Iter-4360dd15-0062-transcript
第 62 轮执行轨迹
→ call search_memory({"limit":8,"query":"4360dd15 NEXT_FOCUS 剩余 10 条 候选 PMID 研究类型 保留 排除 理由"}) → call list_recent({"n":8})
→ call list_by_tag({"limit":20,"tag":"4360dd15"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0060-transcript", "tags": "iteration transcript", "modified": "20260424200117000", "preview": "!! 第 60 轮执行轨迹
→"}, {"title": "Iter-4360dd15-0059-transcript", "tags": "iteration transcript", "modified": "20260424195947000", "preview": "!! 第 59 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS PMID 10 条候选 研究类型 保留 排除 理由\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0061-reflection", "modified": "20260424200233000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424200233000", "tags": "pinned focus"}, {"title": "先确保可输出再做细化", "modified": "20260424200233000", "tags": "lesson evidence-retrieval clinical-trials encoding"}, {"title": "Iter-4360dd15-0061-transcript", "modified": "20260424200227000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0061-candidate-audit-10-remaining-pmids", "modified": "20260424200221000", "tags": "4360dd15 knowledge fact classification clinical-trials"}, {"title": "Iter-4360dd15-0060-reflection", "modified": "20260424200123000", "tags": "iteration reflection"}, {"title": "先拿原始候选表再分类", "modified": "20260424200123000", "tags": "lesson evidence-retrieval classification clinical-trials"}, {"title": "Iter-4360dd15-0060-transcript", "modified": "20260424200117000", "tags": "iteration transcript"}]}
【tool:list_by_tag】
{"ok": true, "items": [{"title": "Iter-4360dd15-0061-candidate-audit-10-remaining-pmids", "modified": "20260424200221000"}, {"title": "PMID 38310895 is a review, not a primary trial", "modified": "20260424200109000"}, {"title": "PMID 35040506 longitudinal analysis is embedded in primary trial", "modified": "20260424195939000"}, {"title": "Iter-4360dd15-0058-longevity-evidence-proximity-tagging", "modified": "20260424195827000"}, {"title": "Iter-4360dd15-0057-study-design-taxonomy-for-retained-trials", "modified": "20260424195711000"}, {"title": "Iter-4360dd15-0056-pubmed-boundary-confirmation", "modified": "20260424195548000"}, {"title": "Longitudinal analysis is not an automatic exclusion in trial titles", "modified": "20260424195414000"}, {"title": "Iter-4360dd15-0053-final-audit-14-candidates", "modified": "20260424194939000"}, {"title": "Iter-4360dd15-0052-rapamycin-older-cohort-pmid-mapping", "modified": "20260424194711000"}, {"title": "Iter-4360dd15-0051-secondary-analysis-exclusion-lexicon", "modified": "20260424194517000"}, {"title": "Iter-4360dd15-0050-candidate-audit-originality-check", "modified": "20260424194345000"}, {"title": "Iter-4360dd15-0049-crossref-candidate-overgeneration-critique", "modified": "20260424194224000"}, {"title": "Iter-4360dd15-0048-crossref-trialish-candidate-extraction", "modified": "20260424194106000"}, {"title": "PMID 38310895 access topology verified", "modified": "20260424193545000"}, {"title": "Iter-4360dd15-0042-crossref-family-collap
→ call read_note({"title":"NEXT_FOCUS"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission `4360dd15` · Iter-0061）\n\n补齐并成功输出剩余 10 条候选的完整可审计表，逐条给出 PMID、研究类型、保留/排除理由。"}
→ call read_note({"title":"Iter-4360dd15-0061-candidate-audit-10-remaining-pmids"})
【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0061-candidate-audit-10-remaining-pmids", "tags": "4360dd15 knowledge fact classification clinical-trials", "text": "!! 第 61 轮：剩余 10 条候选 PMID 的研究类型审计完成\n\n本轮把上一轮留下的“剩余 10 条候选”逐条核对，并与已知的 4 条二次/延伸研究合并成 14 条完整清单。\n\n!! 结论\n- 保留 10 条：均可视为原始临床研究\n- 排除 4 条：标题明确指向 ancillary / follow-up / extension / postextension\n\n!! 保留 PMID\n- 33977284\n- 22367193\n- 29408453\n- 22115710\n- 35040506\n- 25525171\n- 24618547\n- 18037627\n- 27613521\n- 29992557\n\n!! 排除 PMID\n- 29806044\n- 31781682\n- 30564495\n- 34693520\n\n!! 最小可复现判定规则\n1. 标题若显式包含 `ancillary` / `follow-up` / `extension` / `postextension`，则排除为非原始研究。\n2. 标题若包含 `randomized` / `placebo-controlled` / `phase` / `pilot` / `proof-of-concept` / `single-arm`，不要自动排除；它们仍可能是原始临床研究。\n3. `longitudinal analysis` 若嵌在主试验题名中，只作为主试验附带分析，不单独构成排除理由。\n\n!! 复现备注\n- 先用记忆回忆上一轮留下的候选上下文\n- 再逐条对照题名进行结构化分类\n- 本轮已把“剩余 10 条候选”从噪声中清理为可审计的保留/排除结果"}
→ call pubmed_search({"limit":1,"query":"33977284"})
→ call pubmed_search({"limit":1,"query":"22367193"})
→ call pubmed_search({"limit":1,"query":"29408453"})
→ call pubmed_search({"limit":1,"query":"22115710"})
→ call pubmed_search({"limit":1,"query":"35040506"})
→ call pubmed_search({"limit":1,"query":"25525171"})
→ call pubmed_search({"limit":1,"query":"24618547"})
→ call pubmed_search({"limit":1,"query":"18037627"})
→ call pubmed_search({"limit":1,"query":"27613521"})
→ call pubmed_search({"limit":1,"query":"29992557"})
【tool:pubmed_search】
{"ok": true, "query": "33977284", "results": [{"pmid": "33977284", "title": "Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials.", "source": "Lancet Healthy Longev", "pubdate": "2021 May", "authors": ["Mannick JB", "Teo G", "Bernardo P", "Quinn D", "Russell K", "Klickstein L", "Marshall W", "Shergill S"], "url": "https://pubmed.ncbi.nlm.nih.gov/33977284/"}]}
【tool:pubmed_search】
{"ok": true, "query": "22367193", "results": [{"pmid": "22367193", "title": "A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults.", "source": "Cancer Chemother Pharmacol", "pubdate": "2012 Jun", "authors": ["Boni JP", "Leister C", "Hug B", "Burns J", "Sonnichsen D"], "url": "https://pubmed.ncbi.nlm.nih.gov/22367193/"}]}
【tool:pubmed_search】
{"ok": true, "query": "29408453", "results": [{"pmid": "29408453", "title": "A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects.", "source": "Exp Gerontol", "pubdate": "2018 May", "authors": ["Kraig E", "Linehan LA", "Liang H", "Romo TQ", "Liu Q", "Wu Y", "Benavides AD", "Curiel TJ"], "url": "https://pubmed.ncbi.nlm.nih.gov/29408453/"}]}
【tool:pubmed_search】
{"ok": true, "query": "22115710", "results": [{"pmid": "22115710", "title": "A randomized, dose-escalation study of subconjunctival and intravitreal injections of sirolimus in patients with diabetic macular edema.", "source": "Ophthalmology", "pubdate": "2012 Jan", "authors": ["Dugel PU", "Blumenkranz MS", "Haller JA", "Williams GA", "Solley WA", "Kleinman DM", "Naor J"], "url": "https://pubmed.ncbi.nlm.nih.gov/22115710/"}]}
【tool:pubmed_search】
{"ok": true, "query": "35040506", "results": [{"pmid": "35040506", "title": "mTOR Inhibition with Sirolimus in Multiple System Atrophy: A Randomized, Double-Blind, Placebo-Controlled Futility Trial and 1-Year Biomarker Longitudinal Analysis.", "source": "Mov Disord", "pubdate": "2022 Apr", "authors": ["Palma JA", "Martinez J", "Millar Vernetti P", "Ma T", "Perez MA", "Zhong J", "Qian Y", "Dutta S"], "url": "https://pubmed.ncbi.nlm.nih.gov/35040506/"}]}
【tool:pubmed_search】
{"ok": true, "query": "25525171", "results": [{"pmid": "25525171", "title": "Intravitreal sirolimus for the treatment of geographic atrophy: results of a phase I/II clinical trial.", "source": "Invest Ophthalmol Vis Sci", "pubdate": "2014 Dec 18", "authors": ["Petrou PA", "Cunningham D", "Shimel K", "Harrington M", "Hammel K", "Cukras CA", "Ferris FL", "Chew EY"], "url": "https://pubmed.ncbi.nlm.nih.gov/25525171/"}]}
【tool:pubmed_search】
{"ok": true, "query": "24618547", "results": [{"pmid": "24618547", "title": "Everolimus in patients with severe pulmonary hypertension: a safety and efficacy pilot trial.", "source": "Pulm Circ", "pubdate": "2013 Sep", "authors": ["Seyfarth HJ", "Hammerschmidt S", "Halank M", "Neuhaus P", "Wirtz HR"], "url": "https://pubmed.ncbi.nlm.nih.gov/24618547/"}]}
【tool:pubmed_search】
{"ok": true, "query": "18037627", "results": [{"pmid": "18037627", "title": "Everolimus in patients with rheumatoid arthritis receiving concomitant methotrexate: a 3-month, double-blind, randomised, placebo-controlled, parallel-group, proof-of-concept study.", "source": "Ann Rheum Dis", "pubdate": "2008 Aug", "authors": ["Bruyn GA", "Tate G", "Caeiro F", "Maldonado-Cocco J", "Westhovens R", "Tannenbaum H", "Bell M", "Forre O"], "url": "https://pubmed.ncbi.nlm.nih.gov/18037627/"}]}
【tool:pubmed_search】
{"ok": true, "query": "27613521", "results": [{"pmid": "27613521", "title": "Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study.", "source": "Lancet", "pubdate": "2016 Oct 29", "authors": ["French JA", "Lawson JA", "Yapici Z", "Ikeda H", "Polster T", "Nabbout R", "Curatolo P", "de Vries PJ"], "url": "https://pubmed.ncbi.nlm.nih.gov/27613521/"}]}
【tool:pubmed_search】
{"ok": true, "query": "29992557", "results": [{"pmid": "29992557", "title": "Efficacy and safety of everolimus plus exemestane in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative locally advanced or metastatic breast cancer: Results of the single-arm, phase IIIB 4EVER trial.", "source": "Int J Cancer", "pubdate": "2019 Feb 15", "authors": ["Tesch H", "Stoetzer O", "Decker T", "Kurbacher CM", "Marmé F", "Schneeweiss A", "Mundhenke C", "Distelrath A"], "url": "https://pubmed.ncbi.nlm.nih.gov/29992557/"}]}
→ call write_note({"tags":["4360dd15","knowledge","fact","clinical-trials","pubmed-verification"],"text":"!! 第 62 轮：对剩余 10 条候选 PMID 做 PubMed 标题级复核\n\n本轮不再做抽象分类，而是把 10 条 PMID 逐一查到 PubMed 题名，用题名证据验证上一轮“均为原始临床研究”的结论。\n\n!! 复核结果\n- 33977284 — ''Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials.''\n - 结论：保留；明确是随机临床试验\n- 22367193 — ''A)
【tool:write_note】
{"ok": true, "path": "C:\\Users\\yh599\\Documents\\GitHub\\LLM-yh\\Sisyphus\\wiki\\tiddlers\\Iter-4360dd15-0062-pubmed-title-verification-10-pmids.tid", "title": "Iter-4360dd15-0062-pubmed-title-verification-10-pmids"}
【assistant】
本轮已把“剩余 10 条候选”做了 PubMed 题名级复核，并确认它们都应保留为原始临床研究，而不是被 follow-up / extension / ancillary 误删。
关键收获：
- 33977284：phase 2b/3 randomised trials
- 22367193：single-dose placebo- and moxifloxacin-controlled study
- 29408453：randomized control trial
- 22115710：randomized dose-escalation study
- 35040506：主试验 + longitudinal analysis，仍保留
- 25525171：phase I/II clinical trial
- 24618547：safety and efficacy pilot trial
- 18037627：double-blind randomized placebo-controlled proof-of-concept study
- 27613521：phase 3 randomized double-blind placebo-controlled study
- 29992557：single-arm phase IIIB trial
这轮新增的可复用判断：
- 题名出现 phase / randomized / double-blind / placebo-controlled / pilot / proof-of-concept / single-arm / dose-escalation 时，默认倾向“原始临床研究”。
- “longitudinal analysis” 若嵌在主试验题名中，不应自动排除。
- 非典型适应症不应先验排斥，应该留到更高层的“与长寿相关性”筛选再判断。
<NEXT_FOCUS>把这 10 条保留研究进一步按“与衰老/寿命干预相关性强弱”分层，找出最值得优先深挖的 1–3 条。</NEXT_FOCUS>