Iter-4360dd15-0017-transcript
第 17 轮执行轨迹
→ call search_memory({"limit":10,"query":"4360dd15 rapamycin 2024 systematic review 19 studies table included studies endpoints"}) → call list_recent({"n":8})
→ call list_tools({})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0012-transcript", "tags": "iteration transcript", "modified": "20260424180501000", "preview": "!! 第 12 轮执行轨迹 【tool:list_recent】
{"ok": true, "items": [{"title": "Error-20260425-021157", "modified": "20260424181157000", "tags": "error iteration"}, {"title": "Error-20260425-021048", "modified": "20260424181048000", "tags": "error iteration"}, {"title": "Iter-4360dd15-0014-reflection", "modified": "20260424181027000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424181027000", "tags": "pinned focus"}, {"title": "先用可访问入口锁定表格", "modified": "20260424181027000", "tags": "lesson evidence retrieval rapamycin human-trials"}, {"title": "Iter-4360dd15-0014-transcript", "modified": "20260424181020000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0013-reflection", "modified": "20260424180750000", "tags": "iteration reflection"}, {"title": "先找可访问的二级证据入口", "modified": "20260424180750000", "tags": "lesson evidence retrieval rapamycin human-trials"}]}
【tool:list_tools】
{"ok": true, "tools": [{"name": "search_memory", "description": "在 TiddlyWiki 长期记忆中按关键字搜索（支持中文空格分隔），返回标题、标签、预览。每轮迭代开始前应先调用以回忆。", "custom": false}, {"name": "read_note", "description": "读取某一条 tiddler 的完整正文。", "custom": false}, {"name": "write_note", "description": "向 TiddlyWiki 写入（或覆盖）一条 tiddler。这是 Sisyphus 的长期记忆入口——每轮至少写一条。建议标签：knowledge, experiment, reflection, plan, idea, fact, question, lesson。TiddlyWiki 标记：!! 小标题，''粗体''，斜体，其它tiddler。", "custom": false}, {"name": "list_recent", "description": "列出最近修改过的 tiddler。", "custom": false}, {"name": "list_by_tag", "description": "按标签列出相关 tiddler。", "custom": false}, {"name": "run_python", "description": "在 workspace/ 下以子进程执行一段 Python 代码，返回 stdout/stderr。用于计算、模拟、验证假设、抓取公开数据（禁止任何破坏性操作）。", "custom": false}, {"name": "read_file", "description": "读取 workspace/ 下的某个文件。", "custom": false}, {"name": "write_file", "description": "向 workspace/ 下写入文件（默认覆盖，append=true 时追加）。", "custom": false}, {"name": "list_files", "description": "列出 workspace/ 下的文件。", "custom": false}, {"name": "web_fetch", "description": "抓取任意公开 URL（GET），返回剥离 HTML 后的纯文本。适合读论文摘要、文档、博客、百科。", "custom": false}, {"name": "web_search", "description": "用 DuckDuckGo 搜索互联网，返回 title/url/snippet 列表。找入口、找链接、调研时用。", "custom": false}, {"name": "wiki_search", "description": "维基百科搜索：返回若干条目的摘要和 URL。lang 默认 en，可传 zh 等。", "custom": false}, {"name": "arxiv_search", "description": "arXiv 论文检索：标题/作者/摘要/链接。理论、数学、物理、CS、bio 类前沿论文的主入口。", "custom": false}, {"name": "pubmed_search", "descriptio
→ call search_memory({"limit":10,"query":"4360dd15 Targeting ageing with rapamycin and its derivatives in humans Europe PMC 19 studies included trials primary endpoints"})
→ call read_note({"title":"NEXT_FOCUS"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0009-transcript", "tags": "iteration transcript", "modified": "20260424175555000", "preview": "!! 第 9 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin mTOR systematic review 2024 trial endpoint PMC table remaining included studies\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\""}, {"title": "Iter-4360dd15-0003-transcript", "tags": "iteration transcript", "modified": "20260424173843000", "preview": "!! 第 3 轮执行轨迹 → call search_memory({\\\"limit\\\":10,\\\"query\\\":\\\"4360dd15 rapamycin senolytics NEXT_F"}, {"title": "Iter-4360dd15-0002-transcript", "tags": "iteration transcript", "modified": "20260424173549000", "preview": "!! 第 2 轮执行轨迹 【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0014）\n\n只攻克一件事：从可访问来源提取这篇综述的19项纳入研究名称及各自主要终点。"}
→ call web_search({"limit":8,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" 19 studies Table 1 Europe PMC"})
→ call pubmed_search({"limit":5,"query":"Targeting ageing with rapamycin and its derivatives in humans"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" 19 studies Table 1 Europe PMC", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "PDF Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.researchgate.net/publication/377976071_Targeting_ageing_with_rapamycin_and_its_derivatives_in_humans_a_systematic_review", "snippet": "A recent systematic review of human studies suggested Rapamycin and its derivatives to be effective in improving the age-related physiological parame
【tool:pubmed_search】
{"ok": true, "query": "Targeting ageing with rapamycin and its derivatives in humans", "results": [{"pmid": "41996004", "title": "Lactate-driven pyrimidine synthesis promotes ferroptosis resistance in hepatocellular carcinoma.", "source": "Mol Biomed", "pubdate": "2026 Apr 17", "authors": ["Park MJ", "Lee S", "Kim DH", "Kim MK", "Jang BK", "Yoon G", "Park M", "Jeong GH"], "url": "https://pubmed.ncbi.nlm.nih.gov/41996004/"}, {"pmid": "41929967", "title": "The Cheung Glutamatergic Regimen as a candidate for primary and secondary prevention of Alzheimer's disease onset.", "source": "J Alzheimers Dis Rep", "pubdate": "2026 Jan-Dec", "authors": ["Cheung N"], "url": "https://pubmed.ncbi.nlm.nih.gov/41929967/"}, {"pmid": "41909987", "title": "Sirolimus and Mimetics: Modulator Sine Qua Non for Cardiac Xenotransplantation?", "source": "FASEB J", "pubdate": "2026 Apr 15", "authors": ["Uzoigwe CE"], "url": "https://pubmed.ncbi.nlm.nih.gov/41909987/"}, {"pmid": "41787128", "title": "Metabolic regulation by tanycyte-derived extracellular vesicles through insulin precursor-mediated neuronal recognition and mTORC component delivery.", "source": "Nat Metab", "pubdate": "2026 Mar", "authors": ["Choi Y", "Kim MW", "Go G", "Cai D"], "url": "https://pubmed.ncbi.nlm.nih.gov/41787128/"}, {"pmid": "41484271", "title": "Curcumin attenuates PM2.5-triggered pulmonary senescence via the mTOR/S6K1 signaling pathway.", "source": "Biogerontology", "pubdate": "2026 Jan 3", "authors": ["Liu K", "Shi M", "Li
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" table included studies endpoint"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" PDF table 1 study endpoint"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" table included studies endpoint", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "PDF Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immun
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" PDF table 1 study endpoint", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.researchgate.net/publication/377976071_Targeting_ageing_with_rapamycin_and_its_derivatives_in_humans_a_systematic_revie
→ call web_fetch({"max_chars":12000,"url":"https://europepmc.org/article/MED/38310895"})
→ call web_fetch({"max_chars":14000,"url":"https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf"})
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/38310895", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":10,"query":"\"PIIS2666-7568(23)00258-1\" mmc1 pdf rapamycin supplementary appendix"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" supplementary appendix table study endpoint"})
→ call web_search({"limit":10,"query":"site:europepmc.org 38310895 supplementary appendix rapamycin study"})
【tool:web_search】
{"ok": true, "query": "\"PIIS2666-7568(23)00258-1\" mmc1 pdf rapamycin supplementary appendix", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" supplementary appendix table study endpoint", "results": [{"title": "PDF Supplementary appendix - The Lancet", "url": "https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf", "snippet": "Supplementary appendix This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Lee DJW, Hodzic Kuerec A, Maier AB. Targeting ageing with rapamycin and its derivatives in humans : a systematic review. Lancet Healthy Longev 2024; 5: e152-62. Table of Contents"}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a
【tool:web_search】
{"ok": true, "query": "site:europepmc.org 38310895 supplementary appendix rapamycin study", "results": []}
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" \"study characteristics\""})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" trial names"})
→ call web_search({"limit":10,"query":"\"rapamycin and its derivatives in humans\" included studies names"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" \"study characteristics\"", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" trial names", "results": []}
【tool:web_search】
{"ok": true, "query": "\"rapamycin and its derivatives in humans\" included studies names", "results": []}
→ call web_fetch({"max_chars":20000,"url":"https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" pdf repository"})
→ call web_search({"limit":10,"query":"\"PIIS2666-7568(23)00258-1\" filetype:pdf"})
→ call web_search({"limit":10,"query":"\"38310895\" rapamycin ageing humans pdf"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" pdf repository", "results": []}
【tool:web_search】
{"ok": true, "query": "\"PIIS2666-7568(23)00258-1\" filetype:pdf", "results": []}
【tool:web_search】
{"ok": true, "query": "\"38310895\" rapamycin ageing humans pdf", "results": []}
→ call web_search({"limit":10,"query":"38310895 PMCID rapamycin humans review"})
→ call web_search({"limit":10,"query":"\"38310895\" PMCID"})
→ call web_search({"limit":10,"query":"site:pmc.ncbi.nlm.nih.gov 38310895 rapamycin humans"})
【tool:web_search】
{"ok": true, "query": "38310895 PMCID rapamycin humans review", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Rapamycin for longevity: the pros, the cons, and future perspectives", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12226543/", "snippet": "Further, the long-term effects and safety of chronic mTOR inhibition in healthy humans and whether rapamycin can truly \"slow\" human aging or prevent age-related diseases without unacceptable side effects is unknown. The mTOR pathway and the function of rapamycin"}, {"title": "Rapamycin's Effects on Human Aging Explored in New Study", "url": "https://www.newsweek.com/anti-aging-rapamycin-off-label-study-2110873", "snippet": "A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans:
【tool:web_search】
{"ok": true, "query": "\"38310895\" PMCID", "results": [{"title": "A systematic review study of Rapamycin", "url": "https://rapamycinlongevitylab.substack.com/p/a-systematic-review-study-of-rapamycin", "snippet": "Last month Ajla Hodzic Kuerec, Deborah Lee and Andrea Maier published a very interesting systematic review of Rapamycin and rapalogs (pubmed: 38310895 ). A systematic review is a review that gathers together different research studies within an area and based on that analyzes and summarizes these. These types of reviews are generally seen as a way of providing the highest level of scientific ..."}, {"title": "Sirolimus - mobile.fpnotebook.com", "url": "https://mobile.fpnotebook.com/Surgery/Pharm/Srlms.htm", "snippet": "Lee (2024) Lancet Healthy Longev 5 (2):e152-e162 +PMID: 38310895 [PubMed] Mechanism mTOR Inhibitor See Mammalian Target of Rapamycin Pathway (mTOR Pathway) Medications Sirolimus (Rapamune, Rapamycin) Tablets: 0.5 mg, 1 mg, 2 mg Solution: 1 mg/ml Dosing See other references for specific dosing regimens per indication"}, {"title": "Systemic review study of Rapamycin : r/Rapamycin - Reddit", "url": "https://www.reddit.com/r/Rapamycin/comments/1bo5ogp/systemic_review_study_of_rapamycin/", "snippet": "Last month Ajla Hodzic Kuerec, Deborah Lee and Andrea Maier published a very interesting systematic review of Rapamycin and rapalogs (pubmed: 38310895 ). A systematic review is a review that gathers together different research studies within an area and based
【tool:web_search】
{"ok": true, "query": "site:pmc.ncbi.nlm.nih.gov 38310895 rapamycin humans", "results": [{"title": "Rapamycin for longevity: the pros, the cons, and future perspectives", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12226543/", "snippet": "Further, the long-term effects and safety of chronic mTOR inhibition in healthy humans and whether rapamycin can truly \"slow\" human aging or prevent age-related diseases without unacceptable side effects is unknown. The mTOR pathway and the function of rapamycin"}, {"title": "Rapamycin: one drug, many effects - PMC", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3972801/", "snippet": "The mammalian target of rapamycin (mTOR) signaling pathway is a master regulator of cell growth and metabolism. Deregulation of the mTOR pathway has been implicated in a number of human diseases such as cancer, diabetes, obesity, neurological ..."}, {"title": "Rapamycin: Extending Health Span and Life Span - PMC", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9173851/", "snippet": "Rapamycin treatment has increased life span by 25% to 60% in most species it has been tested on. 1 When rapamycin was given to 20-month (elderly) mice, females lived 14% longer and males lived 9% longer. 2 This is equal to an increase of approximately 7 years in the life span. These results suggest that rapamycin started late in life may also improve health and extend life span in elderly humans ."}, {"title": "Effect of rapamycin on aging and age-related diseases—past a
→ call web_fetch({"max_chars":12000,"url":"https://research.vu.nl/en/publications/targeting-ageing-with-rapamycin-and-its-derivatives-in-humans-a-s"})
→ call web_search({"limit":10,"query":"site:research.vu.nl \"Targeting ageing with rapamycin and its derivatives in humans\" PDF"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" \"list of studies\""})
【tool:web_fetch】
{"ok": true, "url": "https://research.vu.nl/en/publications/targeting-ageing-with-rapamycin-and-its-derivatives-in-humans-a-s/", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Targeting ageing with rapamycin and its derivatives in humans: a systematic review - Vrije Universiteit Amsterdam Skip to main navigation Skip to search Skip to main content Vrije Universiteit Amsterdam Home Help & FAQ Link opens in a new tab Search content at Vrije Universiteit Amsterdam Home Profiles Research units Research output Co
```