📜 mission-4360dd15.log

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╭─── Iter 0091  [analyst]  @gpt-5.4-mini  mission=4360dd15 ─────────────
│ 目标: 找到让人类长生不老的方法
│ 视角: 以系统分析师视角，严格拆解、量化、对比各条可能路径。
╰───────────────────────────────────────────────────────────────────────

── round 1 ──
  ⟶ task_view({"max_depth": 6})
  ⟵ {"ok": true, "tree": "GOAL: 找到让人类长生不老的方法\n· [✓ done       ] root: 找到让人类长生不老的方法\n├─   [✓ done       ] n1: 建立 marker 锚定后的局部交换判定框架   ← 已完成 marker 锚定后的局部交换判定框架：固定 μ 锚点、排除触及 μ 的交换、用 greedy witness span 压缩候选窗口，并在触及 wit\n│  ├─   [✓ done       ] n5: 规范化 witness：固定 μ 锚点并限制一次交换的位置   ← 完成 w…

── round 2 ──
  ⟶ search_memory({"limit": 8, "mission_only": false, "query": "ABT-263 topical skin inflammation macrophage wound healing recovery interval"})
  ⟵ {"ok": true, "results": [{"title": "Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing", "tags": "fact method lesson 4360dd15", "mission": "", "modified": "20260425030358000", "preview": "!! Topical ABT-263 treatment reduces aged skin sen…

── round 3 ──
  ⟶ pubmed_search({"limit": 5, "query": "topical ABT-263 skin inflammation macrophage wound healing recovery topical navitoclax aged skin"})
  ⟵ {"ok": true, "query": "topical ABT-263 skin inflammation macrophage wound healing recovery topical navitoclax aged skin", "results": []}
  ⟶ web_search({"limit": 5, "query": "topical ABT-263 aged skin inflammation macrophage wound healing recovery"})
  ⟵ {"ok": false, "error": "[Errno 101] Network is unreachable"}

── round 4 ──
  ⟶ read_note({"title": "Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing"})
  ⟵ {"ok": true, "title": "Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing", "tags": "fact method lesson 4360dd15", "text": "!! Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing\n''Original study'…

── round 5 ──
  ⟶ pubmed_search({"limit": 10, "query": "39630941 navitoclax skin macrophage infiltration inflammation"})
  ⟵ {"ok": true, "query": "39630941 navitoclax skin macrophage infiltration inflammation", "results": [{"pmid": "39630941", "title": "Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing.", "source": "Aging (Albany NY)", "pubdate": "2024 Dec 3"…

── round 6 ──
  ⟶ pubmed_search({"limit": 10, "query": "39630941 macrophage infiltration inflammatory response topical ABT-263 skin"})
  ⟵ {"ok": true, "query": "39630941 macrophage infiltration inflammatory response topical ABT-263 skin", "results": [{"pmid": "39630941", "title": "Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing.", "source": "Aging (Albany NY)", "pubdate"…

── round 7 ──
  ⟶ web_fetch({"max_chars": 7000, "url": "https://pubmed.ncbi.nlm.nih.gov/39630941/"})
  ⟵ {"ok": true, "url": "https://pubmed.ncbi.nlm.nih.gov/39630941/", "status": 200, "content_type": "text/html; charset=utf-8", "text": "Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing - PubMed Clipboard, Search History, and several other …

── round 8 ──
  ⟶ web_fetch({"max_chars": 12000, "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11810067/"})
  ⟵ {"ok": true, "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11810067/", "status": 200, "content_type": "text/html; charset=utf-8", "text": "Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing - PMC Skip to main content An official websit…

── round 9 ──
  ⟶ pubmed_search({"limit": 8, "query": "skin wound healing macrophage infiltration peaks day 3 resolution day 7 review"})
  ⟵ {"ok": true, "query": "skin wound healing macrophage infiltration peaks day 3 resolution day 7 review", "results": []}
  ⟶ pubmed_search({"limit": 8, "query": "cutaneous inflammation resolution macrophage infiltration 7 days mouse skin"})
  ⟵ {"ok": true, "query": "cutaneous inflammation resolution macrophage infiltration 7 days mouse skin", "results": [{"pmid": "29553981", "title": "Local Administration of Interleukin-1 Receptor Antagonist Improves Diabetic Wound Healing.", "source": "Ann Plast Surg", "pubdate": "201…
  ⟶ pubmed_search({"limit": 8, "query": "skin senolytic topical inflammation resolution macrophages days mouse"})
  ⟵ {"ok": true, "query": "skin senolytic topical inflammation resolution macrophages days mouse", "results": []}

── round 10 ──
  ⟶ web_search({"limit": 10, "query": "skin wound healing macrophage infiltration peaks 3 days resolves 7 days review"})
  ⟵ {"ok": false, "error": "[Errno 101] Network is unreachable"}

── round 11 ──
  ⟶ read_note({"title": "ABT-263→OSK 间隔的保守锚定原则"})
  ⟵ {"ok": true, "title": "ABT-263→OSK 间隔的保守锚定原则", "tags": "fact lesson method 4360dd15 [[顺序干预的洗脱间隔先用药代锚定保守下界]] [[ABT-263]] [[OSK]]", "text": "!! ABT-263→OSK 间隔的保守锚定原则\n当 [[Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing]] 这类顺序实验缺少组织级 wash…

── round 12 ──
  ⟶ pubmed_search({"limit": 10, "query": "mouse skin wound macrophage infiltration day 3 day 7 resolution review"})
  ⟵ {"ok": true, "query": "mouse skin wound macrophage infiltration day 3 day 7 resolution review", "results": []}

── round 13 ──
  ⟶ search_memory({"limit": 10, "mission_only": false, "query": "wound healing inflammation phase mouse day 3 day 7 review"})
  ⟵ {"ok": true, "results": [{"title": "Topical ABT-263 treatment reduces aged skin senescence and improves subsequent wound healing", "tags": "fact method lesson 4360dd15", "mission": "", "modified": "20260425030358000", "preview": "!! Topical ABT-263 treatment reduces aged skin sen…

── round 14 ──