Iter-4360dd15-0009-transcript
第 9 轮执行轨迹
→ call search_memory({"limit":8,"query":"4360dd15 rapamycin mTOR systematic review 2024 trial endpoint PMC table remaining included studies"}) → call list_recent({"n":8})
→ call list_by_tag({"limit":20,"tag":"4360dd15"})
【tool:search_memory】
{"ok": true, "results": [{"title": "Iter-4360dd15-0007-transcript", "tags": "iteration transcript", "modified": "20260424174944000", "preview": "!! 第 7 轮执行轨迹
→ call search_memory({\\\"limit\\\":10,\\\"query\\"}, {"title": "Iter-4360dd15-0008-transcript", "tags": "iteration transcript", "modified": "20260424175230000", "preview": "!! 第 8 轮执行轨迹 → call search_memory({\\\"limit\\\":10,\\\"query\\\":\\\"4360dd15 rapamycin rapal"}, {"title": "Iter-4360dd15-0004-transcript", "tags": "iteration transcript", "modified": "20260424174235000", "preview": "!! 第 4 轮执行轨迹 【tool:list_recent】
{"ok": true, "items": [{"title": "Iter-4360dd15-0008-reflection", "modified": "20260424175236000", "tags": "iteration reflection"}, {"title": "NEXT_FOCUS", "modified": "20260424175236000", "tags": "pinned focus"}, {"title": "先锁定综述正文里的表，再追原始试验", "modified": "20260424175236000", "tags": "lesson evidence retrieval human-trials rapamycin"}, {"title": "Iter-4360dd15-0008-transcript", "modified": "20260424175230000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0007-reflection", "modified": "20260424174951000", "tags": "iteration reflection"}, {"title": "先用综述表做骨架再回填原始试验", "modified": "20260424174951000", "tags": "lesson evidence retrieval human-trials rapamycin"}, {"title": "Iter-4360dd15-0007-transcript", "modified": "20260424174944000", "tags": "iteration transcript"}, {"title": "Iter-4360dd15-0006-reflection", "modified": "20260424174710000", "tags": "iteration reflection"}]}
【tool:list_by_tag】
{"ok": true, "items": [{"title": "Added included ADPKD rapalog trial CRAD001ADE12 and its body-weight endpoint", "modified": "20260424174657000"}, {"title": "Rapamycin human trials: completed studies table from PMC review", "modified": "20260424174352000"}, {"title": "Iter-4360dd15-0004-critique-rapamycin-evidence", "modified": "20260424174226000"}, {"title": "Rapamycin human trials: extracted endpoints and outcomes from the 2024 systematic review review pass 1", "modified": "20260424173529000"}, {"title": "Human longevity interventions evidence maturity matrix 2026-04-25", "modified": "20260424173237000"}]}
→ call read_note({"title":"NEXT_FOCUS"})
【tool:read_note】
{"ok": true, "title": "NEXT_FOCUS", "tags": "pinned focus", "text": "!! 下轮焦点（来自 mission 4360dd15 · Iter-0008）\n\n只做一件事：从 2024 系统综述中提取尚未在 PMC 表中出现的其余纳入试验名称与主要终点。"}
→ call read_note({"title":"Rapamycin human trials: completed studies table from PMC review"})
【tool:read_note】
{"ok": true, "title": "Rapamycin human trials: completed studies table from PMC review", "tags": "knowledge fact 4360dd15", "text": "!! PMC review Table 1: completed human rapamycin / rapalog trials\n\nI re-read the accessible PMC review Blazing a trail for the clinical use of rapamycin as a geroprotecTOR (GeroScience 2023; PMCID PMC10643772) and extracted its completed-trial table.\n\n!! What this source actually contains\nThe table lists ''8 completed human studies'' and gives each study’s primary endpoint.\n\n!! Extracted trial list\n| Study | Agent | Population | Primary endpoint |\n|---|---|---|---|\n| Krebs et al. 2007 | rapamycin | 11 men, 28 ± 1 y | Increase in peripheral insulin sensitivity during insulin clamp plus amino acid infusion |\n| Drummond et al. 2009 | rapamycin | 15 men, 29 ± 2 y | Difference in post-resistance-exercise mixed-muscle protein synthesis rates |\n| Gunderman 2014 | rapamycin | 16 men, 26 ± 1 y | Difference in post-blood-flow-restricted resistance-exercise mixed-muscle protein synthesis rates |\n| Mannick et al. 2014 | everolimus | 218 adults ≥65 y | Improvement in influenza vaccination response |\n| Mannick et al. 2018 | everolimus / BEZ235 | 264 adults ≥65 y | Improvement in influenza vaccination response |\n| Kraig et al. 2018 | rapamycin | 25 healthy adults 70–95 y | Immunological response |\n| Chung et al. 2019 | topical rapamycin | 36 adults with aging skin >40 y | Decreased p16-positive senescent cells in skin |\n| Mannick et al. 20
→ call web_search({"limit":5,"query":"2024 systematic review rapamycin mTOR human trials included studies primary endpoints review"})
→ call pubmed_search({"limit":5,"query":"rapamycin mTOR systematic review human trials 2024 primary endpoint"})
→ call arxiv_search({"limit":5,"query":"rapamycin mTOR systematic review human trials 2024"})
【tool:web_search】
{"ok": true, "query": "2024 systematic review rapamycin mTOR human trials included studies primary endpoints review", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Articles included in this systematic review met the following criteria: the mean or median age of the study cohort was 18 years or older; outcomes on ageing-related physiological changes or disease were reported; and they were interventional studies with rapamycin or its derivatives (no restriction on the method). Articles were excluded if in vitro or animal models were used; rapamycin or its ..."}, {"title": "Review - ScienceDirect", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Although studies have reported that rapamycin and its derivatives can enhance learning and memory 49, 50 and reduce neurodegeneration in animal models,51 these effects were not observed in the human studies assessed in this systematic review .36, 41 Moreover, the reported effects on ageing-related macular changes were inconsistent."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://findanexpert.unimelb.edu.au/scholarlywork/1860397-targeting-ageing-with-rapamycin-and-its-derivatives-in-humans--a-systematic-review.", "snippet": "A search across five databases yielded 18 400 unique articles, resultin
【tool:pubmed_search】
{"ok": true, "query": "rapamycin mTOR systematic review human trials 2024 primary endpoint", "results": []}
【tool:arxiv_search】
{"ok": true, "query": "rapamycin mTOR systematic review human trials 2024", "results": [{"title": "Trust and Trustworthiness from Human-Centered Perspective in HRI -- A Systematic Literature Review", "authors": ["Debora Firmino de Souza", "Sonia Sousa", "Kadri Kristjuhan-Ling", "Olga Dunajeva", "Mare Roosileht", "Avar Pentel", "Mati Mõttus", "Mustafa Can Özdemir"], "published": "2025-01-31", "summary": "The Industry 5.0 transition highlights EU efforts to design intelligent devices that can work alongside humans to enhance human capabilities, and such vision aligns with user preferences and needs to feel safe while collaborating with such systems take priority. This demands a human-centric research vision and requires a societal and educational shift in how we perceive technological advancements. To better understand this perspective, we conducted a systematic literature review focusing on understanding how trust and trustworthiness can be key aspects of supporting this move towards Industry 5.0. This review aims to overview the most common methodologies and measurements and collect insights about barriers and facilitators for fostering trustworthy HRI. After a rigorous quality assessment following the Systematic Reviews and Meta-Analyses guidelines, using rigorous inclusion criteria and screening by at least two reviewers, 34 articles were included in the review. The findings underscores the significance of trust and safety as foundational elements for promoting secure and t
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" study table included 19 studies primary endpoint"})
→ call web_fetch({"max_chars":8000,"url":"https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext"})
→ call web_fetch({"max_chars":8000,"url":"https://www.sciencedirect.com/science/article/pii/S2666756823002581"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" study table included 19 studies primary endpoint", "results": [{"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies . Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases."}, {"title": "PDF Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf", "snippet": "A search across five databases yielded 18 400 unique articles, resulting in 19 included studies .
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(23)00258-1/fulltext'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.sciencedirect.com/science/article/pii/S2666756823002581'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":10,"query":"site:pubmed.ncbi.nlm.nih.gov \"Targeting ageing with rapamycin and its derivatives in humans\""})
→ call web_search({"limit":10,"query":"\"rapamycin and its derivatives in humans\" pdf"})
→ call web_search({"limit":10,"query":"\"A search across five databases yielded 18 400 unique articles, resulting in 19 included studies\" rapamycin"})
【tool:web_search】
{"ok": true, "query": "site:pubmed.ncbi.nlm.nih.gov \"Targeting ageing with rapamycin and its derivatives in humans\"", "results": []}
【tool:web_search】
{"ok": true, "query": "\"rapamycin and its derivatives in humans\" pdf", "results": [{"title": "PDF Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf", "snippet": "Deborah J W Lee*, Ajla Hodzic Kuerec*, Andrea B Maier Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the efects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.sciencedirect.com/science/article/pii/S2666756823002581", "snippet": "Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved ..."}, {"title": "Targeting ageing with rapamycin and its derivatives in humans: a ...", "url": "https://www.bohrium.com/paper-details/targeting-ageing-with-rapamycin-and-its-derivatives-in-humans-a-systematic-review/977530253830259671-81675", "snippet": "Rapamycin and it
【tool:web_search】
{"ok": true, "query": "\"A search across five databases yielded 18 400 unique articles, resulting in 19 included studies\" rapamycin", "results": []}
→ call web_fetch({"max_chars":12000,"url":"https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf"})
【tool:web_fetch】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://www.thelancet.com/pdfs/journals/lanhl/PIIS2666-7568(23)00258-1.pdf'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":20,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" trial names everolimus BEZ235 RTB101 sirolimus"})
→ call web_search({"limit":20,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" \"Krebs\" \"Drummond\" \"Gunderman\" \"Mannick\" \"Kraig\" \"Chung\""})
→ call web_search({"limit":20,"query":"site:pmc.ncbi.nlm.nih.gov rapamycin humans everolimus BEZ235 RTB101 trial aging review table"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" trial names everolimus BEZ235 RTB101 sirolimus", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" \"Krebs\" \"Drummond\" \"Gunderman\" \"Mannick\" \"Kraig\" \"Chung\"", "results": []}
【tool:web_search】
{"ok": true, "query": "site:pmc.ncbi.nlm.nih.gov rapamycin humans everolimus BEZ235 RTB101 trial aging review table", "results": []}
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" supplementary appendix"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" \"Figure 1\" trials"})
→ call web_search({"limit":10,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" reference list trial"})
→ call web_search({"limit":10,"query":"\"Deborah J W Lee\" rapamycin humans systematic review pdf"})
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" supplementary appendix", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" \"Figure 1\" trials", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Targeting ageing with rapamycin and its derivatives in humans\" reference list trial", "results": []}
【tool:web_search】
{"ok": true, "query": "\"Deborah J W Lee\" rapamycin humans systematic review pdf", "results": []}
→ call web_search({"limit":20,"query":"rapamycin human trial age-related disease 2024 review included studies immune cardiovascular integumentary names"})
→ call web_search({"limit":20,"query":"rapamycin everolimus BEZ235 RTB101 aging-related disease trial review immune cardiovascular skin endpoint names"})
→ call web_search({"limit":20,"query":"site:pubmed.ncbi.nlm.nih.gov rapamycin everolimus BEZ235 RTB101 elderly influenza vaccine skin senescence cardiovascular trial"})
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=rapamycin+human+trial+age-related+disease+2024+review+included+studies+immune+cardiovascular+integumentary+names'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=rapamycin+everolimus+BEZ235+RTB101+aging-related+disease+trial+review+immune+cardiovascular+skin+endpoint+names'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=site%3Apubmed.ncbi.nlm.nih.gov+rapamycin+everolimus+BEZ235+RTB101+elderly+influenza+vaccine+skin+senescence+cardiovascular+trial'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":20,"query":"rapamycin human trial elderly immune response everolimus everolimus BEZ235 RTB101 age-related review"})
→ call web_search({"limit":20,"query":"rapamycin human trial skin aging topical rapamycin Chung 2019 primary endpoint study"})
→ call web_search({"limit":20,"query":"rapamycin human trial cardiovascular ageing review older adults study endpoint"})
→ call web_search({"limit":20,"query":"rapamycin human trial disease ageing review study names primary endpoint influenza respiratory illness"})
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=rapamycin+human+trial+elderly+immune+response+everolimus+everolimus+BEZ235+RTB101+age-related+review'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=rapamycin+human+trial+skin+aging+topical+rapamycin+Chung+2019+primary+endpoint+study'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=rapamycin+human+trial+cardiovascular+ageing+review+older+adults+study+endpoint'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=rapamycin+human+trial+disease+ageing+review+study+names+primary+endpoint+influenza+respiratory+illness'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":20,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" abstract 19 included studies trial names"})
→ call web_search({"limit":20,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" \"19 included studies\" \"Table 1\""})
→ call web_search({"limit":20,"query":"\"Targeting ageing with rapamycin and its derivatives in humans\" \"ageing-related diseases\" rapamycin derivatives trial names"})
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=%22Targeting+ageing+with+rapamycin+and+its+derivatives+in+humans%22+abstract+19+included+studies+trial+names'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=%22Targeting+ageing+with+rapamycin+and+its+derivatives+in+humans%22+%2219+included+studies%22+%22Table+1%22'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=%22Targeting+ageing+with+rapamycin+and+its+derivatives+in+humans%22+%22ageing-related+diseases%22+rapamycin+derivatives+trial+names'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_search({"limit":10,"query":"rapamycin 2024 systematic review included study ADPKD body weight CRAD001ADE12"})
→ call web_search({"limit":10,"query":"rapamycin 2024 systematic review included study diabetic nephropathy everolimus"})
→ call web_search({"limit":10,"query":"rapamycin 2024 systematic review included study chronic kidney disease human trial mTOR"})
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=rapamycin+2024+systematic+review+included+study+ADPKD+body+weight+CRAD001ADE12'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=rapamycin+2024+systematic+review+included+study+diabetic+nephropathy+everolimus'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
【tool:web_search】
{"ok": false, "error": "Client error '403 Forbidden' for url 'https://html.duckduckgo.com/html/?q=rapamycin+2024+systematic+review+included+study+chronic+kidney+disease+human+trial+mTOR'\nFor more information check: https://developer.mozilla.org/en-US/docs/Web/HTTP/Status/403"}
→ call web_fetch({"max_chars":10000,"url":"https://findanexpert.unimelb.edu.au/scholarlywork/1860397-targeting-ageing-with-rapamycin-and-its-derivatives-in-humans--a-systematic-review."})
→ call web_fetch({"max_chars":10000,"url":"https://www.rapamycin.news/t/targeting-ageing-with-rapamycin-and-its-derivatives-in-humans-a-systematic-review/12262"})
→ call web_fetch({"max_chars":10000,"url":"https://www.bohrium.com/paper-details/targeting-ageing-with-rapamycin-and-its-derivatives-in-humans-a-systematic-review/977530253830259671-81675"})
【tool:web_fetch】
{"ok": true, "url": "https://findanexpert.unimelb.edu.au/scholarlywork/1860397-targeting-ageing-with-rapamycin-and-its-derivatives-in-humans--a-systematic-review", "status": 200, "content_type": "text/html; charset=utf-8", "text": "Targeting ageing with rapamycin and its derivatives in humans: a systematic review : Find an Expert : The University of Melbourne Find an Expert Contact Search Menu Help Report an issue Journal article Targeting ageing with rapamycin and its derivatives in humans: a systematic review DJW Lee, A Hodzic Kuerec, AB Maier Lancet Healthy Longevity | Published : 2024 DOI: 10.1016/S2666-7568(23)00258-1 Download PDF Cite Abstract Rapamycin and its derivatives (rapalogs) are inhibitors of mTOR, a major regulator of the ageing process. We aimed to summarise the effects of rapamycin and its derivatives on the severity of ageing-related physiological changes and disease in adults. A search across five databases yielded 18 400 unique articles, resulting in 19 included studies. Rapamycin and its derivatives improved physiological parameters associated with ageing in the immune, cardiovascular, and integumentary systems of healthy individuals or individuals with ageing-related diseases. Overall, no significant effects on the endocrine, muscular, or neurological systems were found. The effects of rapamycin or its derivatives.. View full abstract University of Melbourne Researchers Andrea Maier Author Grants Citation metrics 108 Scopus 134 Dimensions Keywords 4206
【tool:web_fetch】
{"ok": true, "url": "https://www.rapamycin.news/t/targeting-ageing-with-rapamycin-and-its-derivatives-in-humans-a-sys
```