Iter-4360dd15-0048-transcript

修改：20260424194115000

第 48 轮执行轨迹

  → call search_memory({"limit":8,"query":"4360dd15 PMID 38310895 mmc1 pdf 19 纳入研究"})
  → call list_recent({"n":6})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0047-transcript", "tags": "iteration transcript", "modified": "20260424193836000", "preview": "!! 第 47 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 mmc1 pdf 19 纳入研究 NEXT_FOCUS\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0046-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424193551000\", \"preview\": \"!! 第 46 轮执行轨迹

   → call search_memory({\\\"limit\\\":8,\\\"query\\\":\\\"4360dd15 PMID 38310895 mmc1.pdf supplementary tabl"}, {"title": "Iter-4360dd15-0046-transcript", "tags": "iteration transcript", "modified": "20260424193551000", "preview": "!! 第 46 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 mmc1.pdf supplementary table 19 studies NEXT_FOCUS\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0037-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424191347000\", \"preview\": \"!! 第 37 轮执"}, {"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"}) → call list_recent({\"n\":8}) → call list_tools({}) 【too 【tool:list_recent】 {"ok": true, "items": [{"title": "Iter-4360dd15-0047-reflection", "modified": "20260424193842000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424193842000", "tags": "pinned focus"}, {"title": "先确认可读副本再抽取", "modified": "20260424193842000", "tags": "lesson evidence-retrieval supplementary-material access-block"}, {"title": "Iter-4360dd15-0047-transcript", "modified": "20260424193836000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0046-reflection", "modified": "20260424193558000", "tags": "iteration reflection"}, {"title": "先拿到可读副本再做抽取", "modified": "20260424193558000", "tags": "lesson evidence-retrieval supplementary-material access-block"}]} → call read_note({"title":"NEXT_FOCUS"}) → call read_note({"title":"Iter-4360dd15-0047-reflection"}) 【tool:read_note】 {"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission `4360dd15` · Iter-0047）\n\n只做一件事：找到一个可打开的 mmc1.pdf 镜像/转载，并直接抽取前 13 条人类临床候选对应项。"} 【tool:read_note】 {"ok": true, "title": "Iter-4360dd15-0047-reflection", "tags": "iteration reflection", "text": "!! 本轮进展\n本轮确认了 PMID 38310895 的可访问拓扑：摘要/书目信息可取，但官方 mmc1.pdf 仍不可直达。\n\n!! 失败 / 盲点\n反复搜索镜像与关键词却没有找到任何可读副本，未推进到补充表抽取本身。\n\n!! 下轮焦点\n只做一件事：找到一个可打开的 mmc1.pdf 镜像/转载，并直接抽取前 13 条人类临床候选对应项。\n"} → call web_search({"limit":8,"query":"PMID 38310895 mmc1 pdf mirror supplementary table humans clinical candidates"}) → call web_search({"limit":8,"query":"38310895 supplementary mmc1 pdf researchgate drive"}) → call web_search({"limit":8,"query":"38310895 site:pmc.ncbi.nlm.nih.gov supplementary pdf"}) 【tool:web_search】 {"ok": true, "query": "PMID 38310895 mmc1 pdf mirror supplementary table humans clinical candidates", "results": []} 【tool:web_search】 {"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=38310895+supplementary+mmc1+pdf+researchgate+drive'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"} 【tool:web_search】 {"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=38310895+site%3Apmc.ncbi.nlm.nih.gov+supplementary+pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"} → call search_memory({"limit":8,"query":"38310895 title review rapamycin human clinical candidates"}) → call web_search({"limit":8,"query":"\"38310895\" review rapamycin human clinical trial supplementary"}) → call wiki_search({"lang":"en","limit":5,"query":"rapamycin human clinical trial review 2024"}) → call pubmed_search({"limit":5,"query":"38310895"})

【tool:search_memory】 {"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹

   → cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1 included trials endpoint\"}) → call list_recent({\"n\":6}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹

   → call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0009-transcript", "tags": "iteration transcript", "modified": "20260424175555000", "preview": "!! 第 9 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin mTOR systematic review 2024 trial endpoint PMC table remaining included studies\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\

【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=%2238310895%22+review+rapamycin+human+clinical+trial+supplementary'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}

【tool:wiki_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://en.wikipedia.org/w/api.php?action=query&list=search&srsearch=rapamycin+human+clinical+trial+review+2024&srlimit=5&format=json'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}

【tool:pubmed_search】
{"ok": true, "query": "38310895", "results": [{"pmid": "38310895", "title": "Targeting ageing with rapamycin and its derivatives in humans: a systematic review.", "source": "Lancet Healthy Longev", "pubdate": "2024 Feb", "authors": ["Lee DJW", "Hodzic Kuerec A", "Maier AB"], "url": "https://pubmed.ncbi.nlm.nih.gov/38310895/"}]}

→ call web_fetch({"max_chars":6000,"url":"https://pubmed.ncbi.nlm.nih.gov/38310895/"})

【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://pubmed.ncbi.nlm.nih.gov/38310895/'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}

→ call search_memory({"limit":10,"query":"38310895 target ageing rapamycin systematic review included studies Table 1 transcript"})

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"})    → call list_recent({\"n\":8})    → call list_tools({})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹

   → cal"}, {"title": "Iter-4360dd15-0029-transcript", "tags": "iteration transcript", "modified": "20260424185112000", "preview": "!! 第 29 轮执行轨迹

→ call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS rapamycin Table 1 full text mirror\"}) → call list_recent({\"n\":8}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0025-tra

→ call read_note({"title":"Iter-4360dd15-0037-transcript"})

→ call read_note({"title":"Iter-4360dd15-0040-transcript"})

→ call read_note({"title":"Iter-4360dd15-0010-transcript"})

【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "text": "!! 第 37 轮执行轨迹\n\n

\n  → call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"})\n\n  → call list_recent({\"n\":8})\n\n  → call list_tools({})\n\n【tool:search_memory】\n{\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹

→ call search_memory({\\\"limit\\\":8,\\\"query\\\":\\\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\\\"}) → call list_recent({\\\"n\\\":8}) → call list_by_tag({\\\"limit\\\":20,\\\"tag\\\":\\\"4360dd15\\\"}) 【tool:search_memory】 {\\\"ok\\\": true, \\\"results\\\": [{\\\"title\\\": \\\"Iter-4360dd15-0007-transcript\\\", \\\"tags\\\": \\\"iteration transcript\\\", \\\"modified\\\": \\\"20260424174944000\\\", \\\"preview\\\": \\\"!! 第 7 轮执行轨迹

   → cal\"}, {\"title\": \"Iter-4360dd15-0011-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424180153000\", \"preview\": \"!! 第 11 轮执行轨迹

→ call search_memory({\\\"limit\\\":8,\\\"query\\\":\\\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1 included trials endpoint\\\"}) → call list_recent({\\\"n\\\":6}) 【tool:search_memory】 {\\\"ok\\\": true, \\\"results\\\": [{\\\"title\\\": \\\"Iter-4360dd15-0010-transcript\\\", \\\"tags\\\": \

【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0040-transcript", "tags": "iteration transcript", "text": "!! 第 40 轮执行轨迹\n\n

\n  → call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 38310895 rapalog trial human trial 14 candidate 11 remaining\"})\n\n  → call list_recent({\"n\":8})\n\n  → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"})\n\n【tool:search_memory】\n{\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹

   → cal\"}, {\"title\": \"Iter-4360dd15-0011-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424180153000\", \"preview\": \"!! 第 11 轮执行轨迹

【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "text": "!! 第 10 轮执行轨迹\n\n

\n  → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"})\n\n  → call list_recent({\"n\":8})\n\n  → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"})\n\n【tool:search_memory】\n{\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹

→ call search_memory({\\\"limit\\\":10,\\\"query\\\":\\\"4360dd15 rapamycin rapalog human trial Table 1 remaining endpoint PMC review trial name primary endpoint\\\"}) 【tool:search_memory】 {\\\"ok\\\": true, \\\"results\\\": [{\\\"title\\\": \\\"Iter-4360dd15-0006-transcript\\\", \\\"tags\\\": \\\"iteration transcript\\\", \\\"modified\\\": \\\"20260424174703000\\\", \\\"preview\\\": \\\"!! 第 6 轮执行轨迹

   → call search_memory({\\\\\\\"limit\\\\\\\":10,\\\\\\\"query\\\\\"}, {\"title\": \"Iter-4360dd15-0009-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175555000\", \"preview\": \"!! 第 9 轮执行轨迹

→ call search_memory({\\\"limit\\\":8,\\\"query\\\":\\\"4360dd15 rapamycin mTOR systematic review 2024 trial endpoint PMC table remaining included studies\\\"}) → call list_recent({\\\"n\\\":8}) → call list_by_tag({\\\"limit\\\":20,\\\"tag\\\":\\\"4360dd15\\\"}) 【tool:search_memory】 {\\\"ok\\\": true, \\\"results\\\": [{\

→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" ResearchGate"})

→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" \"ResearchGate\" pdf"})

→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" \"mmc1.pdf\""})

→ call web_search({"limit":10,"query":"\"PIIS2666-7568(23)00258-1\" ResearchGate"})

【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=%22Targeting+ageing+with+rapamycin+and+its+derivatives+in+humans%22+ResearchGate'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}

【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=%22Targeting+ageing+with+rapamycin+and+its+derivatives+in+humans%22+%22ResearchGate%22+pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}

【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=%22Targeting+ageing+with+rapamycin+and+its+derivatives+in+humans%22+%22mmc1.pdf%22'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}

【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=%22PIIS2666-7568%2823%2900258-1%22+ResearchGate'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}

→ call search_memory({"limit":10,"query":"4360dd15 researchgate drive mirror mmc1 pdf pdf"})

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0046-transcript", "tags": "iteration transcript", "modified": "20260424193551000", "preview": "!! 第 46 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 mmc1.pdf supplementary table 19 studies NEXT_FOCUS\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":10,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0037-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424191347000\", \"preview\": \"!! 第 37 轮执"}, {"title": "Iter-4360dd15-0047-transcript", "tags": "iteration transcript", "modified": "20260424193836000", "preview": "!! 第 47 轮执行轨迹

   → call search_memory({\\\"limit\\\":8,\\\"query\\\":\\\"4360dd15 PMID 38310895 mmc1.pdf supplementary tabl"}, {"title": "Iter-4360dd15-0029-transcript", "tags": "iteration transcript", "modified": "20260424185112000", "preview": "!! 第 29 轮执行轨迹

→ call search_memory({"limit":10,"query":"4360dd15 14 candidates trialish list rapamycin everolimus sirolimus"})

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"})    → call list_recent({\"n\":8})    → call list_tools({})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹

   → cal"}, {"title": "Iter-4360dd15-0038-transcript", "tags": "iteration transcript", "modified": "20260424191624000", "preview": "!! 第 38 轮执行轨迹

→ call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"}) → call list_recent({\"n\":8}) → call list_tools({}) 【tool:searc

→ call define_tool({"name":"crossref_trialish_refs","description":"Fetch Crossref references for a DOI and heuristically filter rapamycin/rapalog human-trial-like citations; returns compact JSON for reproducible candidate extraction.","code":"import re, json\nfrom urllib.request import Request, urlopen\n\nKW = re.compile(r'rapamycin|sirolimus|everolimus|temsirolimus|rapalog|mTOR inhibitor|mammalian target of rapamyc)

→ call web_fetch({"max_chars":12000,"url":"https://api.crossref.org/works/10.1016/S2666-7568(23)00258-1"})

→ call read_note({"title":"Iter-4360dd15-0038-crossref-human-trial-filter-method"})

【tool:define_tool】
{"ok": false, "error": "参数错误: tool_define_tool() missing 1 required positional argument: 'parameters'"}

【tool:web_fetch】
{"ok": true, "url": "https://api.crossref.org/works/10.1016/S2666-7568(23)00258-1", "status": 200, "content_type": "application/json", "text": "{\"status\":\"ok\",\"message-type\":\"work\",\"message-version\":\"1.0.0\",\"message\":{\"indexed\":{\"date-parts\":2026,4,16,\"date-time\":\"2026-04-16T16:09:43Z\",\"timestamp\":1776355783729,\"version\":\"3.51.2\"},\"reference-count\":75,\"publisher\":\"Elsevier BV\",\"issue\":\"2\",\"license\":[{\"start\":{\"date-parts\":2024,2,1,\"date-time\":\"2024-02-01T00:00:00Z\",\"timestamp\":1706745600000},\"content-version\":\"tdm\",\"delay-in-days\":0,\"URL\":\"https:\\/\\/www.elsevier.com\\/tdm\\/userlicense\\/1.0\\/\"},{\"start\":{\"date-parts\":2024,2,1,\"date-time\":\"2024-02-01T00:00:00Z\",\"timestamp\":1706745600000},\"content-version\":\"tdm\",\"delay-in-days\":0,\"URL\":\"https:\\/\\/www.elsevier.com\\/legal\\/tdmrep-license\"},{\"start\":{\"date-parts\":2023,11,24,\"date-time\":\"2023-11-24T00:00:00Z\",\"timestamp\":1700784000000},\"content-version\":\"vor\",\"delay-in-days\":0,\"URL\":\"http:\\/\\/creativecommons.org\\/licenses\\/by\\/4.0\\/\"}],\"funder\":[{\"DOI\":\"10.13039\\/100020054\",\"name\":\"Lien Foundation\",\"doi-asserted-by\":\"publisher\",\"id\":[{\"id\":\"10.13039\\/100020054\",\"id-type\":\"DOI\",\"asserted-by\":\"publisher\"}]}],\"content-domain\":{\"domain\":[\"thelancet.com\",\"elsevier.com\",\"sciencedirect.com\"],\"crossmark-restriction\":true},\"short-container-title\":[\"The Lancet Healthy L

【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0038-crossref-human-trial-filter-method", "tags": "knowledge experiment fact 4360dd15", "text": "!! 本轮进展\n用 Crossref 机器可读 references（DOI 10.1016/S2666-7568(23)00258-1，共 75 条）做了本地过滤，得到一个可复现的“rapalog + human trial-ish”候选集。\n\n!! 可复现方法\n

\nimport requests, re\n\ndoi='10.1016/S2666-7568(23)00258-1'\nmsg=requests.get(f'https://api.crossref.org/works/{doi}', timeout=30,\n                 headers={'User-Agent':'Mozilla/5.0'}).json()['message']\nrefs=msg['reference']\n\nkw = re.compile(r'rapamycin|sirolimus|everolimus|temsirolimus|rapalog|mtor inhibitor|mammalian target of rapamycin', re.I)\nhuman = re.compile(r'clinical|trial|patients?|subjects?|healthy volunteers?|randomi[sz]ed|placebo|double blind|phase\\s*[1-4]|crossover|human|proof-of-concept|pilot|feasibility|futility', re.I)\n\ntrialish=[]\nfor r in refs:\n    txt=' | '.join(str(r.get(k,'')) for k in ['article-title','journal-title','author','DOI','unstructured'])\n    if any(t in (r.get('article-title') or r.get('unstructured') or '').lower()\n           for t in ['trial','randomized','randomised','placebo','phase','proof-of-concept','feasibility','futility','extension']) \\\n       and any(dr in txt.lower() for dr in ['rapamycin','sirolimus','everolimus','temsirolimus']):\n        trialish.append(r)\n\nprint('trial_title_count', len(trialish))\n

\n\n!! 结果\n- 75 条 references 中，trial_title_count = 14。\n- 其中 1 条是动物研究：

Mechanisms of life span extension by rapamycin in the fruit 
  → call run_python({"code":"import requests, re, json\n\ndoi='10.1016/S2666-7568(23)00258-1'\nmsg=requests.get(f'https://api.crossref.org/works/{doi}', timeout=30,\n                 headers={'User-Agent':'Mozilla/5.0'}).json()['message']\nrefs=msg['reference']\n\nkw = re.compile(r'rapamycin|sirolimus|everolimus|temsirolimus|rapalog|mTOR inhibitor|mammalian target of rapamycin', re.I)\ntrialish_markers = re.compile(r)

【tool:run_python】 {"ok": true, "stdout": "andomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: immunological, physical performance, and cognitive effects\",\n \"journal\": \"Exp Gerontol\",\n \"year\": \"2018\",\n \"doi\": \"10.1016/j.exger.2017.12.026\"\n },\n {\n \"idx\": 34,\n \"animal\": false,\n \"title\": \"A randomized, dose-escalation study of subconjunctival and intravitreal injections of sirolimus in patients with diabetic macular edema\",\n \"journal\": \"Ophthalmology\",\n \"year\": \"2012\",\n \"doi\": \"10.1016/j.ophtha.2011.07.034\"\n },\n {\n \"idx\": 35,\n \"animal\": false,\n \"title\": \"Treatment of geographic atrophy with intravitreal sirolimus: the Age-Related Eye Disease Study 2 ancillary study\",\n \"journal\": \"Ophthalmol Retina\",\n \"year\": \"2018\",\n \"doi\": \"10.1016/j.oret.2017.08.015\"\n },\n {\n \"idx\": 36,\n \"animal\": true,\n \"title\": \"Intravitreal sirolimus for persistent, exudative age-related macular degeneration: a pilot study\",\n \"journal\": \"Int J Retina Vitreous\",\n \"year\": \"2021\",\n \"doi\": \"10.1186/s40942-021-00281-0\"\n },\n {\n \"idx\": 38,\n \"animal\": false,\n \"title\": \"m``