Iter-4360dd15-0014-transcript
第 14 轮执行轨迹
→ call search_memory({"limit":8,"query":"4360dd15 rapamycin 2024 systematic review 19 studies Table Europe PMC NEXT_FOCUS"})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0012-transcript", "tags": "iteration transcript", "modified": "20260424180501000", "preview": "!! 第 12 轮执行轨迹 → call list_recent({"n":6})
【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0013-reflection", "modified": "20260424180750000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424180750000", "tags": "pinned focus"}, {"title": "先找可访问的二级证据入口", "modified": "20260424180750000", "tags": "lesson evidence retrieval rapamycin human-trials"}, {"title": "Iter-4360dd15-0013-transcript", "modified": "20260424180743000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0012-reflection", "modified": "20260424180508000", "tags": "iteration reflection"}, {"title": "先拿到可访问全文表格", "modified": "20260424180508000", "tags": "lesson evidence retrieval human-trials rapamycin"}]}
→ call read_note({"title":"NEXT_FOCUS"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0013）\n\n下一轮必须只做一件事：从可访问来源提取这篇综述的19项纳入研究清单及其主要终点。"}
→ call web_search({"limit":5,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" full text PMC"})
→ call web_search({"limit":5,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" Europe PMC"})
→ call web_search({"limit":5,"query":"rapamycin derivatives humans systematic review 19 studies Europe PMC"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" full text PMC", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of t
【tool:web_search】
{"ok": false, "error": "[SSL: UNEXPECTED_EOF_WHILE_READING] EOF occurred in violation of protocol (_ssl.c:1028)"}
【tool:web_search】
{"ok": true, "query": "rapamycin derivatives humans systematic review 19 studies Europe PMC", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in ... - Europe PMC", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies ."}, {"title": "Rapamycin for longevity: the pros, the cons, and future perspectives - PMC", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12226543/", "snippet": "A systematic review evaluated the effects of rapamycin and its derivatives on aging-related physiological changes and diseases and found improvements in the immune, cardiovascular, and integumentary systems but not in the endocrine, muscular, or neurological systems (Lee et al., 2024)."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_fetch({"max_chars":12000,"url":"https://europepmc.org/article/MED/38310895"})
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/38310895", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
→ call web_search({"limit":10,"query":"38310895 Europe PMC table 1 rapamycin included studies"})
→ call web_search({"limit":10,"query":"\"38310895\" rapamycin table 1 included studies"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" Table 1"})
【tool:web_search】
{"ok": true, "query": "38310895 Europe PMC table 1 rapamycin included studies", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in ... - Europe PMC", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies ."}, {"title": "Influence of rapamycin on safety and healthspan metrics after one year ...", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12074816/", "snippet": "Of the 114 who completed the study, 40 received 5 mg/week of rapamycin , 35 received 10 mg/week of rapamycin , and 39 received placebo (Supplementary Figure 1 ). Importantly, in the midst of this trial, we learned that compounded rapamycin , which was used for this work due to placebo generation considerations, could have reduced bioavailability ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiologi
【tool:web_search】
{"ok": true, "query": "\"38310895\" rapamycin table 1 included studies", "results": [{"title": "A systematic review study of Rapamycin", "url": "https://rapamycinlongevitylab.substack.com/p/a-systematic-review-study-of-rapamycin", "snippet": "Last month Ajla Hodzic Kuerec, Deborah Lee and Andrea Maier published a very interesting systematic review of Rapamycin and rapalogs (pubmed: 38310895 ). A systematic review is a review that gathers together different research studies within an area and based on that analyzes and summarizes these."}, {"title": "Systemic review study of Rapamycin : r/Rapamycin - Reddit", "url": "https://www.reddit.com/r/Rapamycin/comments/1bo5ogp/systemic_review_study_of_rapamycin/", "snippet": "Last month Ajla Hodzic Kuerec, Deborah Lee and Andrea Maier published a very interesting systematic review of Rapamycin and rapalogs (pubmed: 38310895 ). A systematic review is a review that gathers together different research studies within an area and based on that analyzes and summarizes these."}, {"title": "#rapamycin #longevityscience #healthspan #metabolichealth # ...", "url": "https://www.linkedin.com/posts/ranulf-crooke_rapamycin-longevityscience-healthspan-activity-7411401877105491968-uGEr", "snippet": "In humans, a 2024 Lancet Healthy Longevity review (PMID: 38310895 ) shows that rapamycin and its derivatives can improve some specific immune and skin-ageing markers, but we still lack long-term ..."}, {"title": "Rapamycin Longevity Lab's Substack | S
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" Table 1", "results": []}
→ call web_fetch({"max_chars":20000,"url":"https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":10,"query":"PMID 38310895 rapamycin included studies names endpoints"})
→ call web_search({"limit":10,"query":"38310895 references rapamycin trial table main endpoint"})
→ call web_search({"limit":10,"query":"\"38310895\" \"rapamycin\" trial endpoint"})
【tool:web_search】
{"ok": true, "query": "PMID 38310895 rapamycin included studies names endpoints", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies ."}, {"title": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/", "snippet": "PubMed® comprises more than 40 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "http://47.251.13.51:8081/38310895/", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568
【tool:web_search】
{"ok": true, "query": "38310895 references rapamycin trial table main endpoint", "results": [{"title": "PDF Randomized, double-blind, placebo-controlled trial of rapamycin in ...", "url": "https://www.nature.com/articles/s41467-023-40734-8.pdf", "snippet": "A total of 23 over 42 individuals (55%) in the rapamycin group and 11 over 21 individuals (52%) in the placebo group had one or more AEs during the trial ( Table S16)."}, {"title": "Researcher View | NCT02844270 | Galaxy Rapamycin Drug-Eluting ...", "url": "https://clinicaltrials.gov/study/NCT02844270?tab=table", "snippet": "The goal is to access the feasibility, safety and efficacy of Rapamycin Drug-Eluting Bioresorbable Coronary Stent System in the treatment of patients with de novo coronary lesion."}, {"title": "Blazing a trail for the clinical use of rapamycin as a geroprotecTOR", "url": "https://www.researchgate.net/publication/374504334_Blazing_a_trail_for_the_clinical_use_of_rapamycin_as_a_geroprotecTOR", "snippet": "Request PDF | Blazing a trail for the clinical use of rapamycin as a geroprotecTOR | Treatment with rapamycin , an inhibitor of the mechanistic Target Of Rapamycin Complex One (mTORC1) protein ..."}, {"title": "PDF Delayed-release rapamycin halts progression of left ventricular ...", "url": "https://avmajournals.avma.org/downloadpdf/view/journals/javma/261/11/javma.23.04.0187.pdf", "snippet": "supported by a toxicokinetic study17 conducted by the sponsor hat demonstrated the safety of repeated dosing wi
【tool:web_search】
{"ok": true, "query": "\"38310895\" \"rapamycin\" trial endpoint", "results": []}
→ call web_fetch({"max_chars":20000,"url":"http://47.251.13.51:8081/38310895/"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'http://47.251.13.51:8081/38310895/'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call search_memory({"limit":10,"query":"4360dd15 19 included studies rapamycin human trial names endpoint table"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin mTOR systematic review 2024 trial endpoint PMC table remaining included studies\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\""}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call web_search({"limit":10,"query":"\"Blazing a trail for the clinical use of rapamycin as a geroprotecTOR\" Table 1 PMC"})
【tool:web_search】
{"ok": true, "query": "\"Blazing a trail for the clinical use of rapamycin as a geroprotecTOR\" Table 1 PMC", "results": [{"title": "Blazing a trail for the clinical use of rapamycin as a geroprotecTOR - PMC", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10643772/", "snippet": "The goal of this review is to ( 1 ) briefly showcase how mTORC1 inhibition by rapamycin and rapamycin analogs (rapalogs) can extend healthspan by maintaining, improving, or restoring select indices of physiological function in pre-clinical and some human studies ( Table 1 ); (2) discuss potential risks and key knowledge gaps regarding the clinical ..."}, {"title": "Blazing a trail for the clinical use of rapamycin as a geroprotecTOR", "url": "https://link.springer.com/article/10.1007/s11357-023-00935-x", "snippet": "Treatment with rapamycin, an inhibitor of the mechanistic Target Of Rapamycin Complex One (mTORC1) protein kinase, has been repeatedly demonstrated to extend lifespan and prevent or delay age-related diseases in diverse model systems. Concerns over the risk of potentially serious side effects in humans, including immunosuppression and metabolic disruptions, have cautiously limited the ..."}, {"title": "Blazing a trail for the clinical use of rapamycin as a geroprotecTOR ...", "url": "https://europepmc.org/article/pmc/10643772", "snippet": "The goal of this review is to ( 1 ) briefly showcase how mTORC1 inhibition by rapamycin and rapamycin analogs (rapalogs) can extend healthspan by mai
→ call web_search({"limit":8,"query":"Europe PMC 38310895 full text xml"})
→ call web_search({"limit":8,"query":"site:europepmc.org/article/MED/38310895 xml"})
→ call web_search({"limit":8,"query":"Europe PMC REST 38310895 fullTextXML"})
【tool:web_search】
{"ok": true, "query": "Europe PMC 38310895 full text xml", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in ... - Europe PMC", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 ..."}, {"title": "FullTextClient API Reference | PyEuropePMC Documentation", "url": "https://jonasheinickebio.github.io/pyEuropePMC/api/fulltext-client.html", "snippet": "Download XML full text directly from Europe PMC FTP OA bulk archives only. This method downloads from the Europe PMC FTP OA archives (. xml .gz files) without trying the REST API first."}, {"title": "PMC Article Datasets", "url": "https://pmc.ncbi.nlm.nih.gov/tools/textmining/", "snippet": "February 12, 2026: Changes to PMC Article Datasets Distribution Services Coming in 2026 PMC will make major changes to our Article Dataset Distribution Services in 2026. In August 2026, you will need to access full text article data files through the PMC Cloud Service instead of the PMC FTP Service. This change will provide you with more reliable performance, faster retrieval times, and ..."}, {"title": "Fetch Europe PMC full texts — epmc_ftxt • europepmc - rOpenSci", "url": "https://docs.ropensci.org/europepmc/r
【tool:web_search】
{"ok": true, "query": "site:europepmc.org/article/MED/38310895 xml", "results": []}
【tool:web_search】
{"ok": true, "query": "Europe PMC REST 38310895 fullTextXML", "results": [{"title": "FullTextClient API Reference | PyEuropePMC Documentation", "url": "https://jonasheinickebio.github.io/pyEuropePMC/api/fulltext-client.html", "snippet": "View on GitHub FullTextClient API Reference The FullTextClient provides access to full-text content from Europe PMC articles in various formats (PDF, XML, HTML). Important: Europe PMC Endpoint Architecture Europe PMC has different endpoint architectures for different content types: XML Full Text Primary Endpoint: Direct REST API (/PMC{id ..."}, {"title": "pyeuropepmc · PyPI", "url": "https://pypi.org/project/pyeuropepmc/", "snippet": "A Python package for working with the Europe PMC API to search and retrieve scientific literature."}, {"title": "europepmc - R Interface to Europe PMC RESTful Web Service", "url": "https://cran.r-project.org/web/packages/europepmc/readme/README.html", "snippet": "europepmc facilitates access to the Europe PMC RESTful Web Service. The client furthermore supports the Europe PMC Annotations API to retrieve text-mined concepts and terms per article. Europe PMC covers life science literature and gives access to open access full texts."}, {"title": "Europe PMC", "url": "https://europepmc.org/", "snippet": "Comprehensive search Search life sciences literature from trusted sources around the globe, all in one search, accessible by anyone anywhere, for free. Learn more About Europe PMC ."}, {"title": "Modifying a GET req
→ call web_fetch({"max_chars":20000,"url":"https://www.rapamycin.news/uploads/short-url/yQYiGzy0d8R9iNsywQUoCgJfEZ4.pdf"})
【tool:web_fetch】
{"ok": true, "url": "https://www.rapamycin.news/uploads/short-url/yQYiGzy0d8R9iNsywQUoCgJfEZ4.pdf", "status": 200, "content_type": "application/pdf", "text": "%PDF-1.6\r%����\r\n743 0 obj\r<</Filter/FlateDecode/First 73/Length 1282/N 9/Type/ObjStm>>stream\r\nh��V�r�:\u0010~\u0002��?a�tV�ȗ\u0019���\u0017�9�\u0002)P(\u001dF��DűS[.\rOϮl9n�\u0005~��l�Z��?�V�\u0012F�Ü0\u000e\u001c7�\u0017w\\����1zG�o�1�\u0013T\u0012�M|�$\f=\\\u000f\u0015��<�<\u000e{�э\u0013�\f3��\u0002-�Ù����0=�7U�\u0014\u0005�N\u001c\u0017�����G8�M\u001c]�\u0012fG��������J���~9�BKH\u0005�U�.���&\u0019�f���L�h�~�V�*��I���Q�xO幬e����� �v\tm��?��ʶ�G�����C^@���M\u0018���y��Oڭ�Ie�\u001d�y>��+��\u000b턡\u0007�\u000bQϤ~\n�J�\u0012�vy!�F�KȪ�\u00105�dM� ��5��%\u0010b!s�i5�\u0002�hY+�ª@�i�\\\nX�W\u000bYR\u0006Ue�\u0014�Y�OYW@��?*ЋZJȫ��e\\Kh�\r4�\u001ac\f@(\u0015:�UQ�h^�N�W-�Ƽ�X�\u001a�Zl\f�f�a\u0002S=؇\u0003x\t��\u0010����5�\u0016�1��w�\u001efp\u0002\u001f�#|�S�\f_�\u0016�w��>1\u000b�Gݒ�2�\u0015�U-A�\u0005��\u0001��9,@�%|�\u0002�PB\u0005+��\u001a\u001a�\u0010��\u001fp\u0003k��\u0015I�Ҫ�$���:�Ԩ�Ea>G�U�,3�LW&�5�@68vaUW=*n�\t�o[h�*�X�պ���IR�-�\u001fv\u0000&k\u0014vN��]慼�v��y�4�.�>\u0019Zm����zFgд�N\u0010�pP�y��\u0001\u001cT��N����$bf\u000e\u000f-�M����\u0003�T�������YgP����'t���XJ8��{���?��^�[j?���Z�ta\u000f\"�>u\u001d\u001c0\u0006�Z\u0014*���Bґ�r�щ��\u0010�+���JW5���\u001fp6\u001cFr����\u0000\u0019�28U�h:/���̆��絰.܃Y{�\t\u0005Aq��Pb\u000bg�\t�n�\u0003D$�L/�3\u001e�N���+��q&�!J�\t�\u0013�H��\u001b�\u001e�:��ȉ�\u0018-��\u00
【assistant】
本轮结论：
- 已再次确认目标综述是 **PMID 38310895 / “Targeting ageing with rapamycin and its derivatives in humans”**，且摘要明确写明 **纳入 19 项人类研究**。
- **Lancet 正式全文/PDF 仍 403**，说明继续硬闯出版社站点是低效死路。
- **Europe PMC 入口可访问**，但当前页面主要是元数据，**不足以直接还原 19 项研究清单**。
- 已找到一个更现实的可访问替代源：**rapamycin.news 上挂出的 PDF 镜像**，这是本任务最可能继续推进的入口。
- 但本轮仍**没有成功提取出 19 项纳入研究及其主要终点**；当前最危险的失败点是把“找到入口”误当成“完成提取”。
<NEXT_FOCUS>下一轮只做一件事：用可访问的 PDF 镜像把该综述的 Table 1 /
```