Iter-4360dd15-0040-transcript

修改：20260424192058000

第 40 轮执行轨迹

  → call search_memory({"limit":10,"query":"4360dd15 PMID 38310895 rapalog trial human trial 14 candidate 11 remaining"})
  → call list_recent({"n":8})
  → call list_by_tag({"limit":20,"tag":"4360dd15"})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹

   → cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1 included trials endpoint\"}) → call list_recent({\"n\":6}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹

   → call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0001-transcript", "tags": "iteration transcript", "modified": "20260424173243000", "preview": "!! 第 1 轮执行轨迹

→ call search_memory({\"limit\":10,\"query\":\"4360dd15 长生不老 immortality 抗衰老目标\"}) → call list_recent({\"n\":10}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"GOAL\", \"tags\"

【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0039-reflection", "modified": "20260424191824000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424191824000", "tags": "pinned focus"}, {"title": "先用可机读引用链缩窄候选，再补全文表", "modified": "20260424191824000", "tags": "lesson evidence-retrieval crossref reference-chain"}, {"title": "Iter-4360dd15-0039-transcript", "modified": "20260424191818000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0039-crossref-candidate-family-critique", "modified": "20260424191812000", "tags": "fact 4360dd15 crossref rapalog human trial"}, {"title": "Critique of Crossref trialish filtering for PMID 38310895 reference chain", "modified": "20260424191745000", "tags": "lesson critique 4360dd15 evidence retrieval"}, {"title": "Iter-4360dd15-0038-reflection", "modified": "20260424191630000", "tags": "iteration reflection"}, {"title": "先拿引用数组再做精筛", "modified": "20260424191630000", "tags": "lesson evidence-retrieval crossref reference-chain"}]}

【tool:list_by_tag】
{"ok": true, "items": [{"title": "Iter-4360dd15-0039-crossref-candidate-family-critique", "modified": "20260424191812000"}, {"title": "Critique of Crossref trialish filtering for PMID 38310895 reference chain", "modified": "20260424191745000"}, {"title": "Iter-4360dd15-0038-crossref-human-trial-filter-method", "modified": "20260424191618000"}, {"title": "Iter-4360dd15-0030-vu-research-portal-entry-without-direct-pdf-link", "modified": "20260424185400000"}, {"title": "2024 rapamycin systematic review: abstract-level constraints and what remains missing", "modified": "20260424175824000"}, {"title": "Added included ADPKD rapalog trial CRAD001ADE12 and its body-weight endpoint", "modified": "20260424174657000"}, {"title": "Rapamycin human trials: completed studies table from PMC review", "modified": "20260424174352000"}, {"title": "Iter-4360dd15-0004-critique-rapamycin-evidence", "modified": "20260424174226000"}, {"title": "Rapamycin human trials: extracted endpoints and outcomes from the 2024 systematic review review pass 1", "modified": "20260424173529000"}, {"title": "Human longevity interventions evidence maturity matrix 2026-04-25", "modified": "20260424173237000"}]}

→ call read_note({"title":"NEXT_FOCUS"})

→ call read_note({"title":"Iter-4360dd15-0038-crossref-human-trial-filter-method"})

→ call read_note({"title":"Iter-4360dd15-0039-crossref-candidate-family-critique"})

→ call search_memory({"limit":10,"query":"4360dd15 14 candidates remaining 11 trial names included studies review"})

【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0039）\n\n把这篇综述的 14 个候选逐一对照正文/补充材料，精确补齐并去重出剩余 11 项纳入 human trial。"}

【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0038-crossref-human-trial-filter-method", "tags": "knowledge experiment fact 4360dd15", "text": "!! 本轮进展\n用 Crossref 机器可读 references（DOI 10.1016/S2666-7568(23)00258-1，共 75 条）做了本地过滤，得到一个可复现的“rapalog + human trial-ish”候选集。\n\n!! 可复现方法\n

\nimport requests, re\n\ndoi='10.1016/S2666-7568(23)00258-1'\nmsg=requests.get(f'https://api.crossref.org/works/{doi}', timeout=30,\n                 headers={'User-Agent':'Mozilla/5.0'}).json()['message']\nrefs=msg['reference']\n\nkw = re.compile(r'rapamycin|sirolimus|everolimus|temsirolimus|rapalog|mtor inhibitor|mammalian target of rapamycin', re.I)\nhuman = re.compile(r'clinical|trial|patients?|subjects?|healthy volunteers?|randomi[sz]ed|placebo|double blind|phase\\s*[1-4]|crossover|human|proof-of-concept|pilot|feasibility|futility', re.I)\n\ntrialish=[]\nfor r in refs:\n    txt=' | '.join(str(r.get(k,'')) for k in ['article-title','journal-title','author','DOI','unstructured'])\n    if any(t in (r.get('article-title') or r.get('unstructured') or '').lower()\n           for t in ['trial','randomized','randomised','placebo','phase','proof-of-concept','feasibility','futility','extension']) \\\n       and any(dr in txt.lower() for dr in ['rapamycin','sirolimus','everolimus','temsirolimus']):\n        trialish.append(r)\n\nprint('trial_title_count', len(trialish))\n

\n\n!! 结果\n- 75 条 references 中，trial_title_count = 14。\n- 其中 1 条是动物研究：`Mechanisms of life span extension by rapamycin in the fruit

【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0039-crossref-candidate-family-critique", "tags": "fact 4360dd15 crossref rapalog human trial", "text": "!! 第 39 轮：对 Crossref trial-ish 过滤的严格复核\n\n本轮从 PMID 38310895 对应综述的 Crossref reference 数组中，进一步核对了“trial-ish”候选的性质。\n\n!! 复核方法\n

\nimport requests, re\n\ndoi='10.1016/S2666-7568(23)00258-1'\nmsg=requests.get(f'https://api.crossref.org/works/{doi}', timeout=30,\n                 headers={'User-Agent':'Mozilla/5.0'}).json()['message']\nrefs=msg['reference']\n\nmarkers = ['rapamycin','sirolimus','everolimus','temsirolimus']\ntrial_markers = ['trial','randomized','randomised','placebo','phase','proof-of-concept','feasibility','futility','extension','crossover']\n\ncands=[]\nfor r in refs:\n    txt=' | '.join(str(r.get(k,'')) for k in ['article-title','journal-title','author','DOI','unstructured']).lower()\n    if any(m in txt for m in markers) and any(t in txt for t in trial_markers):\n        cands.append(r)\n

\n\n!! 复核结果\n- 观察到的明显 candidate article 数：12\n- 按 study family 人工去重后：至少 10 个 family\n- 其中明显需要合并的 family：EXIST-3（core / extension / postextension）\n\n!! 严格结论\n标题关键词过滤可以作为“候选召回”，但**不能**直接当作“综述纳入研究清单”的证据。\n若继续用它回答“综述究竟纳入了哪些研究”，会把：\n- 治疗疾病研究\n- 药代/剂量研究\n- follow-up / extension 文章\n- 观察性健康寿命用药回顾\n混为一谈，造成假阳性膨胀。\n\n!! 证据指向\n这说明当前最窄、最值得深入的问题不是“再找更多关键词”，而是：\n**如何从候选 family 中排除与 aging-related physiological changes in adults 不匹配的条目，并恢复 19 included studies 的家族级清单。**\n"}

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹

→ cal"}, {"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"})    → call list_recent({\"n\":8})    → call list_tools({})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹

→ call web_search({"limit":8,"query":"PMID 38310895 rapamycin systematic review 19 studies Table 1 included studies pdf"})

→ call web_search({"limit":8,"query":"\"10.1016/S2666-7568(23)00258-1\" full text table 1 included studies"})

→ call web_search({"limit":8,"query":"site:pmc.ncbi.nlm.nih.gov rapamycin systematic review 19 studies included"})

→ call web_search({"limit":8,"query":"PubMed 38310895 rapamycin human trials systematic review supplement"})

【tool:web_search】
{"ok": true, "query": "PMID 38310895 rapamycin systematic review 19 studies Table 1 included studies pdf", "results": [{"title": "PDF Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf", "snippet": "Articles included in this systematic review met the following criteria: the mean or median age of the study cohort was 18 years or older; outcomes on ageing-related physiological changes or disease were reported; and they were interventional studies with rapamycin or its derivatives (no restriction on the method)."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies ."}, {"title": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/", "snippet": "PubMed® comprises more than 40 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites."}, {"title": "Targeting ageing with rapamycin and its d

【tool:web_search】
{"ok": true, "query": "\"10.1016/S2666-7568(23)00258-1\" full text table 1 included studies", "results": []}

【tool:web_search】
{"ok": true, "query": "site:pmc.ncbi.nlm.nih.gov rapamycin systematic review 19 studies included", "results": [{"title": "Rapamycin for longevity: the pros, the cons, and future perspectives", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12226543/", "snippet": "A systematic review evaluated the effects of rapamycin and its derivatives on aging-related physiological changes and diseases and found improvements in the immune, cardiovascular, and integumentary systems but not in the endocrine, muscular, or neurological systems (Lee et al., 2024)."}, {"title": "Influence of rapamycin on safety and healthspan metrics after one year ...", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12074816/", "snippet": "The current study, the Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL) trial, aimed to address this gap, and represents the longest clinical study of rapamycin use for healthy aging performed to date. RESULTS A total of 114 participants completed the study and were included in data analysis."}, {"title": "Molecular and therapeutic insights of rapamycin: a multi-faceted drug ...", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9875782/", "snippet": "The main focus of the current review is to explore the origin, development, molecular mechanistic action, and the current therapeutic aspects of rapamycin . Also, this review article revealed the potential of rapamycin and the progress of rapamycin research."}, {"title": "A Systematic Review of the Effic

【tool:web_search】
{"ok": true, "query": "PubMed 38310895 rapamycin human trials systematic review supplement", "results": [{"title": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/", "snippet": "PubMed ® comprises more than 40 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "A systematic review study of Rapamycin", "url": "https://rapamycinlongevitylab.substack.com/p/a-systematic-review-study-of-rapamycin", "snippet": "Last month Ajla Hodzic Kuerec, Deborah Lee and Andrea Maier published a very interesting systematic review of Rapamycin and rapalogs ( pubmed : 38310895 ). A systematic review is a review that gathers together different research studies within an area and based on that analyzes and summarizes these."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "The articles were organised and managed using Covidence systematic review softwar

→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext"})

→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf"})

【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}

【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}

→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" Table 1 study names"})

→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" EXIST-3 sirolimus table"})

→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" included studies rapamycin everolimus sirolimus"})

→ call web_search({"limit":10,"query":"site:pmc.ncbi.nlm.nih.gov \"Targeting ageing with rapamycin and its derivatives in humans\""})

【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" Table 1 study names", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.researchgate.net/publication/377976071_Targeting_ageing_with_rapamycin_and_its_derivatives_in_humans_a_systematic_review", "sn

【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" EXIST-3 sirolimus table", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "PDF Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf", "snippet": "Deborah J W Lee*, Ajla Hodzic Kuerec*, An

【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" included studies rapamycin everolimus sirolimus", "results": []}

【tool:web_search】
{"ok": true, "query": "site:pmc.ncbi.nlm.nih.gov \"Targeting ageing with rapamycin and its derivatives in humans\"", "results": []}

→ call web_search({"limit":8,"query":"site:europepmc.org 38310895 supplementary appendix rapamycin included studies"})

→ call web_search({"limit":8,"query":"site:research.vu.nl 38310895 rapamycin appendix pdf"})

→ call web_search({"limit":8,"query":"\"mmc1.pdf\" rapamycin ageing humans included studies"})

→ call web_search({"limit":8,"query":"\"S2666-7568(23)00258-1\" supplementary appendix pdf included studies"})

【tool:web_search】
{"ok": true, "query": "site:europepmc.org 38310895 supplementary appendix rapamycin included studies", "results": []}

【tool:web_search】
{"ok": true, "query": "site:research.vu.nl 38310895 rapamycin appendix pdf", "results": []}

【tool:web_search】
{"ok": true, "query": "\"mmc1.pdf\" rapamycin ageing humans included studies", "results": []}

【tool:web_search】
{"ok": true, "query": "\"S2666-7568(23)00258-1\" supplementary appendix pdf included studies", "results": []}

→ call web_fetch({"max_chars":14000,"url":"https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf"})

→ call web_fetch({"max_chars":14000,"url":"https://www.sciencedirect.com/science/article/pii/S2666756823002581"})

【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}

【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.sciencedirect.com/science/article/pii/S2666756823002581'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}

→ call search_memory({"limit":20,"query":"4360dd15 included studies Table 1 rapamycin everolimus sirolimus study names"})

→ call search_memory({"limit":20,"query":"4360dd15 EXIST-3 CRAD001ADE12 low-dose sirolimus follow-up trial family"})

→ call list_by_tag({"limit":20,"tag":"knowledge"})

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"})    → call list_recent({\"n\":8})    → call list_tools({})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10"}, {"title": "Iter-4360dd15-0038-transcript", "tags": "iteration transcript", "modified": "20260424191624000", "preview": "!! 第 38 轮执行轨迹

→ call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"}) → call list_recent({\"n\":8}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0037-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424191347000\", \"preview\": \"!! 第 3"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": 【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹

   → cal"}, {"title": "Iter-4360dd15-0037-transcript", "tags": "iteration transcript", "modified": "20260424191347000", "preview": "!! 第 37 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"}) → call list_recent({\"n\":8}) → call list_tools({}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10"}, {"title": "Iter-4360dd15-0038-transcript", "tags": "iteration transcript", "modified": "20260424191624000", "preview": "!! 第 38 轮执行轨迹

   → call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus\"})    → call list_recent({\"n\":8})    → call list_t