Iter-4360dd15-0012-transcript
第 12 轮执行轨迹
→ call search_memory({"limit":8,"query":"4360dd15 rapamycin 2024 systematic review 19 studies table trial names endpoints"})【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ cal"}, {"title": "Iter-4360dd15-0011-transcript", "tags": "iteration transcript", "modified": "20260424180153000", "preview": "!! 第 11 轮执行轨迹 → call search_memory({\\\"limit\\"}, {"title": "Iter-4360dd15-0009-transcript", "tags": "iteration transcript", "modified": "20260424175555000", "preview": "!! 第 9 轮执行轨迹 → call list_recent({"n":6})
【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0011-reflection", "modified": "20260424180159000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424180159000", "tags": "pinned focus"}, {"title": "先锁定可访问综述表格再补全缺口", "modified": "20260424180159000", "tags": "lesson evidence retrieval rapamycin human-trials"}, {"title": "Iter-4360dd15-0011-transcript", "modified": "20260424180153000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0010-reflection", "modified": "20260424175843000", "tags": "iteration reflection"}, {"title": "先用可访问综述骨架锁定缺口", "modified": "20260424175843000", "tags": "lesson evidence retrieval human-trials rapamycin"}]}
→ call read_note({"title":"NEXT_FOCUS"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0011）\n\n只攻克一件事：从2024综述中反推出剩余11项纳入试验的名称列表。"}
→ call search_memory({"limit":10,"query":"4360dd15 2024 review rapamycin 19 studies PMC table included trials"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0010-transcript", "tags": "iteration transcript", "modified": "20260424175830000", "preview": "!! 第 10 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin review 2024 trial endpoint remaining 11\"}) → call list_recent({\"n\":8}) → call list_by_tag({\"limit\":20,\"tag\":\"4360dd15\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0007-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424174944000\", \"preview\": \"!! 第 7 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1 included trials endpoint\"}) → call list_recent({\"n\":6}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0010-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424175830000\", \"preview\": \"!! 第 10 轮执行轨迹 → call search_memory({\"limit\":10,\"query\":\"4360dd15 rapamycin rapalog human trial Table 1 remaining endpoint PMC review trial name primary endpoint\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Ite → call web_search({"limit":8,"query":"2024 rapamycin systematic review 19 studies human trial PMC table included studies"})
→ call pubmed_search({"limit":8,"query":"rapamycin systematic review 2024 human trials 19 studies"})
→ call arxiv_search({"limit":5,"query":"rapamycin human trials systematic review 2024"})
【tool:web_search】
{"ok": true, "query": "2024 rapamycin systematic review 19 studies human trial PMC table included studies", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Articles included in this systematic review met the following criteria: the mean or median age of the study cohort was 18 years or older; outcomes on ageing-related physiological changes or disease were reported; and they were interventional studies with rapamycin or its derivatives (no restriction on the method). Articles were excluded if in vitro or animal models were used; rapamycin or its ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in ... - Europe PMC", "url": "https://europepmc.org/article/MED/38310895", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major
【tool:pubmed_search】
{"ok": true, "query": "rapamycin systematic review 2024 human trials 19 studies", "results": []}
【tool:arxiv_search】
{"ok": true, "query": "rapamycin human trials systematic review 2024", "results": [{"title": "Trust and Trustworthiness from Human-Centered Perspective in HRI -- A Systematic Literature Review", "authors": ["Debora Firmino de Souza", "Sonia Sousa", "Kadri Kristjuhan-Ling", "Olga Dunajeva", "Mare Roosileht", "Avar Pentel", "Mati Mõttus", "Mustafa Can Özdemir"], "published": "2025-01-31", "summary": "The Industry 5.0 transition highlights EU efforts to design intelligent devices that can work alongside humans to enhance human capabilities, and such vision aligns with user preferences and needs to feel safe while collaborating with such systems take priority. This demands a human-centric research vision and requires a societal and educational shift in how we perceive technological advancements. To better understand this perspective, we conducted a systematic literature review focusing on understanding how trust and trustworthiness can be key aspects of supporting this move towards Industry 5.0. This review aims to overview the most common methodologies and measurements and collect insights about barriers and facilitators for fostering trustworthy HRI. After a rigorous quality assessment following the Systematic Reviews and Meta-Analyses guidelines, using rigorous inclusion criteria and screening by at least two reviewers, 34 articles were included in the review. The findings underscores the significance of trust and safety as foundational elements for promoting secure and trustw
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext"})
→ call web_fetch({"max_chars":12000,"url":"https://europepmc.org/article/MED/38310895"})
→ call web_fetch({"max_chars":12000,"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11053165/"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": true, "url": "https://europepmc.org/article/MED/38310895", "status": 200, "content_type": "text/html;charset=UTF-8", "text": "Europe PMC Europe PMC 1 Sign in | Create an account https://orcid.org https://plus.europepmc.org Europe PMC Menu About About Europe PMC Preprints in Europe PMC Funders Become a funder Governance Roadmap Outreach Tools Tools overview Article status monitor Grant finder External links service RSS feeds About SciLite annotations Annotations submission service Developers Developer resources Articles RESTful API Grants RESTful API API case studies SOAP web service Annotations API OAI service Bulk downloads Developers Forum Support User guide Search syntax guide Contact us Contact us Helpdesk Feedback Twitter Blog Tech blog Developer Forum Europe PMC plus NOTICE: The ORCID Claiming tool has been temporarily disabled, because of technical issues. Please check back in later.", "truncated": false}
【tool:web_fetch】
{"ok": true, "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11053165/", "status": 200, "content_type": "text/html; charset=utf-8", "text": "NASA GeneLab derived microarray studies of Mus musculus and Homo sapiens organisms in altered gravitational conditions - PMC Skip to main content An official website of the United States government Here's how you know Here's how you know Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( Lock Locked padlock icon ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites. Search Log in Dashboard Publications Account settings Log out Search… Search NCBI Primary site navigation Search Logged in as: Dashboard Publications Account settings Log in Search PMC Full-Text Archive Search in PMC Journal List User Guide PERMALINK Copy As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice NPJ Microgravity . 2024 Apr 26;10:49. doi: 10.1038/s41526-024-00392-6 Search in PMC Search in PubMed View in NLM Catalog Add to search NASA GeneLab derived microarray studies of Mus musculus and Homo sapiens organisms in altered gravitational conditions Konstantinos I Adamopoulos Konstantinos I Adamopoulos 1 Nat
→ call search_memory({"limit":10,"query":"targeting ageing rapamycin derivatives humans systematic review 19 included studies"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0009-transcript", "tags": "iteration transcript", "modified": "20260424175555000", "preview": "!! 第 9 轮执行轨迹
→ call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin human trial systematic review endpoints safety\"}) 【tool:search_memory】 {\"ok\": true, \"results\": [{\"title\": \"Iter-4360dd15-0002-transcript\", \"tags\": \"iteration transcript\", \"modified\": \"20260424173549000\", \"preview\": \"!! 第 2 轮执行轨迹 → call search_memory({\"limit\":8,\"query\":\"4360dd15 rapamycin 2024 systematic review 19 studies Table 1 included trials endpoint\"}) → call list_recent({\"n\":6}) 【tool:search_memory】 {\"ok\": true, \"results\": [{ → call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" table included studies trial names"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" supplementary appendix"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" trial names rapamycin everolimus sirolimus"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" table included studies trial names", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.researchgate.net/publication/377976071_Targeting_ageing_with_rapamycin_and_its_derivatives_in_humans_a_systematic_review", "snippet": "A recent systematic review of human studies suggested Rap
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" supplementary appendix", "results": [{"title": "PDF Supplementary appendix - The Lancet", "url": "https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf", "snippet": "Supplementary appendix This appendix formed part of the original submission and has been peer reviewed. We post it as supplied by the authors. Supplement to: Lee DJW, Hodzic Kuerec A, Maier AB. Targeting ageing with rapamycin and its derivatives in humans : a systematic review. Lancet Healthy Longev 2024; 5: e152-62. Table of Contents"}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of th
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" trial names rapamycin everolimus sirolimus", "results": []}
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/cms/10.1016/S2666-7568(23)00258-1/attachment/6dc4a44a-1910-4435-ab52-a506c5f070b4/mmc1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" \"Table 1\" trial names"})
→ call web_search({"limit":10,"query":"\"rapamycin and its derivatives in humans\" \"19 included studies\" trial names"})
→ call web_search({"limit":10,"query":"site:scholar.google.com rapamycin derivatives humans systematic review 19 included studies"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" \"Table 1\" trial names", "results": []}
【tool:web_search】
{"ok": true, "query": "\"rapamycin and its derivatives in humans\" \"19 included studies\" trial names", "results": []}
【tool:web_search】
{"ok": true, "query": "site:scholar.google.com rapamycin derivatives humans systematic review 19 included studies", "results": []}
→ call web_search({"limit":10,"query":"\"6dc4a44a-1910-4435-ab52-a506c5f070b4\" rapamycin"})
→ call web_search({"limit":10,"query":"\"PIIS2666-7568(23)00258-1\" supplementary appendix table"})
→ call web_search({"limit":10,"query":"\"Lee Hodzic Kuerec Maier\" rapamycin appendix trial names"})
【tool:web_search】
{"ok": true, "query": "\"6dc4a44a-1910-4435-ab52-a506c5f070b4\" rapamycin", "results": []}
【tool:web_search】
{"ok": true, "query": "\"PIIS2666-7568(23)00258-1\" supplementary appendix table", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Lee Hodzic Kuerec Maier\" rapamycin appendix trial names", "results": []}
→ call web_search({"limit":10,"query":"\"10.1016/S2666-7568(23)00258-1\" trial names rapamycin everolimus sirolimus"})
【tool:web_search】
{"ok": true, "query": "\"10.1016/S2666-7568(23)00258-1\" trial names rapamycin everolimus sirolimus", "results": []}
→ call web_search({"limit":10,"query":"rapamycin human trials review 2024 studies Atherosclerosis gingival mucosa inflammation trial names"})
【tool:web_search】
{"ok": true, "query": "rapamycin human trials review 2024 studies Atherosclerosis gingival mucosa inflammation trial names", "results": [{"title": "UW periodontal study receives FDA approval for anti-aging drug use", "url": "https://dental.washington.edu/uw-periodontal-study-receives-fda-approval-for-anti-aging-drug-use/", "snippet": "The FDA has approved Dr. Jonathan An from UW Oral Health Sciences to lead the first-ever study to evaluate rapamycin in older adults with periodontal disease."}, {"title": "Rapamycin's Role in Periodontal Health and Therapeutics: A Scoping Review", "url": "https://journals.sagepub.com/doi/10.1177/23800844251366967", "snippet": "Animal studies confirmed rapamycin's role in alveolar bone preservation, inhibition of biofilm formation, immune modulation, and periodontal inflammation attenuation. Clinical studies primarily focused on rapamycin's effects on gingival overgrowth in transplant recipients, with limited data on periodontitis outcomes."}, {"title": "Blazing a trail for the clinical use of rapamycin as a geroprotecTOR", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10643772/", "snippet": "It is important to note that this is not an endorsement for or against the use of mTOR inhibitors, but rather a compendium of upcoming clinical trials leveraging the last two decades of pre-clinical data to help advance our understanding of the impact of rapamycin on human healthspan."}, {"title": "Targeting ageing with rapamycin and its d
→ call web_search({"limit":10,"query":"\"Past and Ongoing Human Rapamycin Trials\" rapamycin news review"})
→ call web_search({"limit":10,"query":"\"Blazing a trail for the clinical use of rapamycin as a geroprotecTOR\" trial names"})
→ call web_fetch({"max_chars":12000,"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10643772/"})
【tool:web_search】
{"ok": true, "query": "\"Past and Ongoing Human Rapamycin Trials\" rapamycin news review", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Blazing a trail for the clinical use of rapamycin as a geroprotecTOR\" trial names", "results": [{"title": "Blazing a trail for the clinical use of rapamycin as a geroprotecTOR", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10643772/", "snippet": "The Rapalog Pharmacology (RAP PAC) Trial led by Dr. Adam Konopka and colleagues at the University of Wisconsin-Madison will identify a recommended phase 2 weekly dose (RP2D) for the mTOR inhibitors rapamycin and everolimus by performing a phase I, dose finding trial in healthy older men and women (n =18 per drug per sex, 55-80years)."}, {"title": "New Review: Past and Ongoing Human Rapamycin Trials", "url": "https://www.rapamycin.news/t/new-review-past-and-ongoing-human-rapamycin-trials/9861", "snippet": "Blazing a trail for the clinical use of rapamycin as a geroprotecTOR Adam R. Konopka, Dudley W. Lamming, RAP PAC Investigators & EVERLAST Investigators GeroScience (2023) 06 October 2023 …Concerns over the risk of potentially serious side effects in humans, including immunosuppression and metabolic disruptions, have cautiously limited the translation of rapamycin and its analogs as a ..."}, {"title": "Blazing a trail for the clinical use of rapamycin as a geroprotecTOR", "url": "https://link.springer.com/article/10.1007/s11357-023-00935-x", "snippet": "Treatment with rapamycin, an inhibitor of the mechanistic Target Of Rapamycin Complex One (mTORC1) protein kinase, has been repeatedly demonstrated to ex
【tool:web_fetch】
{"ok": true, "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10643772/", "status": 200, "content_type": "text/html; charset=utf-8", "text": "Blazing a trail for the clinical use of rapamycin as a geroprotecTOR - PMC Skip to main content An official website of the United States government Here's how you know Here's how you know Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( Lock Locked padlock icon ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites. Search Log in Dashboard Publications Account settings Log out Search… Search NCBI Primary site navigation Search Logged in as: Dashboard Publications Account settings Log in Search PMC Full-Text Archive Search in PMC Journal List User Guide PERMALINK Copy As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Learn more: PMC Disclaimer | PMC Copyright Notice GeroScience . 2023 Oct 6;45(5):2769–2783. doi: 10.1007/s11357-023-00935-x Search in PMC Search in PubMed View in NLM Catalog Add to search Blazing a trail for the clinical use of rapamycin as a geroprotecTOR Adam R Konopka Adam R Konopka 1 Division of Geriatrics, Department of Medicine, University of Wisconsin-Madison, Madison, WI 53705 USA 2 William S. Middlet
【assistant】
本轮结论：
1. 已再次确认目标综述的精确出处：
**Lee DJW, Hodzic Kuerec A, Maier AB. _Targeting ageing with rapamycin and its derivatives in humans: a systematic review_**
期刊：**Lancet Healthy Longevity (2024)**，摘要明确写到 **19 included studies**。
2. 已拿到一个可访问、可核对的“骨架来源”：
- **PMC 综述 _Blazing a trail for the clinical use of rapamycin as a geroprotecTOR_ (2023)** 的 **Table 1** 给出了**8项已完成临床试验**的清单与主要终点框架。
- 这 8 项分别是：
- **Krebs et al. 2007**
- **Drummo