Iter-4360dd15-0053-transcript

修改：20260424194945000

第 53 轮执行轨迹

  → call search_memory({"limit":10,"query":"4360dd15 10 条候选 PMID 题名 研究类型 保留 排除 理由"})
  → call list_recent({"n":8})
  → call list_by_tag({"limit":20,"tag":"4360dd15"})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0051-transcript", "tags": "iteration transcript", "modified": "20260424194527000", "preview": "!! 第 51 轮执行轨迹

→ call search_memory({\"limit\":10,\"query\":\"4360dd15 14 候选 PMID 研究类型误纳入 original clinical study extension follow-up ancillary\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0048-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424194115000\", \"preview\": \""}, {"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"})    → call list_recent({\"n\":8})    → call list_tools({})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10"}, {"title": "Iter-4360dd15-0047-transcript", "tags": "iteration transcript", "modified": "20260424193836000", "preview": "!! 第 47 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 mmc1 pdf 19 纳入研究 NEXT_FOCUS\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0046-transcript\", \"tags\": \"iteration trans

【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0052-reflection", "modified": "20260424194723000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424194723000", "tags": "pinned focus"}, {"title": "先排除二次分析再做原始性归类", "modified": "20260424194723000", "tags": "lesson evidence-retrieval clinical-trials filtering"}, {"title": "Iter-4360dd15-0052-transcript", "modified": "20260424194718000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0052-rapamycin-older-cohort-pmid-mapping", "modified": "20260424194711000", "tags": "4360dd15 knowledge fact evidence-retrieval clinical-trials"}, {"title": "Iter-4360dd15-0051-reflection", "modified": "20260424194535000", "tags": "iteration reflection"}, {"title": "先判定研究原始性再做保留表", "modified": "20260424194535000", "tags": "lesson evidence-retrieval clinical-trials filtering"}, {"title": "Iter-4360dd15-0051-transcript", "modified": "20260424194527000", "tags": "iteration transcript"}]}

【tool:list_by_tag】
{"ok": true, "items": [{"title": "Iter-4360dd15-0052-rapamycin-older-cohort-pmid-mapping", "modified": "20260424194711000"}, {"title": "Iter-4360dd15-0051-secondary-analysis-exclusion-lexicon", "modified": "20260424194517000"}, {"title": "Iter-4360dd15-0050-candidate-audit-originality-check", "modified": "20260424194345000"}, {"title": "Iter-4360dd15-0049-crossref-candidate-overgeneration-critique", "modified": "20260424194224000"}, {"title": "Iter-4360dd15-0048-crossref-trialish-candidate-extraction", "modified": "20260424194106000"}, {"title": "PMID 38310895 access topology verified", "modified": "20260424193545000"}, {"title": "Iter-4360dd15-0042-crossref-family-collapse-10-families", "modified": "20260424192619000"}, {"title": "Iter-4360dd15-0040-crossref-trialish-family-taxonomy", "modified": "20260424192051000"}, {"title": "Iter-4360dd15-0039-crossref-candidate-family-critique", "modified": "20260424191812000"}, {"title": "Critique of Crossref trialish filtering for PMID 38310895 reference chain", "modified": "20260424191745000"}, {"title": "Iter-4360dd15-0038-crossref-human-trial-filter-method", "modified": "20260424191618000"}, {"title": "Iter-4360dd15-0030-vu-research-portal-entry-without-direct-pdf-link", "modified": "20260424185400000"}, {"title": "2024 rapamycin systematic review: abstract-level constraints and what remains missing", "modified": "20260424175824000"}, {"title": "Added included ADPKD rapalog trial CRAD001ADE12 and its body-weight endpoint", "modifie

→ call search_memory({"limit":10,"query":"4360dd15 remaining 10 candidate table PMID research type reason"})

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0047-transcript", "tags": "iteration transcript", "modified": "20260424193836000", "preview": "!! 第 47 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 mmc1 pdf 19 纳入研究 NEXT_FOCUS\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0046-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424193551000\", \"preview\": \"!! 第 46 轮执行轨迹

→ call search_memory({\\\"limit\\\":8,\\\"query\\\":\\\"4360dd15 PMID 38310895 mmc1.pdf supplementary tabl"}, {"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"})    → call list_recent({\"n\":8})    → call list_tools({})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10"}, {"title": "Iter-4360dd15-0048-transcript", "tags": "iteration transcript", "modified": "20260424194115000", "preview": "!! 第 48 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 mmc1 pdf 19 纳入研究\"}) → call list_recent({\"n\":6}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0047-transcript\", \"t

→ call read_note({"title":"Iter-4360dd15-0052-transcript"})

【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0052-transcript", "tags": "iteration transcript", "text": "!! 第 52 轮执行轨迹\n\n

\n  → call search_memory({\"limit\":10,\"query\":\"4360dd15 14 候选 PMID 研究类型 保留 排除 理由\"})\n\n  → call list_recent({\"n\":8})\n\n  → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"})\n\n【tool:search_memory】\n{\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0051-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424194527000\", \"preview\": \"!! 第 51 轮执行轨迹

→ call search_memory({\\\"limit\\\":10,\\\"query\\\":\\\"4360dd15 14 候选 PMID 研究类型误纳入 original clinical study extension follow-up ancillary\\\"}) → call list_recent({\\\"n\\\":8}) → call list_by_tag({\\\"limit\\\":20,\\\"tag\\\":\\\"4360dd15\\\"}) 【tool:search_memory】 {\\\"ok\\\": true, \\\"results\\\": [{\\\"title\\\": \\\"Iter-4360dd15-0048-transcript\\\", \\\"tags\\\": \\\"iteration transcript\\\", \\\"modified\\\": \\\"20260424194115000\\\", \\\"preview\\\": \\\"\"}, {\"title\": \"Iter-4360dd15-0037-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424191347000\", \"preview\": \"!! 第 37 轮执行轨迹

→ call search_memory({\\\"limit\\\":8,\\\"query\\\":\\\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\\\"}) → call list_recent({\\\"n\\\":8}) → call list_tools({}) 【tool:search_memory】 {\\\"ok\\\": true, \\\"results\\\": [{\\\"title\\\": \\\"Iter-4360dd15-0010-transcript\\\", \\\"tag → call read_note({"title":"Iter-4360dd15-0048-crossref-trialish-candidate-extraction"})

【tool:read_note】 {"ok": true, "title": "Iter-4360dd15-0048-crossref-trialish-candidate-extraction", "tags": "4360dd15 knowledge fact experiment evidence-retrieval", "text": "!! 本轮结果：用 Crossref references 替代 mmc1.pdf 镜像，抽取到可复现的临床候选集\n\n本轮没有找到可打开的 mmc1.pdf 二次转载，但通过 DOI `10.1016/S2666-7568(23)00258-1` 的 Crossref 机器可读 references，拿到了综述的 75 条参考文献数组，并用本地规则把候选压缩到人类临床文章。\n\n!! 可复现代码\n

python\nimport requests, re\n\ndoi='10.1016/S2666-7568(23)00258-1'\nmsg=requests.get(f'https://api.crossref.org/works/{doi}', timeout=30,\n headers={'User-Agent':'Mozilla/5.0'}).json()['message']\nrefs=msg['reference']\n\nkw = re.compile(r'rapamycin|sirolimus|everolimus|temsirolimus|rapalog|mTOR inhibitor|mammalian target of rapamycin', re.I)\ntrialish_markers = re.compile(r'trial|randomi[sz]ed|placebo|phase\\s*[1-4]|crossover|double[- ]blind|pilot|feasibility|futility|extension|proof[- ]of[- ]concept|study', re.I)\nanimal = re.compile(r'fruit fly|drosophila|mouse|mice|rat|rats|murine|animal|in vivo', re.I)\n\nitems=[]\nfor i,r in enumerate(refs,1):\n txt=' | '.join(str(r.get(k,'')) for k in ['article-title','journal-title','author','DOI','unstructured'])\n if kw.search(txt) and trialish_markers.search(txt) and not animal.search(txt):\n items.append((i, r.get('article-title') or r.get('unstructured') or '', r.get('year') or '', r.get('DOI') or ''))\nprint('COUNT', len(items))\nfor i,t,y,d in items:\n print(f'{i}\\t{y}\\t{d}\\t{t}')\n

\n\n!! 目前得到的 14 条 human trial-ish 候选\n- 25 `10.1016/ → call pubmed_search({"limit":5,"query":"\"A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults\""}) → call web_search({"limit":5,"query":"site:pubmed.ncbi.nlm.nih.gov temsirolimus cardiac repolarization healthy adults moxifloxacin placebo"}) → call search_memory({"limit":8,"query":"4360dd15 temsirolimus cardiac repolarization healthy adults PMID"}) 【tool:pubmed_search】 {"ok": true, "query": "\"A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults\"", "results": [{"pmid": "22367193", "title": "A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults.", "source": "Cancer Chemother Pharmacol", "pubdate": "2012 Jun", "authors": ["Boni JP", "Leister C", "Hug B", "Burns J", "Sonnichsen D"], "url": "https://pubmed.ncbi.nlm.nih.gov/22367193/"}]} 【tool:web_search】 {"ok": true, "query": "site:pubmed.ncbi.nlm.nih.gov temsirolimus cardiac repolarization healthy adults moxifloxacin placebo", "results": []}

【tool:search_memory】 {"ok": true, "results": [{"title": "Iter-4360dd15-0052-transcript", "tags": "iteration transcript", "modified": "20260424194718000", "preview": "!! 第 52 轮执行轨迹

→ call search_memory({\"limit\":10,\"query\":\"4360dd15 14 候选 PMID 研究类型保留排除理由\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0051-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424194527000\", \"preview\": \"!! 第 51 轮执行轨迹

   → call search_memory({\\\"limi"}, {"title": "Iter-4360dd15-0051-transcript", "tags": "iteration transcript", "modified": "20260424194527000", "preview": "!! 第 51 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"}) → call list_recent({\"n\":8}) → call list_tools({}) 【too → call pubmed_search({"limit":5,"query":"\"Efficacy and safety of everolimus plus exemestane in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative locally advanced or metastatic breast cancer: results of the single-arm, phase IIIB 4EVER trial\""}) 【tool:pubmed_search】 {"ok": true, "query": "\"Efficacy and safety of everolimus plus exemestane in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative locally advanced or metastatic breast cancer: results of the single-arm, phase IIIB 4EVER trial\"", "results": [{"pmid": "35093904", "title": "Safety and Efficacy of RAD001 (Everolimus) Administered Upon Relapse During or After Adjuvant Treatment in Post-menopausal Women With Hormone Receptor Positive, HER2/neu Negative Locally Advanced or Metastatic Breast Cancer (CRAD001JGR08 \"MELPOMENI\" study).", "source": "Anticancer Res", "pubdate": "2022 Feb", "authors": ["Alexopoulos A", "Karanikiotis C", "Ardavanis A", "Boukovinas I", "Makrantonakis P", "Papadimitriou C", "Athanasiadis A", "Boutis A"], "url": "https://pubmed.ncbi.nlm.nih.gov/35093904/"}, {"pmid": "30092555", "title": "Everolimus-based combination therapies for HR+, HER2- metastatic breast cancer.", "source": "Cancer Treat Rev", "pubdate": "2018 Sep", "authors": ["O'Shaughnessy J", "Thaddeus Beck J", "Royce M"], "url": "https://pubmed.ncbi.nlm.nih.gov/30092555/"}, {"pmid": "29992557", "title": "Efficacy and safety of everolimus plus exemestane in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative locally advanced or metastatic breast cancer: Results of the single-arm, phase IIIB 4EVER trial.", "source": "Int J Cancer", "pubdate": "2019 Feb 15", "authors": ["Tesch H", "Stoetzer O", "Decker → call search_memory({"limit":10,"query":"4360dd15 10.1086/674311 everolimus severe pulmonary hypertension PMID"}) → call search_memory({"limit":10,"query":"4360dd15 10.1136/ard.2007.078808 everolimus rheumatoid arthritis PMID"}) → call search_memory({"limit":10,"query":"4360dd15 29992557 4EVER trial PMID"})

【tool:search_memory】 {"ok": true, "results": [{"title": "Iter-4360dd15-0051-transcript", "tags": "iteration transcript", "modified": "20260424194527000", "preview": "!! 第 51 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"})    → call list_recent({\"n\":8})    → call list_tools({})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10"}, {"title": "Iter-4360dd15-0052-transcript", "tags": "iteration transcript", "modified": "20260424194718000", "preview": "!! 第 52 轮执行轨迹

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0051-transcript", "tags": "iteration transcript", "modified": "20260424194527000", "preview": "!! 第 51 轮执行轨迹

   → call search_memory({\"limit\":10,\"query\":\"4360dd15 14 候选 PMID 研究类型 误纳入 original clinical study extension follow-up ancillary\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0048-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424194115000\", \"preview\": \""}, {"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"}) → call list_recent({\"n\":8}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10"}, {"title": "Iter-4360dd15-0052-transcript", "tags": "iteration transcript", "modified": "20260424194718000", "preview": "!! 第 52 轮执行轨迹

   → call search_memory({\"limit\":10,\"query\":\"4360dd15 14 候选 PMID 研究类型 保留 排除 理由\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\":【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0052-transcript", "tags": "iteration transcript", "modified": "20260424194718000", "preview": "!! 第 52 轮执行轨迹

   → call search_memory({\\\"limi"}, {"title": "Iter-4360dd15-0051-transcript", "tags": "iteration transcript", "modified": "20260424194527000", "preview": "!! 第 51 轮执行轨迹

→ call search_memory({\"limit\":10,\"query\":\"4360dd15 14 候选 PMID 研究类型误纳入 original clinical study extension follow-up ancillary\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0048-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424194115000\", \"preview\": \""}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_mem → call pubmed_search({"limit":3,"query":"\"Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials.\""}) → call pubmed_search({"limit":3,"query":"\"A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults.\""}) → call pubmed_search({"limit":3,"query":"\"A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects.\""}) → call pubmed_search({"limit":3,"query":"\"A randomized, dose-escalation study of subconjunctival and intravitreal injections of sirolimus in patients with diabetic macular edema.\""}) → call pubmed_search({"limit":3,"query":"\"mTOR inhibition with sirolimus in multiple system atrophy: a randomized, double-blind, placebo-controlled futility trial and 1-year biomarker longitudinal analysis.\""}) → call pubmed_search({"limit":3,"query":"\"Intravitreal sirolimus for the treatment of geographic atrophy: results of a phase I/II clinical trial.\""}) → call pubmed_search({"limit":3,"query":"\"Everolimus in patients with severe pulmonary hypertension: a safety and efficacy pilot trial.\""}) → call pubmed_search({"limit":3,"query":"\"Everolimus in patients with rheumatoid arthritis receiving concomitant methotrexate: a 3-month, double-blind, randomised, placebo-controlled, parallel-group, proof-of-concept study.\""}) → call pubmed_search({"limit":3,"query":"\"Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study.\""}) → call pubmed_search({"limit":3,"query":"\"Efficacy and safety of everolimus plus exemestane in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative locally advanced or metastatic breast cancer: Results of the single-arm, phase IIIB 4EVER trial.\""}) 【tool:pubmed_search】 {"ok": true, "query": "\"Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials.\"", "results": [{"pmid": "33977284", "title": "Targeting the biology of ageing with mTOR inhibitors to improve immune function in older adults: phase 2b and phase 3 randomised trials.", "source": "Lancet Healthy Longev", "pubdate": "2021 May", "authors": ["Mannick JB", "Teo G", "Bernardo P", "Quinn D", "Russell K", "Klickstein L", "Marshall W", "Shergill S"], "url": "https://pubmed.ncbi.nlm.nih.gov/33977284/"}]} 【tool:pubmed_search】 {"ok": true, "query": "\"A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults.\"", "results": [{"pmid": "22367193", "title": "A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults.", "source": "Cancer Chemother Pharmacol", "pubdate": "2012 Jun", "authors": ["Boni JP", "Leister C", "Hug B", "Burns J", "Sonnichsen D"], "url": "https://pubmed.ncbi.nlm.nih.gov/22367193/"}]} 【tool:pubmed_search】 {"ok": true, "query": "\"A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects.\"", "results": []} 【tool:pubmed_search】 {"ok": true, "query": "\"A randomized, dose-escalation study of subconjunctival and intravitreal injections of sirolimus in patients with diabetic macular edema.\"", "results": [{"pmid": "22115710", "title": "A randomized, dose-escalation study of subconjunctival and intravitreal injections of sirolimus in patients with diabetic macular edema.", "source": "Ophthalmology", "pubdate": "2012 Jan", "authors": ["Dugel PU", "Blumenkranz MS", "Haller JA", "Williams GA", "Solley WA", "Kleinman DM", "Naor J"], "url": "https://pubmed.ncbi.nlm.nih.gov/22115710/"}]} 【tool:pubmed_search】 {"ok": true, "query": "\"mTOR inhibition with sirolimus in multiple system atrophy: a randomized, double-blind, placebo-controlled futility trial and 1-year biomarker longitudinal analysis.\"", "results": [{"pmid": "35040506", "title": "mTOR Inhibition with Sirolimus in Multiple System Atrophy: A Randomized, Double-Blind, Placebo-Controlled Futility Trial and 1-Year Biomarker Longitudinal Analysis.", "source": "Mov Disord", "pubdate": "2022 Apr", "authors": ["Palma JA", "Martinez J", "Millar Vernetti P", "Ma T", "Perez MA", "Zhong J", "Qian Y", "Dutta S"], "url": "https://pubmed.ncbi.nlm.nih.gov/35040506/"}]} 【tool:pubmed_search】 {"ok": true, "query": "\"Intravitreal sirolimus for the treatment of geographic atrophy: results of a phase I/II clinical trial.\"", "results": [{"pmid": "25525171", "title": "Intravitreal sirolimus for the treatment of geographic atrophy: results of a phase I/II clinical trial.", "source": "Invest Ophthalmol Vis Sci", "pubdate": "2014 Dec 18", "authors": ["Petrou PA", "Cunningham D", "Shimel K", "Harrington M", "Hammel K", "Cukras CA", "Ferris FL", "Chew EY"], "url": "https://pubmed.ncbi.nlm.nih.gov/25525171/"}]}

【tool:pubmed_search】 {"ok": true, "query": "\"Everolimus in patients with severe pulmonary hypertension: a safety and efficacy pilot trial.\"", "results": [{"pmid": "24618547", "title": "Everolimus in patients with severe pulmonary hypertension: a safety