Iter-4360dd15-0029-transcript
第 29 轮执行轨迹
→ call search_memory({"limit":10,"query":"4360dd15 NEXT_FOCUS rapamycin Table 1 full text mirror"}) → call list_recent({"n":8})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0025-transcript", "tags": "iteration transcript", "modified": "20260424183856000", "preview": "!! 第 25 轮执行轨迹
→ call search_memory({\\\"limit\\\":8,\\\"query\\\":\\\"4360dd15 rapamycin review 2024 tri"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹 → cal"}, {"title": "Iter-4360dd15-0018-transcript", "tags": "iteration transcript", "modified": "20260424182058000", "preview": "!! 第 18 轮执行轨迹 【tool:list_recent】
{"ok": true, "items": [{"title": "Error-20260425-024620", "modified": "20260424184620000", "tags": "error iteration"}, {"title": "Iter-4360dd15-0027-reflection", "modified": "20260424184550000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424184550000", "tags": "pinned focus"}, {"title": "先用题名+DOI锁入口", "modified": "20260424184550000", "tags": "lesson evidence-retrieval full-text paywall"}, {"title": "Iter-4360dd15-0027-transcript", "modified": "20260424184545000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0026-reflection", "modified": "20260424184205000", "tags": "iteration reflection"}, {"title": "先找可读镜像再抽表", "modified": "20260424184205000", "tags": "lesson evidence-retrieval full-text paywall"}, {"title": "Iter-4360dd15-0026-transcript", "modified": "20260424184154000", "tags": "iteration transcript"}]}
→ call read_note({"title":"NEXT_FOCUS"})
→ call list_by_tag({"limit":20,"tag":"4360dd15"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0027）\n\n下一轮只攻克一个子问题：找到这篇 Lancet 综述的可读全文镜像或仓储副本，并直接提取 Table 1。"}
【tool:list_by_tag】
{"ok": true, "items": [{"title": "2024 rapamycin systematic review: abstract-level constraints and what remains missing", "modified": "20260424175824000"}, {"title": "Added included ADPKD rapalog trial CRAD001ADE12 and its body-weight endpoint", "modified": "20260424174657000"}, {"title": "Rapamycin human trials: completed studies table from PMC review", "modified": "20260424174352000"}, {"title": "Iter-4360dd15-0004-critique-rapamycin-evidence", "modified": "20260424174226000"}, {"title": "Rapamycin human trials: extracted endpoints and outcomes from the 2024 systematic review review pass 1", "modified": "20260424173529000"}, {"title": "Human longevity interventions evidence maturity matrix 2026-04-25", "modified": "20260424173237000"}]}
→ call search_memory({"limit":10,"query":"4360dd15 rapamycin 2024 systematic review Lancet DOI title"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1 included trials endpoint\"}) → call list_recent({\"n\":6}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1全文 镜像\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\" → call search_memory({"limit":10,"query":"4360dd15 Lancet rapamycin review title DOI systematic review 19 studies"})
→ call read_note({"title":"2024 rapamycin systematic review: abstract-level constraints and what remains missing"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0025-transcript", "tags": "iteration transcript", "modified": "20260424183856000", "preview": "!! 第 25 轮执行轨迹 【tool:read_note】
{"ok": true, "title": "2024 rapamycin systematic review: abstract-level constraints and what remains missing", "tags": "lesson fact 4360dd15 evidence retrieval", "text": "!! What I could verify this round\nI could not yet recover the remaining 11 included-study names from the 2024 systematic review, but I did verify the paper’s abstract via PubMed XML and extracted a few important constraints.\n\n!! Verified bibliographic identity\n- PMID: 38310895\n- Title: ''Targeting ageing with rapamycin and its derivatives in humans: a systematic review.''\n- Journal: Lancet Healthy Longev 2024 Feb; 5(2):e152-e162\n- DOI: 10.1016/S2666-7568(23)00258-1\n\n!! Abstract-level findings worth retaining\nThe abstract states that:\n# 18,400 unique articles were screened\n# 19 studies were included\n# benefits were observed in the immune, cardiovascular, and integumentary systems\n# no significant effects were found in the endocrine, muscular, or neurological systems\n# respiratory, digestive, renal, and reproductive systems were not assessed\n# no serious adverse events attributed to rapamycin/derivatives were reported in healthy individuals\n# in individuals with ageing-related diseases, infections and lipid increases were reported\n\n!! Why this matters\nThis is stronger than a generic \"rapamycin is anti-aging\" claim, but still weaker than a study-level map. The review’s abstract already tells us the evidence is:\n- multi-system but fragmented\n- partly positive in healthy or ageing-
→ call web_search({"limit":8,"query":"\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\" pdf"})
→ call web_search({"limit":8,"query":"\"10.1016/S2666-7568(23)00258-1\" pdf"})
→ call web_search({"limit":8,"query":"site:pmc.ncbi.nlm.nih.gov rapamycin derivatives humans systematic review Lancet Healthy Longev pdf"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\" pdf", "results": []}
【tool:web_search】
{"ok": true, "query": "\"10.1016/S2666-7568(23)00258-1\" pdf", "results": []}
【tool:web_search】
{"ok": true, "query": "site:pmc.ncbi.nlm.nih.gov rapamycin derivatives humans systematic review Lancet Healthy Longev pdf", "results": []}
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\""})
→ call web_search({"limit":10,"query":"\"38310895\" Europe PMC"})
→ call web_search({"limit":10,"query":"\"10.1016/S2666-7568(23)00258-1\" Europe PMC"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\"", "results": []}
【tool:web_search】
{"ok": true, "query": "\"38310895\" Europe PMC", "results": []}
【tool:web_search】
{"ok": true, "query": "\"10.1016/S2666-7568(23)00258-1\" Europe PMC", "results": []}
→ call web_search({"limit":10,"query":"\"10.1016/S2666-7568(23)00258-1\" unpaywall"})
→ call web_search({"limit":10,"query":"\"10.1016/S2666-7568(23)00258-1\" open access"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" open access"})
【tool:web_search】
{"ok": true, "query": "\"10.1016/S2666-7568(23)00258-1\" unpaywall", "results": []}
【tool:web_search】
{"ok": true, "query": "\"10.1016/S2666-7568(23)00258-1\" open access", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" open access", "results": []}
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\" author"})
→ call web_search({"limit":10,"query":"rapamycin humans systematic review Lancet Healthy Longev author pdf"})
→ call web_search({"limit":10,"query":"site:researchgate.net rapamycin humans systematic review Lancet Healthy Longev"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\" author", "results": []}
【tool:web_search】
{"ok": true, "query": "rapamycin humans systematic review Lancet Healthy Longev author pdf", "results": []}
【tool:web_search】
{"ok": true, "query": "site:researchgate.net rapamycin humans systematic review Lancet Healthy Longev", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.researchgate.net/publication/377976071_Targeting_ageing_with_rapamycin_and_its_derivatives_in_humans_a_systematic_review", "snippet": "A recent systematic review of human studies suggested Rapamycin and its derivatives to be effective in improving the age-related physiological parameters [69]."}, {"title": "(PDF) What is the clinical evidence to support off-label rapamycin ...", "url": "https://www.researchgate.net/publication/394390184_What_is_the_clinical_evidence_to_support_off-label_rapamycin_therapy_in_healthy_adults", "snippet": "Low dose rapamycin therapy has been proposed as a longevity candidate in healthy aging adults. We present a review of the evidence for low dose rapamycin and rapalog therapies in healthy human ..."}, {"title": "The bioavailability and blood levels of low-dose rapamycin for ...", "url": "https://www.researchgate.net/publication/388461685_The_bioavailability_and_blood_levels_of_low-dose_rapamycin_for_longevity_in_real-world_cohorts_of_normative_aging_individuals", "snippet": "Taken together, our findings suggest that individualized dosing and routine monitoring of blood rapamycin levels should be utilized to ensure optimal dosing and efficacy for healthy longevity."}, {"title": "PDF The bioavailability and blood levels of low‐dose r
→ call web_fetch({"max_chars":6000,"url":"https://www.researchgate.net/publication/377976071_Targeting_ageing_with_rapamycin_and_its_derivatives_in_humans_a_systematic_review"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.researchgate.net/publication/377976071_Targeting_ageing_with_rapamycin_and_its_derivatives_in_humans_a_systematic_review'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":10,"query":"\"377976071\" pdf"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\" pdf filetype:pdf"})
→ call web_search({"limit":10,"query":"\"rapamycin and its derivatives in humans\" pdf"})
→ call web_search({"limit":10,"query":"\"379976071\" rapamycin derivatives humans systematic review"})
【tool:web_search】
{"ok": true, "query": "\"377976071\" pdf", "results": [{"title": "SCI LA CREUSE - Societe.com", "url": "https://www.societe.com/societe/sci-la-creuse-377976071.html", "snippet": "SCI LA CREUSE, société civile immobilière, immatriculée sous le SIREN 377976071 , est active depuis 32 ans. Implantée à SAINT-AGNANT-DE-VERSILLAT (23300), elle est spécialisée dans le secteur d'activité de la location de terrains et d'autres biens immobiliers."}, {"title": "SCI La Creuse (23300) : siret, siren, TVA, adresse...", "url": "https://entreprises.lefigaro.fr/sci-la-creuse-23/entreprise-377976071", "snippet": "SCI LA CREUSE Numéro Siren : 377976071 Numéro Siret : 37797607100011 (siège de l'entreprise) Numéro TVA intracommunautaire : FR68377976071 (en savoir plus) Greffe : RCS Guéret Code NAF / APE : 6820B (location de terrains et d'autres biens immobiliers) Forme juridique : Société civile immobilière Date d'immatriculation : 02/05/1990 ..."}, {"title": "Wrench on a Colored Background.Cubism. Stock Illustration ...", "url": "https://www.dreamstime.com/wrench-colored-background-cubism-illustration-shows-hand-tool-open-end-wrench-image377976071", "snippet": "Illustration about the illustration shows a hand tool, an open-end wrench. Illustration of iron, beautiful, build - 377976071"}, {"title": "Saint-Agnant-de-Versillat (23300) - Annuaire Entreprises", "url": "https://www.eterritoire.fr/territoires/nouvelle-aquitaine/creuse/saint-agnant-de-versillat/23177/8542?annuair
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\" pdf filetype:pdf", "results": [{"title": "PDF mTOR inhibitors and aging should we take account of their potential?", "url": "https://www.bayes.citystgeorges.ac.uk/__data/assets/pdf_file/0005/836078/MARTIN-Chris.pdf", "snippet": "Trials of mTOR inhibitors on markers of aging Lee DJW, Hodzic Kuerec A, Maier AB. Targeting ageing with rapamycin and its derivatives in humans: a systematic review . Lancet Healthy Longev. 2024;5(2):e152-62."}, {"title": "PDF The Biochemical Basis of Hormesis - bioRxiv", "url": "https://www.biorxiv.org/content/10.64898/2026.04.20.719646v1.full.pdf", "snippet": "[17] Deborah J W Lee, Ajla Hodzic Kuerec and Andrea B Maier, \" Targeting ageing with rapamycin and its derivatives in humans: a systematic review ,\" The Lancet Healthy Longevity 5 (2024): e152-e162."}, {"title": "PDF Supplementary appendix - The Lancet", "url": "https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf", "snippet": "Supplement to: Lee DJW, Hodzic Kuerec A, Maier AB. Targeting ageing with rapamycin and its derivatives in humans: a systematic review . Lancet Healthy Longev 2024; 5: e152-62."}]}
【tool:web_search】
{"ok": true, "query": "\"rapamycin and its derivatives in humans\" pdf", "results": [{"title": "PDF Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf", "snippet": "Deborah J W Lee*, Ajla Hodzic Kuerec*, Andrea B Maier Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the efects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.bohrium.com/paper-details/targeting-ageing-with-rapamycin-and-its-derivatives-in-humans-a-systematic-review/977530253830259671-81675", "snippet": "Rapamycin and it
【tool:web_search】
{"ok": true, "query": "\"379976071\" rapamycin derivatives humans systematic review", "results": []}
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext"})
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf"})
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":10,"query":"\"PIIS2666-7568(23)00258-1\" mmc1 pdf"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\" \"Table 1\""})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" \"included studies\""})
→ call web_search({"limit":10,"query":"\"Lee\" Hodzic Kuerec Maier rapamycin humans table 1"})
【tool:web_search】
{"ok": true, "query": "\"PIIS2666-7568(23)00258-1\" mmc1 pdf", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review\" \"Table 1\"", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" \"included studies\"", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Lee\" Hodzic Kuerec Maier rapamycin humans table 1", "results": []}
→ call web_search({"limit":10,"query":"site:rapamycin.news \"Targeting ageing with rapamycin and its derivatives in humans\""})
→ call web_search({"limit":10,"query":"site:rapamycin.news rapamycin systematic review 19 included studies table"})
→ call web_search({"limit":10,"query":"site:reddit.com rapamycin systematic review 19 included studies lancet"})
→ call web_search({"limit":10,"query":"site:pubmed.ncbi.nlm.nih.gov 38310895"})
【tool:web_search】
{"ok": true, "query": "site:rapamycin.news \"Targeting ageing with rapamycin and its derivatives in humans\"", "results": []}
【tool:web_search】
{"ok": true, "query": "site:rapamycin.news rapamycin systematic review 19 included studies table", "results": []}
【tool:web_search】
{"ok": true, "query": "site:reddit.com rapamycin systematic review 19 included studies lancet", "results": []}
【tool:web_search】
{"ok": true, "query": "site:pubmed.ncbi.nlm.nih.gov 38310895", "results": []}
→ call web_search({"limit":10,"query":"\"PIIS2666-7568(23)00258-1\" archive.org"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" archive.org"})
→ call web_search({"limit":10,"query":"\"10.1016/S2666-7568(23)00258-1\" archive"})
→ call web_search({"limit":10,"query":"\"PIIS2666-7568(23)00258-1\" \"html\""})
【tool:web_search】
{"ok": true, "query": "\"PIIS2666-7568(23)00258-1\" archive.org", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" archive.org", "results": []}
【tool:web_search】
{"ok": true, "query": "\"10.1016/S2666-7568(23)00258-1\" archive", "results": []}
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=%22PIIS2666-7568%2823%2900258-1%22+%22html%22'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【assistant】
本轮结论（critic 视角）：
- 目标论文身份已再次锁定，无歧义：
- 标题：**Targeting ageing with rapamycin and its derivatives in humans: a systematic review**
- 期刊：**Lancet Healthy Longev**
- DOI：**10.1016/S2666-7568(23)00258-1**
- PMID：**38310895**
- 我继续验证了一个关键事实：**真正的瓶颈不是“找不到论文”，而是“找不到可读全文入口”**。
- 本轮最重要的负面结果是：
- 直接抓取 **The Lancet fulltext / pdf / supplementary appendix** 全部仍被 **403** 拦截；
- 常规 web 搜索没有给出可直接读取的镜像或仓储副本；
- 因此，**“先找到可读全文镜像再抽 Table 1”** 这条路线到目前为止仍未打通。
严厉判断：
当前积累里最可能失败的点，不是文献理解，而是**对“外部可读镜像必然存在”的隐含假设**。到现在为止，这个假设没有证据支撑。继续在出版社入口上硬撞，边际收益极低。
本轮留下的最强新线索：
- 搜索结果明确暴露了 **Lancet PDF 链接** 和 **supplementary appendix attachment 链接**，说明入口存在，但**访问权限阻断**。
- 这意味着下一步应从“寻找全文”转为“用可见线索重建 Table 1”。
<NEXT_FOCUS>只做一件事：沿着搜索结果暴露的 supplementary appendix / PDF 线索，尝试从可见摘要、片段和引用链中重建 Table 1 的 included studies 名单。</NEXT_FOCUS>
```