Iter-4360dd15-0013-transcript
第 13 轮执行轨迹
→ call search_memory({"limit":8,"query":"4360dd15 rapamycin 2024 systematic review 19 studies table"})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0012-transcript", "tags": "iteration transcript", "modified": "20260424180501000", "preview": "!! 第 12 轮执行轨迹 → call list_recent({"n":6})
→ call search_memory({"limit":10,"query":"4360dd15 NEXT_FOCUS 2024 rapamycin review 19 studies"})
【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0012-reflection", "modified": "20260424180508000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424180508000", "tags": "pinned focus"}, {"title": "先拿到可访问全文表格", "modified": "20260424180508000", "tags": "lesson evidence retrieval human-trials rapamycin"}, {"title": "Iter-4360dd15-0012-transcript", "modified": "20260424180501000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0011-reflection", "modified": "20260424180159000", "tags": "iteration reflection"}, {"title": "先锁定可访问综述表格再补全缺口", "modified": "20260424180159000", "tags": "lesson evidence retrieval rapamycin human-trials"}]}
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1 included trials endpoint\"}) → call list_recent({\"n\":6}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies table trial names endpoints\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcri → call web_search({"limit":8,"query":"2024 systematic review rapamycin rapalogs human trials 19 studies Table 1"})
→ call pubmed_search({"limit":8,"query":"rapamycin rapalogs systematic review human trials 2024 19 studies"})
【tool:web_search】
{"ok": true, "query": "2024 systematic review rapamycin rapalogs human trials 19 studies Table 1", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives ( rapalogs ) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives ( rapalogs ) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies ."}, {"title": "Blazing a trail for the clinical use of rapamycin as a geroprotecTOR", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10643772/", "snippet": "The goal of this review is to ( 1 ) briefly showcase how mTORC1 inhibition by rapamycin and rapamycin analogs ( rapalogs )
【tool:pubmed_search】
{"ok": true, "query": "rapamycin rapalogs systematic review human trials 2024 19 studies", "results": []}
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" pdf"})
→ call web_search({"limit":10,"query":"\"PIIS2666-7568(23)00258-1\" pdf"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" pdf", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "PDF Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf", "snippet": "Deborah J W Lee*, Ajla Hodzic Kuerec*, Andrea B Maier Rapamyc
【tool:web_search】
{"ok": true, "query": "\"PIIS2666-7568(23)00258-1\" pdf", "results": []}
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf"})
→ call web_fetch({"max_chars":12000,"url":"https://europepmc.org/article/MED/38310895"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/38310895", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" Table 1 trial names"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" included studies trial names"})
→ call web_search({"limit":10,"query":"\"38310895\" rapamycin trial names"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" Table 1 trial names", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.researchgate.net/publication/377976071_Targeting_ageing_with_rapamycin_and_its_derivatives_in_humans_a_systematic_review", "sn
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" included studies trial names", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "PDF Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune,
【tool:web_search】
{"ok": true, "query": "\"38310895\" rapamycin trial names", "results": []}
→ call web_fetch({"max_chars":20000,"url":"https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" \"supplementary appendix\""})
→ call web_search({"limit":10,"query":"\"Lancet Healthy Longevity\" rapamycin supplementary appendix table 1 19 included studies"})
→ call web_search({"limit":10,"query":"\"S2666-7568(23)00258-1\" supplement pdf"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" \"supplementary appendix\"", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Lancet Healthy Longevity\" rapamycin supplementary appendix table 1 19 included studies", "results": []}
【tool:web_search】
{"ok": true, "query": "\"S2666-7568(23)00258-1\" supplement pdf", "results": []}
→ call web_search({"limit":10,"query":"\"6dc4a44a-1910-4435-ab52-a506c5f070b4\""})
→ call web_search({"limit":10,"query":"\"mmc1.pdf\" \"S2666-7568(23)00258-1\""})
→ call web_search({"limit":10,"query":"\"PIIS2666-7568(23)00258-1\" \"mmc1\""})
【tool:web_search】
{"ok": true, "query": "\"6dc4a44a-1910-4435-ab52-a506c5f070b4\"", "results": []}
【tool:web_search】
{"ok": true, "query": "\"mmc1.pdf\" \"S2666-7568(23)00258-1\"", "results": []}
【tool:web_search】
{"ok": true, "query": "\"PIIS2666-7568(23)00258-1\" \"mmc1\"", "results": []}
→ call web_search({"limit":10,"query":"site:sciencedirect.com 10.1016/S2666-7568(23)00258-1 supplementary appendix pdf"})
【tool:web_search】
{"ok": true, "query": "site:sciencedirect.com 10.1016/S2666-7568(23)00258-1 supplementary appendix pdf", "results": []}
→ call search_memory({"limit":10,"query":"4360dd15 rapamycin completed trials 8 names"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹
→ call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹 → cal"}, {"title": "Iter-4360dd15-0003-transcript", "tags": "iteration transcript", "modified": "20260424173843000", "preview": "!! 第 3 轮执行轨迹 → call search_memory({"limit":8,"query":"4360dd15 Table 1 8 trial names rapamycin"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1 included trials endpoint\"}) → call list_recent({\"n\":6}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies table trial names endpoints\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcri → call web_search({"limit":10,"query":"PMID 38310895 rapamycin systematic review references trial names"})
→ call web_search({"limit":10,"query":"\"38310895\" \"rapamycin\" \"trial\""})
→ call wiki_search({"lang":"en","limit":5,"query":"rapamycin systematic review 38310895"})
【tool:web_search】
{"ok": true, "query": "PMID 38310895 rapamycin systematic review references trial names", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "PubMed", "url": "https://pubmed.ncbi.nlm.nih.gov/", "snippet": "PubMed® comprises more than 40 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "The articles were organised and managed using Covidence systematic review software (Veritas Health Innovation, Melbourne, VIC, Australia). To establish the progress of rapamycin and its derivatives in ongoing human studies, we searched ClinicalTrials.gov for relevant trials from database inception to July 2, 2023."}, {"title": "A systematic review study of Rapamycin", "url": "https://rapamycinlongevitylab.substack.com/p/a-systematic-review-study-of-rapamycin", "snippet": "Last month Ajla Hodzic Kuerec, Deborah Lee and Andrea Maier published
【tool:web_search】
{"ok": true, "query": "\"38310895\" \"rapamycin\" \"trial\"", "results": []}
【tool:wiki_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://en.wikipedia.org/w/api.php?action=query&list=search&srsearch=rapamycin+systematic+review+38310895&srlimit=5&format=json'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【assistant】
本轮结论：
- 已再次确认目标综述就是这篇 2024 文章：
- **Title**: *Targeting ageing with rapamycin and its derivatives in humans: a systematic review*
- **PMID**: **38310895**
- **PII**: **PIIS2666-7568(23)00258-1**
- 可检索到的公开摘要与搜索结果一致说明：
- 该综述最终纳入 **19 项研究**
- 作者还检索了 **ClinicalTrials.gov**，截至 **2023-07-02**
- 我还确认到它确实有一个**补充材料 / 附录**入口：
- `mmc1.pdf`（Supplementary appendix）
- 但对 Lancet 域名的直接抓取仍然是 **403**
- 因此，本轮没有拿到“剩余 11 项纳入试验”的具体名单，也没有拿到 Table 1 原文。
最小可验证判断：
- **这条路不是“文献不存在”，而是“文献存在但主站/附件抓取受阻”**。
- 下一步最值得做的，不是继续泛搜标题，而是**专门找这个补充附录的可访问镜像/转载页/二次索引**，从中提取 Table 1。
<NEXT_FOCUS>只做一件事：找到 Lancet 这篇综述的可访问 Supplementary appendix（mmc1.pdf）镜像或转载页，并从 Table 1 直接抄出剩余 11 项纳入试验名称。</NEXT_FOCUS>