Iter-4360dd15-0037-transcript
第 37 轮执行轨迹
→ call search_memory({"limit":8,"query":"4360dd15 PMID 38310895 reference chain Crossref 75 references human trial rapamycin everolimus sirolimus"}) → call list_recent({"n":8})
→ call list_tools({})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0009-transcript", "tags": "iteration transcript", "modified": "20260424175555000", "preview": "!! 第 9 轮执行轨迹 【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0036-reflection", "modified": "20260424191122000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424191122000", "tags": "pinned focus"}, {"title": "先用 Crossref 参考数组替代网页正文", "modified": "20260424191122000", "tags": "lesson evidence-retrieval reference-chain crossref"}, {"title": "Iter-4360dd15-0036-transcript", "modified": "20260424191116000", "tags": "iteration transcript"}, {"title": "Error-20260425-030741", "modified": "20260424190741000", "tags": "error iteration"}, {"title": "Error-20260425-030601", "modified": "20260424190601000", "tags": "error iteration"}, {"title": "Iter-4360dd15-0033-reflection", "modified": "20260424190238000", "tags": "iteration reflection"}, {"title": "先找机器可读源", "modified": "20260424190238000", "tags": "lesson evidence-retrieval reference-chain crossref"}]}
【tool:list_tools】
{"ok": true, "tools": [{"name": "search_memory", "description": "在 TiddlyWiki 长期记忆中按关键字搜索（支持中文空格分隔），返回标题、标签、预览。每轮迭代开始前应先调用以回忆。", "custom": false}, {"name": "read_note", "description": "读取某一条 tiddler 的完整正文。", "custom": false}, {"name": "write_note", "description": "向 TiddlyWiki 写入（或覆盖）一条 tiddler。这是 Sisyphus 的长期记忆入口——每轮至少写一条。建议标签：knowledge, experiment, reflection, plan, idea, fact, question, lesson。TiddlyWiki 标记：!! 小标题，''粗体''，斜体，其它tiddler。", "custom": false}, {"name": "list_recent", "description": "列出最近修改过的 tiddler。", "custom": false}, {"name": "list_by_tag", "description": "按标签列出相关 tiddler。", "custom": false}, {"name": "run_python", "description": "在 workspace/ 下以子进程执行一段 Python 代码，返回 stdout/stderr。用于计算、模拟、验证假设、抓取公开数据（禁止任何破坏性操作）。", "custom": false}, {"name": "read_file", "description": "读取 workspace/ 下的某个文件。", "custom": false}, {"name": "write_file", "description": "向 workspace/ 下写入文件（默认覆盖，append=true 时追加）。", "custom": false}, {"name": "list_files", "description": "列出 workspace/ 下的文件。", "custom": false}, {"name": "web_fetch", "description": "抓取任意公开 URL（GET），返回剥离 HTML 后的纯文本。适合读论文摘要、文档、博客、百科。", "custom": false}, {"name": "web_search", "description": "用 DuckDuckGo 搜索互联网，返回 title/url/snippet 列表。找入口、找链接、调研时用。", "custom": false}, {"name": "wiki_search", "description": "维基百科搜索：返回若干条目的摘要和 URL。lang 默认 en，可传 zh 等。", "custom": false}, {"name": "arxiv_search", "description": "arXiv 论文检索：标题/作者/摘要/链接。理论、数学、物理、CS、bio 类前沿论文的主入口。", "custom": false}, {"name": "pubmed_search", "descriptio
→ call read_note({"title":"NEXT_FOCUS"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0036）\n\n把该综述 DOI 的 75 条 references 本地解析并按“human trial / rapamycin / everolimus / sirolimus / 2024 review missing studies”精准过滤出剩余 11 项。"}
→ call search_memory({"limit":10,"query":"4360dd15 PMID 38310895 DOI Crossref references 75"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0033-transcript", "tags": "iteration transcript", "modified": "20260424190229000", "preview": "!! 第 33 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 38310895 Crossref reference rapamycin sirolimus everolimus mTOR\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS Table 1 rapamycin 2024 review PMID 38310895\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":12,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_mem → call search_memory({"limit":10,"query":"PMID 38310895 title DOI rapamycin review 2024"})
→ call search_memory({"limit":10,"query":"38310895 crossref DOI references 75 rapamycin everolimus sirolimus"})
→ call read_note({"title":"Iter-4360dd15-0036-reflection"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹
→ call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹 → cal"}, {"title": "Iter-4360dd15-0018-transcript", "tags": "iteration transcript", "modified": "20260424182058000", "preview": "!! 第 18 轮执行轨迹 【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0033-transcript", "tags": "iteration transcript", "modified": "20260424190229000", "preview": "!! 第 33 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 38310895 Crossref reference rapamycin sirolimus everolimus mTOR\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS Table 1 rapamycin 2024 review PMID 38310895\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":12,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin mTOR systematic review 2024 trial endpoint PMC table remaining included studies\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0036-reflection", "tags": "iteration reflection", "text": "!! 本轮进展\n已确认 PMID 38310895 对应综述并通过 Crossref 取到其 DOI 参考文献数组（75 条），为机器可读的引用链追踪打通了入口。\n\n!! 失败 / 盲点\n本轮主要耗在 PubMed 403、Python 编码报错和工具定义语法错误上，未把已拿到的参考列表继续过滤成“剩余 11 项人类研究”。\n\n!! 下轮焦点\n把该综述 DOI 的 75 条 references 本地解析并按“human trial / rapamycin / everolimus / sirolimus / 2024 review missing studies”精准过滤出剩余 11 项。\n"}
→ call search_memory({"limit":10,"query":"PMID 38310895 DOI title review rapamycin everolimus sirolimus"})
→ call search_memory({"limit":10,"query":"38310895 doi crossref title"})
→ call search_memory({"limit":10,"query":"4360dd15 38310895 75 references"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹
→ call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹 → cal"}, {"title": "Iter-4360dd15-0033-transcript", "tags": "iteration transcript", "modified": "20260424190229000", "preview": "!! 第 33 轮执行轨迹 【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0033-transcript", "tags": "iteration transcript", "modified": "20260424190229000", "preview": "!! 第 33 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 38310895 Crossref reference rapamycin sirolimus everolimus mTOR\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 38310895 reference chain remaining 11 studies\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 PMID 38310895 reference chain remaining 11 studies rapamycin review\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transc【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0013-transcript", "tags": "iteration transcript", "modified": "20260424180743000", "preview": "!! 第 13 轮执行轨迹 → call pubmed_search({"limit":5,"query":"38310895"})
→ call web_search({"limit":5,"query":"PMID 38310895 rapamycin review DOI Crossref"})
→ call web_search({"limit":5,"query":"38310895 PubMed rapamycin everolimus sirolimus review"})
【tool:pubmed_search】
{"ok": true, "query": "38310895", "results": [{"pmid": "38310895", "title": "Targeting ageing with rapamycin and its derivatives in humans: a systematic review.", "source": "Lancet Healthy Longev", "pubdate": "2024 Feb", "authors": ["Lee DJW", "Hodzic Kuerec A", "Maier AB"], "url": "https://pubmed.ncbi.nlm.nih.gov/38310895/"}]}
【tool:web_search】
{"ok": true, "query": "PMID 38310895 rapamycin review DOI Crossref", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "Crossref Metadata Search", "url": "https://search.crossref.org/", "snippet": "Search the metadata of journal articles, books, standards, datasets & more"}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved physiological parameters associated with ag
【tool:web_search】
{"ok": true, "query": "38310895 PubMed rapamycin everolimus sirolimus review", "results": [{"title": "The effect of rapamycin and its analogues on age-related ... - PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/35861940/", "snippet": "Results: Fourteen studies met the inclusion criteria and were analyzed. The effect of rapamycin and other rapalogues, including everolimus and temsirolimus, on bone, muscle and joints have been evaluated in humans; however, considerable variability concerning the subjects' age, inclusion criteria, and drug administration protocols was identified."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "The protocol of this systematic review was registered with PROSPERO (CRD42022345827). We searched PubMed , Embase, SCOPUS, Cochrane, and Web of Science for full-text articles published from database inception to July 18, 2022. Key search terms included \" rapamycin \", \" sirolimus \", \" everolimus \", and \"temsirolimus\" (appendix pp 1-14)."}, {"title": "PDF The effect of rapamycin and its analogues on age-related ...", "url": "https://link.springer.com/content/pdf/10.1007/s40520-022-02190-0.pdf", "snippet": "Results Fourteen studies met the inclusion criteria and were analyzed. The efect of rapamycin and other rapalogues, including everolimus and temsirolimus, on bone, muscle and joints have been evaluate
→ call search_memory({"limit":8,"query":"Targeting ageing with rapamycin and its derivatives in humans DOI"})
→ call search_memory({"limit":8,"query":"Lancet Healthy Longev 2024 rapamycin derivatives humans DOI"})
→ call search_memory({"limit":8,"query":"Sisyphus 38310895 DOI"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0009-transcript", "tags": "iteration transcript", "modified": "20260424175555000", "preview": "!! 第 9 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin mTOR systematic review 2024 trial endpoint PMC table remaining included studies\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\""}, {"title": "Iter-4360dd15-0003-transcript", "tags": "iteration transcript", "modified": "20260424173843000", "preview": "!! 第 3 轮执行轨迹 → call search_memory({\\\"limit\\\":10,\\\"query\\\":\\\"4360dd15 rapamycin senolytics NEXT_F"}, {"title": "Iter-4360dd15-0017-transcript", "tags": "iteration transcript", "modified": "20260424181633000", "preview": "!! 第 17 轮执行轨迹 【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0029-transcript", "tags": "iteration transcript", "modified": "20260424185112000", "preview": "!! 第 29 轮执行轨迹
→ call search_memory({\"limit\":10,\"query\":\"4360dd15 NEXT_FOCUS rapamycin Table 1 full text mirror\"}) → call list_recent({\"n\":8}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0025-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424183856000\", \"preview\": \"!! 第 25 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin human trial systematic review endpoints safety\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0002-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424173549000\", \"preview\": \"!! 第 2 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies table included studies endpoints\"}) → call list_recent({\"n\":8}) → call list_tools({}) 【tool:search_memor【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0033-transcript", "tags": "iteration transcript", "modified": "20260424190229000", "preview": "!! 第 33 轮执行轨迹
→ call search_memory({\\\"limit\\\":8,\\\"query\\\":\\\"4360dd15 rapamycin review 2"}, {"title": "Iter-4360dd15-0036-transcript", "tags": "iteration transcript", "modified": "20260424191116000", "preview": "!! 第 36 轮执行轨迹 → "}, {"title": "Iter-4360dd15-0031-transcript", "tags": "iteration transcript", "modified": "20260424185743000", "preview": "!! 第 31 轮执行轨迹 → call web_fetch({"max_chars":8000,"url":"https://api.crossref.org/works/10.1016/S2666-7568(23)00258-1"})
→ call web_fetch({"max_chars":8000,"url":"https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext"})
→ call web_search({"limit":8,"query":"\"10.1016/S2666-7568(23)00258-1\" references rapamycin everolimus sirolimus"})
【tool:web_fetch】
{"ok": true, "url": "https://api.crossref.org/works/10.1016/S2666-7568(23)00258-1", "status": 200, "content_type": "application/json", "text": "{\"status\":\"ok\",\"message-type\":\"work\",\"message-version\":\"1.0.0\",\"message\":{\"indexed\":{\"date-parts\":2026,4,16,\"date-time\":\"2026-04-16T16:09:43Z\",\"timestamp\":1776355783729,\"version\":\"3.51.2\"},\"reference-coun
```