Iter-4360dd15-0067-transcript
第 67 轮执行轨迹
→ call search_memory({"limit":8,"query":"4360dd15 33977284 29408453 abstract endpoint aging criteria"})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹 → cal"}, {"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹 → call read_note({"title":"NEXT_FOCUS"})
→ call list_recent({"n":6})
→ call list_by_tag({"limit":10,"tag":"4360dd15"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0066）\n\n只做一件事：从 PMID 33977284 和 29408453 的可访问摘要里抽出主要终点与最直接的衰老相关判据。"}
【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0066-reflection", "modified": "20260424200940000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424200940000", "tags": "pinned focus"}, {"title": "绕开 PubMed HTML，优先用 PMC/Europe PMC 抽摘要", "modified": "20260424200940000", "tags": "lesson pubmed-verification europe-pmc abstract-extraction"}, {"title": "Iter-4360dd15-0066-transcript", "modified": "20260424200932000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0066-TierA-abstracts-and-endpoints-for-aging-criteria", "modified": "20260424200925000", "tags": "4360dd15 knowledge fact method stratification"}, {"title": "Iter-4360dd15-0065-reflection", "modified": "20260424200801000", "tags": "iteration reflection"}]}
【tool:list_by_tag】
{"ok": true, "items": [{"title": "Iter-4360dd15-0066-TierA-abstracts-and-endpoints-for-aging-criteria", "modified": "20260424200925000"}, {"title": "Iter-4360dd15-0065-minimal-relevance-decision-rules-for-retained-mtor-trials", "modified": "20260424200748000"}, {"title": "Iter-4360dd15-0064-relevance-tiering-10-pmids", "modified": "20260424200602000"}, {"title": "Iter-4360dd15-0063-10-pmid-audit-table", "modified": "20260424200432000"}, {"title": "Iter-4360dd15-0062-pubmed-title-verification-10-pmids", "modified": "20260424200328000"}, {"title": "Iter-4360dd15-0061-candidate-audit-10-remaining-pmids", "modified": "20260424200221000"}, {"title": "PMID 38310895 is a review, not a primary trial", "modified": "20260424200109000"}, {"title": "PMID 35040506 longitudinal analysis is embedded in primary trial", "modified": "20260424195939000"}, {"title": "Iter-4360dd15-0058-longevity-evidence-proximity-tagging", "modified": "20260424195827000"}, {"title": "Iter-4360dd15-0057-study-design-taxonomy-for-retained-trials", "modified": "20260424195711000"}]}
→ call web_search({"limit":5,"query":"PMID 33977284 Europe PMC abstract primary endpoint"})
→ call web_search({"limit":5,"query":"PMID 29408453 Europe PMC abstract primary endpoint"})
【tool:web_search】
{"ok": true, "query": "PMID 33977284 Europe PMC abstract primary endpoint", "results": [{"title": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/", "snippet": "PubMed® comprises more than 40 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites."}, {"title": "Europe PMC", "url": "https://europepmc.org/", "snippet": "Comprehensive search Search life sciences literature from trusted sources around the globe, all in one search, accessible by anyone anywhere, for free. Learn more About Europe PMC ."}, {"title": "PMC Home", "url": "https://pmc.ncbi.nlm.nih.gov/", "snippet": "PMC is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM)."}, {"title": "Advanced Search Results - PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/advanced/", "snippet": "Advanced Search Results - PubMed Your history is currently empty! As you use PubMed your recent searches will appear here."}, {"title": "Homepage | BMJ Open", "url": "https://bmjopen.bmj.com/", "snippet": "BMJ Open is a leading multidisciplinary open access medical journal publishing high-quality peer-reviewed content."}]}
【tool:web_search】
{"ok": true, "query": "PMID 29408453 Europe PMC abstract primary endpoint", "results": [{"title": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/", "snippet": "PubMed® comprises more than 40 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites."}, {"title": "Europe PMC", "url": "https://europepmc.org/", "snippet": "Comprehensive search Search life sciences literature from trusted sources around the globe, all in one search, accessible by anyone anywhere, for free. Learn more About Europe PMC ."}, {"title": "Crossref Metadata Search", "url": "https://search.crossref.org/", "snippet": "Search the metadata of journal articles, books, standards, datasets & more"}, {"title": "PMC Home", "url": "https://pmc.ncbi.nlm.nih.gov/", "snippet": "PMC is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM)."}, {"title": "Advanced Search Results - PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/advanced/", "snippet": "Advanced Search Results - PubMed Your history is currently empty! As you use PubMed your recent searches will appear here."}]}
→ call pubmed_search({"limit":3,"query":"33977284"})
→ call pubmed_search({"limit":3,"query":"29408453"})
【tool:pubmed_search】
{"ok": true, "query": "33977284", "results": [{"pmid": "33977284", "title": "Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials.", "source": "Lancet Healthy Longev", "pubdate": "2021 May", "authors": ["Mannick JB", "Teo G", "Bernardo P", "Quinn D", "Russell K", "Klickstein L", "Marshall W", "Shergill S"], "url": "https://pubmed.ncbi.nlm.nih.gov/33977284/"}]}
【tool:pubmed_search】
{"ok": true, "query": "29408453", "results": [{"pmid": "29408453", "title": "A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects.", "source": "Exp Gerontol", "pubdate": "2018 May", "authors": ["Kraig E", "Linehan LA", "Liang H", "Romo TQ", "Liu Q", "Wu Y", "Benavides AD", "Curiel TJ"], "url": "https://pubmed.ncbi.nlm.nih.gov/29408453/"}]}
→ call web_search({"limit":10,"query":"\"Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults\" Europe PMC"})
→ call web_search({"limit":10,"query":"\"A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort\" Europe PMC"})
【tool:web_search】
{"ok": true, "query": "\"Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults\" Europe PMC", "results": [{"title": "Targeting the biology of ageing with mTOR inhibitors to improve immune ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00062-3/fulltext", "snippet": "Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults : phase 2b and phase 3 randomised trials"}]}
【tool:web_search】
{"ok": true, "query": "\"A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort\" Europe PMC", "results": [{"title": "A Randomized Control Trial to Establish the Feasibility and Safety of ...", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5869166/", "snippet": "A Randomized Control Trial to Establish the Feasibility and Safety of Rapamycin Treatment in an Older Human Cohort : Immunological, Physical Performance, and Cognitive Effects"}, {"title": "A randomized control trial to establish the feasibility ... - Europe PMC", "url": "https://europepmc.org/article/MED/29408453", "snippet": "A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort : Immunological, physical performance, and cognitive effects."}, {"title": "A Randomized Control Trial To Establish The Feasibility and Safety of ...", "url": "https://www.scribd.com/document/891489723/A-Randomized-Control-Trial-to-Establish-the-Feasibility-and-Safety-of-Rapamycin-Treatment-in-an-Older-Human-Cohort-Immunological-Physical-Performanc", "snippet": "A Randomized Control Trial To Establish The Feasibility and Safety of Rapamycin Treatment in An Older Human Cohort - Immunological, Physical Performance, and Cognitive Effects - ScienceDirect This study evaluated the feasibility and safety of rapamycin (RAPA) treatment in a cohort of healthy older adults aged 70-95 years."}, {"title": "Targeting ageing with rapa
→ call web_fetch({"max_chars":8000,"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5869166/"})
→ call web_fetch({"max_chars":8000,"url":"https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00062-3/fulltext"})
【tool:web_fetch】
{"ok": true, "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5869166/", "status": 200, "content_type": "text/html; charset=utf-8", "text": "A Randomized Control Trial to Establish the Feasibility and Safety of Rapamycin Treatment in an Older Human Cohort: Immunological, Physical Performance, and Cognitive Effects - PMC Skip to main content An official website of the United States government Here's how you know Here's how you know Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( Lock Locked padlock icon ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites. Search Log in Dashboard Publications Account settings Log out Search… Search NCBI Primary site navigation Search Logged in as: Dashboard Publications Account settings Log in Search PMC Full-Text Archive Search in PMC Journal List User Guide PERMALINK Copy As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Exp Gerontol . Author manuscript; available in PMC: 2019 May 1. Published in final edited form as: Exp Gerontol. 2018 Feb 3;105:53–69. doi: 10.1016/j.exger.2017.12.026 Search in PMC Search in PubMed View in NLM Catalog Add to search A Randomized Control Tria
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00062-3/fulltext'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":10,"query":"\"Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults\" abstract"})
→ call web_search({"limit":10,"query":"\"33977284\" Europe PMC abstract"})
→ call web_search({"limit":10,"query":"\"Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults\" PMC"})
【tool:web_search】
{"ok": true, "query": "\"Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults\" abstract", "results": [{"title": "Targeting the biology of ageing with mTOR inhibitors to improve immune ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00062-3/fulltext", "snippet": "Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults : phase 2b and phase 3 randomised trials"}, {"title": "(PDF) Targeting the biology of ageing with mTOR ... - ResearchGate", "url": "https://www.researchgate.net/publication/351374712_Targeting_the_biology_of_ageing_with_mTOR_inhibitors_to_improve_immune_function_in_older_adults_phase_2b_and_phase_3_randomised_trials", "snippet": "Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults : phase 2b and phase 3 randomised trials"}, {"title": "Targeting the biology of aging with mTOR inhibitors - Nature", "url": "https://www.nature.com/articles/s43587-023-00416-y", "snippet": "Mannick, J. B. et al. Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults : phase 2b and phase 3 randomised trials. Lancet Healthy Longev. 2, e250-e262 ..."}]}
【tool:web_search】
{"ok": true, "query": "\"33977284\" Europe PMC abstract", "results": [{"title": "Mis12m - coViki", "url": "https://coviki.org/cov/index.php?title=Mis12m", "snippet": "IFIT Proteins Are Involved in CXCL10 Expression in Human Glomerular Endothelial Cells Treated with a Toll-Like Receptor 3 Agonist. 33977284 2021. Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials. 33915103 2021."}, {"title": "Zero human longevity data around Rapamycin", "url": "https://www.rapamycin.news/t/zero-human-longevity-data-around-rapamycin/11513", "snippet": "First I want to lift the human research data on the mTOR inhibitors, rapalog Everolimus and the mTORC1 inhibitor RTB101, which has shown improvement of the aged immune system and improvement of the response of influenza vaccine (pubmed: 25540326, 29997249, 33977284 ). This research has been done by the researcher Joan Mannick."}, {"title": "Rapamycin: One year self-experimentation summary : r/Rapamycin - Reddit", "url": "https://www.reddit.com/r/Rapamycin/comments/1ao0t2n/rapamycin_one_year_selfexperimentation_summary/", "snippet": "The thing that I thought was extra interesting was that she found that many different antiviral genes were upregulated due to the mTOR inhibition effect (pubmed: 33977284 ). But I have also seen some anecdotal reports of people who have got more severe common cold symptoms or increased incidence of common cold."}, {"title": "Counting C
【tool:web_search】
{"ok": true, "query": "\"Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults\" PMC", "results": []}
→ call web_search({"limit":10,"query":"33977284 PMCID"})
→ call web_search({"limit":10,"query":"\"33977284\" PMCID PMC"})
【tool:web_search】
{"ok": true, "query": "33977284 PMCID", "results": [{"title": "First-in-human study of JNJ-67571244, a CD33 × CD3 bispecific ... - PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/38494922/", "snippet": "Relapsed/refractory (r/r) acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) outcomes remain poor. A targeted cluster of differentiation (CD)33 × CD3 bispecific antibody, JNJ-67571244, was assessed to identify the maximum tolerated dose (MTD), recommended phase II dose (RP2D), safety an …"}, {"title": "Study Details | NCT03915379 - ClinicalTrials.gov", "url": "https://clinicaltrials.gov/study/NCT03915379", "snippet": "Details for study NCT03915379, | ClinicalTrials.gov This is first-in-human (FIH) Phase 1, open-label, multicenter, dose escalation study with dose expansion to evaluate the safety, tolerability, and preliminary antitumor activity of JNJ-67571244 in adult participants with relapsed or refractory acute myeloid leukemia (AML) or high-risk or very high-risk myelodysplastic syndromes (MDS) who are ..."}, {"title": "Targeting the biology of ageing with mTOR inhibitors to improve immune ...", "url": "https://europepmc.org/article/MED/33977284", "snippet": "The COVID-19 pandemic highlights the need for therapies that improve immune function in older adults, including interferon (IFN)-induced antiviral immunity that declines with age. In a previous phase 2a trial, RTB101 (previously known as BEZ235), an oral mechanistic target of rapamycin (mTOR ..."}, {"tit
【tool:web_search】
{"ok": true, "query": "\"33977284\" PMCID PMC", "results": [{"title": "Zero human longevity data around Rapamycin", "url": "https://www.rapamycin.news/t/zero-human-longevity-data-around-rapamycin/11513", "snippet": "First I want to lift the human research data on the mTOR inhibitors, rapalog Everolimus and the mTORC1 inhibitor RTB101, which has shown improvement of the aged immune system and improvement of the response of influenza vaccine (pubmed: 25540326, 29997249, 33977284 ). This research has been done by the researcher Joan Mannick."}, {"title": "Mis12m - coViki", "url": "https://coviki.org/cov/index.php?title=Mis12m", "snippet": "IFIT Proteins Are Involved in CXCL10 Expression in Human Glomerular Endothelial Cells Treated with a Toll-Like Receptor 3 Agonist. 33977284 2021. Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials. 33915103 2021."}, {"title": "Counting Cells by Age Tells Us About How, and Why, and When, We Grow ...", "url": "https://www.academia.edu/120984498/Counting_Cells_by_Age_Tells_Us_About_How_and_Why_and_When_We_Grow_and_Become_Old_and_Ill", "snippet": "PMID: 33977284 ; PMCID : PMC8102040. 45 Meron E, Thaysen M, Angeli S, Antebi A, Barzilai N, Baur JA, Bekker-Jensen S, Birkisdottir M, Bischof E, Bruening J, Brunet A, Buchwalter A, Cabreiro F, Cai S, Chen BH, Ermolaeva M, Ewald CY, Ferrucci L, Florian MC, Fortney K, Freund A, Georgievskaya A, Gladyshev VN, Glass D, Golat
→ call web_fetch({"max_chars":8000,"url":"https://europepmc.org/article/MED/33977284"})
→ call web_fetch({"max_chars":8000,"url":"https://europepmc.org/article/MED/29408453"})
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/33977284", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/29408453", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
→ call web_fetch({"max_chars":12000,"url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33977284%20AND%20SRC:MED&format=json"})
→ call web_fetch({"max_chars":12000,"url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29408453%20AND%20SRC:MED&format=json"})
【tool:web_fetch】
{"ok": true, "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:33977284%20AND%20SRC:MED&format=json", "status": 200, "content_type": "application/json;charset=UTF-8", "text": "{\"version\":\"6.9\",\"hitCount\":1,\"request\":{\"queryString\":\"EXT_ID:33977284 AND SRC:MED\",\"internalQuery\":\"EXT_ID:33977284 AND SRC:MED\",\"resultType\":\"LITE\",\"cursorMark\":\"*\",\"pageSize\":25,\"sort\":\"\",\"synonym\":false},\"resultList\":{\"result\":[{\"id\":\"33977284\",\"source\":\"MED\",\"pmid\":\"33977284\",\"pmcid\":\"PMC8102040\",\"fullTextIdList\":{\"fullTextId\":[\"PMC8102040\"]},\"doi\":\"10.1016/s2666-7568(21)00062-3\",\"title\":\"Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials.\",\"authorString\":\"Mannick JB, Teo G, Bernardo P, Quinn D, Russell K, Klickstein L, Marshall W, Shergill S.\",\"journalTitle\":\"Lancet Healthy Longev\",\"issue\":\"5\",\"journalVolume\":\"2\",\"pubYear\":\"2021\",\"journalIssn\":\"2666-7568\",\"pageInfo\":\"e250-e262\",\"pubType\":\"clinical trial, phase iii; clinical trial, phase ii; research-article; randomized controlled trial; journal article; research support, n.i.h., extramural\",\"isOpenAccess\":\"Y\",\"inEPMC\":\"Y\",\"inPMC\":\"Y\",\"hasPDF\":\"Y\",\"hasBook\":\"N\",\"hasSuppl\":\"Y\",\"citedByCount\":81,\"hasReferences\":\"Y\",\"hasTextMinedTerms\":\"Y\",\"hasDbCrossReferences\":\"N\",\"hasLabsLinks\":\"Y\",\"hasTMAccessionNu
【tool:web_fetch】
{"ok": true, "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29408453%20AND%20SRC:MED&format=json", "status": 200, "content_type": "application/json;charset=UTF-8", "text": "{\"version\":\"6.9\",\"hitCount\":1,\"request\":{\"queryString\":\"EXT_ID:29408453 AND SRC:MED\",\"internalQuery\":\"EXT_ID:29408453 AND SRC:MED\",\"resultType\":\"LITE\",\"cursorMark\":\"*\",\"pageSize\":25,\"sort\":\"\",\"synonym\":false},\"resultList\":{\"result\":[{\"id\":\"29408453\",\"source\":\"MED\",\"pmid\":\"29408453\",\"pmcid\":\"PMC5869166\",\"fullTextIdList\":{\"fullTextId\":[\"PMC5869166\"]},\"doi\":\"10.1016/j.exger.2017.12.026\",\"title\":\"A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects.\",\"authorString\":\"Kraig E, Linehan LA, Liang H, Romo TQ, Liu Q, Wu Y, Benavides AD, Curiel TJ, Javors MA, Musi N, Chiodo L, Koek W, Gelfond JAL, Kellogg DL.\",\"journalTitle\":\"Exp Gerontol\",\"journalVolume\":\"105\",\"pubYear\":\"2018\",\"journalIssn\":\"0531-5565; 1873-6815; \",\"pageInfo\":\"53-69\",\"pubType\":\"clinical trial, phase ii; research support, non-u.s. gov't; research-article; randomized controlled trial; journal article; research support, n.i.h., extramural\",\"isOpenAccess\":\"N\",\"inEPMC\":\"Y\",\"inPMC\
```