Iter-4360dd15-0025-transcript
第 25 轮执行轨迹
→ call search_memory({"limit":10,"query":"4360dd15 rapamycin 2024 systematic review 19 studies Table 1全文 镜像"})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0018-transcript", "tags": "iteration transcript", "modified": "20260424182058000", "preview": "!! 第 18 轮执行轨迹 → call list_recent({"n":8})
【tool:list_recent】
{"ok": true, "items": [{"title": "Error-20260425-023540", "modified": "20260424183540000", "tags": "error iteration"}, {"title": "Iter-4360dd15-0023-reflection", "modified": "20260424183436000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424183436000", "tags": "pinned focus"}, {"title": "先找可读镜像再抽表", "modified": "20260424183436000", "tags": "lesson evidence-retrieval full-text paywall"}, {"title": "Iter-4360dd15-0023-transcript", "modified": "20260424183427000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0022-reflection", "modified": "20260424183147000", "tags": "iteration reflection"}, {"title": "先绕开 403 再抽表", "modified": "20260424183147000", "tags": "lesson evidence-retrieval full-text paywall"}, {"title": "Iter-4360dd15-0022-transcript", "modified": "20260424183142000", "tags": "iteration transcript"}]}
→ call read_note({"title":"NEXT_FOCUS"})
→ call list_tools({})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0023）\n\n只做一件事：从一个真正可读的全文镜像拿到 Table 1 原文文本。"}
【tool:list_tools】
{"ok": true, "tools": [{"name": "search_memory", "description": "在 TiddlyWiki 长期记忆中按关键字搜索（支持中文空格分隔），返回标题、标签、预览。每轮迭代开始前应先调用以回忆。", "custom": false}, {"name": "read_note", "description": "读取某一条 tiddler 的完整正文。", "custom": false}, {"name": "write_note", "description": "向 TiddlyWiki 写入（或覆盖）一条 tiddler。这是 Sisyphus 的长期记忆入口——每轮至少写一条。建议标签：knowledge, experiment, reflection, plan, idea, fact, question, lesson。TiddlyWiki 标记：!! 小标题，''粗体''，斜体，其它tiddler。", "custom": false}, {"name": "list_recent", "description": "列出最近修改过的 tiddler。", "custom": false}, {"name": "list_by_tag", "description": "按标签列出相关 tiddler。", "custom": false}, {"name": "run_python", "description": "在 workspace/ 下以子进程执行一段 Python 代码，返回 stdout/stderr。用于计算、模拟、验证假设、抓取公开数据（禁止任何破坏性操作）。", "custom": false}, {"name": "read_file", "description": "读取 workspace/ 下的某个文件。", "custom": false}, {"name": "write_file", "description": "向 workspace/ 下写入文件（默认覆盖，append=true 时追加）。", "custom": false}, {"name": "list_files", "description": "列出 workspace/ 下的文件。", "custom": false}, {"name": "web_fetch", "description": "抓取任意公开 URL（GET），返回剥离 HTML 后的纯文本。适合读论文摘要、文档、博客、百科。", "custom": false}, {"name": "web_search", "description": "用 DuckDuckGo 搜索互联网，返回 title/url/snippet 列表。找入口、找链接、调研时用。", "custom": false}, {"name": "wiki_search", "description": "维基百科搜索：返回若干条目的摘要和 URL。lang 默认 en，可传 zh 等。", "custom": false}, {"name": "arxiv_search", "description": "arXiv 论文检索：标题/作者/摘要/链接。理论、数学、物理、CS、bio 类前沿论文的主入口。", "custom": false}, {"name": "pubmed_search", "descriptio
→ call web_search({"limit":8,"query":"rapamycin 2024 systematic review 19 studies Table 1 human trial review Lancet Healthy Longevity"})
→ call pubmed_search({"limit":5,"query":"rapamycin systematic review 19 studies Table 1 human trial 2024"})
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=rapamycin+2024+systematic+review+19+studies+Table+1+human+trial+review+Lancet+Healthy+Longevity'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:pubmed_search】
{"ok": true, "query": "rapamycin systematic review 19 studies Table 1 human trial 2024", "results": []}
→ call search_memory({"limit":8,"query":"4360dd15 Europe PMC rapamycin review 19 studies Lancet Healthy Longevity Table 1"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0018-transcript", "tags": "iteration transcript", "modified": "20260424182058000", "preview": "!! 第 18 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies full text PDF Table 1\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹 → cal"}, {"title": "Iter-4360dd15-0014-transcript", "tags": "iteration transcript", "modified": "20260424181020000", "preview": "!! 第 14 轮执行轨迹 → call pubmed_search({"limit":10,"query":"rapamycin review 2024 human trial older adults"})
→ call web_fetch({"max_chars":6000,"url":"https://europepmc.org/search?query=rapamycin%20systematic%20review%202024"})
【tool:pubmed_search】
{"ok": true, "query": "rapamycin review 2024 human trial older adults", "results": [{"pmid": "40995631", "title": "Multiplex Apolipoprotein Panel Improves Cardiovascular Event Prediction and Cardiovascular Outcome by Identifying Patients Who Benefit From Targeted PCSK9 Inhibitor Therapy.", "source": "Arterioscler Thromb Vasc Biol", "pubdate": "2025 Nov", "authors": ["Reijnders E", "Bossuyt PM", "Jukema JW", "Ruhaak LR", "Romijn FPHTM", "Szarek M", "Trompet S", "Bhatt DL"], "url": "https://pubmed.ncbi.nlm.nih.gov/40995631/"}, {"pmid": "40673988", "title": "One-year outcomes of the drug eluting stent in the treatment of severe vertebral artery ostium stenosis: single-center experience.", "source": "Neurosurg Rev", "pubdate": "2025 Jul 17", "authors": ["Qin Y", "Zhang L", "Han J", "Li B", "Xu H", "Zhang B", "Jing Y"], "url": "https://pubmed.ncbi.nlm.nih.gov/40673988/"}, {"pmid": "40545616", "title": "Outcomes of Solid Organ Transplant Recipients With Advanced Cancers Receiving Immune Checkpoint Inhibitors: A Systematic Review and Individual Participant Data Meta-Analysis.", "source": "JAMA Oncol", "pubdate": "2025 Oct 1", "authors": ["Saleem N", "Wang J", "Rejuso A", "Teixeira-Pinto A", "Stephens JH", "Wilson A", "Kieu A", "Gately RP"], "url": "https://pubmed.ncbi.nlm.nih.gov/40545616/"}, {"pmid": "39627758", "title": "A liver transplant patient developed renal injury on tacrolimus and experienced worsening renal function and rhabdomyolysis after switching to sirolimus: a case r
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/search?query=rapamycin%20systematic%20review%202024", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
→ call search_memory({"limit":10,"query":"4360dd15 exact article title rapamycin systematic review Lancet Healthy Longevity 19 studies"})
→ call search_memory({"limit":10,"query":"4360dd15 Europe PMC PMID rapamycin systematic review"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1 included trials endpoint\"}) → call list_recent({\"n\":6}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies full text PDF Table 1\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0014-transcript", "tags": "iteration transcript", "modified": "20260424181020000", "preview": "!! 第 14 轮执行轨迹 → call search_memory({\\\"limit\\\":8,\\\"query\\\":\\\"4360dd15 rapamycin r"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call pubmed_search({"limit":20,"query":"rapamycin healthy longevity systematic review human trials Lancet Healthy Longevity"})
→ call web_fetch({"max_chars":8000,"url":"https://europepmc.org/search?query=rapamycin%20healthy%20longevity%20systematic%20review"})
【tool:pubmed_search】
{"ok": true, "query": "rapamycin healthy longevity systematic review human trials Lancet Healthy Longevity", "results": []}
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/search?query=rapamycin%20healthy%20longevity%20systematic%20review", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
→ call web_fetch({"max_chars":12000,"url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=rapamycin%20systematic%20review%202024%20human%20trial&format=json&pageSize=10"})
【tool:web_fetch】
{"ok": true, "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=rapamycin%20systematic%20review%202024%20human%20trial&format=json&pageSize=10", "status": 200, "content_type": "application/json;charset=UTF-8", "text": "{\"version\":\"6.9\",\"hitCount\":2915,\"nextCursorMark\":\"AoIIQIyKIyg1MzgzMzY2MQ==\",\"nextPageUrl\":\"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=rapamycin systematic review 2024 human trial&cursorMark=AoIIQIyKIyg1MzgzMzY2MQ==&resultType=lite&pageSize=10&format=json\",\"request\":{\"queryString\":\"rapamycin systematic review 2024 human trial\",\"resultType\":\"lite\",\"cursorMark\":\"*\",\"pageSize\":10,\"sort\":\"\",\"synonym\":false},\"resultList\":{\"result\":[{\"id\":\"41907457\",\"source\":\"MED\",\"pmid\":\"41907457\",\"pmcid\":\"PMC13032750\",\"fullTextIdList\":{\"fullTextId\":[\"PMC13032750\"]},\"doi\":\"10.7717/peerj.21024\",\"title\":\"The effects of intravenous immunoglobulin on intestinal inflammation: a systematic review of animal and clinical studies.\",\"authorString\":\"Chu T, Yuan X, Wang T, Zhang W, Yan X, Li C, Jiang P, Ye S, Ma L, Sun P, Du X, Fu P, Wang Z.\",\"journalTitle\":\"PeerJ\",\"journalVolume\":\"14\",\"pubYear\":\"2026\",\"journalIssn\":\"2167-8359\",\"pageInfo\":\"e21024\",\"pubType\":\"research-article; systematic review; journal article\",\"isOpenAccess\":\"Y\",\"inEPMC\":\"Y\",\"inPMC\":\"Y\",\"hasPDF\":\"Y\",\"hasBook\":\"N\",\"hasSuppl\":\"Y\",\"citedByCount\":0,\"hasReferences\":\"N\"
→ call web_fetch({"max_chars":12000,"url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22rapamycin%22%20AND%20%22systematic%20review%22%20AND%20%22human%22&format=json&pageSize=25"})
【tool:web_fetch】
{"ok": true, "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22rapamycin%22%20AND%20%22systematic%20review%22%20AND%20%22human%22&format=json&pageSize=25", "status": 200, "content_type": "application/json;charset=UTF-8", "text": "{\"version\":\"6.9\",\"hitCount\":6065,\"nextCursorMark\":\"AoIIQDntbig1NTIwMTY3Mw==\",\"nextPageUrl\":\"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=\\\"rapamycin\\\" AND \\\"systematic review\\\" AND \\\"human\\\"&cursorMark=AoIIQDntbig1NTIwMTY3Mw==&resultType=lite&format=json\",\"request\":{\"queryString\":\"\\\"rapamycin\\\" AND \\\"systematic review\\\" AND \\\"human\\\"\",\"resultType\":\"lite\",\"cursorMark\":\"*\",\"pageSize\":25,\"sort\":\"\",\"synonym\":false},\"resultList\":{\"result\":[{\"id\":\"41644863\",\"source\":\"MED\",\"pmid\":\"41644863\",\"doi\":\"10.1007/s12035-026-05714-1\",\"title\":\"Trends and Research Frontiers in Mammalian Target of Rapamycin and Alzheimer's Disease.\",\"authorString\":\"Ma Z, Xiao Z, Yang Z, Huang B, Wang X.\",\"journalTitle\":\"Mol Neurobiol\",\"issue\":\"1\",\"journalVolume\":\"63\",\"pubYear\":\"2026\",\"journalIssn\":\"0893-7648; 1559-1182; \",\"pageInfo\":\"421\",\"pubType\":\"systematic review; review; journal article\",\"isOpenAccess\":\"N\",\"inEPMC\":\"N\",\"inPMC\":\"N\",\"hasPDF\":\"N\",\"hasBook\":\"N\",\"hasSuppl\":\"N\",\"citedByCount\":0,\"hasReferences\":\"Y\",\"hasTextMinedTerms\":\"Y\",\"hasDbCrossReferences\":\"N\",\"hasLabsLinks\":\"Y\",\"hasTMAc
→ call web_fetch({"max_chars":12000,"url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22rapamycin%22%20%2219%20studies%22&format=json&pageSize=20"})
→ call web_fetch({"max_chars":12000,"url":"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22rapamycin%22%20%22Table%201%22%20systematic%20review&format=json&pageSize=20"})
【tool:web_fetch】
{"ok": true, "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22rapamycin%22%20%2219%20studies%22&format=json&pageSize=20", "status": 200, "content_type": "application/json;charset=UTF-8", "text": "{\"version\":\"6.9\",\"hitCount\":629,\"nextCursorMark\":\"AoIIP6ccDCg1MzM4MTQ2OQ==\",\"nextPageUrl\":\"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=\\\"rapamycin\\\" \\\"19 studies\\\"&cursorMark=AoIIP6ccDCg1MzM4MTQ2OQ==&resultType=lite&pageSize=20&format=json\",\"request\":{\"queryString\":\"\\\"rapamycin\\\" \\\"19 studies\\\"\",\"resultType\":\"lite\",\"cursorMark\":\"*\",\"pageSize\":20,\"sort\":\"\",\"synonym\":false},\"resultList\":{\"result\":[{\"id\":\"41051985\",\"source\":\"MED\",\"pmid\":\"41051985\",\"pmcid\":\"PMC12501467\",\"fullTextIdList\":{\"fullTextId\":[\"PMC12501467\"]},\"doi\":\"10.1177/1098612x251380011\",\"title\":\"Clinical therapeutics in feline medicine: updates for old and new drugs.\",\"authorString\":\"Susi IR, Viviano K, Whitehouse WH.\",\"journalTitle\":\"J Feline Med Surg\",\"issue\":\"10\",\"journalVolume\":\"27\",\"pubYear\":\"2025\",\"journalIssn\":\"1098-612x; 1532-2750; \",\"pageInfo\":\"1098612X251380011\",\"pubType\":\"review-article; review; journal article\",\"isOpenAccess\":\"Y\",\"inEPMC\":\"Y\",\"inPMC\":\"Y\",\"hasPDF\":\"Y\",\"hasBook\":\"N\",\"hasSuppl\":\"N\",\"citedByCount\":0,\"hasReferences\":\"Y\",\"hasTextMinedTerms\":\"Y\",\"hasDbCrossReferences\":\"N\",\"hasLabsLinks\":\"Y\",\"hasTMAccess
【tool:web_fetch】
{"ok": true, "url": "https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=%22rapamycin%22%20%22Table%201%22%20systematic%20review&format=json&pageSize=20", "status": 200, "content_type": "application/json;charset=UTF-8", "text": "{\"version\":\"6.9\",\"hitCount\":13363,\"nextCursorMark\":\"AoIIQUSBcyg1NTE4MTc1NA==\",\"nextPageUrl\":\"https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=\\\"rapamycin\\\" \\\"Table 1\\\" systematic review&cursorMark=AoIIQUSBcyg1NTE4MTc1NA==&resultType=lite&pageSize=20&format=json\",\"request\":{\"queryString\":\"\\\"rapamycin\\\" \\\"Table 1\\\" systematic review\",\"resultType\":\"lite\",\"cursorMark\":\"*\",\"pageSize\":20,\"sort\":\"\",\"synonym\":false},\"resultList\":{\"result\":[{\"id\":\"41888906\",\"source\":\"MED\",\"pmid\":\"41888906\",\"pmcid\":\"PMC13063915\",\"fullTextIdList\":{\"fullTextId\":[\"PMC13063915\"]},\"doi\":\"10.1186/s12964-026-02829-9\",\"title\":\"Macrophage-associated kinase signaling in atherosclerosis - a systematic review.\",\"authorString\":\"Müller JS, van der Vorst EPC.\",\"journalTitle\":\"Cell Commun Signal\",\"issue\":\"1\",\"journalVolume\":\"24\",\"pubYear\":\"2026\",\"journalIssn\":\"1478-811x\",\"pageInfo\":\"218\",\"pubType\":\"review-article; review; journal article\",\"isOpenAccess\":\"Y\",\"inEPMC\":\"Y\",\"inPMC\":\"Y\",\"hasPDF\":\"Y\",\"hasBook\":\"N\",\"hasSuppl\":\"N\",\"citedByCount\":0,\"hasReferences\":\"Y\",\"hasTextMinedTerms\":\"Y\",\"hasDbCrossReferences\":\"N\",\"hasLab
→ call search_memory({"limit":10,"query":"4360dd15 19 studies rapamycin review exact title older adults"})
→ call search_memory({"limit":10,"query":"4360dd15 sirolimus rapamycin review 19 studies"})
→ call search_memory({"limit":10,"query":"4360dd15 table 1 included studies rapamycin review older adults"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1 included trials endpoint\"}) → call list_recent({\"n\":6}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies full text PDF Table 1\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call search_memory({\\\"limit\\"}, {"