "results": [{"pmid": "19188252", "title": "Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis.", "source": "J Physiol", "pubdate": "2009 Apr 1", "authors": ["Drummond MJ", "Fry CS", "Glynn EL", "Dreyer HC", "Dhanani S", "Timmerman KL", "Volpi E", "Rasmussen BB"], "url": "https://pubmed.ncbi.nlm.nih.gov/19188252/"}]}
→ call search_memory({"limit":10,"query":"4360dd15 22959478 19188252 trial classification mechanistic"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"}) → call list_recent({\"n\":10}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 38310895 NEXT_FOCUS 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":10}) → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, → call web_fetch({"max_chars":7000,"url":"https://pubmed.ncbi.nlm.nih.gov/22959478/"})
→ call web_fetch({"max_chars":7000,"url":"https://pubmed.ncbi.nlm.nih.gov/19188252/"})
→ call web_fetch({"max_chars":7000,"url":"https://pubmed.ncbi.nlm.nih.gov/29408453/"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://pubmed.ncbi.nlm.nih.gov/22959478/'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://pubmed.ncbi.nlm.nih.gov/19188252/'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://pubmed.ncbi.nlm.nih.gov/29408453/'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":5,"query":"Europe PMC 22959478 abstract rapamycin human skeletal muscle"})
【tool:web_search】
{"ok": true, "query": "Europe PMC 22959478 abstract rapamycin human skeletal muscle", "results": [{"title": "Rapamycin does not affect post-absorptive protein ... - Europe PMC", "url": "https://europepmc.org/article/MED/22959478", "snippet": "Administration of the mTORC1 inhibitor, rapamycin , to humans blocks the increase in skeletal muscle protein synthesis in response to resistance exercise or amino acid ingestion. Short-term rapamycin administration may only impair protein synthesis in human skeletal muscle when combined with a ..."}, {"title": "Rapamycin does not affect post-absorptive protein metabolism in human ...", "url": "https://pubmed.ncbi.nlm.nih.gov/22959478/", "snippet": "Abstract Administration of the mTORC1 inhibitor, rapamycin , to humans blocks the increase in skeletal muscle protein synthesis in response to resistance exercise or amino acid ingestion. Objective: To determine whether rapamycin administration influences basal post-absorptive protein synthesis or breakdown in human skeletal muscle ."}, {"title": "Rapamycin does not affect post-absorptive protein metabolism in human ...", "url": "https://www.researchgate.net/publication/230836844_Rapamycin_does_not_affect_post-absorptive_protein_metabolism_in_human_skeletal_muscle", "snippet": "Objective: To determine whether rapamycin administration influences basal post-absorptive protein synthesis or breakdown in human skeletal muscle ."}, {"title": "Rapamycin administration in humans blocks the contraction
→ call web_search({"limit":5,"query":"Europe PMC 19188252 abstract rapamycin humans blocks contraction-induced increase skeletal muscle protein synthesis"})
【tool:web_search】
{"ok": true, "query": "Europe PMC 19188252 abstract rapamycin humans blocks contraction-induced increase skeletal muscle protein synthesis", "results": [{"title": "Rapamycin administration in humans blocks the contraction-induced ...", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC2678224/", "snippet": "We conclude that mTORC1 signalling is, in part, playing a key role in regulating the contraction-induced stimulation of muscle protein synthesis in humans , while dual activation of mTORC1 and ERK1/2 stimulation may be required for full stimulation of human skeletal muscle protein synthesis ."}, {"title": "Rapamycin administration in humans blocks the contraction ... - Europe PMC", "url": "https://europepmc.org/article/MED/19188252", "snippet": "We conclude that mTORC1 signalling is, in part, playing a key role in regulating the contraction-induced stimulation of muscle protein synthesis in humans , while dual activation of mTORC1 and ERK1/2 stimulation may be required for full stimulation of human skeletal muscle protein synthesis ."}, {"title": "Rapamycin administration in humans blocks the contraction-induced ...", "url": "https://www.ovid.com/journals/jphy/fulltext/10.1113/jphysiol.2008.163816~rapamycin-administration-in-humans-blocks-the", "snippet": "Here we show that rapamycin treatment blocks the early (1-2 h) acute contraction-induced increase (∼40%) in human muscle protein synthesis . In addition, several downstream components of the mTORC1 signalling pathway were
→ call web_search({"limit":5,"query":"Europe PMC 29408453 abstract feasibility safety rapamycin older human cohort"})
【tool:web_search】
{"ok": true, "query": "Europe PMC 29408453 abstract feasibility safety rapamycin older human cohort", "results": [{"title": "A randomized control trial to establish the feasibility ... - Europe PMC", "url": "https://europepmc.org/article/MED/29408453", "snippet": "A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort : Immunological, physical performance, and cognitive effects."}, {"title": "A randomized control trial to establish the feasibility and safety of ...", "url": "https://ichgcp.net/clinical-trials-registry/publications/153324-a-randomized-control-trial-to-establish-the-feasibility-and-safety-of-rapamycin-treatment-in-an", "snippet": "A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort : Immunological, physical performance, and cognitive effects."}, {"title": "A randomized control trial to establish the feasibility and safety of ...", "url": "https://database.clin-star.org/display/pmid-29408453", "snippet": "Erythrocyte Indices Female Glucose Tolerance Test Hand Strength Humans Immunosuppressive Agents Insulin Resistance Male Myeloid Cells Physical Fitness Pilot Projects Prospective Studies Sirolimus T-Lymphocytes, Regulatory TOR Serine-Threonine Kinases Texas Walk Test Blood cell subsets Cytokines Geriatrics Physiological outcomes Rapamycin mTOR ..."}, {"title": "A randomized control trial to establish the feasibility and safety of ...", "url"
→ call web_fetch({"max_chars":6000,"url":"https://europepmc.org/article/MED/22959478"})
→ call web_fetch({"max_chars":6000,"url":"https://europepmc.org/article/MED/19188252"})
→ call web_fetch({"max_chars":6000,"url":"https://europepmc.org/article/MED/29408453"})
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/22959478", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/19188252", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/29408453", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}