Iter-4360dd15-0095-transcript
第 95 轮执行轨迹
→ call search_memory({"limit":10,"query":"4360dd15 38310895 NEXT_FOCUS 原始人类试验 PMID 主要终点"}) → call list_recent({"n":8})
→ call list_by_tag({"limit":10,"tag":"4360dd15"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→"}, {"title": "Iter-4360dd15-0094-transcript", "tags": "iteration transcript", "modified": "20260424210844000", "preview": "!! 第 94 轮执行轨迹 → call search_m"}, {"title": "Iter-4360dd15-0090-transcript", "tags": "iteration transcript", "modified": "20260424210019000", "preview": "!! 第 90 轮执行轨迹 【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0094-reflection", "modified": "20260424210848000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424210848000", "tags": "pinned focus"}, {"title": "先从参考链锁定单个原始试验", "modified": "20260424210848000", "tags": "lesson evidence-chain clinical-trials endpoint-classification"}, {"title": "Iter-4360dd15-0094-transcript", "modified": "20260424210844000", "tags": "iteration transcript"}, {"title": "PMID 22367193 is cardiac-repolarization safety, not longevity evidence", "modified": "20260424210833000", "tags": "4360dd15 knowledge fact critique clinical-trials endpoint-classification"}, {"title": "Iter-4360dd15-0093-reflection", "modified": "20260424210659000", "tags": "iteration reflection"}, {"title": "先从综述引用链提取唯一原始 PMID", "modified": "20260424210659000", "tags": "lesson evidence-chain clinical-trials endpoint-classification"}, {"title": "Iter-4360dd15-0093-transcript", "modified": "20260424210654000", "tags": "iteration transcript"}]}
【tool:list_by_tag】
{"ok": true, "items": [{"title": "PMID 22367193 is cardiac-repolarization safety, not longevity evidence", "modified": "20260424210833000"}, {"title": "PMID 24691032 is muscle-protein-synthesis endpoint, not longevity evidence", "modified": "20260424210355000"}, {"title": "PMID 22115710 is phase I ocular safety study, not longevity evidence", "modified": "20260424210145000"}, {"title": "PMID 29408453 is feasibility/safety pilot, not direct longevity evidence", "modified": "20260424210012000"}, {"title": "PMID 31761958 is skin-senescence endpoint, not longevity evidence", "modified": "20260424205759000"}, {"title": "PMID 33977284 is RTI incidence endpoint, not direct longevity evidence", "modified": "20260424204839000"}, {"title": "PMID 25540326 is immune-response endpoint, not longevity evidence", "modified": "20260424204718000"}, {"title": "PMID 27883166 is a pilot safety feasibility trial not direct longevity evidence", "modified": "20260424204543000"}, {"title": "PEARL trial is not direct longevity evidence", "modified": "20260424203525000"}, {"title": "Iter-4360dd15-0078-two-pmid-evidence-verification", "modified": "20260424203242000"}]}
→ call read_note({"title":"NEXT_FOCUS"})
→ call search_memory({"limit":8,"query":"38310895"})
→ call search_memory({"limit":8,"query":"4360dd15 rapamycin systematic review human trial PMID reference chain"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0094）\n\n从 38310895 的参考文献中找出 1 个尚未审计的原始人类试验 PMID，并立即确认它的主要终点。"}
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0044-transcript", "tags": "iteration transcript", "modified": "20260424193140000", "preview": "!! 第 44 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 38310895 19 纳入研究 表 补充材料 NEXT_FOCUS\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0037-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424191347000\", \"preview\": \"!! 第 37 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 引用链 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":8,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 参考文献 原始人类试验 PMID mTOR rapalog 主要终点\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"ite【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0009-transcript", "tags": "iteration transcript", "modified": "20260424175555000", "preview": "!! 第 9 轮执行轨迹 → call search_memory({"limit":12,"query":"38310895 PMID candidate reference human trial rapamycin everolimus sirolimus original trial"})
→ call search_memory({"limit":12,"query":"38310895 reference list PMID 19 included studies human trial"})
→ call web_search({"limit":5,"query":"38310895 rapamycin systematic review reference PMID human trial"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0009-transcript", "tags": "iteration transcript", "modified": "20260424175555000", "preview": "!! 第 9 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin mTOR systematic review 2024 trial endpoint PMC table remaining included studies\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\""}, {"title": "Iter-4360dd15-0040-transcript", "tags": "iteration transcript", "modified": "20260424192058000", "preview": "!! 第 40 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 19 项 纳入研究 家族 清单\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"res【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0040-transcript", "tags": "iteration transcript", "modified": "20260424192058000", "preview": "!! 第 40 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 mmc1 pdf 19 纳入研究 NEXT_FOCUS\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0046-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424193551000\", \"preview\": \"!! 第 46 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"}) → call list_recent({\"n\":10}) → call list_tools({}) 【tool:search_memory【tool:web_search】
{"ok": true, "query": "38310895 rapamycin systematic review reference PMID human trial", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/", "snippet": "PubMed® comprises more than 40 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://nutrition-evidence.com/article/501551/targeting-ageing-with-rapamycin-and-its-derivatives-in-humans-a-systematic-review", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults."}, {"title": "A systematic review study of Rapamycin", "url": "https://rapamycinlongevitylab.substack.com/p/a-systematic-review-study-of-rapamycin", "snippet": "Last month Ajla Hodzic Kuerec, Deborah Lee and Andrea Maier published a very interesting s
→ call web_fetch({"max_chars":12000,"url":"https://europepmc.org/article/MED/38310895"})
→ call pubmed_search({"limit":5,"query":"38310895 rapamycin humans references trial primary endpoint"})
→ call web_search({"limit":10,"query":"site:pubmed.ncbi.nlm.nih.gov rapamycin human trial PMID primary endpoint everolimus sirolimus review 38310895"})
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/38310895", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
【tool:pubmed_search】
{"ok": true, "query": "38310895 rapamycin humans references trial primary endpoint", "results": [{"pmid": "40214962", "title": "Analysis of Sirolimus Blood Concentration and Influencing Factors in Pediatric Patients: Implications for Individualized Drug Therapy.", "source": "Drugs R D", "pubdate": "2025 Mar", "authors": ["Xu X", "Mao X", "Liu B", "Sun Y", "Cheng X", "Wang X", "Mao H"], "url": "https://pubmed.ncbi.nlm.nih.gov/40214962/"}, {"pmid": "39952378", "title": "Prospective randomized single-blind multicenter study to assess the safety and effectiveness of the SELUTION SLR 014 drug eluting balloon in the treatment of subjects with in-stent restenosis: Rationale and design.", "source": "Am Heart J", "pubdate": "2025 Jun", "authors": ["Cutlip DE", "Mehran R", "Doros G", "Kaplinskiy V", "Lee J", "Zheng L", "Kausik M", "Osborn E"], "url": "https://pubmed.ncbi.nlm.nih.gov/39952378/"}, {"pmid": "38098249", "title": "Percutaneous coronary intervention with ridaforolimus eluting-stents in small vessel coronary artery disease.", "source": "Catheter Cardiovasc Interv", "pubdate": "2024 Jan", "authors": ["Arow Z", "Konigstein M", "Vaknin-Assa H", "Witberg G", "Jonas M", "Kerner A", "Cafri C", "Rubinshtein R"], "url": "https://pubmed.ncbi.nlm.nih.gov/38098249/"}, {"pmid": "37860860", "title": "Targeted therapy with a localised abluminal groove, low-dose sirolimus-eluting, biodegradable-polymer coronary stent - five-year results of the TARGET All Comers randomised clinical trial.",
【tool:web_search】
{"ok": true, "query": "site:pubmed.ncbi.nlm.nih.gov rapamycin human trial PMID primary endpoint everolimus sirolimus review 38310895", "results": [{"title": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/", "snippet": "PubMed® comprises more than 40 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites ."}, {"title": "Target of rapamycin inhibitors (sirolimus and everolimus) for primary ...", "url": "https://pubmed.ncbi.nlm.nih.gov/16699448/", "snippet": "Abstract Background: Target of rapamycin inhibitors (TOR-I) have a novel mode of action but uncertain clinical role. We performed a systematic review of randomized trials where immunosuppressive regimens containing TOR-I were compared with other regimens as initial therapy for kidney transplant recipients."}, {"title": "Sirolimus: a comprehensive review - PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/11825325/", "snippet": "Sirolimus (Rapamune), Wyeth-Ayerst, Madison, NJ) is a new, potent, immunosuppressant that is emerging as a foundation for long-term immunosuppressive therapy in renal transplantation. The drug acts during both co-stimulatory activation and cytokine-driven pathways via a unique mechanism: inhibition …"}, {"title": "Inhibition of the mammalian target of rapamycin (mTOR) in advanced ...", "url": "https://pubmed.ncbi.nlm.nih.gov/20630061/", "snippet": "In Study B, eve
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" references PMID"})
→ call web_search({"limit":10,"query":"38310895 references rapamycin human trial sirolimus everolimus PMID"})
→ call web_search({"limit":10,"query":"\"38310895\" \"primary endpoint\" rapamycin trial"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" references PMID", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of
【tool:web_search】
{"ok": true, "query": "38310895 references rapamycin human trial sirolimus everolimus PMID", "results": [{"title": "Rapalog Pharmacology (RAP PAC) Study - ClinicalTrials.gov", "url": "https://clinicaltrials.gov/study/NCT05949658", "snippet": "The objective of RAP PAC is to identify safe and effective weekly dose (s) for the mTOR inhibitors sirolimus and everolimus that intervene on the underlying fundamental biology of aging. Participants who are 55-89 years old that are free of overt chronic diseases will be assigned to either 6 weeks of sirolimus or everolimus (5 mg, 10 mg, or 15 mg once per week). The investigators will complete ..."}, {"title": "Target of rapamycin inhibitors (TOR‐I; sirolimus and everolimus) for ...", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6953317/", "snippet": "The place of target of rapamycin inhibitors (TOR‐I) ( sirolimus , everolimus ), which have different modes of action from other commonly used immunosuppressive agents, in kidney transplantation remains uncertain."}, {"title": "Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA‐EX‐01 ...", "url": "https://onlinelibrary.wiley.com/doi/10.1002/jcsm.70274", "snippet": "Conclusion In this exploratory trial , once-weekly sirolimus ( rapamycin ) 6 mg did not enhance, and in sensitivity analyses, it may have modestly attenuated short-term functional improvements from a home exercise programme in older adults. The regimen also increased the burden of minor adverse events and may have
【tool:web_search】
{"ok": true, "query": "\"38310895\" \"primary endpoint\" rapamycin trial", "results": []}
→ call web_fetch({"max_chars":30000,"url":"https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext"})
→ call web_fetch({"max_chars":30000,"url":"https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call search_memory({"limit":12,"query":"4360dd15 38310895 candidate PMID everolimus sirolimus healthy older adults trial"})
→ call search_memory({"limit":12,"query":"4360dd15 38310895 19 included studies PMID list"})
→ call search_memory({"limit":12,"query":"4360dd15 rapamycin trial primary endpoint PMID transplant everolimus sirolimus"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0053-transcript", "tags": "iteration transcript", "modified": "20260424194945000", "preview": "!! 第 53 轮执行轨迹
→ call search_memory({\\\""}, {"title": "Iter-4360dd15-0052-transcript", "tags": "iteration transcript", "modified": "20260424194718000", "preview": "!! 第 52 轮执行轨迹 → call search_memory({\\\"limi"}, {"title": "Iter-4360dd15-0055-transcript", "tags": "iteration transcript", "modified": "20260424195425000", "preview": "!! 第 55 轮执行轨迹 【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"}) → call list_recent({\"n\":10}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 38310895 NEXT_FOCUS 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":10}) → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 ```