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Iter-4360dd15-0091-transcript

iteration transcript

修改：20260424210157000

第 91 轮执行轨迹

  → call search_memory({"limit":10,"query":"4360dd15 38310895 原始人类试验 PMID 主要终点"})
  → call list_recent({"n":10})
  → call list_by_tag({"limit":20,"tag":"4360dd15"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"}) → call list_recent({\"n\":10}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹 
   →"}, {"title": "Iter-4360dd15-0090-transcript", "tags": "iteration transcript", "modified": "20260424210019000", "preview": "!! 第 90 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 原始人类试验 PMID 主要终点\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":8,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 
   → call search_memory({\\\"limit"}, {"title": "Iter-4360dd15-0051-transcript", "tags": "iteration transcript", "modified": "20260424194527000", "preview": "!! 第 51 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 14 候选 PMID 研究类型 误纳入 original clinical study extension follow-up ancillary\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}

【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0090-reflection", "modified": "20260424210023000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424210023000", "tags": "pinned focus"}, {"title": "先从综述引用链落到原始试验", "modified": "20260424210023000", "tags": "lesson evidence-chain clinical-trials citation-chain"}, {"title": "Iter-4360dd15-0090-transcript", "modified": "20260424210019000", "tags": "iteration transcript"}, {"title": "PMID 29408453 is feasibility/safety pilot, not direct longevity evidence", "modified": "20260424210012000", "tags": "fact knowledge clinical-trials 4360dd15"}, {"title": "Iter-4360dd15-0089-reflection", "modified": "20260424205810000", "tags": "iteration reflection"}, {"title": "先从综述引用链下钻到原始试验", "modified": "20260424205810000", "tags": "lesson evidence-chain clinical-trials citation-chain"}, {"title": "Iter-4360dd15-0089-transcript", "modified": "20260424205805000", "tags": "iteration transcript"}, {"title": "PMID 31761958 is skin-senescence endpoint, not longevity evidence", "modified": "20260424205759000", "tags": "lesson endpoint-classification clinical-trials 4360dd15"}, {"title": "Iter-4360dd15-0088-reflection", "modified": "20260424205610000", "tags": "iteration reflection"}]}

【tool:list_by_tag】
{"ok": true, "items": [{"title": "PMID 29408453 is feasibility/safety pilot, not direct longevity evidence", "modified": "20260424210012000"}, {"title": "PMID 31761958 is skin-senescence endpoint, not longevity evidence", "modified": "20260424205759000"}, {"title": "PMID 33977284 is RTI incidence endpoint, not direct longevity evidence", "modified": "20260424204839000"}, {"title": "PMID 25540326 is immune-response endpoint, not longevity evidence", "modified": "20260424204718000"}, {"title": "PMID 27883166 is a pilot safety feasibility trial not direct longevity evidence", "modified": "20260424204543000"}, {"title": "PEARL trial is not direct longevity evidence", "modified": "20260424203525000"}, {"title": "Iter-4360dd15-0078-two-pmid-evidence-verification", "modified": "20260424203242000"}, {"title": "Iter-4360dd15-0077-unified-longevity-classification-four-pmids", "modified": "20260424203137000"}, {"title": "Iter-4360dd15-0075-abstract-field-extraction-two-pmids", "modified": "20260424202951000"}, {"title": "Iter-4360dd15-0072-review-exclusion-first-rule", "modified": "20260424202103000"}, {"title": "Iter-4360dd15-0071-minimal-audit-rules", "modified": "20260424201843000"}, {"title": "Iter-4360dd15-0069-standardized-audit-table-two-trials", "modified": "20260424201621000"}, {"title": "Iter-4360dd15-0068-abstract-endpoint-extraction", "modified": "20260424201407000"}, {"title": "Iter-4360dd15-0067-abstract-endpoints-aging-criteria", "modified": "20260424201141000"}, {"title"

→ call search_memory({"limit":10,"query":"4360dd15 38310895 PMID 候选 原始试验"})

→ call read_note({"title":"NEXT_FOCUS"})

→ call read_note({"title":"Iter-4360dd15-0061-candidate-audit-10-remaining-pmids"})

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹 

   → call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"})    → call list_recent({\"n\":10})    → call list_tools({})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹
→"}, {"title": "Iter-4360dd15-0090-transcript", "tags": "iteration transcript", "modified": "20260424210019000", "preview": "!! 第 90 轮执行轨迹 
   → call search_memory({\"limit\":8,\"query\":\"4360dd15 38310895 原始人类试验 PMID 主要终点\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":8,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹
→ call search_memory({\\\"limit"}, {"title": "Iter-4360dd15-0051-transcript", "tags": "iteration transcript", "modified": "20260424194527000", "preview": "!! 第 51 轮执行轨迹 
   → call search_memory({\"limit\":10,\"query\":\"4360dd15 14 候选 PMID 研究类型 误纳入 original clinical study extension follow-up ancillary\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission `4360dd15` · Iter-0090）\n\n从 PMID 38310895 的参考文献里精确挑出 1 个尚未审计的原始人类试验 PMID，并只核实其主要终点。"}
【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0061-candidate-audit-10-remaining-pmids", "tags": "4360dd15 knowledge fact classification clinical-trials", "text": "!! 第 61 轮：剩余 10 条候选 PMID 的研究类型审计完成\n\n本轮把上一轮留下的“剩余 10 条候选”逐条核对，并与已知的 4 条二次/延伸研究合并成 14 条完整清单。\n\n!! 结论\n- 保留 10 条：均可视为原始临床研究\n- 排除 4 条：标题明确指向 ancillary / follow-up / extension / postextension\n\n!! 保留 PMID\n- 33977284\n- 22367193\n- 29408453\n- 22115710\n- 35040506\n- 25525171\n- 24618547\n- 18037627\n- 27613521\n- 29992557\n\n!! 排除 PMID\n- 29806044\n- 31781682\n- 30564495\n- 34693520\n\n!! 最小可复现判定规则\n1. 标题若显式包含 `ancillary` / `follow-up` / `extension` / `postextension`，则排除为非原始研究。\n2. 标题若包含 `randomized` / `placebo-controlled` / `phase` / `pilot` / `proof-of-concept` / `single-arm`，不要自动排除；它们仍可能是原始临床研究。\n3. `longitudinal analysis` 若嵌在主试验题名中，只作为主试验附带分析，不单独构成排除理由。\n\n!! 复现备注\n- 先用记忆回忆上一轮留下的候选上下文\n- 再逐条对照题名进行结构化分类\n- 本轮已把“剩余 10 条候选”从噪声中清理为可审计的保留/排除结果"}
  → call search_memory({"limit":10,"query":"22115710 22367193 35040506 25525171 24618547 18037627 27613521 29992557 38310895"})
  → call list_recent({"n":5})
  → call list_tools({})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0073-transcript", "tags": "iteration transcript", "modified": "20260424202419000", "preview": "!! 第 73 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 摘要 研究类型 年龄判据 主要终点 候选\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 
   → call search_memory({\\\"lim"}, {"title": "Iter-4360dd15-0062-transcript", "tags": "iteration transcript", "modified": "20260424200332000", "preview": "!! 第 62 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条 候选 PMID 研究类型 保留 排除 理由\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 
   → call search"}, {"title": "Iter-4360dd15-0074-transcript", "tags": "iteration transcript", "modified": "20260424202717000", "preview": "!! 第 74 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 候选 摘要 年龄判据 主要终点 分类\"}) → call list_recent({\"n\":8}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"t

【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0090-reflection", "modified": "20260424210023000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424210023000", "tags": "pinned focus"}, {"title": "先从综述引用链落到原始试验", "modified": "20260424210023000", "tags": "lesson evidence-chain clinical-trials citation-chain"}, {"title": "Iter-4360dd15-0090-transcript", "modified": "20260424210019000", "tags": "iteration transcript"}, {"title": "PMID 29408453 is feasibility/safety pilot, not direct longevity evidence", "modified": "20260424210012000", "tags": "fact knowledge clinical-trials 4360dd15"}]}

【tool:list_tools】
{"ok": true, "tools": [{"name": "search_memory", "description": "在 TiddlyWiki 长期记忆中按关键字搜索（支持中文空格分隔），返回标题、标签、预览。每轮迭代开始前应先调用以回忆。", "custom": false}, {"name": "read_note", "description": "读取某一条 tiddler 的完整正文。", "custom": false}, {"name": "write_note", "description": "向 TiddlyWiki 写入（或覆盖）一条 tiddler。这是 Sisyphus 的长期记忆入口——每轮至少写一条。建议标签：knowledge, experiment, reflection, plan, idea, fact, question, lesson。TiddlyWiki 标记：!! 小标题，''粗体''，斜体，其它tiddler。", "custom": false}, {"name": "list_recent", "description": "列出最近修改过的 tiddler。", "custom": false}, {"name": "list_by_tag", "description": "按标签列出相关 tiddler。", "custom": false}, {"name": "run_python", "description": "在 workspace/ 下以子进程执行一段 Python 代码，返回 stdout/stderr。用于计算、模拟、验证假设、抓取公开数据（禁止任何破坏性操作）。", "custom": false}, {"name": "read_file", "description": "读取 workspace/ 下的某个文件。", "custom": false}, {"name": "write_file", "description": "向 workspace/ 下写入文件（默认覆盖，append=true 时追加）。", "custom": false}, {"name": "list_files", "description": "列出 workspace/ 下的文件。", "custom": false}, {"name": "web_fetch", "description": "抓取任意公开 URL（GET），返回剥离 HTML 后的纯文本。适合读论文摘要、文档、博客、百科。", "custom": false}, {"name": "web_search", "description": "用 DuckDuckGo 搜索互联网，返回 title/url/snippet 列表。找入口、找链接、调研时用。", "custom": false}, {"name": "wiki_search", "description": "维基百科搜索：返回若干条目的摘要和 URL。lang 默认 en，可传 zh 等。", "custom": false}, {"name": "arxiv_search", "description": "arXiv 论文检索：标题/作者/摘要/链接。理论、数学、物理、CS、bio 类前沿论文的主入口。", "custom": false}, {"name": "pubmed_search", "descriptio

→ call pubmed_search({"limit":3,"query":"22115710"})

→ call pubmed_search({"limit":3,"query":"22367193"})

→ call pubmed_search({"limit":3,"query":"35040506"})

【tool:pubmed_search】
{"ok": true, "query": "22115710", "results": [{"pmid": "22115710", "title": "A randomized, dose-escalation study of subconjunctival and intravitreal injections of sirolimus in patients with diabetic macular edema.", "source": "Ophthalmology", "pubdate": "2012 Jan", "authors": ["Dugel PU", "Blumenkranz MS", "Haller JA", "Williams GA", "Solley WA", "Kleinman DM", "Naor J"], "url": "https://pubmed.ncbi.nlm.nih.gov/22115710/"}]}

【tool:pubmed_search】
{"ok": true, "query": "22367193", "results": [{"pmid": "22367193", "title": "A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults.", "source": "Cancer Chemother Pharmacol", "pubdate": "2012 Jun", "authors": ["Boni JP", "Leister C", "Hug B", "Burns J", "Sonnichsen D"], "url": "https://pubmed.ncbi.nlm.nih.gov/22367193/"}]}

【tool:pubmed_search】
{"ok": true, "query": "35040506", "results": [{"pmid": "35040506", "title": "mTOR Inhibition with Sirolimus in Multiple System Atrophy: A Randomized, Double-Blind, Placebo-Controlled Futility Trial and 1-Year Biomarker Longitudinal Analysis.", "source": "Mov Disord", "pubdate": "2022 Apr", "authors": ["Palma JA", "Martinez J", "Millar Vernetti P", "Ma T", "Perez MA", "Zhong J", "Qian Y", "Dutta S"], "url": "https://pubmed.ncbi.nlm.nih.gov/35040506/"}]}

→ call search_memory({"limit":5,"query":"22367193"})

→ call search_memory({"limit":5,"query":"22115710"})

→ call search_memory({"limit":5,"query":"35040506"})

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0073-transcript", "tags": "iteration transcript", "modified": "20260424202419000", "preview": "!! 第 73 轮执行轨迹 

   → call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 摘要 研究类型 年龄判据 主要终点 候选\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹
→ call search_memory({\\\"lim"}, {"title": "Iter-4360dd15-0064-transcript", "tags": "iteration transcript", "modified": "20260424200608000", "preview": "!! 第 64 轮执行轨迹 
   → call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 10 条 PMID 审计表 保留 相关性 强弱 分层\"})    → call search_memory({\"limit\":10,\"query\":\"4360dd15 10-pmid-audit-table PMID 题名 研究类型 保留 理由\"})    → call list_recent({\"n\":6})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"prev"}, {"title": "Iter-4360dd15-0062-transcript", "tags": "iteration transcript", "modified": "20260424200332000", "preview": "!! 第 62 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条 候选 PMID 研究类型 保留 排除 理由\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0073-transcript", "tags": "iteration transcript", "modified": "20260424202419000", "preview": "!! 第 73 轮执行轨迹 

   → call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 摘要 研究类型 年龄判据 主要终点 候选\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹
→ call search_memory({\\\"lim"}, {"title": "Iter-4360dd15-0062-transcript", "tags": "iteration transcript", "modified": "20260424200332000", "preview": "!! 第 62 轮执行轨迹 
   → call search_memory({\"limit\":8,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条 候选 PMID 研究类型 保留 排除 理由\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹
→ call search"}, {"title": "Iter-4360dd15-0064-transcript", "tags": "iteration transcript", "modified": "20260424200608000", "preview": "!! 第 64 轮执行轨迹 
   → call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 10 条 PMID 审计表 保留 相关性 强弱 分层\"})    → call search_memory({\"limit\":10,\"query\":\"4360dd15 10-pmid-audit-table PMID 题名 研究类型 保留 理由\"})    → call list_rec
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0074-transcript", "tags": "iteration transcript", "modified": "20260424202717000", "preview": "!! 第 74 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 候选 摘要 年龄判据 主要终点 分类\"}) → call list_recent({\"n\":8}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 
   → call search_memory({\\\"limit\\\":10,\\\"query\\\":\\\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID "}, {"title": "Iter-4360dd15-0078-transcript", "tags": "iteration transcript", "modified": "20260424203248000", "preview": "!! 第 78 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 候选 摘要 年龄判据 主要终点 保留 排除\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 
   → call search_memory({\\\"li"}, {"title": "Iter-4360dd15-0059-transcript", "tags": "iteration transcript", "modified": "20260424195947000", "preview": "!! 第 59 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\

→ call pubmed_search({"limit":1,"query":"22115710"})

→ call web_fetch({"max_chars":5000,"url":"https://pubmed.ncbi.nlm.nih.gov/22115710/"})

【tool:pubmed_search】
{"ok": true, "query": "22115710", "results": [{"pmid": "22115710", "title": "A randomized, dose-escalation study of subconjunctival and intravitreal injections of sirolimus in patients with diabetic macular edema.", "source": "Ophthalmology", "pubdate": "2012 Jan", "authors": ["Dugel PU", "Blumenkranz MS", "Haller JA", "Williams GA", "Solley WA", "Kleinman DM", "Naor J"], "url": "https://pubmed.ncbi.nlm.nih.gov/22115710/"}]}

【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://pubmed.ncbi.nlm.nih.gov/22115710/'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}

→ call web_search({"limit":5,"query":"\"22115710\" sirolimus diabetic macular edema primary endpoint abstract"})

→ call web_search({"limit":5,"query":"\"A randomized, dose-escalation study of subconjunctival and intravitreal injections of sirolimus in patients with diabetic macular edema\""})

→ call web_search({"limit":5,"query":"PMID 22115710 sirolimus diabetic macular edema endpoint"})

【tool:web_search】
{"ok": true, "query": "\"22115710\" sirolimus diabetic macular edema primary endpoint abstract", "results": [{"title": "Date", "url": "https://engine.freerice.com/stats/rice/daily.html", "snippet": "22115710 2025-03-31 16857240 2025-03-30 10199600 2025-03-29 10466800 2025-03-28 27045180 2025-03-27 29908970 2025-03-26 22744450 2025-03-25 19307370 2025-03-24 18442040 2025-03-23 8745060 2025-03-22 8984300 2025-03-21 20045420 2025-03-20 21950900 2025-03-19 19312190 2025-03-18 19033850 2025-03-17 24650470 2025-03-16 11409980 2025-03-15 13732740 ..."}]}

【tool:web_search】
{"ok": true, "query": "\"A randomized, dose-escalation study of subconjunctival and intravitreal injections of sirolimus in patients with diabetic macular edema\"", "results": [{"title": "A Randomized, Dose-Escalation Study of Subconjunctival ... - ScienceDirect", "url": "https://www.sciencedirect.com/science/article/pii/S0161642011006889", "snippet": "A Randomized, Dose-Escalation Study of Subconjunctival and Intravitreal Injections of Sirolimus in Patients with Diabetic Macular Edema"}, {"title": "A Randomized, Dose-Escalation Study of Subconjunctival ... - ResearchGate", "url": "https://www.researchgate.net/publication/51829057_A_Randomized_Dose-Escalation_Study_of_Subconjunctival_and_Intravitreal_Injections_of_Sirolimus_in_Patients_with_Diabetic_Macular_Edema", "snippet": "Request PDF | A Randomized, Dose-Escalation Study of Subconjunctival and Intravitreal Injections of Sirolimus in Patients with Diabetic Macular Edema | To evaluate the safety and tolerability of a ..."}, {"title": "A Randomized, Dose-Escalation Study of Subconjunctival ... - ScienceDirect", "url": "https://www.sciencedirect.com/science/article/abs/pii/S0161642011006889", "snippet": "Original article A Randomized, Dose-Escalation Study of Subconjunctival and Intravitreal Injections of Sirolimus in Patients with Diabetic Macular Edema Presented at: the American Academy of Ophthalmology Annual Meeting, Atlanta, Georgia, November 2008."}, {"title": "A Randomized, Dose-Escalation Study of Subconjunctival ...

【tool:web_search】
{"ok": true, "query": "PMID 22115710 sirolimus diabetic macular edema endpoint", "results": [{"title": "A randomized, dose-escalation study of subconjunctival and ... - PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/22115710/", "snippet": "Abstract Objective: To evaluate the safety and tolerability of a single subconjunctival (SCJ) or intravitreal (IVT) injection of an ophthalmic sirolimus formulation in eyes with diabetic macular edema (DME). Design: Randomized, open-label, dose-escalating phase I study."}, {"title": "A randomized, dose-escalation study of subconjunctival and intravitreal ...", "url": "https://europepmc.org/article/MED/22115710", "snippet": "To evaluate the safety and tolerability of a single subconjunctival (SCJ) or intravitreal (IVT) injection of an ophthalmic sirolimus formulation in eyes with diabetic macular edema (DME). No dose-limiting toxicities were observed and ocular adverse events were mostly mild and transient. Conjunctival ..."}, {"title": "A Randomized, Dose-Escalation Study of Subconjunctival and Intravitreal ...", "url": "https://www.aaojournal.org/article/S0161-6420(11)00688-9/pdf", "snippet": "Objective: To evaluate the safety and tolerability of a single subconjunctival (SCJ) or intravitreal (IVT) injection of an ophthalmic sirolimus formulation in eyes with diabetic macular edema (DME). Design: Randomized, open-label, dose-escalating phase I study."}, {"title": "Sirolimus to Treat Diabetic Macular Edema (SDME)", "url": "https://clinica

→ call web_fetch({"max_chars":6000,"url":"https://europepmc.org/article/MED/22115710"})

【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/22115710", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}

→ call write_note({"tags":["4360dd15","fact","clinical-trials","knowledge"],"text":"!! PMID 22115710 的主要终点核实\n\n''试验身份''\n- PMID: 22115710\n- 题名: A randomized, dose-escalation study of subconjunctival and intravitreal injections of sirolimus in patients with diabetic macular edema.\n- 设计: randomized, open-label, dose-escalating phase I study\n\n''主要终点''\n- 目标是评估单次结膜下（SCJ）或玻璃体内（IVT）sirolimus 注射的 安全性与耐受性\n- 这意味着它)

【tool:write_note】
{"ok": true, "path": "C:\\Users\\yh599\\Documents\\GitHub\\LLM-yh\\Sisyphus\\wiki\\tiddlers\\PMID_22115710_is_phase_I_ocular_s
```