Iter-4360dd15-0083-transcript

修改：20260424204550000

第 83 轮执行轨迹

  → call search_memory({"limit":10,"query":"4360dd15 原始人类试验 PMID 综述 引用链 主要终点 生存 健康寿命 失能自由生存"})
  → call list_recent({"n":8})
  → call list_by_tag({"limit":20,"tag":"4360dd15"})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹

→ call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型保留排除理由 extension follow-up secondary analysis\"}) → call list_recent({\"n\":10}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹

   →"}, {"title": "Iter-4360dd15-0059-transcript", "tags": "iteration transcript", "modified": "20260424195947000", "preview": "!! 第 59 轮执行轨迹

→ call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型保留排除理由 extension follow-up secondary analysis\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0055-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195425000\", \"previe"}, {"title": "Iter-4360dd15-0079-transcript", "tags": "iteration transcript", "modified": "20260424203535000", "preview": "!! 第 79 轮执行轨迹

→ call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS PMID 候选摘要年龄判据主要终点\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0060-transcript\", \"tags\": \"iteration transcript\", \" 【tool:list_recent】 {"ok": true, "items": [{"title": "Error-20260425-044207", "modified": "20260424204207000", "tags": "error iteration"}, {"title": "Error-20260425-044037", "modified": "20260424204037000", "tags": "error iteration"}, {"title": "Error-20260425-043651", "modified": "20260424203651000", "tags": "error iteration"}, {"title": "Iter-4360dd15-0079-reflection", "modified": "20260424203542000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424203542000", "tags": "pinned focus"}, {"title": "先锁原始试验再谈长寿终点", "modified": "20260424203542000", "tags": "lesson classification endpoint citation-chain"}, {"title": "Iter-4360dd15-0079-transcript", "modified": "20260424203535000", "tags": "iteration transcript"}, {"title": "PEARL trial is not direct longevity evidence", "modified": "20260424203525000", "tags": "4360dd15 lesson fact classification"}]} 【tool:list_by_tag】 {"ok": true, "items": [{"title": "PEARL trial is not direct longevity evidence", "modified": "20260424203525000"}, {"title": "Iter-4360dd15-0078-two-pmid-evidence-verification", "modified": "20260424203242000"}, {"title": "Iter-4360dd15-0077-unified-longevity-classification-four-pmids", "modified": "20260424203137000"}, {"title": "Iter-4360dd15-0075-abstract-field-extraction-two-pmids", "modified": "20260424202951000"}, {"title": "Iter-4360dd15-0072-review-exclusion-first-rule", "modified": "20260424202103000"}, {"title": "Iter-4360dd15-0071-minimal-audit-rules", "modified": "20260424201843000"}, {"title": "Iter-4360dd15-0069-standardized-audit-table-two-trials", "modified": "20260424201621000"}, {"title": "Iter-4360dd15-0068-abstract-endpoint-extraction", "modified": "20260424201407000"}, {"title": "Iter-4360dd15-0067-abstract-endpoints-aging-criteria", "modified": "20260424201141000"}, {"title": "Iter-4360dd15-0066-TierA-abstracts-and-endpoints-for-aging-criteria", "modified": "20260424200925000"}, {"title": "Iter-4360dd15-0065-minimal-relevance-decision-rules-for-retained-mtor-trials", "modified": "20260424200748000"}, {"title": "Iter-4360dd15-0064-relevance-tiering-10-pmids", "modified": "20260424200602000"}, {"title": "Iter-4360dd15-0063-10-pmid-audit-table", "modified": "20260424200432000"}, {"title": "Iter-4360dd15-0062-pubmed-title-verification-10-pmids", "modified": "20260424200328000"}, {"title": "Iter-4360dd15-0061-candidate-audit-10-remaining-pmids", "modified": " → call read_note({"title":"NEXT_FOCUS"}) → call read_note({"title":"Iter-4360dd15-0079-reflection"}) → call read_note({"title":"PMID 38310895 is a review, not a primary trial"}) 【tool:read_note】 {"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission `4360dd15` · Iter-0079）\n\n沿综述引用链只追踪一个尚未审计的原始人类试验 PMID，并核对其主要终点是否为死亡、生存、健康寿命或失能自由生存。"} 【tool:read_note】 {"ok": true, "title": "Iter-4360dd15-0079-reflection", "tags": "iteration reflection", "text": "!! 本轮进展\n本轮把剩余候选试验按终点语境完成了统一排除/归类，并再次把任务焦点收束到“从综述引用链中找未审计的原始人类试验”。\n\n!! 失败 / 盲点\n检索方向仍停留在回忆与二次文献层面，未真正锁定并审计到一个新的原始人类试验条目，导致进展主要是判别规则而非证据增量。\n\n!! 下轮焦点\n沿综述引用链只追踪一个尚未审计的原始人类试验 PMID，并核对其主要终点是否为死亡、生存、健康寿命或失能自由生存。\n"} 【tool:read_note】 {"ok": true, "title": "PMID 38310895 is a review, not a primary trial", "tags": "4360dd15 fact method clinical-trials classification", "text": "!! PMID 38310895 的审计结论\n- PMID 38310895 = [[Targeting ageing with rapamycin and its derivatives in humans: a systematic review.]]（Lancet Healthy Longev, 2024 Feb）\n- 证据来源：PubMed 检索结果与 Europe PMC 页面。\n- 该文是 //systematic review//，不是原始临床试验；在当前候选审计里应判为 ''secondary analysis / review'' 并排除。\n\n!! 为什么重要\n- 它明确报告“19 included studies”，说明它更像是证据汇总与参考链入口，而不是待纳入的独立试验。\n- 对剩余候选的判定要继续优先剔除 extension / follow-up / secondary analysis / review。\n\n!! 可复用规则\n- 若题名或摘要明确含有 systematic review / review / meta-analysis / secondary analysis，默认排除。\n- 但要保留它作为“参考链入口”：从文中提取被综述的原始人类试验，再逐条审计原始试验本身。\n\n!! 可引用来源\n- PubMed: https://pubmed.ncbi.nlm.nih.gov/38310895/\n- Europe PMC: https://europepmc.org/article/MED/38310895\n- 综述线索：检索摘要显示该文“resulting in 19 included studies”。"} → call web_search({"limit":5,"query":"38310895 systematic review rapamycin humans included studies PMID trial"}) → call web_fetch({"max_chars":5000,"url":"https://pubmed.ncbi.nlm.nih.gov/38310895/"}) → call web_search({"limit":8,"query":"site:pubmed.ncbi.nlm.nih.gov rapamycin humans systematic review included studies PMID trial everolimus sirolimus"}) 【tool:web_search】 {"ok": true, "query": "38310895 systematic review rapamycin humans included studies PMID trial", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies ."}, {"title": "Influence of rapamycin on safety and healthspan metrics after one year ...", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12074816/", "snippet": "An important gap in the clinical understanding of rapamycin for longevity is that to date, no long-term randomized controlled trials (RCT) have been conducted to explore the safety and effectiveness of low-dose, intermittent rapamycin regimens for improving multiple healthspan metrics in normative aging cohorts."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Articles included in this systematic review met the following criteria: the mean or median age of the study cohort was 18 years or older; outcomes on ageing-related physiological changes or disease were reported; and they were interventional 【tool:web_fetch】 {"ok": false, "error": "Client error '403 Forbidden' for url 'https://pubmed.ncbi.nlm.nih.gov/38310895/'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"} 【tool:web_search】 {"ok": false, "error": "[WinError 10054] An existing connection was forcibly closed by the remote host"} → call search_memory({"limit":20,"query":"rapamycin review included studies PMID trial everolimus sirolimus not yet audited"}) → call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" PMID included studies"}) → call web_search({"limit":10,"query":"rapamycin derivatives humans review included studies reference PMID"}) → call web_search({"limit":10,"query":"site:pubmed.ncbi.nlm.nih.gov rapamycin older adults trial PMID sirolimus everolimus review"})

【tool:search_memory】 {"ok": true, "results": [{"title": "Iter-4360dd15-0009-transcript", "tags": "iteration transcript", "modified": "20260424175555000", "preview": "!! 第 9 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin mTOR systematic review 2024 trial endpoint PMC table remaining included studies\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\""}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1 included trials endpoint\"})    → call list_recent({\"n\":6})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹

→ call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\" 【tool:web_search】 {"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" PMID included studies", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.researchgate.net/publication/377976071_Targeting_ageing_with_rapamycin_and_its_derivatives_in_humans_a_systematic_review", "snippet": "A recent systematic review of human studies suggested Rapamycin and it 【tool:web_search】 {"ok": true, "query": "rapamycin derivatives humans review included studies reference PMID", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies ."}, {"title": "Rapamycin for longevity: the pros, the cons, and future perspectives", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12226543/", "snippet": "Translating these findings to humans remains uncertain, as the complexity of human aging and lack of validated endpoints complicate 【tool:web_search】 {"ok": true, "query": "site:pubmed.ncbi.nlm.nih.gov rapamycin older adults trial PMID sirolimus everolimus review", "results": []} → call search_memory({"limit":20,"query":"4360dd15 remaining candidate PMID rapamycin trial reference chain"})

【tool:search_memory】 {"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹

   → cal"}, {"title": "Iter-4360dd15-0079-transcript", "tags": "iteration transcript", "modified": "20260424203535000", "preview": "!! 第 79 轮执行轨迹

   → call search_memory({\\\"limit\\\":10,\\\"query\\\":\\\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹

→ call web_fetch({"max_chars":7000,"url":"https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext"})

【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}

→ call search_memory({"limit":20,"query":"24552879 4360dd15 Mannick immune function elderly audited"})

→ call search_memory({"limit":20,"query":"mTOR inhibition improves immune function in the elderly 4360dd15"})

→ call web_search({"limit":10,"query":"\"mTOR inhibition improves immune function in the elderly\" PMID"})

→ call web_search({"limit":10,"query":"site:pubmed.ncbi.nlm.nih.gov \"mTOR inhibition improves immune function in the elderly\""})

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹

   → call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS 剩余 10 条候选 PMID 研究类型 保留 排除 理由 extension follow-up secondary analysis\"})    → call list_recent({\"n\":10})    → call list_tools({})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0059-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424195947000\", \"preview\": \"!! 第 59 轮执行轨迹

→"}, {"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"})    → call list_recent({\"n\":8})    → call list_tools({})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10"}, {"title": "Iter-4360dd15-0059-transcript", "tags": "iteration transcript", "modified": "20260424195947000", "preview": "!! 第 59 轮执行轨迹

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0002-transcript", "tags": "iteration transcript", "modified": "20260424173549000", "preview": "!! 第 2 轮执行轨迹

   → call search_memory({\"limit\":10,\"query\":\"4360dd15 rapamycin senolytics NEXT_FOCUS human trial review\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0001-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424173243000\", \"preview\": \"!! 第 1 轮执行轨迹

→ ca"}, {"title": "Iter-4360dd15-0003-transcript", "tags": "iteration transcript", "modified": "20260424173843000", "preview": "!! 第 3 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin human trial systematic review endpoints safety\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0002-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424173549000\", \"preview\": \"!! 第 2 轮执行轨迹

→ call search_memory({\\\"limit\\\":10,\\\"query\\\":\\\"4360dd15 rapamycin senolytics NEXT_F"}, {"title": "Iter-4360dd15-0009-transcript", "tags": "iteration transcript", "modified": "20260424175555000", "preview": "!! 第 9 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin mTOR systematic review 2024 trial endpoint PMC table remaining included studies\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":20,\
【tool:web_search】
{"ok": true, "query": "\"mTOR inhibition improves immune function in the elderly\" PMID", "results": []}
【tool:web_search】
{"ok": true, "query": "site:pubmed.ncbi.nlm.nih.gov \"mTOR inhibition improves immune function in the elderly\"", "results": []}
  → call search_memory({"limit":20,"query":"25273328 Mannick rapamycin elderly trial endpoint PMID 4360dd15"})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹

   → cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1 included trials endpoint\"}) → call list_recent({\"n\":6}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹

   → call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0007-transcript", "tags": "iteration transcript", "modified": "20260424174944000", "preview": "!! 第 7 轮执行轨迹

→ call search_memory({\"limit\":10,\"query\":\"4360dd15 rapamycin rapalog human trial Table 1 remaining endpoint PMC review trial name primary endpoint\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Ite

→ call pubmed_search({"limit":5,"query":"25273328"})

→ call web_search({"limit":8,"query":"PMID 25273328 rapamycin elderly trial primary endpoint"})

→ call web_search({"limit":8,"query":"25273328 everolimus elderly trial immune function"})

→ call web_search({"limit":8,"query":"site:pubmed.ncbi.nlm.nih.gov 25273328 rapamycin elderly immune function"})

【tool:pubmed_search】
{"ok": true, "query": "25273328", "results": [{"pmid": "25273328", "title": "Breast pathology second review identifies clinically significant discrepancies in over 10% of patients.", "source": "J Surg Oncol", "pubdate": "2015 Feb", "authors": ["Khazai L", "Middleton LP", "Goktepe N", "Liu BT", "Sahin AA"], "url": "https://pubmed.ncbi.nlm.nih.gov/25273328/"}]}

【tool:web_search】
{"ok": true, "query": "PMID 25273328 rapamycin elderly trial primary endpoint", "results": [{"title": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/", "snippet": "PubMed® comprises more than 40 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites."}, {"title": "Rapamycin treatment for Alzheimer's disease and related ... - Nature", "url": "https://www.nature.com/articles/s43856-025-00904-9", "snippet": "Gonzales et al. conducted an open-label phase 1 clinical trial of rapamycin for mild cognitive impairment and dementia due to Alzheimer's disease. Rapamycin is not detected in cerebrospinal ..."}, {"title": "PDF Rapamycin exerts its geroprotective effects in the ageing ... - bioRxiv", "url": "https://www.biorxiv.org/content/10.1101/2025.08.15.670559v1.full.pdf", "snippet": "To test this in vivo, we conducted a placebo-controlled experimental medicine trial in older adults administered with low-dose rapamycin . p21, a marker of DNA damage-induced senescence, was significantly reduced in immune cells from the rapamycin compared to placebo group."}, {"title": "PDF Blazing a trail for the clinical use of rapamycin as a geroprotecTOR", "url": "https://www.rapamycin.news/uploads/short-url/yQYiGzy0d8R9iNsywQUoCgJfEZ4.pdf", "snippet": "*Studies are presented as observational study first, followed by studies with increasing rapamycin tr

【tool:web_search】
{"ok": true, "query": "25273328 everolimus elderly trial immune function", "results": [{"title": "NCT05835999 | Everolimus Aging Study - ClinicalTrials.gov", "url": "https://clinicaltrials.gov/study/NCT05835999", "snippet": "Using a double-blinded, randomized, placebo-controlled clinical trial , the investigators will perform a battery of gold-standard and innovative techniques to test the hypothesis that daily low dose or weekly everolimus treatment will improve 4 inter-related domains of physiological aging: metabolic, cardiac, cognitive, and physical function ."}, {"title": "Aging Clinical Trial - Everolimus Aging Study NCT05835999", "url": "https://inclinicaltrials.com/aging/NCT05835999/details/", "snippet": "Using a double-blinded, randomized, placebo-controlled clinical trial , the investigators will perform a battery of gold-standard and innovative techniques to test the hypothesis that daily low dose or weekly everolimus treatment will improve 4 inter-related domains of
```