Iter-4360dd15-0026-transcript

修改：20260424184154000

第 26 轮执行轨迹

  → call search_memory({"limit":8,"query":"4360dd15 rapamycin 2024 systematic review Table 1 full text mirror Europe PMC"})
  → call list_recent({"n":8})
  → call list_tools({})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0025-transcript", "tags": "iteration transcript", "modified": "20260424183856000", "preview": "!! 第 25 轮执行轨迹

→ call search_memory({\"limit\":10,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1全文镜像\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹

   → call search_memory({\\\"limit\\\":8,\\\"query\\\":\\\"4360dd15 rapamycin review 2024 tri"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹

   → cal"}, {"title": "Iter-4360dd15-0018-transcript", "tags": "iteration transcript", "modified": "20260424182058000", "preview": "!! 第 18 轮执行轨迹

【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0025-reflection", "modified": "20260424183902000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424183902000", "tags": "pinned focus"}, {"title": "先锁定可读全文入口", "modified": "20260424183902000", "tags": "lesson evidence-retrieval full-text paywall"}, {"title": "Iter-4360dd15-0025-transcript", "modified": "20260424183856000", "tags": "iteration transcript"}, {"title": "Error-20260425-023540", "modified": "20260424183540000", "tags": "error iteration"}, {"title": "Iter-4360dd15-0023-reflection", "modified": "20260424183436000", "tags": "iteration reflection"}, {"title": "先找可读镜像再抽表", "modified": "20260424183436000", "tags": "lesson evidence-retrieval full-text paywall"}, {"title": "Iter-4360dd15-0023-transcript", "modified": "20260424183427000", "tags": "iteration transcript"}]}

【tool:list_tools】
{"ok": true, "tools": [{"name": "search_memory", "description": "在 TiddlyWiki 长期记忆中按关键字搜索（支持中文空格分隔），返回标题、标签、预览。每轮迭代开始前应先调用以回忆。", "custom": false}, {"name": "read_note", "description": "读取某一条 tiddler 的完整正文。", "custom": false}, {"name": "write_note", "description": "向 TiddlyWiki 写入（或覆盖）一条 tiddler。这是 Sisyphus 的长期记忆入口——每轮至少写一条。建议标签：knowledge, experiment, reflection, plan, idea, fact, question, lesson。TiddlyWiki 标记：!! 小标题，''粗体''，斜体，其它tiddler。", "custom": false}, {"name": "list_recent", "description": "列出最近修改过的 tiddler。", "custom": false}, {"name": "list_by_tag", "description": "按标签列出相关 tiddler。", "custom": false}, {"name": "run_python", "description": "在 workspace/ 下以子进程执行一段 Python 代码，返回 stdout/stderr。用于计算、模拟、验证假设、抓取公开数据（禁止任何破坏性操作）。", "custom": false}, {"name": "read_file", "description": "读取 workspace/ 下的某个文件。", "custom": false}, {"name": "write_file", "description": "向 workspace/ 下写入文件（默认覆盖，append=true 时追加）。", "custom": false}, {"name": "list_files", "description": "列出 workspace/ 下的文件。", "custom": false}, {"name": "web_fetch", "description": "抓取任意公开 URL（GET），返回剥离 HTML 后的纯文本。适合读论文摘要、文档、博客、百科。", "custom": false}, {"name": "web_search", "description": "用 DuckDuckGo 搜索互联网，返回 title/url/snippet 列表。找入口、找链接、调研时用。", "custom": false}, {"name": "wiki_search", "description": "维基百科搜索：返回若干条目的摘要和 URL。lang 默认 en，可传 zh 等。", "custom": false}, {"name": "arxiv_search", "description": "arXiv 论文检索：标题/作者/摘要/链接。理论、数学、物理、CS、bio 类前沿论文的主入口。", "custom": false}, {"name": "pubmed_search", "descriptio

→ call read_note({"title":"NEXT_FOCUS"})

【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0025）\n\n下一轮只做一件事：锁定该综述的可读全文镜像并直接提取 Table 1 原文。"}

→ call search_memory({"limit":10,"query":"4360dd15 rapamycin 19 studies Lancet Healthy Longevity review Table 1"})

→ call pubmed_search({"limit":5,"query":"rapamycin 19 studies review Lancet Healthy Longevity Table 1"})

→ call web_search({"limit":8,"query":"site:thelancet.com rapamycin 19 studies review Lancet Healthy Longevity Table 1"})

【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0025-transcript", "tags": "iteration transcript", "modified": "20260424183856000", "preview": "!! 第 25 轮执行轨迹

   → call search_memory({\"limit\":10,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1全文 镜像\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹

→ call search_memory({\\\"limit\\\":8,\\\"query\\\":\\\"4360dd15 rapamycin review 2024 tri"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹

   → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"})    → call list_recent({\"n\":8})    → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"})  【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹

→ cal"}, {"title": "Iter-4360dd15-0018-transcript", "tags": "iteration transcript", "modified": "20260424182058000", "preview": "!! 第 18 轮执行轨迹

→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies full text PDF Table 1\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:pubmed_search】 {"ok": true, "query": "rapamycin 19 studies review Lancet Healthy Longevity Table 1", "results": []} 【tool:web_search】 {"ok": true, "query": "site:thelancet.com rapamycin 19 studies review Lancet Healthy Longevity Table 1", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in ... - The Lancet", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "PDF Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the efects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies ."}, {"title": "The Lancet Healthy Longevity Home Page", "url": "https://www.thelancet.com/journals/lanhl/home", "snippet": "Read open access articles from The Lancet Healthy Longevity , a multi-disciplinary journal that publishes clinically-focused longevity and healthy ageing research and review"}, {"title": "The Lancet", "url": "https://www.thel → call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext"}) → call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf"}) → call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf"}) 【tool:web_fetch】 {"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"} 【tool:web_fetch】 {"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"} 【tool:web_fetch】 {"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"} → call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" PDF"}) → call web_search({"limit":10,"query":"\"PIIS2666-7568(23)00258-1\" PDF"}) → call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" manuscript repository"}) 【tool:web_search】 {"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" PDF", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "PDF Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf", "snippet": "Deborah J W Lee*, Ajla Hodzic Kuerec*, Andrea B Maier Rapamyc 【tool:web_search】 {"ok": true, "query": "\"PIIS2666-7568(23)00258-1\" PDF", "results": []} 【tool:web_search】 {"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" manuscript repository", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.researchgate.net/publication/377976071_Targeting_ageing_with_rapamycin_and_its_derivatives_in_humans_a_systematic_review", " → call web_fetch({"max_chars":12000,"url":"https://europepmc.org/article/MED/38310895"}) → call web_fetch({"max_chars":12000,"url":"https://www.research.vu.nl/en/publications/targeting-ageing-with-rapamycin-and-its-derivatives-in-humans-a-s"}) → call web_fetch({"max_chars":12000,"url":"https://nutrition-evidence.com/article/501551/targeting-ageing-with-rapamycin-and-its-derivatives-in-humans-a-systematic-review"}) 【tool:web_fetch】 {"ok": true, "url": "https://europepmc.org/article/MED/38310895", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false} 【tool:web_fetch】 {"ok": false, "error": "[SSL: UNEXPECTED_EOF_WHILE_READING] EOF occurred in violation of protocol (_ssl.c:1028)"} 【tool:web_fetch】 {"ok": true, "url": "https://nutrition-evidence.com/article/501551/targeting-ageing-with-rapamycin-and-its-derivatives-in-humans-a-systematic-review", "status": 200, "content_type": "text/html; charset=utf-8", "text": "Article - Targeting ageing with rapamycin and its derivatives in humans: a systematic review. - Nutrition Evidence Database Search NED Journals NED Infobites NED Articles Login Search Advanced search Home Search NED Journals Infobites Editorial board Expert Reviewers Dashboard Alerts Favourites Searches Account management Logout 1) { setInterval(() => { this.currentIndex = (this.currentIndex + 1) % this.advertisements.length; }, 5000); } } }\" class=\"w-full px-4 pt-6 print:hidden\" > Targeting ageing with rapamycin and its derivatives in humans: a systematic review. Andrea B Maier, Deborah J W Lee, Ajla Hodzic Kuerec Journal: The lancet. Healthy longevity 2024;5(2):e152-e162 PMID: 38310895 Free Full Text on Elsevier Science View on PubMed Abstract Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or ind → call web_search({"limit":10,"query":"Europe PMC full text XML API article PMID 38310895"}) 【tool:web_search】 {"ok": false, "error": "[SSL: UNEXPECTED_EOF_WHILE_READING] EOF occurred in violation of protocol (_ssl.c:1028)"} → call web_search({"limit":8,"query":"\"38310895\" Europe PMC XML full text"}) → call web_search({"limit":8,"query":"\"PMID 38310895\" full text xml Europe PMC"}) → call web_search({"limit":8,"query":"site:europepmc.org/article/MED/38310895 xml"}) 【tool:web_search】 {"ok": true, "query": "\"38310895\" Europe PMC XML full text", "results": [{"title": "A systematic review study of Rapamycin", "url": "https://rapamycinlongevitylab.substack.com/p/a-systematic-review-study-of-rapamycin", "snippet": "Last month Ajla Hodzic Kuerec, Deborah Lee and Andrea Maier published a very interesting systematic review of Rapamycin and rapalogs (pubmed: 38310895 ). A systematic review is a review that gathers together different research studies within an area and based on that analyzes and summarizes these. These types of reviews are generally seen as a way of providing the highest level of scientific ..."}, {"title": "Rapamycin Longevity Lab's Substack - reletter.com", "url": "https://reletter.com/publications/rapamycin-longevity-labs-substack", "snippet": "Last month Ajla Hodzic Kuerec, Deborah Lee and Andrea Maier published a very interesting systematic review of Rapamycin and rapalogs (pubmed: 38310895 ). A systematic review is a review that gathers together different research studies within..."}]} 【tool:web_search】 {"ok": true, "query": "\"PMID 38310895\" full text xml Europe PMC", "results": []} 【tool:web_search】 {"ok": true, "query": "site:europepmc.org/article/MED/38310895 xml", "results": []} → call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" \"Table 1\""}) → call web_search({"limit":10,"query":"\"rapamycin and its derivatives\" \"Table 1\" included studies"}) → call web_search({"limit":10,"query":"\"e152-e162\" rapamycin Table 1"}) 【tool:web_search】 {"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" \"Table 1\"", "results": []} 【tool:web_search】 {"ok": true, "query": "\"rapamycin and its derivatives\" \"Table 1\" included studies", "results": []} 【tool:web_search】 {"ok": true, "query": "\"e152-e162\" rapamycin Table 1", "results": []} → call web_fetch({"max_chars":12000,"url":"https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/fullTextXML"}) → call web_fetch({"max_chars":12000,"url":"https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/"}) → call web_fetch({"max_chars":12000,"url":"https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/abstract"}) 【tool:web_fetch】 {"ok": false, "error": "Client error '404 Not Found' for url 'https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/fullTextXML'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/404"} 【tool:web_fetch】 {"ok": false, "error": "Client error '404 Not Found' for url 'https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/404"} 【tool:web_fetch】 {"ok": false, "error": "Client error '404 Not Found' for url 'https://www.ebi.ac.uk/europepmc/webservices/rest/MED/38310895/abstract'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/404"} → call web_fetch({"max_chars":12000,"url":"https://www.sciencedirect.com/science/article/pii/S2666756823002581"}) → call web_search({"limit":8,"query":"\"S2666756823002581\" open access table 1"}) → call web_search({"limit":8,"query":"\"PIIS2666-7568(23)00258-1\" open access"}) 【tool:web_fetch】 {"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.sciencedirect.com/science/article/pii/S2666756823002581'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"} 【tool:web_search】 {"ok": true, "query": "\"S2666756823002581\" open access table 1", "results": []} 【tool:web_search】 {"ok": true, "query": "\"PIIS2666-7568(23)00258-1\" open access", "results": []} → call web_search({"limit":10,"query":"Europe PMC \"Targeting ageing with rapamycin and its derivatives in humans\" PMCID"}) → call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" PMCID"}) → call web_search({"limit":10,"query":"site:pmc.ncbi.nlm.nih.gov rapamycin derivatives humans systematic review 2024"}) 【tool:web_search】 {"ok": true, "query": "Europe PMC \"Targeting ageing with rapamycin and its derivatives in humans\" PMCID", "results": []} 【tool:web_search】 {"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" PMCID", "results": []} 【tool:web_search】 {"ok": true, "query": "site:pmc.ncbi.nlm.nih.gov rapamycin derivatives humans systematic review 2024", "results": []} → call run_python({"code":"import requests, json, re\nurl='https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:38310895&format=json&pageSize=5'\nresp=requests.get(url,timeout=20)\nprint(resp.status_code)\nprint(resp.text[:2000])", "timeout": 30}) 【tool:run_python】 {"ok": true, "stdout": "200\n{\"version\":\"6.9\",\"hitCount\":1,\"request\":{\"queryString\":\"EXT_ID:38310895\",\"resultType\":\"lite\",\"cursorMark\":\"*\",\"pageSize\":5,\"sort\":\"\",\"synonym\":false},\"resultList\":{\"result\":[{\"id\":\"38310895\",\"source\":\"MED\",\"pmid\":\"38310895\",\"doi\":\"10.1016/s2666-7568(23)00258-1\",\"title\":\"Targeting ageing with rapamycin and its derivatives in humans: a systematic review.\",\"authorString\":\"Lee DJW, Hodzic Kuerec A, Maier AB.\",\"journalTitle\":\"Lancet Healthy Longev\",\"issue\":\"2\",\"journalVolume\":\"5\",\"pubYear\":\"2024\",\"journalIssn\":\"2666-7568\",\"pageInfo\":\"e152-e162\",\"pubType\":\"research support, non-u.s. gov't; systematic review; journal article\",\"isOpenAccess\":\"N\",\"inEPMC\":\"N\",\"inPMC\":\"N\",\"hasPDF\":\"N\",\"hasBook\":\"N\",\"hasSuppl\":\"N\",\"citedByCount\":96,\"hasReferences\":\"Y\",\"hasTextMinedTerms\":\"Y\",\"hasDbCrossReferences\":\"N\",\"hasLabsLinks\":\"Y\",\"hasTMAccessionNumbers\":\"N\",\"firstIndexDate\":\"2024-02-05\",\"firstPublicationDate\":\"2024-02-01\"}]}}\n", "stderr": "", "returncode": 0} → call web_search({"limit":10,"query":"\"10.1016/S2666-7568(23)00258-1\" pdf filetype:pdf"}) → call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" filetype:pdf"}) → call web_search({"limit":10,"query":"\"Lee DJW\" rapamycin derivatives humans pdf"}) 【tool:web_search】 {"ok": true, "query": "\"10.1016/S2666-7568(23)00258-1\" pdf filetype:pdf", "results": []} 【tool:web_search】 {"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" filetype:pdf", "results": []} 【tool:web_search】 {"ok": true, "query": "\"Lee DJW\" rapamycin derivatives humans pdf", "results": []} 【assistant】本轮结论： - 已**确认目标综述**的精确信息： **Targeting ageing with rapamycin and its derivatives in humans: a systematic review** PMID **38310895**，DOI **10.1016/S2666-7568(23)00258-1**，发表于 **Lancet Healthy Longev. 2024;5(2):e152–e162**。 - 通过多条入口验证后，当前**仍没有拿到可解析全文镜像**： - The Lancet fulltext / PDF / supplementary appendix 均 **403** - ScienceDirect 页面也 **403** - Europe PMC 元数据明确显示 **isOpenAccess = N**, **inPMC = N**, **hasPDF = N** - 因此，本轮的有效状态是：**目标文献已锁定，但 Table 1 原文仍未可得**。现在不能继续泛搜摘要层面，必须转向**能暴露表格文本的二级镜像/索引页**。

<NEXT_FOCUS>下一轮只做一件事：搜索能直接暴露该综述 Table 1 文本的二级镜像或文本抓取源（如转载页、引用页、缓存页、镜像 PDF OCR 结果），并把 Table 1 的条目原文逐行提取出来。</NEXT_FOCUS>