Iter-4360dd15-0094-transcript
第 94 轮执行轨迹
→ call search_memory({"limit":10,"query":"4360dd15 38310895 NEXT_FOCUS 原始人类试验 PMID 主要终点"}) → call list_recent({"n":10})
→ call list_by_tag({"limit":10,"tag":"4360dd15"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→"}, {"title": "Iter-4360dd15-0090-transcript", "tags": "iteration transcript", "modified": "20260424210019000", "preview": "!! 第 90 轮执行轨迹 → call search_memory({\\\"limit"}, {"title": "Iter-4360dd15-0051-transcript", "tags": "iteration transcript", "modified": "20260424194527000", "preview": "!! 第 51 轮执行轨迹 【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0093-reflection", "modified": "20260424210659000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424210659000", "tags": "pinned focus"}, {"title": "先从综述引用链提取唯一原始 PMID", "modified": "20260424210659000", "tags": "lesson evidence-chain clinical-trials endpoint-classification"}, {"title": "Iter-4360dd15-0093-transcript", "modified": "20260424210654000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0092-reflection", "modified": "20260424210407000", "tags": "iteration reflection"}, {"title": "先锁定唯一 PMID 再判终点", "modified": "20260424210407000", "tags": "lesson evidence-chain clinical-trials endpoint-classification"}, {"title": "Iter-4360dd15-0092-transcript", "modified": "20260424210400000", "tags": "iteration transcript"}, {"title": "PMID 24691032 is muscle-protein-synthesis endpoint, not longevity evidence", "modified": "20260424210355000", "tags": "4360dd15 fact knowledge clinical-trials endpoint-classification"}, {"title": "Iter-4360dd15-0091-reflection", "modified": "20260424210210000", "tags": "iteration reflection"}, {"title": "先锁定唯一引用再看终点", "modified": "20260424210210000", "tags": "lesson evidence-chain clinical-trials endpoint-classification"}]}
【tool:list_by_tag】
{"ok": true, "items": [{"title": "PMID 24691032 is muscle-protein-synthesis endpoint, not longevity evidence", "modified": "20260424210355000"}, {"title": "PMID 22115710 is phase I ocular safety study, not longevity evidence", "modified": "20260424210145000"}, {"title": "PMID 29408453 is feasibility/safety pilot, not direct longevity evidence", "modified": "20260424210012000"}, {"title": "PMID 31761958 is skin-senescence endpoint, not longevity evidence", "modified": "20260424205759000"}, {"title": "PMID 33977284 is RTI incidence endpoint, not direct longevity evidence", "modified": "20260424204839000"}, {"title": "PMID 25540326 is immune-response endpoint, not longevity evidence", "modified": "20260424204718000"}, {"title": "PMID 27883166 is a pilot safety feasibility trial not direct longevity evidence", "modified": "20260424204543000"}, {"title": "PEARL trial is not direct longevity evidence", "modified": "20260424203525000"}, {"title": "Iter-4360dd15-0078-two-pmid-evidence-verification", "modified": "20260424203242000"}, {"title": "Iter-4360dd15-0077-unified-longevity-classification-four-pmids", "modified": "20260424203137000"}]}
→ call read_note({"title":"NEXT_FOCUS"})
→ call search_memory({"limit":12,"query":"38310895 rapamycin review references original human trial PMID"})
→ call search_memory({"limit":12,"query":"4360dd15 38310895 reference chain PMID not yet audited"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0093）\n\n从 38310895 的参考文献中精确挑出 1 个尚未审计的原始人类试验 PMID，并只核实它的主要终点。"}
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0009-transcript", "tags": "iteration transcript", "modified": "20260424175555000", "preview": "!! 第 9 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin mTOR systematic review 2024 trial endpoint PMC table remaining included studies\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\""}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹 【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"}) → call list_recent({\"n\":10}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":8,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 14 候选 PMID 研究类型 误纳入 original clinical study extension follow-up ancillary\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"} → call pubmed_search({"limit":5,"query":"38310895"})
→ call web_search({"limit":5,"query":"PMID 38310895 rapamycin review references trial primary endpoint"})
→ call search_memory({"limit":10,"query":"4360dd15 38310895 trial PMID audited primary endpoint"})
【tool:pubmed_search】
{"ok": true, "query": "38310895", "results": [{"pmid": "38310895", "title": "Targeting ageing with rapamycin and its derivatives in humans: a systematic review.", "source": "Lancet Healthy Longev", "pubdate": "2024 Feb", "authors": ["Lee DJW", "Hodzic Kuerec A", "Maier AB"], "url": "https://pubmed.ncbi.nlm.nih.gov/38310895/"}]}
【tool:web_search】
{"ok": true, "query": "PMID 38310895 rapamycin review references trial primary endpoint", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "Influence of rapamycin on safety and healthspan metrics after one year ...", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12074816/", "snippet": "An important gap in the clinical understanding of rapamycin for longevity is that to date, no long-term randomized controlled trials (RCT) have been conducted to explore the safety and effectiveness of low-dose, intermittent rapamycin regimens for improving multiple healthspan metrics in normative aging cohorts."}, {"title": "Targeting ageing with rapamycin and its derivati
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0090-transcript", "tags": "iteration transcript", "modified": "20260424210019000", "preview": "!! 第 90 轮执行轨迹
→ call search_memory({\\\"limit"}, {"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹 →"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹 → call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext"})
→ call web_fetch({"max_chars":12000,"url":"https://europepmc.org/article/MED/38310895"})
→ call search_memory({"limit":20,"query":"4360dd15 38310895 included studies PMID rapamycin everolimus sirolimus trial"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/38310895", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0083-transcript", "tags": "iteration transcript", "modified": "20260424204550000", "preview": "!! 第 83 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 原始人类试验 PMID 综述 引用链 主要终点 生存 健康寿命 失能自由生存\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"}) → call list_recent({\"n\":8}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹 → call read_note({"title":"Iter-4360dd15-0060-transcript"})
→ call read_note({"title":"Iter-4360dd15-0053-transcript"})
→ call read_note({"title":"Iter-4360dd15-0077-transcript"})
【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "text": "!! 第 60 轮执行轨迹\n\n
\n → call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"})\n\n → call list_recent({\"n\":10})\n\n → call list_tools({})\n\n【tool:search_memory】\n{\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹 → call search_memory({\\\"limit\\\":10,\\\"query\\\":\\\"4360dd15 NEXT_FOCUS PMID 10 条候选 研究类型 保留 排除 理由\\\"}) → call list_recent({\\\"n\\\":8}) → call list_by_tag({\\\"limit\\\":20,\\\"tag\\\":\\\"4360dd15\\\"}) 【tool:search_memory】 {\\\"ok\\\": true, \\\"results\\\": [{\\\"title\\\": \\\"Iter-4360dd15-0051-transcript\\\", \\\"【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0053-transcript", "tags": "iteration transcript", "text": "!! 第 53 轮执行轨迹\n\n
→ call search_memory({\\\"limit\\\":10,\\\"query\\\":\\\"4360dd15 14 候选 PMID 研究类型 误纳入 original clinical study extension follow-up ancillary\\\"}) → call list_recent({\\\"n\\\":8}) → call list_by_tag({\\\"limit\\\":20,\\\"tag\\\":\\\"4360dd15\\\"}) 【tool:search_memory】 {\\\"ok\\\": true, \\\"results\\\": [{\\\"title\\\": \\\"Iter-4360dd15-0048-transcript\\\", \\\"tags\\\": \\\"iteration transcript\\\", \\\"modified\\\": \\\"20260424194115000\\\", \\\"preview\\\": \\\"\"}, {\"title\": \"Iter-4360dd15-0037-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424191347000\", \"preview\": \"!! 第 37 轮执行轨迹 【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0077-transcript", "tags": "iteration transcript", "text": "!! 第 77 轮执行轨迹\n\n
\n → call search_memory({\"limit\":8,\"query\":\"4360dd15 NEXT_FOCUS PMID 候选 摘要 年龄判据 主要终点\"})\n\n → call list_recent({\"n\":6})\n\n → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"})\n\n【tool:search_memory】\n{\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 →\"}, {\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹 → call search_memory({"limit":10,"query":"4360dd15 22367193 audited primary endpoint"})
→ call search_memory({"limit":10,"query":"4360dd15 24618547 audited primary endpoint"})
→ call search_memory({"limit":10,"query":"4360dd15 29992557 audited primary endpoint"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"}) → call list_recent({\"n\":10}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":8,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": 【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹 →"}, {"title": "Iter-4360dd15-0090-transcript", "tags": "iteration transcript", "modified": "20260424210019000", "preview": "!! 第 90 轮执行轨迹 【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"}) → call list_recent({\"n\":10}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":8,\"ta