Iter-4360dd15-0046-transcript
第 46 轮执行轨迹
→ call search_memory({"limit":8,"query":"4360dd15 PMID 38310895 mmc1.pdf supplementary table 19 studies NEXT_FOCUS"}) → call list_recent({"n":8})
→ call list_by_tag({"limit":10,"tag":"4360dd15"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 38310895 19 纳入研究 表 补充材料 NEXT_FOCUS\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0037-transcript\", \"tags\": \"iteration transc【tool:list_recent】
{"ok": true, "items": [{"title": "Error-20260425-033153", "modified": "20260424193153000", "tags": "error iteration"}, {"title": "Iter-4360dd15-0044-reflection", "modified": "20260424193149000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424193149000", "tags": "pinned focus"}, {"title": "先绕过访问阻断再做抽取", "modified": "20260424193149000", "tags": "lesson access-block evidence-retrieval systematic-review"}, {"title": "Iter-4360dd15-0044-transcript", "modified": "20260424193140000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0043-reflection", "modified": "20260424192851000", "tags": "iteration reflection"}, {"title": "先拿到表，再做映射", "modified": "20260424192851000", "tags": "lesson evidence-retrieval systematic-review access-block"}, {"title": "Iter-4360dd15-0043-transcript", "modified": "20260424192846000", "tags": "iteration transcript"}]}
【tool:list_by_tag】
{"ok": true, "items": [{"title": "Iter-4360dd15-0042-crossref-family-collapse-10-families", "modified": "20260424192619000"}, {"title": "Iter-4360dd15-0040-crossref-trialish-family-taxonomy", "modified": "20260424192051000"}, {"title": "Iter-4360dd15-0039-crossref-candidate-family-critique", "modified": "20260424191812000"}, {"title": "Critique of Crossref trialish filtering for PMID 38310895 reference chain", "modified": "20260424191745000"}, {"title": "Iter-4360dd15-0038-crossref-human-trial-filter-method", "modified": "20260424191618000"}, {"title": "Iter-4360dd15-0030-vu-research-portal-entry-without-direct-pdf-link", "modified": "20260424185400000"}, {"title": "2024 rapamycin systematic review: abstract-level constraints and what remains missing", "modified": "20260424175824000"}, {"title": "Added included ADPKD rapalog trial CRAD001ADE12 and its body-weight endpoint", "modified": "20260424174657000"}, {"title": "Rapamycin human trials: completed studies table from PMC review", "modified": "20260424174352000"}, {"title": "Iter-4360dd15-0004-critique-rapamycin-evidence", "modified": "20260424174226000"}]}
→ call read_note({"title":"NEXT_FOCUS"})
→ call read_note({"title":"Iter-4360dd15-0044-reflection"})
→ call read_note({"title":"Iter-4360dd15-0042-crossref-family-collapse-10-families"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission `4360dd15` · Iter-0044）\n\n只攻克一个子问题：找到 mmc1.pdf 的可访问镜像或替代转载，并直接抽取前 13 条人类临床候选对应项。"}
【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0044-reflection", "tags": "iteration reflection", "text": "!! 本轮进展\n已确认 PMID 38310895 对应综述及其补充材料 mmc1.pdf 的准确来源，并锁定了“19 项纳入研究”这一目标表所在位置。\n\n!! 失败 / 盲点\n受出版社 403 阻断影响，仍未拿到补充表的可访问副本，也未能直接提取任何纳入研究条目。\n\n!! 下轮焦点\n只攻克一个子问题：找到 mmc1.pdf 的可访问镜像或替代转载，并直接抽取前 13 条人类临床候选对应项。\n"}
【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0042-crossref-family-collapse-10-families", "tags": "knowledge fact 4360dd15 evidence-retrieval crossref", "text": "!! PMID 38310895 的 14 条 Crossref trial-ish 命中可压缩为 10 个家族\n\n本轮没有继续争夺全文，而是把已知的 14 条 trial-ish 命中做了 //家族级折叠//：\n- 14 条命中里，1 条是非人类（果蝇），排除\n- 剩余 13 条是人类临床候选\n- 这 13 条进一步可归并为 10 个家族，其中有 3 条属于 follow-up / extension / postextension，不能当作独立 trial 计数\n\n!! 可复现的折叠规则\n
→ call web_search({"limit":8,"query":"PMID 38310895 mmc1.pdf mirror supplementary material rapamycin systematic review"})
→ call web_search({"limit":8,"query":"38310895 mmc1 pdf site:pmc.ncbi.nlm.nih.gov rapamycin review supplementary"})
→ call web_search({"limit":8,"query":"\"mmc1.pdf\" rapamycin review 38310895"})
【tool:web_search】
{"ok": true, "query": "PMID 38310895 mmc1.pdf mirror supplementary material rapamycin systematic review", "results": [{"title": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/", "snippet": "PubMed® comprises more than 40 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites."}, {"title": "Google Scholar", "url": "https://scholar.google.com/", "snippet": "Google Scholar provides a simple way to broadly search for scholarly literature. Search across a wide variety of disciplines and sources: articles, theses, books, abstracts and court opinions."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "A systematic review study of Rapamycin", "url": "https://rapamycinlongevitylab.substack.com/p/a-systematic-review-study-of-rapamycin", "snippet": "Last month Ajla Hodzic Kuerec, Deborah Lee and Andrea Maier published a very interesting systematic review of Rapamycin and rapalogs (pubmed: 38310895 ). A systematic review is a review that gathers together different research studies within an area and based on that analyzes and summa
【tool:web_search】
{"ok": true, "query": "38310895 mmc1 pdf site:pmc.ncbi.nlm.nih.gov rapamycin review supplementary", "results": [{"title": "PMC Home", "url": "https://pmc.ncbi.nlm.nih.gov/", "snippet": "PMC is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM)."}, {"title": "Rapamycin for longevity: the pros, the cons, and future perspectives", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12226543/", "snippet": "A systematic review evaluated the effects of rapamycin and its derivatives on aging-related physiological changes and diseases and found improvements in the immune, cardiovascular, and integumentary systems but not in the endocrine, muscular, or neurological systems (Lee et al., 2024)."}, {"title": "Influence of rapamycin on safety and healthspan metrics after one year ...", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12074816/", "snippet": "An additional 11 discontinued participation prior to study completion, and were not included in these analyses. Of the 114 who completed the study, 40 received 5 mg/week of rapamycin , 35 received 10 mg/week of rapamycin , and 39 received placebo ( Supplementary Figure 1)."}, {"title": "Rapamycin: one drug, many effects - PMC", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3972801/", "snippet": "The mammalian target of rapamycin (mTOR) signaling pathway is a master regulator of cell growth and metabolism. Deregulation of the
【tool:web_search】
{"ok": true, "query": "\"mmc1.pdf\" rapamycin review 38310895", "results": [{"title": "mmc1.pdf - Google Drive", "url": "https://drive.google.com/file/d/0B_NjsTBFMv_gRjAzR19SX0tFa00/view?usp=sharing", "snippet": "mmc1.pdf - Google Drive"}, {"title": "(PDF) mmc1.pdf - ResearchGate", "url": "https://www.researchgate.net/publication/372860951_mmc1pdf", "snippet": "PDF | On Aug 3, 2023, GBD 2019 Australia Collaborators and others published mmc1.pdf | Find, read and cite all the research you need on ResearchGate"}, {"title": "(PDF) mmc1.pdf - ResearchGate", "url": "https://www.researchgate.net/publication/372496111_mmc1pdf", "snippet": "PDF | On Jul 21, 2023, Anne S De Groot and others published mmc1.pdf | Find, read and cite all the research you need on ResearchGate"}, {"title": "(PDF) mmc1.pdf - ResearchGate", "url": "https://www.researchgate.net/publication/389131217_mmc1pdf", "snippet": "PDF | On Feb 19, 2025, Xue-Zhou Wang and others published mmc1.pdf | Find, read and cite all the research you need on ResearchGate"}]}
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" mmc1 pdf"})
→ call web_search({"limit":10,"query":"\"10.1016/S2666-7568(23)00258-1\" supplementary pdf"})
→ call web_search({"limit":10,"query":"\"Lee DJW\" Hodzic Kuerec Maier mmc1 pdf"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" mmc1 pdf", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "PDF Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf", "snippet": "Deborah J W Lee*, Ajla Hodzic Kuerec*, Andrea B Maier Ra
【tool:web_search】
{"ok": true, "query": "\"10.1016/S2666-7568(23)00258-1\" supplementary pdf", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Lee DJW\" Hodzic Kuerec Maier mmc1 pdf", "results": []}
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf"})
→ call web_search({"limit":10,"query":"\"PIIS2666-7568(23)00258-1\" \"mmc1.pdf\""})
→ call web_search({"limit":10,"query":"site:researchgate.net \"PIIS2666-7568(23)00258-1\""})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_search】
{"ok": true, "query": "\"PIIS2666-7568(23)00258-1\" \"mmc1.pdf\"", "results": []}
【tool:web_search】
{"ok": true, "query": "site:researchgate.net \"PIIS2666-7568(23)00258-1\"", "results": []}
→ call web_fetch({"max_chars":12000,"url":"https://research.vu.nl/en/publications/targeting-ageing-with-rapamycin-and-its-derivatives-in-humans-a-s"})
→ call web_fetch({"max_chars":12000,"url":"https://europepmc.org/article/MED/38310895"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" supplementary materials research.vu.nl"})
【tool:web_fetch】
{"ok": true, "url": "https://research.vu.nl/en/publications/targeting-ageing-with-rapamycin-and-its-derivatives-in-humans-a-s/", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Targeting ageing with rapamycin and its derivatives in humans: a systematic review - Vrije Universiteit Amsterdam Skip to main navigation Skip to search Skip to main content Vrije Universiteit Amsterdam Home Help & FAQ Link opens in a new tab Search content at Vrije Universiteit Amsterdam Home Profiles Research units Research output Courses Projects Datasets / Software Activities Prizes / Grants Press / Media Targeting ageing with rapamycin and its derivatives in humans: a systematic review Deborah J W Lee , Ajla Hodzic Kuerec , Andrea B Maier Prevention and Rehabilitation AMS - Ageing & Vitality APH - Aging & Later Life APH - Global Health Research output : Contribution to Journal › Review article › Academic › peer-review Overview Fingerprint Abstract Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with agein
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/38310895", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" supplementary materials research.vu.nl", "results": []}
→ call web_search({"limit":10,"query":"\"6dc4a44a-1910-4435-ab52-a506c5f070b4\""})
→ call web_search({"limit":10,"query":"\"mmc1.pdf\" \"6dc4a44a\""})
→ call web_search({"limit":10,"query":"\"PIIS2666-7568(23)00258-1\" \"6dc4a44a\""})
【tool:web_search】
{"ok": true, "query": "\"6dc4a44a-1910-4435-ab52-a506c5f070b4\"", "results": []}
【tool:web_search】
{"ok": true, "query": "\"mmc1.pdf\" \"6dc4a44a\"", "results": []}
【tool:web_search】
{"ok": true, "query": "\"PIIS2666-7568(23)00258-1\" \"6dc4a44a\"", "results": []}
→ call search_memory({"limit":8,"query":"4360dd15 mmc1 pdf mirror alternative转载 19 included studies"})
→ call search_memory({"limit":8,"query":"4360dd15 38310895 included studies names"})
→ call search_memory({"limit":8,"query":"4360dd15 rapamycin systematic review 19 included studies table 1"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"}) → call list_recent({\"n\":8}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10"}, {"title": "Iter-4360dd15-0040-transcript", "tags": "iteration transcript", "modified": "20260424192058000", "preview": "!! 第 40 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 38310895 rapalog trial human trial 14 candidate 11 remaining\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:s【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1全文 镜像\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \ → call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" \"mmc1\" \"pdf\""})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" \"supplementary appendix\""})
→ call web_search({"limit":10,"query":"\"PIIS2666-7568(23)00258-1\" supplementary appendix mmc1"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" \"mmc1\" \"pdf\"", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" \"supplementary appendix\"", "results": []}
【tool:web_search】
{"ok": true, "query": "\"PIIS2666-7568(23)00258-1\" supplementary appendix mmc1", "results": []}
→ call web_search({"limit":12,"query":"\"e152-e162\" rapamycin supplementary material pdf"})
→ call web_search({"limit":12,"query":"\"38110895\" \"supplementary appendix\" rapamycin"})
→ call web_search({"limit":12,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" filetype:pdf"})
【tool:web_search】
{"ok": true, "query": "\"e152-e162\" rapamycin supplementary material pdf", "results": []}
【tool:web_search】
{"ok": true, "query": "\"38110895\" \"supplementary appendix\" rapamycin", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin