Iter-4360dd15-0044-transcript
第 44 轮执行轨迹
→ call search_memory({"limit":10,"query":"4360dd15 PMID 38310895 19 纳入研究 表 补充材料 NEXT_FOCUS"})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"}) → call list_recent({\"n\":8}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0037-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424191347000\", \"preview\": \"!! 第 3"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹 → call list_recent({"n":8})
【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0043-reflection", "modified": "20260424192851000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424192851000", "tags": "pinned focus"}, {"title": "先拿到表，再做映射", "modified": "20260424192851000", "tags": "lesson evidence-retrieval systematic-review access-block"}, {"title": "Iter-4360dd15-0043-transcript", "modified": "20260424192846000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0042-reflection", "modified": "20260424192629000", "tags": "iteration reflection"}, {"title": "候选召回不能替代纳入判定", "modified": "20260424192629000", "tags": "lesson evidence-retrieval systematic-review crossref"}, {"title": "Iter-4360dd15-0042-transcript", "modified": "20260424192623000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0042-crossref-family-collapse-10-families", "modified": "20260424192619000", "tags": "knowledge fact 4360dd15 evidence-retrieval crossref"}]}
→ call read_note({"title":"NEXT_FOCUS"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0043）\n\n下一轮只攻克一个点：找到 PMID 38310895 的 19 项纳入研究表的可访问副本或镜像，并直接提取前 13 条人类临床候选对应项。"}
→ call search_memory({"limit":8,"query":"4360dd15 38310895 title systematic review rapamycin 19 studies"})
→ call web_search({"limit":8,"query":"PMID 38310895 systematic review 19 studies rapamycin table 1 supplement PDF"})
→ call pubmed_search({"limit":5,"query":"38310895"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"}) → call list_recent({\"n\":8}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹 → cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 【tool:web_search】
{"ok": true, "query": "PMID 38310895 systematic review 19 studies rapamycin table 1 supplement PDF", "results": [{"title": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/", "snippet": "PubMed® comprises more than 40 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://europepmc.org/article/MED/38310895", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "PDF Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf", "snippet": "Articles included in this systematic review met the following criteria: the mean or median age of the study cohort was 18 years or older; outcomes on ageing-related physiological changes or disease were reported; and they were interventional studies with rapamycin or its derivatives (no restriction on the method). Articles were excluded if in vitro or animal models were used; rapamycin or its ..."}, {"title": "Targeting ageing with rapamy
【tool:pubmed_search】
{"ok": true, "query": "38310895", "results": [{"pmid": "38310895", "title": "Targeting ageing with rapamycin and its derivatives in humans: a systematic review.", "source": "Lancet Healthy Longev", "pubdate": "2024 Feb", "authors": ["Lee DJW", "Hodzic Kuerec A", "Maier AB"], "url": "https://pubmed.ncbi.nlm.nih.gov/38310895/"}]}
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf"})
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf"})
→ call web_fetch({"max_chars":12000,"url":"https://europepmc.org/article/MED/38310895"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/38310895", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" Table 1 included studies"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" Table 1 included studies", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.researchgate.net/publication/377976071_Targeting_ageing_with_rapamycin_and_its_derivatives_in_humans_a_systematic_review", "snippet": "A recent systematic review of human studies suggested Rapamycin and its derivatives to be effective in improving the age-related physiological paramet
→ call web_search({"limit":10,"query":"\"PIIS2666-7568(23)00258-1\" table 1 included studies mirror"})
→ call web_search({"limit":10,"query":"\"6dc4a44a-1910-4435-ab52-a506c5f070b4\" pdf"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" supplementary appendix table 1 pdf"})
【tool:web_search】
{"ok": true, "query": "\"PIIS2666-7568(23)00258-1\" table 1 included studies mirror", "results": []}
【tool:web_search】
{"ok": true, "query": "\"6dc4a44a-1910-4435-ab52-a506c5f070b4\" pdf", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" supplementary appendix table 1 pdf", "results": [{"title": "PDF Supplementary appendix - The Lancet", "url": "https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf", "snippet": "Supplementary appendix This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Lee DJW, Hodzic Kuerec A, Maier AB. Targeting ageing with rapamycin and its derivatives in humans : a systematic review. Lancet Healthy Longev 2024; 5: e152-62. Table of Contents"}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major reg
→ call search_memory({"limit":10,"query":"4360dd15 38310895 study names included studies table 1 candidate"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"}) → call list_recent({\"n\":8}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10"}, {"title": "Iter-4360dd15-0038-transcript", "tags": "iteration transcript", "modified": "20260424191624000", "preview": "!! 第 38 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": → call web_fetch({"max_chars":15000,"url":"https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext"})
→ call web_fetch({"max_chars":15000,"url":"https://www.sciencedirect.com/science/article/pii/S2666756823002581"})
→ call web_search({"limit":10,"query":"site:thechinesejournal? \"Targeting ageing with rapamycin and its derivatives in humans\" \"Table 1\""})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.sciencedirect.com/science/article/pii/S2666756823002581'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_search】
{"ok": true, "query": "site:thechinesejournal? \"Targeting ageing with rapamycin and its derivatives in humans\" \"Table 1\"", "results": []}
→ call web_search({"limit":10,"query":"\"Rapamycin and its derivatives\" \"19 included studies\" \"Table 1\" \"Lee\""})
【tool:web_search】
{"ok": true, "query": "\"Rapamycin and its derivatives\" \"19 included studies\" \"Table 1\" \"Lee\"", "results": []}
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" repository pdf"})
→ call web_search({"limit":10,"query":"\"PIIS2666-7568(23)00258-1\" pdf filetype:pdf"})
→ call web_search({"limit":10,"query":"\"38310895\" pdf rapamycin supplementary appendix"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" repository pdf", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "PDF Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf", "snippet": "Deborah J W Lee*, Ajla Hodzic Kuerec*, Andrea B Ma
【tool:web_search】
{"ok": true, "query": "\"PIIS2666-7568(23)00258-1\" pdf filetype:pdf", "results": []}
【tool:web_search】
{"ok": true, "query": "\"38310895\" pdf rapamycin supplementary appendix", "results": []}
→ call web_search({"limit":10,"query":"Europe PMC 38310895 PMCID full text"})
→ call web_search({"limit":10,"query":"\"38310895\" PMCID"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" Europe PMC full text"})
【tool:web_search】
{"ok": true, "query": "Europe PMC 38310895 PMCID full text", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in ... - Europe PMC", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 ..."}, {"title": "PMC Home", "url": "https://pmc.ncbi.nlm.nih.gov/", "snippet": "PMC is a free full-text archive of biomedical and life sciences journal literature at the U.S. National Institutes of Health's National Library of Medicine (NIH/NLM)."}, {"title": "Europe PMC", "url": "https://europepmc.org/", "snippet": "Comprehensive search Search life sciences literature from trusted sources around the globe, all in one search, accessible by anyone anywhere, for free. Learn more About Europe PMC ."}, {"title": "Europe PMC", "url": "https://europepmc.org/article/PMC/", "snippet": "Europe PMC is developed by EMBL-EBI with support from the Europe PMC Funders' Group, in collaboration with the National Library of Medicine (NLM), as part of the PubMed Central International archive network. Europe PMC is an ELIXIR Core Data Resource, Global Core Biodata Resource, and conforms with EMBL-EBI's long term data preservation policies."}, {"title": "Europe PMC", "u
【tool:web_search】
{"ok": true, "query": "\"38310895\" PMCID", "results": [{"title": "Systemic review study of Rapamycin : r/Rapamycin - Reddit", "url": "https://www.reddit.com/r/Rapamycin/comments/1bo5ogp/systemic_review_study_of_rapamycin/", "snippet": "Last month Ajla Hodzic Kuerec, Deborah Lee and Andrea Maier published a very interesting systematic review of Rapamycin and rapalogs (pubmed: 38310895 ). A systematic review is a review that gathers together different research studies within an area and based on that analyzes and summarizes these. These types of reviews are generally seen as a way of providing the highest level of scientific ..."}, {"title": "Rapamycin Longevity Lab's Substack - reletter.com", "url": "https://reletter.com/publications/rapamycin-longevity-labs-substack", "snippet": "Last month Ajla Hodzic Kuerec, Deborah Lee and Andrea Maier published a very interesting systematic review of Rapamycin and rapalogs (pubmed: 38310895 ). A systematic review is a review that gathers together different research studies within..."}, {"title": "Sirolimus - mobile.fpnotebook.com", "url": "https://mobile.fpnotebook.com/Surgery/Pharm/Srlms.htm", "snippet": "Lee (2024) Lancet Healthy Longev 5 (2):e152-e162 +PMID: 38310895 [PubMed] Mechanism mTOR Inhibitor See Mammalian Target of Rapamycin Pathway (mTOR Pathway) Medications Sirolimus (Rapamune, Rapamycin) Tablets: 0.5 mg, 1 mg, 2 mg Solution: 1 mg/ml Dosing See other references for specific dosing regimens per indication"}, {"title": "
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" Europe PMC full text", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "PDF Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf", "snippet": "Deborah J W Lee*, Ajla Hodzic Kuerec*, Andre
→ call web_fetch({"max_chars":12000,"url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:38310895&format=json"})
→ call web_fetch({"max_chars":12000,"url":"https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/fullTextXML"})
【tool:web_fetch】
{"ok": true, "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:38310895&format=json", "status": 200, "content_type": "application/json;charset=UTF-8", "text": "{\"version\":\"6.9\",\"hitCount\":1,\"request\":{\"queryString\":\"EXT_ID:38310895\",\"resultType\":\"lite\",\"cursorMark\":\"*\",\"pageSize\":25,\"sort\":\"\",\"synonym\":false},\"resultList\":{\"result\":[{\"id\":\"38310895\",\"source\":\"MED\",\"pmid\":\"38310895\",\"doi\":\"10.1016/s2666-7568(23)00258-1\",\"title\":\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review.\",\"authorString\":\"Lee DJW, Hodzic Kuerec A, Maier AB.\",\"journalTitle\":\"Lancet Healthy Longev\",\"issue\":\"2\",\"journalVolume\":\"5\",\"pubYear\":\"2024\",\"journalIssn\":\"2666-7568\",\"pageInfo\":\"e152-e162\",\"pubType\":\"research support, non-u.s. gov't; systematic review; journal article\",\"isOpenAccess\":\"N\",\"inEPMC\":\"N\",\"inPMC\":\"N\",\"hasPDF\":\"N\",\"hasBook\":\"N\",\"hasSuppl\":\"N\",\"citedByCount\":96,\"hasReferences\":\"Y\",\"hasTextMinedTerms\":\"Y\",\"hasDbCrossReferences\":\"N\",\"hasLabsLinks\":\"Y\",\"hasTMAccessionNumbers\":\"N\",\"firstIndexDate\":\"2024-02-05\",\"firstPublicationDate\":\"2024-02-01\"}]}}", "truncated": false}
【tool:web_fetch】
{"ok": false, "error": "Client error '404 Not Found' for url 'https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/fullTextXML'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/404"}
→ call web_search({"limit":10,"query":"\"mmc1.pdf\" \"S2666-7568(23)00258-1\""})
→ call web_searc