Iter-4360dd15-0022-transcript
第 22 轮执行轨迹
→ call search_memory({"limit":10,"query":"4360dd15 rapamycin 2024 systematic review 19 studies table 1"}) → call list_recent({"n":10})
→ call list_by_tag({"limit":20,"tag":"pinned focus"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0018-transcript", "tags": "iteration transcript", "modified": "20260424182058000", "preview": "!! 第 18 轮执行轨迹 【tool:list_recent】
{"ok": true, "items": [{"title": "Error-20260425-022733", "modified": "20260424182733000", "tags": "error iteration"}, {"title": "Iter-4360dd15-0020-reflection", "modified": "20260424182646000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424182646000", "tags": "pinned focus"}, {"title": "先拿可访问全文入口", "modified": "20260424182646000", "tags": "lesson evidence-retrieval full-text paywall"}, {"title": "Iter-4360dd15-0020-transcript", "modified": "20260424182641000", "tags": "iteration transcript"}, {"title": "Error-20260425-022327", "modified": "20260424182327000", "tags": "error iteration"}, {"title": "Iter-4360dd15-0018-reflection", "modified": "20260424182104000", "tags": "iteration reflection"}, {"title": "先找可抓取全文入口", "modified": "20260424182104000", "tags": "lesson evidence-retrieval full-text paywall"}, {"title": "Iter-4360dd15-0018-transcript", "modified": "20260424182058000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0017-reflection", "modified": "20260424181640000", "tags": "iteration reflection"}]}
【tool:list_by_tag】
{"ok": true, "items": []}
→ call read_note({"title":"NEXT_FOCUS"})
→ call list_tools({})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0020）\n\n下一轮只攻一个最窄问题：从可访问的全文镜像或替代来源拿到该综述Table 1，并逐行抽取19项纳入研究名称与各自主要终点。"}
【tool:list_tools】
{"ok": true, "tools": [{"name": "search_memory", "description": "在 TiddlyWiki 长期记忆中按关键字搜索（支持中文空格分隔），返回标题、标签、预览。每轮迭代开始前应先调用以回忆。", "custom": false}, {"name": "read_note", "description": "读取某一条 tiddler 的完整正文。", "custom": false}, {"name": "write_note", "description": "向 TiddlyWiki 写入（或覆盖）一条 tiddler。这是 Sisyphus 的长期记忆入口——每轮至少写一条。建议标签：knowledge, experiment, reflection, plan, idea, fact, question, lesson。TiddlyWiki 标记：!! 小标题，''粗体''，斜体，其它tiddler。", "custom": false}, {"name": "list_recent", "description": "列出最近修改过的 tiddler。", "custom": false}, {"name": "list_by_tag", "description": "按标签列出相关 tiddler。", "custom": false}, {"name": "run_python", "description": "在 workspace/ 下以子进程执行一段 Python 代码，返回 stdout/stderr。用于计算、模拟、验证假设、抓取公开数据（禁止任何破坏性操作）。", "custom": false}, {"name": "read_file", "description": "读取 workspace/ 下的某个文件。", "custom": false}, {"name": "write_file", "description": "向 workspace/ 下写入文件（默认覆盖，append=true 时追加）。", "custom": false}, {"name": "list_files", "description": "列出 workspace/ 下的文件。", "custom": false}, {"name": "web_fetch", "description": "抓取任意公开 URL（GET），返回剥离 HTML 后的纯文本。适合读论文摘要、文档、博客、百科。", "custom": false}, {"name": "web_search", "description": "用 DuckDuckGo 搜索互联网，返回 title/url/snippet 列表。找入口、找链接、调研时用。", "custom": false}, {"name": "wiki_search", "description": "维基百科搜索：返回若干条目的摘要和 URL。lang 默认 en，可传 zh 等。", "custom": false}, {"name": "arxiv_search", "description": "arXiv 论文检索：标题/作者/摘要/链接。理论、数学、物理、CS、bio 类前沿论文的主入口。", "custom": false}, {"name": "pubmed_search", "descriptio
→ call web_search({"limit":8,"query":"rapamycin 2024 systematic review 19 studies Table 1 human trials primary endpoints"})
→ call pubmed_search({"limit":8,"query":"rapamycin systematic review 2024 19 studies human trials"})
→ call arxiv_search({"limit":5,"query":"rapamycin systematic review 2024 human trials"})
【tool:web_search】
{"ok": true, "query": "rapamycin 2024 systematic review 19 studies Table 1 human trials primary endpoints", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Articles included in this systematic review met the following criteria: the mean or median age of the study cohort was 18 years or older; outcomes on ageing-related physiological changes or disease were reported; and they were interventional studies with rapamycin or its derivatives (no restriction on the method). Articles were excluded if in vitro or animal models were used; rapamycin or its ..."}, {"title": "Big Review paper: Targeting ageing with rapamycin and its derivatives ...", "url": "https://www.rapamycin.news/t/big-review-paper-targeting-ageing-with-rapamycin-and-its-derivatives-in-humans-lancetlongevity/11965", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "Blazing a trail for the clinical use of rapamycin as a geroprotecTOR", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10643772/", "snippet": "It is important to note that this is not an endorsement for or against the use of m
【tool:pubmed_search】
{"ok": true, "query": "rapamycin systematic review 2024 19 studies human trials", "results": []}
【tool:arxiv_search】
{"ok": true, "query": "rapamycin systematic review 2024 human trials", "results": [{"title": "Trust and Trustworthiness from Human-Centered Perspective in HRI -- A Systematic Literature Review", "authors": ["Debora Firmino de Souza", "Sonia Sousa", "Kadri Kristjuhan-Ling", "Olga Dunajeva", "Mare Roosileht", "Avar Pentel", "Mati Mõttus", "Mustafa Can Özdemir"], "published": "2025-01-31", "summary": "The Industry 5.0 transition highlights EU efforts to design intelligent devices that can work alongside humans to enhance human capabilities, and such vision aligns with user preferences and needs to feel safe while collaborating with such systems take priority. This demands a human-centric research vision and requires a societal and educational shift in how we perceive technological advancements. To better understand this perspective, we conducted a systematic literature review focusing on understanding how trust and trustworthiness can be key aspects of supporting this move towards Industry 5.0. This review aims to overview the most common methodologies and measurements and collect insights about barriers and facilitators for fostering trustworthy HRI. After a rigorous quality assessment following the Systematic Reviews and Meta-Analyses guidelines, using rigorous inclusion criteria and screening by at least two reviewers, 34 articles were included in the review. The findings underscores the significance of trust and safety as foundational elements for promoting secure and trustw
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext"})
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" Table 1 PDF mirror"})
→ call web_search({"limit":10,"query":"site:pmc.ncbi.nlm.nih.gov \"Targeting ageing with rapamycin and its derivatives in humans\""})
→ call web_search({"limit":10,"query":"\"PIIS2666-7568(23)00258-1\" PDF"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" Table 1 PDF mirror", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.researchgate.net/publication/377976071_Targeting_ageing_with_rapamycin_and_its_derivatives_in_humans_a_systematic_review", "sni
【tool:web_search】
{"ok": true, "query": "site:pmc.ncbi.nlm.nih.gov \"Targeting ageing with rapamycin and its derivatives in humans\"", "results": []}
【tool:web_search】
{"ok": true, "query": "\"PIIS2666-7568(23)00258-1\" PDF", "results": []}
→ call web_fetch({"max_chars":12000,"url":"https://europepmc.org/article/MED/38310895"})
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/38310895", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
→ call web_search({"limit":10,"query":"\"10.1016/S2666-7568(23)00258-1\" full text"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" institutional repository pdf"})
→ call web_search({"limit":10,"query":"\"38310895\" rapamycin full text"})
【tool:web_search】
{"ok": true, "query": "\"10.1016/S2666-7568(23)00258-1\" full text", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" institutional repository pdf", "results": []}
【tool:web_search】
{"ok": true, "query": "\"38310895\" rapamycin full text", "results": []}
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" mmc1 pdf"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" supplementary appendix"})
→ call web_search({"limit":10,"query":"\"Lancet Healthy Longev\" rapamycin appendix table 1"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" mmc1 pdf", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" supplementary appendix", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Lancet Healthy Longev\" rapamycin appendix table 1", "results": []}
→ call web_search({"limit":10,"query":"\"19 included studies\" rapamycin derivatives humans review study names"})
→ call web_search({"limit":10,"query":"\"rapamycin and its derivatives in humans\" 19 studies table 1"})
→ call web_search({"limit":10,"query":"\"Deborah J W Lee\" rapamycin table 1 studies"})
【tool:web_search】
{"ok": true, "query": "\"19 included studies\" rapamycin derivatives humans review study names", "results": []}
【tool:web_search】
{"ok": true, "query": "\"rapamycin and its derivatives in humans\" 19 studies table 1", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Deborah J W Lee\" rapamycin table 1 studies", "results": []}
→ call web_search({"limit":10,"query":"rapamycin human trial healthy volunteers randomized trial review study names endpoint"})
→ call web_search({"limit":10,"query":"everolimus human trial rapamycin review study names endpoint immune cardiovascular skin"})
→ call web_search({"limit":10,"query":"site:pmc.ncbi.nlm.nih.gov rapamycin humans trial endpoint review"})
【tool:web_search】
{"ok": true, "query": "rapamycin human trial healthy volunteers randomized trial review study names endpoint", "results": [{"title": "Participatory Evaluation (of) Aging (With) Rapamycin (for) Longevity ...", "url": "https://clinicaltrials.gov/study/NCT04488601", "snippet": "A randomized , double-blind, placebo-controlled trial assessing the effects of low and high doses of intermittent Rapamycin on a weekly schedule. The researchers aim to establish a long-term safety profile, determine the long-term efficacy of Rapamycin in reducing clinical aging measures, and biochemical and physiological endpoints associated ..."}, {"title": "PEARL lands: decoding rapamycin's first human longevity trial", "url": "https://therelaymag.com/pearl-lands-decoding-rapamycins-first-human-longevity-trial", "snippet": "The first randomized human longevity trial of rapamycin just published. Here is what PEARL delivered on safety and early signals, what it did not, and the fastest credible route to an actual label with outcomes that matter."}, {"title": "The Largest Rapamycin Trial Ever Conducted in Humans Is Now Underway ...", "url": "https://www.gethealthspan.com/research/article/human-rapamycin-trial-longevity-evidence", "snippet": "In a recent conversation with Dr. Matt Kaeberlein, one of the leading figures in rapamycin and longevity research, Dr. LaFleur detailed the design, rationale, and early pharmacokinetic data behind what will be the largest and longest randomized controlled trial o
【tool:web_search】
{"ok": true, "query": "everolimus human trial rapamycin review study names endpoint immune cardiovascular skin", "results": [{"title": "NCT05835999 | Everolimus Aging Study - ClinicalTrials.gov", "url": "https://clinicaltrials.gov/study/NCT05835999", "snippet": "Using a double-blinded, randomized, placebo-controlled clinical trial , the investigators will perform a battery of gold-standard and innovative techniques to test the hypothesis that daily low dose or weekly everolimus treatment will improve 4 inter-related domains of physiological aging: metabolic, cardiac, cognitive, and physical function."}, {"title": "Can Rapamycin slow aging? - Konopka Lab - UW-Madison", "url": "https://konopkalab.medicine.wisc.edu/clinical-trials/everlast/", "snippet": "The purpose of this research study is to learn if the rapamycin analog everolimus can help improve or maintain the health and function of adults 55-80 years old who may have insulin resistance or pre-diabetes. As a part of this study , you will be asked to take low doses of everolimus or placebo once daily and once weekly for 24-weeks."}, {"title": "Rapamycin Anti-Aging: 2026 Human Trial Evidence | GLP-1.science", "url": "https://www.glp-1.science/blog/rapamycin-human-trials-2026-evidence", "snippet": "A systematic review published in Lancet Healthy Longevity consolidated 19 human studies and concluded that rapamycin and its derivatives improved physiological parameters across immune , cardiovascular , and skin systems, with no
【tool:web_search】
{"ok": true, "query": "site:pmc.ncbi.nlm.nih.gov rapamycin humans trial endpoint review", "results": [{"title": "Blazing a trail for the clinical use of rapamycin as a geroprotecTOR", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10643772/", "snippet": "Results from these early phase studies will help guide the design of phase 3 clinical trials to determine whether rapamycin can be used safely to inhibit mTORC1 for the treatment and prevention of age-related diseases in humans ."}, {"title": "Rapamycin for longevity: the pros, the cons, and future perspectives", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12226543/", "snippet": "A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: immunological, physical performance, and cognitive effects."}, {"title": "Influence of rapamycin on safety and healthspan metrics after one year ...", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12074816/", "snippet": "An important gap in the clinical understanding of rapamycin for longevity is that to date, no long-term randomized controlled trials (RCT) have been conducted to explore the safety and effectiveness of low-dose, intermittent rapamycin regimens for improving multiple healthspan metrics in normative aging cohorts."}, {"title": "Rapamycin: one drug, many effects - PMC", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3972801/", "snippet": "The mammalian target of rapamycin (mTOR) signaling pathway is a master re
→ call web_fetch({"max_chars":15000,"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12226543/"})
→ call web_fetch({"max_chars":15000,"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12074816/"})
→ call web_fetch({"max_chars":15000,"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10643772/"})
【tool:web_fetch】
{"ok": true, "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12226543/", "status": 200, "content_type": "text/html; charset=utf-8", "text": "Rapamycin for longevity: the pros, the cons, and future perspectives - PMC Skip to main content An official website of the United States government Here's how you know Here's how you know Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( Lock Locked padlock icon ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites. Search Log in Dashboard Publications Account settings Log out Search… Search NCBI Primary site navigation Search Logged in as: Dashboard Publications Account settings Log in Search PMC Full-Text Archive Search in PMC Journal List User Guide PERMALINK Copy As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Front Aging . 2025 Jun 20;6:1628187. doi: 10.3389/fragi.2025.1628187 Search in PMC Search in PubMed View in NLM Catalog Add to search Rapamycin for longevity: the pros, the cons, and future perspectives Kelley M Roark Kelley M Roark 1 Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, United States Find articles by Kelley M Roark
【tool:web_fetch】
{"ok": true, "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12074816/", "status": 200, "content_type": "text/html; charset=utf-8", "text": "Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results - PMC Skip to main content An official website of the United States government Here's how you know Here's how you know Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( Lock Locked padlock icon ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites. Search Log in Dashboard Publications Account settings Log out Search… Search NCBI Primary site navigation Search Logged in as: Dashboard Publications Account settings Log in Search PMC Full-Text Archive Search in PMC Journal List User Guide PERMALINK Copy As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice Aging (Albany NY) . 2025 Apr 4;17(4):908–936. doi: 10.18632/aging.206235 Search in PMC Search in PubMed View in NLM Catalog Add to search Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results Mauricio Moel Mauricio Moel 1 AgelessRx, Ann Arbor, MI 48104, USA 2 Division of Research and Applied Sciences,
【tool:web_fetch】
{"ok": true, "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10643772/", "status": 200, "content_type": "text/html; charset=utf-8", "text": "Blazing a trail for the clinical use of rapamycin as a geroprotecTOR - PMC Skip to main content An official website of the United States government Here's how you know Here's how you know Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( Lock Locked padlock icon ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites. Search Log in Dashboard Publications Account settings Log out Search… Search NCBI Primary site navigation Search Logged in as: Dashboard Publications Account settings Log in Search PMC Full-Text Archive Search in PMC Journal List User Guide PERMALINK Copy As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice GeroScience . 2023 Oct 6;45(5):2769–2783. doi: 10.1007/s11357-023-00935-x Search in PMC Search in PubMed View in NLM Catalog Add to search Blazing a trail for the clinical use of rapamycin as a geroprotecTOR Adam R Konopka Adam R Konopka 1 Division of Geriatrics, Department of M
```