Iter-4360dd15-0031-transcript
第 31 轮执行轨迹
→ call search_memory({"limit":10,"query":"4360dd15 NEXT_FOCUS Table 1 rapamycin 2024 review PMID 38310895"}) → call list_recent({"n":8})
→ call list_by_tag({"limit":12,"tag":"4360dd15"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → cal"}, {"title": "Iter-4360dd15-0025-transcript", "tags": "iteration transcript", "modified": "20260424183856000", "preview": "!! 第 25 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1全文 镜像\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹 → call search_memory({\\\"limit\\\":8,\\\"query\\\":\\\"4360dd15 rapamycin review 2024 tri"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1 included trials endpoint\"}) → call list_recent({\"n\":6}) 【tool:search_memory】 {\"ok\": true, \"results\":【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0030-reflection", "modified": "20260424185413000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424185413000", "tags": "pinned focus"}, {"title": "先用可访问元数据逼近全文表格", "modified": "20260424185413000", "tags": "lesson evidence-retrieval full-text paywall"}, {"title": "Iter-4360dd15-0030-transcript", "modified": "20260424185406000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0030-vu-research-portal-entry-without-direct-pdf-link", "modified": "20260424185400000", "tags": "fact knowledge 4360dd15 evidence retrieval"}, {"title": "Iter-4360dd15-0029-reflection", "modified": "20260424185116000", "tags": "iteration reflection"}, {"title": "先锁具体入口,再谈全文", "modified": "20260424185116000", "tags": "lesson evidence-retrieval full-text paywall"}, {"title": "Iter-4360dd15-0029-transcript", "modified": "20260424185112000", "tags": "iteration transcript"}]}
【tool:list_by_tag】
{"ok": true, "items": [{"title": "Iter-4360dd15-0030-vu-research-portal-entry-without-direct-pdf-link", "modified": "20260424185400000"}, {"title": "2024 rapamycin systematic review: abstract-level constraints and what remains missing", "modified": "20260424175824000"}, {"title": "Added included ADPKD rapalog trial CRAD001ADE12 and its body-weight endpoint", "modified": "20260424174657000"}, {"title": "Rapamycin human trials: completed studies table from PMC review", "modified": "20260424174352000"}, {"title": "Iter-4360dd15-0004-critique-rapamycin-evidence", "modified": "20260424174226000"}, {"title": "Rapamycin human trials: extracted endpoints and outcomes from the 2024 systematic review review pass 1", "modified": "20260424173529000"}, {"title": "Human longevity interventions evidence maturity matrix 2026-04-25", "modified": "20260424173237000"}]}
→ call read_note({"title":"NEXT_FOCUS"})
→ call read_note({"title":"Iter-4360dd15-0030-vu-research-portal-entry-without-direct-pdf-link"})
→ call read_note({"title":"2024 rapamycin systematic review: abstract-level constraints and what remains missing"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点(来自 mission 4360dd15 · Iter-0030)\n\n下一轮只攻克一件事:用 PMID 38310895 的参考文献链和开放元数据把 2024 综述 Table 1 剩余 11 项纳入研究逐条补全。"}
【tool:read_note】
{"ok": true, "title": "Iter-4360dd15-0030-vu-research-portal-entry-without-direct-pdf-link", "tags": "fact knowledge 4360dd15 evidence retrieval", "text": "!! 本轮核实:VU Research Portal 公开记录可访问,但页面未暴露可直接抓取的 PDF/全文链接\n\n我围绕具体条目 Targeting ageing with rapamycin and its derivatives in humans: a systematic review 做了定点验证,而不是继续泛搜。\n\n!! 可复现依据\n# OpenAlex 显示该文存在于多个位置,其中包括\n## The Lancet Healthy Longevity 的 OA 版本\n## Vrije Universiteit Amsterdam 的研究库条目\n# 研究库页面可直接打开并显示完整引文/摘要/元数据:\n## https://research.vu.nl/en/publications/bc864430-4237-4bcd-a3b3-38b3b91b2e60\n# 但我在页面 HTML 中未找到任何可直接提取的 PDF 链接、下载链接或 Table 1 导出入口。\n\n!! 代码记录\n
\nimport requests, re\nfrom bs4 import BeautifulSoup\nurl='https://research.vu.nl/en/publications/bc864430-4237-4bcd-a3b3-38b3b91b2e60'\nhtml=requests.get(url,timeout=30,headers={'User-Agent':'Mozilla/5.0'}).text\nsoup=BeautifulSoup(html,'html.parser')\nlinks=[]\nfor a in soup.find_all('a', href=True):\n h=a['href']\n txt=' '.join(a.get_text(' ',strip=True).split())\n if 'pdf' in h.lower() or 'pdf' in txt.lower() or 'download' in txt.lower() or 'full' in txt.lower():\n links.append((txt,h))\nprint('links', len(links))\nprint('DC.identifier', soup.find('meta', attrs={'name':'DC.identifier'})['content'])\n\n\n!! 结论\n这一步只证明了:具体入口 是开放可读的,但 该入口本身 不提供可直接抓取的全文或 Table 1。下一步应继续追踪它的关联记录(如作者自存档、机构库附件、DOI 解析后的其他镜像),而不是回到关键词泛搜。"}【tool:read_note】
{"ok": true, "title": "2024 rapamycin systematic review: abstract-level constraints and what remains missing", "tags": "lesson fact 4360dd15 evidence retrieval", "text": "!! What I could verify this round\nI could not yet recover the remaining 11 included-study names from the 2024 systematic review, but I did verify the paper’s abstract via PubMed XML and extracted a few important constraints.\n\n!! Verified bibliographic identity\n- PMID: 38310895\n- Title: ''Targeting ageing with rapamycin and its derivatives in humans: a systematic review.''\n- Journal: Lancet Healthy Longev 2024 Feb; 5(2):e152-e162\n- DOI: 10.1016/S2666-7568(23)00258-1\n\n!! Abstract-level findings worth retaining\nThe abstract states that:\n# 18,400 unique articles were screened\n# 19 studies were included\n# benefits were observed in the immune, cardiovascular, and integumentary systems\n# no significant effects were found in the endocrine, muscular, or neurological systems\n# respiratory, digestive, renal, and reproductive systems were not assessed\n# no serious adverse events attributed to rapamycin/derivatives were reported in healthy individuals\n# in individuals with ageing-related diseases, infections and lipid increases were reported\n\n!! Why this matters\nThis is stronger than a generic \"rapamycin is anti-aging\" claim, but still weaker than a study-level map. The review’s abstract already tells us the evidence is:\n- multi-system but fragmented\n- partly positive in healthy or ageing-
→ call read_note({"title":"Rapamycin human trials: completed studies table from PMC review"})
→ call read_note({"title":"Rapamycin human trials: extracted endpoints and outcomes from the 2024 systematic review review pass 1"})
→ call read_note({"title":"Added included ADPKD rapalog trial CRAD001ADE12 and its body-weight endpoint"})
【tool:read_note】
{"ok": true, "title": "Rapamycin human trials: completed studies table from PMC review", "tags": "knowledge fact 4360dd15", "text": "!! PMC review Table 1: completed human rapamycin / rapalog trials\n\nI re-read the accessible PMC review Blazing a trail for the clinical use of rapamycin as a geroprotecTOR (GeroScience 2023; PMCID PMC10643772) and extracted its completed-trial table.\n\n!! What this source actually contains\nThe table lists ''8 completed human studies'' and gives each study’s primary endpoint.\n\n!! Extracted trial list\n| Study | Agent | Population | Primary endpoint |\n|---|---|---|---|\n| Krebs et al. 2007 | rapamycin | 11 men, 28 ± 1 y | Increase in peripheral insulin sensitivity during insulin clamp plus amino acid infusion |\n| Drummond et al. 2009 | rapamycin | 15 men, 29 ± 2 y | Difference in post-resistance-exercise mixed-muscle protein synthesis rates |\n| Gunderman 2014 | rapamycin | 16 men, 26 ± 1 y | Difference in post-blood-flow-restricted resistance-exercise mixed-muscle protein synthesis rates |\n| Mannick et al. 2014 | everolimus | 218 adults ≥65 y | Improvement in influenza vaccination response |\n| Mannick et al. 2018 | everolimus / BEZ235 | 264 adults ≥65 y | Improvement in influenza vaccination response |\n| Kraig et al. 2018 | rapamycin | 25 healthy adults 70–95 y | Immunological response |\n| Chung et al. 2019 | topical rapamycin | 36 adults with aging skin >40 y | Decreased p16-positive senescent cells in skin |\n| Mannick et al. 20
【tool:read_note】
{"ok": true, "title": "Rapamycin human trials: extracted endpoints and outcomes from the 2024 systematic review review pass 1", "tags": "knowledge fact experiment 4360dd15", "text": "!! Rapamycin human trial evidence from a 2024 systematic review\nThis round I narrowed the long-longevity question to a single mechanism: rapamycin / mTOR.\n\n!! Source\nTargeting ageing with rapamycin and its derivatives in humans: a systematic review (Lee, Hodzic Kuerec, Maier), Lancet Healthy Longevity 2024; 5(2):e152-e162. The VU repository page includes the abstract and full bibliographic metadata.\n\n!! Extracted human trial snapshot\nThe review reports: 18,400 unique records screened, 19 included studies. Benefits were seen mainly in immune, cardiovascular, and integumentary systems; no significant effects in endocrine, muscular, or neurological systems.\n\n| Study | Population | Agent | Dose / schedule | Design | Primary endpoint | Result |\n|---|---|---|---|---|---|---|\n| Krebs et al. 2007 | 11 men, 28 +/- 1 y | rapamycin | 6 mg single dose | randomized, double-blind, placebo-controlled, crossover | peripheral insulin sensitivity during insulin clamp + amino acid infusion | met |\n| Drummond et al. 2009 | 15 men, 29 +/- 2 y | rapamycin | 12 mg single dose 2 h before resistance exercise | acute exercise +/- rapamycin | post-exercise mixed-muscle protein synthesis | met |\n| Gunderman 2014 | 16 men, 26 +/- 1 y | rapamycin | 16 mg single dose 1 h before blood-flow-restricted re
【tool:read_note】
{"ok": true, "title": "Added included ADPKD rapalog trial CRAD001ADE12 and its body-weight endpoint", "tags": "knowledge fact 4360dd15", "text": "!! Added included human trial from the 2024 rapamycin/mTOR systematic review\n\nI chased one study that was *not* in the already-extracted 8-study PMC table: the ADPKD everolimus trial subanalysis published in Journal of Cachexia, Sarcopenia and Muscle (2023).\n\n!! Trial identity\n* ''CRAD001ADE12'' — a 2-year randomized controlled trial in adults with autosomal-dominant polycystic kidney disease (ADPKD)\n* Drug: ''everolimus'' (mTOR inhibitor / rapalog), not rapamycin itself\n\n!! Extracted primary endpoint / main outcome focus\nThe publication’s abstract explicitly centers on ''body weight course'' and reports ''sex-specific body weight loss'' during everolimus therapy, especially in women.\n\n!! Key abstract facts (verbatim-level summary)\n- Trial population: 433 adult ADPKD patients (everolimus n=215; placebo n=218)\n- The authors state that within the 2-year CRAD001ADE12 trial, women on everolimus lost more weight than placebo (P=0.0029)\n- They also report lower caloric intake and altered thermogenesis/fat oxidation on everolimus\n\n!! Why this matters for the mission\nThis is a concrete example of how the 2024 review’s 19 included studies are broader than the earlier 8-study completed-table snapshot: it adds an ADPKD / metabolic outcome study under the same mTOR-inhibition umbrella.\n\n!! Citation trail\n- PubMed record:
→ call web_search({"limit":8,"query":"PMID 38310895 references rapamycin systematic review 19 included studies open metadata"})
→ call web_search({"limit":8,"query":"\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\" references"})
→ call web_search({"limit":8,"query":"38310895 Europe PMC citations rapamycin human trials"})
【tool:web_search】
{"ok": false, "error": "[SSL: UNEXPECTED_EOF_WHILE_READING] EOF occurred in violation of protocol (_ssl.c:1028)"}
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=%22Targeting+ageing+with+rapamycin+and+its+derivatives+in+humans%3A+a+systematic+review%22+references'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_search】
{"ok": true, "query": "38310895 Europe PMC citations rapamycin human trials", "results": []}
→ call web_search({"limit": 10, "query":"\"38310895\" rapamycin review references PMID"})
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=%2238310895%22+rapamycin+review+references+PMID'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call pubmed_search({"limit":10,"query":"38310895"})
→ call web_fetch({"max_chars":5000,"url":"https://pubmed.ncbi.nlm.nih.gov/38310895/"})
→ call web_fetch({"max_chars":5000,"url":"https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=38310895&retmode=xml"})
【tool:pubmed_search】
{"ok": true, "query": "38310895", "results": [{"pmid": "38310895", "title": "Targeting ageing with rapamycin and its derivatives in humans: a systematic review.", "source": "Lancet Healthy Longev", "pubdate": "2024 Feb", "authors": ["Lee DJW", "Hodzic Kuerec A", "Maier AB"], "url": "https://pubmed.ncbi.nlm.nih.gov/38310895/"}]}
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://pubmed.ncbi.nlm.nih.gov/38310895/'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": true, "url": "https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pubmed&id=38310895&retmode=xml", "status": 200, "content_type": "text/xml; charset=UTF-8", "text": "38310895 2024 02 14 2026 03 17 2666-7568 5 2 2024 Feb The lancet. Healthy longevity Lancet Healthy Longev Targeting ageing with rapamycin and its derivatives in humans: a systematic review. e152 e162 e152-e162 10.1016/S2666-7568(23)00258-1 S2666-7568(23)00258-1 Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases. Overall, no significant effects on the endocrine, muscular, or neurological systems were found. The effects of rapamycin or its derivatives on the respiratory, digestive, renal, and reproductive systems were not assessed. No serious adverse events attributed to rapamycin and its derivatives were reported in healthy individuals; however, there were increased numbers of infections and increases in total cholesterol, LDL cholesterol, and triglycerides in individuals with ageing-related
→ call web_search({"limit":10,"query":"OpenAlex PMID 38310895 references"})
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=OpenAlex+PMID+38310895+references'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_fetch({"max_chars":8000,"url":"https://api.openalex.org/works/https://doi.org/10.1016/S2666-7568(23)00258-1"})
→ call web_fetch({"max_chars":8000,"url":"https://api.openalex.org/works?filter=doi:10.1016/S2666-7568(23)00258-1"})
→ call web_fetch({"max_chars":8000,"url":"https://api.crossref.org/works/10.1016/S2666-7568(23)00258-1"})
【tool:web_fetch】
{"ok": true, "url": "https://api.openalex.org/works/https://doi.org/10.1016/S2666-7568(23)00258-1", "status": 200, "content_type": "application/json", "text": "{\"id\":\"https://openalex.org/W4391544908\",\"doi\":\"https://doi.org/10.1016/s2666-7568(23)00258-1\",\"title\":\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\",\"display_name\":\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\",\"publication_year\":2024,\"publication_date\":\"2024-02-01\",\"ids\":{\"openalex\":\"https://openalex.org/W4391544908\",\"doi\":\"https://doi.org/10.1016/s2666-7568(23)00258-1\",\"pmid\":\"https://pubmed.ncbi.nlm.nih.gov/38310895\"},\"language\":\"en\",\"primary_location\":{\"id\":\"doi:10.1016/s2666-7568(23)00258-1\",\"is_oa\":true,\"landing_page_url\":\"https://doi.org/10.1016/s2666-7568(23)00258-1\",\"pdf_url\":\"http://www.thelancet.com/article/S2666756823002581/pdf\",\"source\":{\"id\":\"https://openalex.org/S4210210722\",\"display_name\":\"The Lancet Healthy Longevity\",\"issn_l\":\"2666-7568\",\"issn\":[\"2666-7568\"],\"is_oa\":true,\"is_in_doaj\":true,\"is_core\":true,\"host_organization\":\"https://openalex.org/P4310320990\",\"host_organization_name\":\"Elsevier BV\",\"host_organization_lineage\":[\"https://openalex.org/P4310320990\"],\"host_organization_lineage_names\":[\"Elsevier BV\"],\"type\":\"journal\"},\"license\":\"cc-by\",\"license_id\":\"https://openalex.org/licenses/cc-by\",\"version\":\"publishedVer
【tool:web_fetch】
{"ok": true, "url": "https://api.openalex.org/works?filter=doi:10.1016/S2666-7568(23)00258-1", "status": 200, "content_type": "application/json", "text": "{\"meta\": {\"count\": 1, \"db_response_time_ms\": 13, \"page\": 1, \"per_page\": 25, \"groups_count\": null, \"cost_usd\": 0.0001}, \"results\": [{\"id\": \"https://openalex.org/W4391544908\", \"doi\": \"https://doi.org/10.1016/s2666-7568(23)00258-1\", \"title\": \"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\", \"display_name\": \"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\", \"publication_year\": 2024, \"publication_date\": \"2024-02-01\", \"ids\": {\"openalex\": \"https://openalex.org/W4391544908\", \"doi\": \"https://doi.org/10.1016/s2666-7568(23)00258-1\", \"pmid\": \"https://pubmed.ncbi.nlm.nih.gov/38310895\"}, \"language\": \"en\", \"primary_location\": {\"id\": \"doi:10.1016/s2666-7568(23)00258-1\", \"is_oa\": true, \"landing_page_url\": \"https://doi.org/10.1016/s2666-7568(23)00258-1\", \"pdf_url\": \"http://www.thelancet.com/article/S2666756823002581/pdf\", \"source\": {\"id\": \"https://openalex.org/S4210210722\", \"display_name\": \"The Lancet Healthy Longevity\", \"issn_l\": \"2666-7568\", \"issn\": [\"2666-7568\"], \"is_oa\": true, \"is_in_doaj\": true, \"is_core\": true, \"host_organization\": \"https://openalex.org/P4310320990\", \"host_organization_name\": \"Elsevier BV\", \"host_organization_lineage\": [\"https://openalex.org/P4
【tool:web_fetch】
{"ok": true, "url": "https://api.crossref.org/works/10.1016/S2666-7568(23)00258-1", "status": 200, "content_type": "application/json", "text": "{\"status\":\"ok\",\"message-type\":\"work\",\"message-version\":\"1.0.0\",\"message\":{\"indexed\":{\"date-parts\":2026,4,16,\"date-time\":\"2026-04-16T16:09:43Z\",\"timestamp\":1776355783729,\"version\":\"3.51.2\"},\"reference-count\":75,\"publisher\":\"Elsevier BV\",\"issue\":\"2\",\"license\":[{\"start\":{\"date-parts\":2024,2,1,\"date-time\":\"2024-02-01T00:00:00Z\",\"timestamp\":1706745600000},\"content-version\":\"tdm\",\"delay-in-days\":0,\"URL\":\"https:\\/\\/www.elsevier.com\\/tdm\\/userlicense\\/1.0\\/\"},{\"start\":{\"date-parts\":2024,2,1,\"date-time\":\"2024-02-01T00:00:00Z\",\"timestamp\":1706745600000},\"content-version\":\"tdm\",\"delay-in-days\":0,\"URL\":\"https:\\/\\/www.elsevier.com\\/legal\\/tdmrep-license\"},{\"start\":{\"date-parts\":2023,11,24,\"date-time\":\"2023-11-24T00:00:00Z\",\"timestamp\":1700784000000},\"content-version\":\"vor\",\"delay-in-days\":0,\"URL\":\"http:\\/\\/creativecommons.org\\/licenses\\/by\\/4.0\\/\"}],\"funder\":[{\"DOI\":\"10.13039\\/100020054\",\"name\":\"Lien Foundation\",\"doi-asserted-by\":\"publisher\",\"id\":[{\"id\":\"10.13039\\/100020054\",\"id-type\":\"DOI\",\"asserted-by\":\"publisher\"}]}],\"content-domain\":{\"domain\":[\"thelancet.com\",\"elsevier.com\",\"sciencedirect.com\"],\"crossmark-restriction\":true},\"short-container-title\":[\"The Lancet Healthy L
→ call web_fetch({"max_chars":8000,"url":"https://www.thelancet.com/article/S2666756823002581/fulltext"})
→ call web_fetch({"max_chars":8000,"url":"https://www.thelancet.com/article/S2666756823002581/pdf"})
→ call web_fetch({"max_chars":8000,"url":"https://doi.org/10.1016/S2666-7568(23)00258-1"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/article/S2666756823002581/fulltext'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/article/S2666756823002581/pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": true, "url": "https://linkinghub.elsevier.com/retrieve/pii/S2666756823002581", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Redirecting", "truncated": false}
→ call run_python({"code":"import requests, json, re\nfrom collections import Counter\nurl='https://api.crossref.org/works/10.1016/S2666-7568(23)00258-1'\nmsg=requests.get(url,timeout=30).json()['message']\nrefs=msg.get('reference',[])\nprint('refs',len(refs))\n# Print all refs with human-trial-like clues\nkeywords=['rapa','sirol','everol','rtb','bez235','mTOR','healthy','vaccine','influenza','skin','trial','humans)
【tool:run_python】
{"ok": true, "stdout": "refs 75\nmatched 59\n---\n{'author': None, 'year': '2020', 'article-title': 'Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950�2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019', 'journal-title': 'Lancet', 'DOI': '10.1016/S0140-6736(20)30977-6', 'PMID': None, 'first-page': '1160'}\n---\n{'author': 'Papadopoli', 'year': '2019', 'article-title': 'mTOR as a central regulator of lifespan and aging', 'journal-title': 'F1000Res', 'DOI': '10.12688/f1000research.17196.1', 'PMID': None, 'first-page': '998'}\n---\n{'author': 'Weichhart', 'year': '2018', 'article-title': 'mTOR as regulator of lifespan, aging, and cellular senescence: a mini-review', 'journal-title': 'Gerontology', 'DOI': '10.1159/000484629', 'PMID': None, 'first-page': '127'}\n---\n{'author': 'Weichhart', 'year': '2015', 'article-title': 'Regulation of innate immune cell function by mTOR', 'journal-title': 'Nat Rev Immunol', 'DOI': '10.1038/nri3901', 'PMID': None, 'first-page': '599'}\n---\n", "stderr": "Traceback (most recent call last):\n File \"C:\\Users\\yh599\\Documents\\GitHub\\LLM-yh\\Sisyphus\\workspace\\_run_1777056984824.py\", line 17, in <module>\n print({k:r.get(k) for k in ['author','year','article-title','journal-title','DOI','PMID','first-page']})\n ~~~~~^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^
→ call run_python({"code":"import requests, json, re, unicodedata\nmsg=requests.get('https://api.crossref.org/works/10.1016/S2666-7568(23)00258-1',timeout=30).json()['message']\nrefs=msg.get('reference',[])\n# normalize and fi
```