Iter-4360dd15-0032-transcript
第 32 轮执行轨迹
→ call search_memory({"limit":10,"query":"4360dd15 PMID 38310895 reference chain remaining 11 studies rapamycin review"})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0025-transcript", "tags": "iteration transcript", "modified": "20260424183856000", "preview": "!! 第 25 轮执行轨迹 → call list_recent({"n":6})
【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0031-reflection", "modified": "20260424185749000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424185749000", "tags": "pinned focus"}, {"title": "先沿参考文献链找可抓取入口", "modified": "20260424185749000", "tags": "lesson evidence-retrieval full-text paywall"}, {"title": "Iter-4360dd15-0031-transcript", "modified": "20260424185743000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0030-reflection", "modified": "20260424185413000", "tags": "iteration reflection"}, {"title": "先用可访问元数据逼近全文表格", "modified": "20260424185413000", "tags": "lesson evidence-retrieval full-text paywall"}]}
→ call read_note({"title":"NEXT_FOCUS"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0031）\n\n下一轮只做一件事：从 PMID 38310895 的参考文献链中逐条定位剩余 11 项纳入研究的可访问元数据或镜像全文。"}
→ call web_search({"limit":5,"query":"PMID 38310895 rapamycin review references included studies Table 1 2024"})
→ call pubmed_search({"limit":5,"query":"38310895 rapamycin review"})
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=PMID+38310895+rapamycin+review+references+included+studies+Table+1+2024'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:pubmed_search】
{"ok": true, "query": "38310895 rapamycin review", "results": [{"pmid": "42021550", "title": "Acupuncture: A Promising Non-Pharmacological Approach to Parkinson's Disease Management.", "source": "Brain Behav", "pubdate": "2026 Apr", "authors": ["Wu XC", "Dong YY", "Ying YC", "Yin P", "Chen YL"], "url": "https://pubmed.ncbi.nlm.nih.gov/42021550/"}, {"pmid": "42020346", "title": "Impact of Modern Strategies for Graft-Versus-Host Disease Prophylaxis on Relapse Risk in Matched-Sibling or Unrelated Donor Hematopoietic Cell Transplantation: A Systematic Review and Meta-Analysis of Randomized Trials.", "source": "Eur J Haematol", "pubdate": "2026 Apr 22", "authors": ["Arcuri LJ", "Natal VHG", "Américo AD", "Perini G", "Kerbauy MN", "Kerbauy LN", "Lima ACM", "De León AG"], "url": "https://pubmed.ncbi.nlm.nih.gov/42020346/"}, {"pmid": "42018354", "title": "Unusual Vascular Anomalies in Pediatric Hand and Plastic Surgery: A Case Series.", "source": "Ann Plast Surg", "pubdate": "2026 Apr 22", "authors": ["Sharma SC", "Jester A", "Vidyadharan R"], "url": "https://pubmed.ncbi.nlm.nih.gov/42018354/"}, {"pmid": "42014336", "title": "[The role and mechanism of autophagy regulator mTOR in renal ischemia-reperfusion injury].", "source": "Sheng Li Xue Bao", "pubdate": "2026 Apr 25", "authors": ["Luo Q", "Yang SH", "Gong X"], "url": "https://pubmed.ncbi.nlm.nih.gov/42014336/"}, {"pmid": "42014335", "title": "[The roles and regulatory mechanisms of serum and glucocorticoid-regulated kinase 1 in m
→ call search_memory({"limit":10,"query":"38310895 title rapamycin review PMID"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1 included trials endpoint\"}) → call list_recent({\"n\":6}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table Europe PMC NEXT_FOCUS\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcri → call pubmed_search({"limit":10,"query":"38310895"})
【tool:pubmed_search】
{"ok": true, "query": "38310895", "results": [{"pmid": "38310895", "title": "Targeting ageing with rapamycin and its derivatives in humans: a systematic review.", "source": "Lancet Healthy Longev", "pubdate": "2024 Feb", "authors": ["Lee DJW", "Hodzic Kuerec A", "Maier AB"], "url": "https://pubmed.ncbi.nlm.nih.gov/38310895/"}]}
→ call web_search({"limit":8,"query":"\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\" references"})
→ call web_search({"limit":8,"query":"\"38310895\" rapamycin review table 1 included studies"})
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=%22Targeting+ageing+with+rapamycin+and+its+derivatives+in+humans%3A+a+systematic+review%22+references'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=%2238310895%22+rapamycin+review+table+1+included+studies'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call search_memory({"limit":20,"query":"4360dd15 38310895 included studies 19 rapamycin table 1"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0018-transcript", "tags": "iteration transcript", "modified": "20260424182058000", "preview": "!! 第 18 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1全文 镜像\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tag → call web_fetch({"max_chars":8000,"url":"https://pubmed.ncbi.nlm.nih.gov/38310895/"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://pubmed.ncbi.nlm.nih.gov/38310895/'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call run_python({"code":"import requests, json\nfrom urllib.parse import quote\npmid='38310895'\n# Europe PMC search by PMID\nurls=[\n f'https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:{pmid}%20SRC:MED&format=json&pageSize=1',\n f'https://api.crossref.org/works?query.title={quote(\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\")}&rows=3',\n f'htt)
【tool:run_python】
{"ok": true, "stdout": "6,4,16]],\"date-time\":\"2026-04-16T16:09:43Z\",\"timestamp\":1776355783729,\"version\":\"3.51.2\"},\"reference-count\":75,\"publisher\":\"Elsevier BV\",\"issue\":\"2\",\"license\":[{\"start\":{\"date-parts\":[[2024,2,1]],\"date-time\":\"2024-02-01T00:00:00Z\",\"timestamp\":1706745600000},\"content-version\":\"tdm\",\"delay-in-days\":0,\"URL\":\"https:\\/\\/www.elsevier.com\\/tdm\\/userlicense\\/1.0\\/\"},{\"start\":{\"date-parts\":[[2024,2,1]],\"date-time\":\"2024-02-01T00:00:00Z\",\"timestamp\":1706745600000},\"content-version\":\"tdm\",\"delay-in-days\":0,\"URL\":\"https:\\/\\/www.elsevier.com\\/legal\\/tdmrep-license\"},{\"start\":{\"date-parts\":[[2023,11,24]],\"date-time\":\"2023-11-24T00:00:00Z\",\"timestamp\":1700784000000},\"content-version\":\"vor\",\"delay-in-days\":0,\"URL\":\"http:\\/\\/creativecommons.org\\/licenses\\/by\\/4.0\\/\"}],\"funder\":[{\"DOI\":\"10.13039\\/100020054\",\"name\":\"Lien Foundation\",\"doi-asserted-by\":\"publisher\",\"id\":[{\"id\":\"10.13039\\/100020054\",\"id-type\":\"DOI\",\"asserted-by\":\"publisher\"}]}],\"content-domain\":{\"domain\":[\"thelancet.com\",\"elsevier.com\",\"sciencedirect.com\"],\"crossmark-restriction\":true},\"short-container-title\":[\"The Lancet Healthy Longevity\"],\"published-print\":{\"date-parts\":[[2024,2]]},\"DOI\":\"10.1016\\/s2666-7568(23)00258-1\",\"type\":\"journal-article\",\"created\":{\"date-parts\":[[2024,2,1]],\"date-time\":\"2024-02-01T21:21:37Z\",\"timestamp\":1706822497000}
→ call run_python({"code":"import requests, json, re\nurl='https://api.crossref.org/works/10.1016/S2666-7568(23)00258-1'\nr=requests.get(url,headers={'User-Agent':'Mozilla/5.0'},timeout=30)\nprint('status',r.status_code)\nobj=r.json()['message']\nprint('keys',obj.keys())\nrefs=obj.get('reference',[])\nprint('nrefs',len(refs))\n# show refs with any title or doi or year keywords matching rapamycin/sirolimus/everolimu)
【tool:run_python】
{"ok": true, "stdout": "status 200\nkeys dict_keys(['indexed', 'reference-count', 'publisher', 'issue', 'license', 'funder', 'content-domain', 'short-container-title', 'published-print', 'DOI', 'type', 'created', 'page', 'update-policy', 'source', 'is-referenced-by-count', 'title', 'prefix', 'volume', 'author', 'member', 'reference', 'container-title', 'original-title', 'language', 'link', 'deposited', 'score', 'resource', 'subtitle', 'short-title', 'issued', 'references-count', 'journal-issue', 'alternative-id', 'URL', 'relation', 'ISSN', 'issn-type', 'subject', 'published', 'assertion'])\nnrefs 75\n\nREF 1\n{'key': '10.1016/S2666-7568(23)00258-1_bib1', 'first-page': '1160', 'article-title': 'Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950�2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019', 'year': '2020', 'DOI': '10.1016/S0140-6736(20)30977-6', 'journal-title': 'Lancet'}\n\nREF 2\n{'key': '10.1016/S2666-7568(23)00258-1_bib2', 'first-page': '1211', 'article-title': 'Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990�2016: a systematic analysis for the Global Burden of Disease Study 2016', 'author': 'Vos', 'year': '2017', 'DOI': '10.1016/S0140-6736(17)32154-2', 'journal-title': 'Lancet'}\n\nREF 3\n{'key': '10.1016/S2666-7568(23)00258-1_bib4', 'first-page': '61
→ call run_python({"code":"import requests, json, re, sys\nsys.stdout.reconfigure(encoding='utf-8')\nurl='https://api.crossref.org/works/10.1016/S2666-7568(23)00258-1'\nobj=requests.get(url,headers={'User-Agent':'Mozilla/5.0'},timeout=30).json()['message']\nrefs=obj.get('reference',[])\nkeywords=['rapamycin','sirolimus','everolimus','temsirolimus','mTOR','rapalog']\nmatches=[]\nfor ref in refs:\n blob=' '.join(s)
【tool:run_python】
{"ok": true, "stdout": "00062-3\njournal-title: Lancet Healthy Longev\n\n--- TRIALISH 4\narticle-title: A single-dose placebo- and moxifloxacin-controlled study of the effects of temsirolimus on cardiac repolarization in healthy adults\nyear: 2012\nDOI: 10.1007/s00280-012-1845-7\njournal-title: Cancer Chemother Pharmacol\n\n--- TRIALISH 5\narticle-title: Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial\nyear: 2019\nDOI: 10.1007/s11357-019-00113-y\njournal-title: Geroscience\n\n--- TRIALISH 6\narticle-title: Rapamycin does not affect post-absorptive protein metabolism in human skeletal muscle\nyear: 2013\nDOI: 10.1016/j.metabol.2012.07.003\njournal-title: Metabolism\n\n--- TRIALISH 7\narticle-title: Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis\nyear: 2009\nDOI: 10.1113/jphysiol.2008.163816\njournal-title: J Physiol\n\n--- TRIALISH 8\narticle-title: Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin\nyear: 2014\nDOI: 10.1152/ajpendo.00600.2013\njournal-title: Am J Physiol Endocrinol Metab\n\n--- TRIALISH 9\narticle-title: Dose-dependent acute effects of everolimus administration on immunological, neuroendocrine and psychological parameters in healthy men\nyear: 2020\nDOI: 10.1111/cts.12812\njournal-title: Clin Transl Sci\n\n--- TRIALISH 10\narticle-title: A r
→ call run_python({"code":"import requests, sys, json, re\nsys.stdout.reconfigure(encoding='utf-8')\nquery='TORC1 inhibition enhances immune function and reduces infections in the elderly'\n# Crossref search exact-ish title\nurl=f'https://api.crossref.org/works?query.title={requests.utils.quote(query)}&rows=5'\nr=requests.get(url,headers={'User-Agent':'Mozilla/5.0'},timeout=30)\nprint('crossref status',r.status_cod)
【tool:run_python】
{"ok": true, "stdout": "crossref status 200\n\nITEM 1\ntitle TORC1 inhibition enhances immune function and reduces infections in the elderly\nDOI 10.1126/scitranslmed.aaq1564\nyear 2018\njournal Science Translational Medicine\n\nITEM 2\ntitle Oral TORC1 Inhibitor Dactolisib Enhances Immune Function and Reduces the Incidence of Respiratory Tract Infections in Elderly Subjects with Asthma\nDOI 10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a2623\nyear 2019\njournal B15. IMMUNOTHERAPY FOR LUNG DISEASE\n\nITEM 3\ntitle TORC1 INHIBITION AS AN IMMUNOTHERAPY TO DECREASE INFECTIONS IN THE ELDERLY\nDOI 10.1093/geroni/igz038.2988\nyear 2019\njournal Innovation in Aging\n\nITEM 4\ntitle TORC1 inhibition as an immunotherapy to reduce infections in the elderly\nDOI 10.1101/230813\nyear 2017\njournal None\n\nITEM 5\ntitle TORC1 INHIBITION AS A POTENTIAL IMMUNOTHERAPY TO REDUCE INFECTIONS IN THE ELDERLY\nDOI 10.1093/geroni/igy023.2011\nyear 2018\njournal Innovation in Aging\n\nEuropePMC query TORC1 inhibition enhances immune function and reduces infections in the elderly status 200\n res 1 pmid 29997249 title TORC1 inhibition enhances immune function and reduces infections in the elderly. journal Sci Transl Med year 2018\n doi 10.1126/scitranslmed.aaq1564\n abstract \n res 2 pmid 41469379 title mTOR signaling networks: mechanistic insights and translational frontiers in disease therapeutics. journal Signal Transduct Target Ther year 2025\n doi 10.1038/s41392-025-02493-4\n abs
→ call define_tool({"name":"crossref_ref_miner","description":"从 Crossref 作品记录中抓取参考文献列表，并按关键词/临床试验特征筛出候选纳入研究；适合从综述 DOI/PMID 的参考链定位可访问元数据。","code":"import requests, re\n\n\ndef run(**kwargs):\n doi = kwargs.get('doi') or ''\n title = kwargs.get('title') or ''\n keywords = kwargs.get('keywords') or ['rapamycin','sirolimus','everolimus','temsirolimus','mTOR','torc1','rapalog']\n max_items = int(kwargs.get(')
【tool:define_tool】
{"ok": false, "error": "参数错误: tool_define_tool() missing 1 required positional argument: 'parameters'"}
【assistant】
本轮结论：
- 我没有继续死磕全文入口，而是**改用综述 DOI 的 Crossref 参考文献链**来反推纳入研究。
- 已确认该综述的参考列表中，能稳定筛出一批与 rapamycin / mTOR / human trial 相关的候选条目；这条路比直接抓全文更可复制。
- 最关键的一个可访问元数据例子是：
- **PMID 29997249**
- **题名**：*TORC1 inhibition enhances immune function and reduces infections in the elderly*
- **期刊**：*Science Translational Medicine*，2018
- **DOI**：10.1126/scitranslmed.aaq1564
- 同时，Crossref 参考链里还可直接识别到多篇高度相关的人体研究元数据，例如：
- *A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort...*
- *Topical rapamycin reduces markers of senescence and aging in human skin...*
- *Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis*
- *Rapamycin does not affect post-absorptive protein metabolism in human skeletal muscle*
- *Dose-dependent acute effects of everolimus administration on immunological, neuroendocrine and psychological parameters in healthy men*
这轮的实质进展是：**把“找不到 Table 1”转成了“能从参考链批量恢复纳入研究清单的可访问元数据”**，下一步可以继续逐条把剩余 11 项纳入研究补齐成标准化表。
<NEXT_FOCUS>下一轮只做一件事：把 Crossref 参考链里识别出的剩余纳入研究逐条映射到 PMID/DOI，并优先补全最像“长寿干预”而非仅机制研究的那几项。</NEXT_FOCUS>