Iter-4360dd15-0088-transcript
第 88 轮执行轨迹
→ call search_memory({"limit":8,"query":"4360dd15 38310895 参考文献 原始人类试验 PMID mTOR rapalog 主要终点"})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→"}, {"title": "Iter-4360dd15-0084-transcript", "tags": "iteration transcript", "modified": "20260424204726000", "preview": "!! 第 84 轮执行轨迹 → cal"}, {"title": "Iter-4360dd15-0051-transcript", "tags": "iteration transcript", "modified": "20260424194527000", "preview": "!! 第 51 轮执行轨迹 → call read_note({"title":"NEXT_FOCUS"})
→ call read_note({"title":"Iter-4360dd15-0087-reflection"})
→ call read_note({"title":"Iter-4360dd15-0085-fact classification clinical-trials longevity"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0087）\n\n从 PMID 38310895 的参考文献中挑出 1 个尚未审计的原始人类试验 PMID，并只核实其主要终点是否直接指向死亡、生存、健康寿命或失能自由生存。"}
【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0087-reflection", "tags": "iteration reflection", "text": "!! 本轮进展\n本轮把线索收敛到 mTOR/rapalog 综述 PMID 38310895，并确认下一步必须回到其引用链里找原始人类试验。\n\n!! 失败 / 盲点\n仍未锁定一个尚未审计的原始试验 PMID，搜索主要停留在综述和泛检索，浪费在入口层而非证据层。\n\n!! 下轮焦点\n从 PMID 38310895 的参考文献中挑出 1 个尚未审计的原始人类试验 PMID，并只核实其主要终点是否直接指向死亡、生存、健康寿命或失能自由生存。\n"}
【tool:read_note】
{"ok": false, "error": "找不到 tiddler: Iter-4360dd15-0085-fact classification clinical-trials longevity"}
→ call search_memory({"limit":10,"query":"38310895 PMID rapalog review references human trial original trial everolimus sirolimus"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0001-transcript", "tags": "iteration transcript", "modified": "20260424173243000", "preview": "!! 第 1 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 长生不老 immortality 抗衰老 目标\"}) → call list_recent({\"n\":10}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"GOAL\", \"tags\": \"goal pinned\", \"modified\": \"20260424172208000\", \"preview\": \"[[目标]]：找到让人类长生不老的方法 Mission ID：`4360dd15` 起始时间：2026-04-25T01:22:08 !! 使用说明 这是 Sisyphus 的北极星。永远围绕这个目标展开。 其它 mis"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹 → cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call pubmed_search({"limit":10,"query":"38310895"})
→ call web_search({"limit":8,"query":"PMID 38310895 rapalog review references human trial mTOR"})
→ call wiki_search({"lang":"en","limit":5,"query":"rapamycin mTOR longevity clinical trial"})
【tool:pubmed_search】
{"ok": true, "query": "38310895", "results": [{"pmid": "38310895", "title": "Targeting ageing with rapamycin and its derivatives in humans: a systematic review.", "source": "Lancet Healthy Longev", "pubdate": "2024 Feb", "authors": ["Lee DJW", "Hodzic Kuerec A", "Maier AB"], "url": "https://pubmed.ncbi.nlm.nih.gov/38310895/"}]}
【tool:web_search】
{"ok": true, "query": "PMID 38310895 rapalog review references human trial mTOR", "results": []}
【tool:wiki_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://en.wikipedia.org/w/api.php?action=query&list=search&srsearch=rapamycin+mTOR+longevity+clinical+trial&srlimit=5&format=json'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" PDF references"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" PMC"})
→ call web_search({"limit":10,"query":"\"Lancet Healthy Longev\" rapamycin humans systematic review references"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" PDF references", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.researchgate.net/publication/377976071_Targeting_ageing_with_rapamycin_and_its_derivatives_in_humans_a_systematic_review", "snippet
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" PMC", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing
【tool:web_search】
{"ok": true, "query": "\"Lancet Healthy Longev\" rapamycin humans systematic review references", "results": []}
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_fetch({"max_chars":12000,"url":"https://europepmc.org/article/MED/38310895"})
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/38310895", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
→ call web_fetch({"max_chars":20000,"url":"https://pubmed.ncbi.nlm.nih.gov/38310895/"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://pubmed.ncbi.nlm.nih.gov/38310895/'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":10,"query":"\"PIIS2666756823002581\" references everolimus healthy volunteers PMID"})
→ call web_search({"limit":10,"query":"\"38310895\" \"PMID\" rapamycin everolimus sirolimus healthy ageing trial"})
→ call web_search({"limit":10,"query":"\"everolimus\" \"healthy aging\" trial PMID rapamycin review"})
【tool:web_search】
{"ok": true, "query": "\"PIIS2666756823002581\" references everolimus healthy volunteers PMID", "results": []}
【tool:web_search】
{"ok": true, "query": "\"38310895\" \"PMID\" rapamycin everolimus sirolimus healthy ageing trial", "results": []}
【tool:web_search】
{"ok": true, "query": "\"everolimus\" \"healthy aging\" trial PMID rapamycin review", "results": []}
→ call search_memory({"limit":20,"query":"4360dd15 remaining candidate PMID rapamycin everolimus sirolimus human trial original reference chain"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 38310895 rapalog trial human trial 14 candidate 11 remaining\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 "}, {"title": "Iter-4360dd15-0041-transcript", "tags": "iteration transcript", "modified": "20260424192431000", "preview": "!! 第 41 轮执行轨迹 → call search_memory({"limit":20,"query":"4360dd15 rapamycin everolimus sirolimus PMID trial candidate audited endpoint"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 原始人类试验 PMID 综述 引用链 主要终点 生存 健康寿命 失能自由生存\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424200117000\", \"preview\": \"!! 第 60 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 原始人类试验 PMID 综述 引用链 主要终点 死亡 生存 健康寿命 失能自由生存\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteratio → call web_search({"limit":5,"query":"Europe PMC 38310895 references api"})
【tool:web_search】
{"ok": true, "query": "Europe PMC 38310895 references api", "results": [{"title": "pyeuropepmc · PyPI", "url": "https://pypi.org/project/pyeuropepmc/", "snippet": "A Python package for working with the Europe PMC API to search and retrieve scientific literature."}, {"title": "Europe PMC", "url": "https://europepmc.org/restfulwebservice", "snippet": "For background information on Europe PMC content refer to the Web Service Reference Guide (Sections 2 and 3) and What am I searching on Europe PMC ? The search module can be used to query search fields. Refer to the fields module, the search syntax reference or the Web Service Reference Guide for a list of available fields."}, {"title": "Python Wrapper Class for Europe PMC API to search and retrieve ...", "url": "https://github.com/JonasHeinickeBio/pyEuropePMC", "snippet": "PyEuropePMC is a robust Python toolkit for automated search, extraction, and analysis of scientific literature from Europe PMC ."}, {"title": "For Developers - PMC", "url": "https://pmc.ncbi.nlm.nih.gov/tools/developers/", "snippet": "Not all articles in PMC are available for text mining and other reuse. The PMC Cloud Service, PMC OAI-PMH Service, PMC FTP Service, E-Utilities and BioC API are the only services that may be used for automated retrieval of PMC content. Systematic retrieval (or bulk retrieval) of articles through any other automated process is prohibited. License terms vary. Please refer to the license ..."}, {"title": "Europe PMC Search: Biomedica
→ call web_search({"limit":10,"query":"Europe PMC 38310895 references PMID"})
→ call web_search({"limit":10,"query":"site:europepmc.org 38310895 references rapamycin review"})
→ call web_search({"limit":10,"query":"\"38310895\" \"reference\" \"Europe PMC\""})
【tool:web_search】
{"ok": true, "query": "Europe PMC 38310895 references PMID", "results": [{"title": "Europe PMC", "url": "https://europepmc.org/", "snippet": "Comprehensive search Search life sciences literature from trusted sources around the globe, all in one search, accessible by anyone anywhere, for free. Learn more About Europe PMC ."}, {"title": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/", "snippet": "PubMed® comprises more than 40 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites."}, {"title": "Search Europe PMC publication database — epmc_search", "url": "https://docs.ropensci.org/europepmc/reference/epmc_search.html", "snippet": "This is the main function to search Europe PMC RESTful Web Service (https:// europepmc .org/RestfulWebService). It fully supports the comprehensive Europe PMC query language."}, {"title": "Cross-reference article identifiers - PMC", "url": "https://pmc.ncbi.nlm.nih.gov/tools/xref-ids/", "snippet": "Cross- reference article identifiers Given a PMID , if you want to find whether or not the full text appears in PMC , you can use E-Link as follows. If the article appears in PMC , then the (numerical) PMCID will be returned in the result:"}, {"title": "Help - PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/help/", "snippet": "To restrict retrieval to citations that have a free full text article available in PubMed
【tool:web_search】
{"ok": true, "query": "site:europepmc.org 38310895 references rapamycin review", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "Effect of rapamycin on aging and age-related diseases-past and future ...", "url": "https://europepmc.org/article/pmc/8190242", "snippet": "Over the past decade, there has been an explosion in the number of reports studying the effect of rapamycin on aging and age-related diseases, and there have been several reviews describing various aspects of rapamycin on aging [7 - 11]."}, {"title": "The effect of rapamycin and its analogues on age-related ...", "url": "https://europepmc.org/article/pmc/9637607", "snippet": "This systematic review aims to provide insights into the effect/s of rapamycin and rapalogues on the most prevalent age-related MSKD in human participants. Some studies measured multiple outcomes, so we focused on measurements/outcomes relevant to the review ."}, {"title": "The effect of rapamycin and its analogues on age-related ...", "url": "https://europepmc.org/article/MED/35861940", "snippet": "Preclinical studies have shown a therapeutic role of the mechanistic/mammalian target of rapamycin complex 1 (mT
【tool:web_search】
{"ok": true, "query": "\"38310895\" \"reference\" \"Europe PMC\"", "results": []}
→ call web_search({"limit":8,"query":"Europe PMC REST references PMID endpoint article references json"})
【tool:web_search】
{"ok": true, "query": "Europe PMC REST references PMID endpoint article references json", "results": [{"title": "Europe PMC", "url": "https://europepmc.org/restfulwebservice", "snippet": "For background information on Europe PMC content refer to the Web Service Reference Guide (Sections 2 and 3) and What am I searching on Europe PMC ? The search module can be used to query search fields. Refer to the fields module, the search syntax reference or the Web Service Reference Guide for a list of available fields."}, {"title": "Europe PMC API | ryanjmccall/protein-seq-to-func | DeepWiki", "url": "https://deepwiki.com/ryanjmccall/protein-seq-to-func/9.2-europe-pmc-api", "snippet": "This page documents the Europe PMC REST API integration used for harvesting Open Access scientific literature. Europe PMC provides a comprehensive database of life sciences publications with programmatic access to metadata, abstracts, and full-text XML for Open Access papers."}, {"title": "For Developers - PMC", "url": "https://pmc.ncbi.nlm.nih.gov/tools/developers/", "snippet": "For Developers PMC hosts a number of important article datasets and makes our APIs and some code available via public code repositories."}, {"title": "API Reference | PyEuropePMC Documentation", "url": "https://jonasheinickebio.github.io/pyEuropePMC/api/", "snippet": "Data Models Article Represents a scientific article from Europe PMC . Attributes: title: Article title authors: List of author names journal: Journal name pub_year:
【assistant】
本轮结论：**未能在工具上限内从 PMID 38310895 的引用链里钉死一个“尚未审计的原始人类试验 PMID”并完成终点核实**。
已确认的事实只有：
- PMID 38310895 是综述：*Targeting ageing with rapamycin and its derivatives in humans: a systematic review*（Lancet Healthy Longev, 2024）
- 公开检索能稳定定位到该综述本身，但当前无法直接抽出其参考文献清单来逐条审计
- 既有已审计候选里，PMID 33977284 的主要终点是 **RTI incidence**，不属于死亡/生存/健康寿命/失能自由生存这类直接长寿终点
因此，这一轮的实际产出是一个**失败结论**：
> **当前还没有拿到新的、可复核的原始人类试验 PMID。**
最小可验证的下一步不是继续泛搜，而是**先把 38310895 的参考文献列表拿出来**，再从中挑 1 个未审计 PMID，只看它的 primary endpoint 是否直接是死亡、生存、健康寿命或失能自由生存。
<NEXT_FOCUS>先用能稳定导出参考文献的途径拿到 PMID 38310895 的完整 reference list，然后从中挑 1 个未审计原始人类试验 PMID，只核实其主要终点是否直接指向死亡、生存、健康寿命或失能自由生存。</NEXT_FOCUS>