Iter-4360dd15-0096-transcript
第 96 轮执行轨迹
→ call search_memory({"limit":10,"query":"4360dd15 38310895 rapamycin review PMID 原始试验 参考文献 主要终点"}) → call list_recent({"n":8})
→ call list_by_tag({"limit":10,"tag":"4360dd15"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":8,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 引用链 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":8,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"resul【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0095-reflection", "modified": "20260424211152000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424211152000", "tags": "pinned focus"}, {"title": "先从综述参考链落到单个原始 PMID", "modified": "20260424211152000", "tags": "lesson evidence-chain clinical-trials endpoint-classification"}, {"title": "Iter-4360dd15-0095-transcript", "modified": "20260424211136000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0094-reflection", "modified": "20260424210848000", "tags": "iteration reflection"}, {"title": "先从参考链锁定单个原始试验", "modified": "20260424210848000", "tags": "lesson evidence-chain clinical-trials endpoint-classification"}, {"title": "Iter-4360dd15-0094-transcript", "modified": "20260424210844000", "tags": "iteration transcript"}, {"title": "PMID 22367193 is cardiac-repolarization safety, not longevity evidence", "modified": "20260424210833000", "tags": "4360dd15 knowledge fact critique clinical-trials endpoint-classification"}]}
【tool:list_by_tag】
{"ok": true, "items": [{"title": "PMID 22367193 is cardiac-repolarization safety, not longevity evidence", "modified": "20260424210833000"}, {"title": "PMID 24691032 is muscle-protein-synthesis endpoint, not longevity evidence", "modified": "20260424210355000"}, {"title": "PMID 22115710 is phase I ocular safety study, not longevity evidence", "modified": "20260424210145000"}, {"title": "PMID 29408453 is feasibility/safety pilot, not direct longevity evidence", "modified": "20260424210012000"}, {"title": "PMID 31761958 is skin-senescence endpoint, not longevity evidence", "modified": "20260424205759000"}, {"title": "PMID 33977284 is RTI incidence endpoint, not direct longevity evidence", "modified": "20260424204839000"}, {"title": "PMID 25540326 is immune-response endpoint, not longevity evidence", "modified": "20260424204718000"}, {"title": "PMID 27883166 is a pilot safety feasibility trial not direct longevity evidence", "modified": "20260424204543000"}, {"title": "PEARL trial is not direct longevity evidence", "modified": "20260424203525000"}, {"title": "Iter-4360dd15-0078-two-pmid-evidence-verification", "modified": "20260424203242000"}]}
→ call search_memory({"limit":10,"query":"38310895 reference PMID rapamycin human trial 38310895 table 1 study PMID"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0047-transcript", "tags": "iteration transcript", "modified": "20260424193836000", "preview": "!! 第 47 轮执行轨迹
→ call search_memory({\\\"limit\\\":8,\\\"query\\\":\\\"4360dd15 PMID 38310895 mmc1.pdf supplementary tabl"}, {"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"}) → call list_recent({\"n\":8}) → call list_tools({}) 【tool:sea → call web_search({"limit":5,"query":"PMID 38310895 rapamycin systematic review references human trial"})
→ call pubmed_search({"limit":5,"query":"38310895"})
→ call web_search({"limit":5,"query":"\"38310895\" rapamycin review"})
→ call wiki_search({"lang":"en","limit":5,"query":"rapamycin systematic review humans 38310895"})
【tool:web_search】
{"ok": true, "query": "PMID 38310895 rapamycin systematic review references human trial", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/", "snippet": "PubMed® comprises more than 40 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://nutrition-evidence.com/article/501551/targeting-ageing-with-rapamycin-and-its-derivatives-in-humans-a-systematic-review", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "The articles were organised and managed using Covidence systematic review s
【tool:pubmed_search】
{"ok": true, "query": "38310895", "results": [{"pmid": "38310895", "title": "Targeting ageing with rapamycin and its derivatives in humans: a systematic review.", "source": "Lancet Healthy Longev", "pubdate": "2024 Feb", "authors": ["Lee DJW", "Hodzic Kuerec A", "Maier AB"], "url": "https://pubmed.ncbi.nlm.nih.gov/38310895/"}]}
【tool:web_search】
{"ok": true, "query": "\"38310895\" rapamycin review", "results": [{"title": "A systematic review study of Rapamycin", "url": "https://rapamycinlongevitylab.substack.com/p/a-systematic-review-study-of-rapamycin", "snippet": "Last month Ajla Hodzic Kuerec, Deborah Lee and Andrea Maier published a very interesting systematic review of Rapamycin and rapalogs (pubmed: 38310895 )."}, {"title": "Systemic review study of Rapamycin : r/Rapamycin - Reddit", "url": "https://www.reddit.com/r/Rapamycin/comments/1bo5ogp/systemic_review_study_of_rapamycin/", "snippet": "Last month Ajla Hodzic Kuerec, Deborah Lee and Andrea Maier published a very interesting systematic review of Rapamycin and rapalogs (pubmed: 38310895 ). A systematic review is a review that gathers together different research studies within an area and based on that analyzes and summarizes these."}, {"title": "Contacts, Subscriber Numbers, Similar Newsletters - Rapamycin Longevity ...", "url": "https://reletter.com/publications/rapamycin-longevity-labs-substack", "snippet": "A systematic review study of Rapamycin Last month Ajla Hodzic Kuerec, Deborah Lee and Andrea Maier published a very interesting systematic review of Rapamycin and rapalogs (pubmed: 38310895 )."}, {"title": "#rapamycin #longevityscience #healthspan #metabolichealth # ...", "url": "https://www.linkedin.com/posts/ranulf-crooke_rapamycin-longevityscience-healthspan-activity-7411401877105491968-uGEr", "snippet": "In humans, a 2024 Lancet Healthy Longevity r
【tool:wiki_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://en.wikipedia.org/w/api.php?action=query&list=search&srsearch=rapamycin+systematic+review+humans+38310895&srlimit=5&format=json'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_fetch({"max_chars":12000,"url":"https://europepmc.org/article/MED/38310895"})
→ call web_fetch({"max_chars":12000,"url":"https://pubmed.ncbi.nlm.nih.gov/38310895/"})
→ call web_fetch({"max_chars":12000,"url":"https://www.sciencedirect.com/science/article/pii/S2666756823002581"})
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/38310895", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://pubmed.ncbi.nlm.nih.gov/38310895/'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.sciencedirect.com/science/article/pii/S2666756823002581'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call search_memory({"limit":10,"query":"4360dd15 38310895 candidate PMID not yet audited rapamycin human trial review reference list"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0094-transcript", "tags": "iteration transcript", "modified": "20260424210844000", "preview": "!! 第 94 轮执行轨迹 → call search_m"}, {"title": "Iter-4360dd15-0089-transcript", "tags": "iteration transcript", "modified": "20260424205805000", "preview": "!! 第 89 轮执行轨迹 → call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" pdf"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" references PMID"})
→ call web_search({"limit":10,"query":"\"38310895\" \"PMID\" \"rapamycin\" \"humans\""})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" pdf", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "PDF Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf", "snippet": "Deborah J W Lee*, Ajla Hodzic Kuerec*, Andrea B Maier Rapamyc
【tool:web_search】
{"ok": false, "error": "[SSL: UNEXPECTED_EOF_WHILE_READING] EOF occurred in violation of protocol (_ssl.c:1028)"}
【tool:web_search】
{"ok": true, "query": "\"38310895\" \"PMID\" \"rapamycin\" \"humans\"", "results": []}
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_fetch({"max_chars":12000,"url":"https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/fullTextXML"})
→ call web_fetch({"max_chars":12000,"url":"https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/references"})
→ call web_fetch({"max_chars":12000,"url":"https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895?format=json"})
【tool:web_fetch】
{"ok": false, "error": "Client error '404 Not Found' for url 'https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/fullTextXML'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/404"}
【tool:web_fetch】
{"ok": true, "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/references", "status": 200, "content_type": "application/xml", "text": "6.9 75 38310895 MED 1 25 33069325 MED JOURNAL ARTICLE Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019. r Lancet 10258 2020 396 0140-6736 1474-547X 1160-1203 1 Y 28919117 MED JOURNAL ARTICLE Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. , Lancet 10100 2017 390 0140-6736 1474-547X 1211-1259 2 Y 37117804 MED JOURNAL ARTICLE The economic value of targeting aging. Scott AJ, Ellison M, Sinclair DA. Nat Aging 7 2021 1 2662-8465 2662-8465 616-623 3 Y 31316753 MED JOURNAL ARTICLE mTOR as a central regulator of lifespan and aging. Papadopoli D, Boulay K, Kazak L, Pollak M, Mallette FA, Topisirovic I, Hulea L. F1000Res 2019 8 2046-1402 2046-1402 F1000 Faculty Rev-998 4 Y 29190625 MED JOURNAL ARTICLE mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review. Weichhart T. Gerontology 2 2017 64 0304-324X 1423-0003 127-134 5 Y 36599349 MED JOURNAL ARTICLE Hallmarks of aging: An expanding universe. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. Cell 2 2023 186 0092-8
【tool:web_fetch】
{"ok": false, "error": "Client error '404 Not Found' for url 'https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895?format=json'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/404"}
→ call web_fetch({"max_chars":50000,"url":"https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/references"})
【tool:web_fetch】
{"ok": true, "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/references", "status": 200, "content_type": "application/xml", "text": "6.9 75 38310895 MED 1 25 33069325 MED JOURNAL ARTICLE Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019. r Lancet 10258 2020 396 0140-6736 1474-547X 1160-1203 1 Y 28919117 MED JOURNAL ARTICLE Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. , Lancet 10100 2017 390 0140-6736 1474-547X 1211-1259 2 Y 37117804 MED JOURNAL ARTICLE The economic value of targeting aging. Scott AJ, Ellison M, Sinclair DA. Nat Aging 7 2021 1 2662-8465 2662-8465 616-623 3 Y 31316753 MED JOURNAL ARTICLE mTOR as a central regulator of lifespan and aging. Papadopoli D, Boulay K, Kazak L, Pollak M, Mallette FA, Topisirovic I, Hulea L. F1000Res 2019 8 2046-1402 2046-1402 F1000 Faculty Rev-998 4 Y 29190625 MED JOURNAL ARTICLE mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review. Weichhart T. Gerontology 2 2017 64 0304-324X 1423-0003 127-134 5 Y 36599349 MED JOURNAL ARTICLE Hallmarks of aging: An expanding universe. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. Cell 2 2023 186 0092-8
→ call web_search({"limit":10,"query":"site:europepmc.org 38310895 rapamycin human trial PMID review included studies"})
【tool:web_search】
{"ok": true, "query": "site:europepmc.org 38310895 rapamycin human trial PMID review included studies", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies ."}, {"title": "A randomized control trial to establish the feasibility and safety of ...", "url": "https://europepmc.org/article/PMC/PMC5869166", "snippet": "A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects."}, {"title": "A Rapamycin-Based GMP-Compatible Process for the Isolation and ...", "url": "https://europepmc.org/article/pmc/5850906", "snippet": "The success of a clinical trial such as the ONE study requires a highly reproducible process for the sustained manufacture of autologous patient-derived Tregs. To date, processes for the isolation of autologous Tregs have predominantly used immunomagnetic bead isolation, offering a versatile means of cell selection in accordance with GMP processes."}, {"title": "Efficacy and Safety of Topical Rapamycin i
→ call search_memory({"limit":20,"query":"4360dd15 38310895 included studies PMID candidates remaining rapamycin human trial"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1 included trials endpoint\"}) → call list_recent({\"n\":6}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 38310895 rapalog trial human trial 14 candidate 11 remaining\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【too → call search_memory({"limit":20,"query":"rapamycin human cohort feasibility safety older human trial PMID"})
→ call search_memory({"limit":20,"query":"everolimus human trial rapalog older adults PMID review 38310895"})
→ call search_memory({"limit":20,"query":"sirolimus older adults human trial PMID review 38310895"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0009-transcript", "tags": "iteration transcript", "modified": "20260424175555000", "preview": "!! 第 9 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID